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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Aspects of Tumor Radiotherapy
edited by
submission deadline 20 Dec 2025 | Viewed by 98 | Submission Open
Keywords: radiotherapy resistance; tumor microenvironment; DNA damage response; metabolic reprogramming; combination therapies
(This special issue belongs to the Section Molecular Oncology)
Redox Physiology
edited by Mateusz Mołoń
submission deadline 21 Dec 2025 | Viewed by 404 | Submission Open
Keywords: redox physiology; reactive oxygen species (ROS); reactive nitrogen species (RNS); oxidative stress; oxidation; redox signaling
(This special issue belongs to the Section Molecular Biology)
Spectroscopic Techniques in Molecular Sciences
edited by
submission deadline 25 Dec 2025 | 5 articles | Viewed by 3256 | Submission Open
Keywords: spectroscopy; the structure; dynamics; interactions; and functions of molecules; chemical; biological; pharmaceutical; and materials systems
(This special issue belongs to the Section Molecular Biology)
25th Anniversary of IJMS: Updates and Advances in “Molecular Immunology”
edited by
submission deadline 25 Dec 2025 | 3 articles | Viewed by 2340 | Submission Open
Keywords: inflammation; innate immunity; adaptive immunity; genetics; epigenetics; immunometabolism; receptors; cytokines; cell therapy; immune checkpoint inhibitors
(This special issue belongs to the Section Molecular Immunology)
Epigenetic Regulation and Molecular Mechanisms in Cardiovascular Diseases submission deadline 25 Dec 2025 | 1 articles | Viewed by 2146 | Submission Open
Keywords: epigenetic regulation; cardiovascular disease; DNA methylation; histone modifications; non-coding RNAs; vascular inflammation; myocardial remodeling; molecular mechanisms; thera-peutic targets
(This special issue belongs to the Section Molecular Genetics and Genomics)
Molecular Endocrine Regulation in Health and Diseases
edited by Fady Hannah-Shmouni
submission deadline 25 Dec 2025 | 1 articles | Viewed by 2100 | Submission Open
Keywords: exposome and endocrine disruptors; endocrine-disrupting chemicals (EDCs); environmental toxicology and hormonal health; epigenetics and endocrine function; endocrine regulation and chronic disease; public health and exposure mitigation; endocrine disruptors in the home and community
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Therapeutic Horizons of Oligosaccharides: Molecular Mechanisms and Therapeutic Potential submission deadline 25 Dec 2025 | 2 articles | Viewed by 1974 | Submission Open
Keywords: oligosaccharides; bacterial infection; multidrug-resistant
(This special issue belongs to the Section Molecular Microbiology)
Molecular and Genetic Advances in Plant Breeding
edited by Francesca Taranto
submission deadline 25 Dec 2025 | 2 articles | Viewed by 1971 | Submission Open
Keywords: genetic diversity; next-generation sequencing; marker-assisted selection; GWAS/QTL mapping; KASP genotyping; molecular biology   TRANSLATE with x English Arabic Hebrew Polish Bulgarian Hindi Portuguese Catalan Hmong Daw Romanian Chinese Simplified Hungarian Russian Chinese Traditional Indonesian Slovak Czech Italian Slovenian Danish Japanese Spanish Dutch Klingon Swedish English Korean Thai Estonian Latvian Turkish Finnish Lithuanian Ukrainian French Malay Urdu German Maltese Vietnamese Greek Norwegian Welsh Haitian Creole Persian   //   TRANSLATE with COPY THE URL BELOW Back EMBED THE SNIPPET BELOW IN YOUR SITE Enable collaborative features and customize widget: Bing Webmaster Portal Back //     This page is in English   Translate to Simplified Chinese         Afrikaans Albanian Amharic Arabic Armenian Azerbaijani Bengali Bulgarian Catalan Croatian Czech Danish Dutch English Estonian Finnish French German Greek Gujarati Haitian Creole Hebrew Hindi Hungarian Icelandic Indonesian Italian Japanese Kannada Kazakh Khmer Korean Kurdish (Kurmanji) Lao Latvian Lithuanian Malagasy Malay Malayalam Maltese Maori Marathi Myanmar (Burmese) Nepali Norwegian Pashto Persian Polish Portuguese Punjabi Romanian Russian Samoan Simplified Chinese Slovak Slovenian Spanish Swedish Tamil Telugu Thai Traditional Chinese Turkish Ukrainian Urdu Vietnamese Welsh   Always translate English to Simplified Chinese Never translate English Never translate admin.mdpi.com
(This special issue belongs to the Section Molecular Plant Sciences)
Skin Cancer: From Molecular Pathophysiology to Novel Treatment
edited by Soon-Hyo Kwon
submission deadline 25 Dec 2025 | 2 articles | Viewed by 1887 | Submission Open
Keywords: basal cell carcinoma; malignant melanoma; molecular genetics; epigenetics; signaling pathways; tumor microenvironment; tumor resistance; biomarkers; molecular target; multiomics; genomics; transcriptomics; proteomics; metabolomics; skin cancer; squamous cell carcinoma
(This special issue belongs to the Section Molecular Oncology)
New Insights into Tryptophan Metabolism
edited by
submission deadline 25 Dec 2025 | Viewed by 273 | Submission Open
Keywords: tryptophan; serotonin; kynurenine; indole; metabolism; IPA; Tph; IDO1; health; disease
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Roots, Transporters, and Signals: Molecular Insights into Plant Mineral Nutrition and Heavy Metals Stress
edited by
submission deadline 25 Dec 2025 | Viewed by 184 | Submission Open
Keywords: plant mineral nutrition; heavy metals; toxic element; transporter; signaling pathway
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Insights in Diabetes submission deadline 25 Dec 2025 | Viewed by 181 | Submission Open
Keywords: insulin signalling pathway; pancreatic beta-cell dysfunction; oxidative stress; epigenetic modifications; metabolic memory; small regulatory RNAs (miRNAs); inflammation and insulin resistance; glucagon-like peptide-1 (GLP-1); glucose-dependent insulinotropic polypeptide (GIP); molecular therapeutic targets; glucose homeostasis regulation
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Microbial Bioconversion of Agri-Food Waste for the Production of Pharmacologically Active Compound
edited by Alicia Paz
submission deadline 25 Dec 2025 | Viewed by 118 | Submission Open
Keywords: microbial bioconversion; agri-food waste valorization; bioactive compounds; bioprocess optimization; pharmaceuticals; functional foods; cosmetic bioactives
(This special issue belongs to the Section Molecular Microbiology)
Emerging Strategy in Bacterial Antibiotic Resistance
edited by Lili Li
submission deadline 28 Dec 2025 | Viewed by 94 | Submission Open
Keywords: fast detection; antimicrobial resistance; virulence; antibacterial action of natural compounds
(This special issue belongs to the Section Molecular Microbiology)
Molecular Investigations in Neurodevelopmental Disorders
edited by Giorgio Medici
submission deadline 30 Dec 2025 | 9 articles | Viewed by 33037 | Submission Open
Keywords: neurodevelopmental disorders; brain; neurons; synapses; molecular research; regulatory networks; molecular pathways; biomarkers; therapies
(This special issue belongs to the Section Molecular Neurobiology)
Recent Research on Hypertension and Related Complications
edited by
submission deadline 30 Dec 2025 | 5 articles | Viewed by 22394 | Submission Open
Keywords: arterial hypertension; cardiovascular disease; pathophysiology; molecular mechanisms; complications
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Musculoskeletal Disorders: From Molecular Pathology to Novel Therapeutic Approach submission deadline 30 Dec 2025 | 9 articles | Viewed by 20680 | Submission Open
Keywords: joints; skeletal muscles; tendons; ligaments; fascia; articular cartilage; intervertebral discs; physiotherapy; novel therapies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Traumatic Brain Injury/Chronic Traumatic Encephalopathy as Cause of Alzheimer’s Disease: Physics and Molecular Biology in the Genesis of Neurodegeneration?
edited by
submission deadline 30 Dec 2025 | 6 articles | Viewed by 19949 | Submission Open
Keywords: traumatic brain injury (TBI); chronic traumatic encephalopathy (CTE); head impacts; Alzheimer's disease (AD); neurodegeneration
(This special issue belongs to the Section Molecular Neurobiology)
Biomedical Applications of Mesenchymal Stem Cells submission deadline 30 Dec 2025 | 7 articles | Viewed by 19245 | Submission Open
Keywords: mesenchymal stem cells; cell differentiation; cell therapy; regenerative medicine; tissue homeostasis; cartilage
(This special issue belongs to the Section Molecular Pharmacology)
Molecular Mechanisms and Treatments in Neurodegenerative Diseases submission deadline 30 Dec 2025 | 7 articles | Viewed by 18898 | Submission Open
Keywords: neurodegenerative diseases; regenerative therapy; neuroprotection; neurodegeneration; pathogenetic mechanisms; cell therapy
(This special issue belongs to the Section Molecular Neurobiology)
Neurobiological Mechanisms of Addictive Disorders
edited by Liliana Marina Cancela
submission deadline 30 Dec 2025 | 7 articles | Viewed by 18545 | Submission Open
(This special issue belongs to the Section Molecular Neurobiology)
The Characterization and Application of Enzymes in Bioprocesses submission deadline 30 Dec 2025 | 9 articles | Viewed by 16766 | Submission Open
Keywords: biocatalysts; enzymatic characterization; enzymatic action; protein engineering; biocatalysts application; bioprocessing
(This special issue belongs to the Section Biochemistry)
Potential Prevention and Treatment of Neurodegenerative Disorders submission deadline 30 Dec 2025 | 5 articles | Viewed by 16455 | Submission Open
Keywords: neurodegenerative disorders; molecular biomarkers; oxidative stress; therapeutic strategies; disease prevention
(This special issue belongs to the Section Molecular Neurobiology)
Challenges and Innovation in Neurodegenerative Diseases, 2nd Edition
edited by
submission deadline 30 Dec 2025 | 7 articles | Viewed by 15717 | Submission Open
Keywords: neurodegenerative diseases; pathogenesis; biomarkers; disease model; natural product; new drug discovery; therapy; machine learning; stem cell therapy
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Mechanisms and Signalling Pathways in Cardiovascular Pathophysiology
edited by Ernesto Alejandro Aiello
submission deadline 30 Dec 2025 | 5 articles | Viewed by 15606 | Submission Open
Keywords: heart; vascular; signaling; cardiovascular disease; mechanism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Animal Research Model for Neurological Diseases, 2nd Edition submission deadline 30 Dec 2025 | 5 articles | Viewed by 13833 | Submission Open
Keywords: experimental models; mouse; rat; zebrafish; neurological disease; Alzheimer’ s disease; Parkinson’ s disease; neurodegeneration; neuroregeneration
(This special issue belongs to the Section Molecular Neurobiology)
Host-Pathogen Interaction, 6th Edition
edited by
submission deadline 30 Dec 2025 | 5 articles | Viewed by 12460 | Submission Open
Keywords: microorganisms; pathogen; bacteria; yeasts; protozoa; host organisms
(This special issue belongs to the Section Molecular Microbiology)
The Role of Toll-Like Receptors (TLRs) in Infection and Inflammation: Third Edition
edited by and
submission deadline 30 Dec 2025 | 7 articles | Viewed by 11918 | Submission Open
Keywords: toll-like receptors (TLR); pathogen associated molecular patterns (PAMPs); sepsis; bacterial infections; viral infections; Myd88; TRIF; NF-kappaB; COVID-19; coagulopathies
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms and Therapeutic Innovations in Neurodegenerative Diseases: 2nd Edition
edited by Melania Maria Serafini and
submission deadline 30 Dec 2025 | 4 articles | Viewed by 10327 | Submission Open
Keywords: Alzheimer’ s disease; strokes; multiple sclerosis; amyotrophic lateral sclerosis; polyneuropathies; pain; diabetic retinopathy; neuroinflammation; dietary supplements; microbiome
(This special issue belongs to the Section Molecular Neurobiology)
Molecular Advances in Cancer and Cell Metabolism—2nd Edition submission deadline 30 Dec 2025 | 7 articles | Viewed by 10011 | Submission Open
Keywords: cell metabolism; cancer metabolism; cancer cell; oxidative stress; gene expression; signaling pathways; metabolic regulation; tumor growth; energy metabolism; metabolic phenotype; metabolic substrates
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Applications of Stem Cells and Extracellular Vesicles in Regenerative Medicine submission deadline 30 Dec 2025 | 3 articles | Viewed by 9414 | Submission Open
Keywords: regenerative medicine; pluripotent stem cells; cell differentiation; tissue engineering; gene editing; therapeutic potential; clinical applications; neurodegenerative disorders; disease modeling
(This special issue belongs to the Section Molecular Biology)
Genetic and Molecular Mechanisms of Obesity submission deadline 30 Dec 2025 | 3 articles | Viewed by 8747 | Submission Open
Keywords: obesity; insulin signal transduction; insulin sensitivity; co-morbidities; genetics; epigenetics; miRNAs; DNA methylation; molecular mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Central and Local Modulators of Reproduction and Fertility: An Update (4th Edition) submission deadline 30 Dec 2025 | 4 articles | Viewed by 8593 | Submission Open
Keywords: reproduction; fertility; HPG axis; testis; ovary; spermatogenesis; ovogenesis; gametes; GnRH; gonadotropins; sex steroids; kisspeptins; GnIH; metabolic sensors; leptin; endocannabinoids; autocrine/paracrine regulators; protein/peptide hormones; lipid mediators; epigenetics
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Pathogenicity and Antibiotic Resistance of Helicobacter pylori
edited by
submission deadline 30 Dec 2025 | 2 articles | Viewed by 8497 | Submission Open
Keywords: Helicobacter pylori; antibiotic resistance; antibiotic tolerance; point mutations; efflux pumps; biofilm formation; coccoid forms; membrane vesicles; virulence factors
(This special issue belongs to the Section Molecular Microbiology)
Mitochondrial Biology and Human Diseases submission deadline 30 Dec 2025 | 4 articles | Viewed by 8343 | Submission Open
Keywords: mitochondria; mitochondrial gene expression; bioenergetics; mitochondriopathies; human diseases
(This special issue belongs to the Section Molecular Biology)
Advances in Molecular Research on Autoimmune Diseases, 2nd Edition
edited by
submission deadline 30 Dec 2025 | 4 articles | Viewed by 8015 | Submission Open
Keywords: autoimmune markers; immunology; pathogenesis; immunogenetics; animal models; immunotherapy
(This special issue belongs to the Section Molecular Immunology)
Chromatin Remodelers as Players and Drivers in Pathological States
edited by Matteo De March
submission deadline 30 Dec 2025 | 3 articles | Viewed by 7476 | Submission Open
Keywords: protein structure/function; chromatin remodelers; DNA repair; oncogene/oncosuppressor; cancer
(This special issue belongs to the Section Molecular Biology)
IJMS 25th Anniversary: Updates and Progress on Bioactives and Nutraceuticals
edited by
submission deadline 30 Dec 2025 | 6 articles | Viewed by 7250 | Submission Open
Keywords: natural products; bioactive; nutraceutical; nutrient; health; dietary; functional food; vitamins; phytochemicals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Omics Technologies in Molecular Biology
edited by
submission deadline 30 Dec 2025 | 3 articles | Viewed by 6842 | Submission Open
Keywords: omics technologies; genomics; transcriptomics; proteomics; metabolomics; lipidomics; phenomics; enviromics; big data; machine learning; molecular biology
(This special issue belongs to the Section Molecular Biology)
25th Anniversary of IJMS: Updates and Advances in Molecular Microbiology
edited by
submission deadline 30 Dec 2025 | 5 articles | Viewed by 6785 | Submission Open
Keywords: bacteria fungi; bacteriophages; microalgae; microbiome; gut microbiota; environmental microbiome; microbiome– brain– gut axis; virus– host interactions; emerging viruses re-emerging viruses; virus mutation; biofilm antimicrobial; SARS-CoV-2 (COVID-19)
(This special issue belongs to the Section Molecular Microbiology)
Non-small Cell Lung Cancer: From Molecular Mechanisms to Therapeutic Strategies
edited by
submission deadline 30 Dec 2025 | 3 articles | Viewed by 6758 | Submission Open
Keywords: NSCLC; predictive and prognostic biomarkers; immunotherapy; targeted therapy; special populations
(This special issue belongs to the Section Molecular Oncology)
Plant and Environmental Interactions (Abiotic Stress)
edited by
submission deadline 30 Dec 2025 | 5 articles | Viewed by 6475 | Submission Open
Keywords: stress response; signal transduction; metabolism and secondary metabolism; material/vesicle transportation; rhizospheric microorganism; interactions between plants and microorganisms
(This special issue belongs to the Section Molecular Plant Sciences)
Biophysical Perspectives on Bone Physiology and Pathology
edited by Atsuhiko Ichimura and Yohei Ueda
submission deadline 30 Dec 2025 | 1 articles | Viewed by 6363 | Submission Open
Keywords: bone formation; bone disorders; physiology; pathology; stem cells; osteoblasts; osteoclasts
(This special issue belongs to the Section Molecular Biophysics)
Molecular Pathogenesis and Therapies for Retinal and Optic Nerve Diseases
edited by
submission deadline 30 Dec 2025 | 1 articles | Viewed by 6221 | Submission Open
Keywords: neurovascular unit; neurovascular cell death; neuroprotection; vasoprotection; regeneration; molecular and cellular pathologies; current and future therapies; drug delivery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Phenolic Accumulation and Application in Human Diseases submission deadline 30 Dec 2025 | 3 articles | Viewed by 6204 | Submission Open
Keywords: antioxidant effects; anticancer/antiproliferative activity; anti-inflammatory activity; antimicrobial effects bioactive polyphenols; chemical identification of plant compounds; chemistry and mechanisms of action; health beneficial effect; medicinal plant; molecular targets; natural products; phytochemicals; structure– activity relationship
(This special issue belongs to the Section Bioactives and Nutraceuticals)
The Effect of Food-Derived Compounds on Brown Fat Cell Function
edited by
submission deadline 30 Dec 2025 | 3 articles | Viewed by 5969 | Submission Open
Keywords: brown adipocyte; beige adipocyte; nutrients; food-derived components; thermogenesis; energy homeostasis; inflammation; obesity; diabetes; insulin resistance; metabolic syndrome; adipokines; lipid and carbohydrate metabolism
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Mechanisms of Bone Development and Differentiation in Health and Disease submission deadline 30 Dec 2025 | 3 articles | Viewed by 5815 | Submission Open
Keywords: bone differentiation; signaling pathways; bone diseases; bone formation; osteoblast; osteocyte; osteoclast
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cirrhosis: From Molecular Mechanisms to Therapeutic Strategies
edited by
submission deadline 30 Dec 2025 | 4 articles | Viewed by 5494 | Submission Open
Keywords: liver; fibrogenesis; cirrhosis; portal hypertension; complications; molecular mechanisms; pathway; therapeutic strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Influence of Environmental Factors on Disease and Health Outcomes
edited by
submission deadline 30 Dec 2025 | 3 articles | Viewed by 5393 | Submission Open
Keywords: environmental factors; ecophysiological determinations; genetic predispositions; gene expression; defensive responses; pathophysiological abnormalities; lifestyle diseases; polymorphisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Plant Natural Products for Human Health and Disease
edited by
submission deadline 30 Dec 2025 | 2 articles | Viewed by 5250 | Submission Open
Keywords: medicinal plants; phytochemistry; bioactive compounds; metabolomics; proteomics; antioxidants; signal transduction; immunomodulation; phytopharmacology; ethnopharmacology
(This special issue belongs to the Section Bioactives and Nutraceuticals)
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