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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Natural Products in Drug Discovery for Anticancer Treatment
edited by and Adrianna Sławińska-Brych
submission deadline 31 Jul 2025 | 4 articles | Viewed by 14242
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Medicinal Chemistry: From Drug Design to Drug Development submission deadline 31 Jul 2025 | 4 articles | Viewed by 9769
Keywords: medicinal chemistry; biological targets; drug synthesis; drug discovery; pharmaceutical chemistry; structure-activity relationships
(This special issue belongs to the Section Molecular Pharmacology)
Cheminformatics in Drug Discovery and Green Synthesis
edited by
submission deadline 31 Jul 2025 | 5 articles | Viewed by 6307
Keywords: cheminformatics; drug discovery; databases; in silico methods; green chemistry
(This special issue belongs to the Section Molecular Informatics)
Molecular Toxicology on the Environmental Impact of Pharmaceuticals submission deadline 31 Jul 2025 | 4 articles | Viewed by 5246
Keywords: pharmaceutic; cosmetic preparations; cosmetic products; cosmetic compounds; molecular mechanisms; environmental toxicity and/or persistence; mobility in soil/water compartment; bioconcentration or bioaccumulation
(This special issue belongs to the Section Molecular Toxicology)
Advancements in Cancer Biomarkers submission deadline 31 Jul 2025 | 6 articles | Viewed by 3761
Keywords: biomarkers; ctDNA; mircroRNA; proteomics; gene methylation; TIL; transcriptomics; micro RNA; tumor microenvironment; gene methylation; proteomics
(This special issue belongs to the Section Molecular Oncology)
Heterocyclic Compounds: Synthesis, Design, and Biological Activity
edited by
submission deadline 31 Jul 2025 | 3 articles | Viewed by 2837
Keywords: heterocycles; bioactive molecules and materials; pharmacophore; design; targeting; computer studies; synthesis and analysis; natural compounds; carbohydrates; physicochemical properties; biological screening
(This special issue belongs to the Section Biochemistry)
Latest Review Papers in Molecular Immunology, 3rd Edition submission deadline 31 Jul 2025 | 1 articles | Viewed by 2114
Keywords: molecular immunology; review; immune cells
(This special issue belongs to the Section Molecular Immunology)
Molecular Mechanisms of Bioactive Nutrients Promoting Health Through Gut Microbiota: 3rd Edition
edited by and
submission deadline 31 Jul 2025 | 2 articles | Viewed by 1947
Keywords: phytochemicals; complex carbohydrates; gut microbiota; prebiotics; probiotics; inflammation; molecular mechanisms; human health
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Natural Medicines and Functional Foods for Human Health
edited by Qiong Wang
submission deadline 31 Jul 2025 | 2 articles | Viewed by 1878
Keywords: functional food; natural medicine; traditional Chinese medicine; memory; depression; dementia; Alzheimer’ s disease; Parkinson’ s disease; space medicine; sleeplessness; anti-inflammation
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Structure-Based Design of Drugs and Biologically Active Molecules Based on Computer-Aided Drug Discovery submission deadline 31 Jul 2025 | 1 articles | Viewed by 1530
Keywords: drug design; virtual screening; bioinformatics; chemoinformatics; quantum chemistry
(This special issue belongs to the Section Molecular Informatics)
Genetic and Genomic Diagnostics for Rare Diseases
edited by
submission deadline 31 Jul 2025 | 3 articles | Viewed by 1340
Keywords: genome sequencing; molecular diagnosis; rare diseases; multi-omics; next-generation sequencing; long-read RNA-Seq
(This special issue belongs to the Section Molecular Genetics and Genomics)
Neurodegenerative Diseases: From Molecular Mechanisms to Pathophysiology (Second Edition)
edited by
submission deadline 31 Jul 2025 | 1 articles | Viewed by 1325
Keywords: neurodegenerative diseases; molecular mechanisms; physiology; cell death; autophagy; oxidative stress; inflammation; genetic factors; diet; cognitive functions; exosomes; blood– brain barrier; immunity
(This special issue belongs to the Section Molecular Neurobiology)
Current Developments in Glioblastoma Research and Therapy: 2nd Edition submission deadline 31 Jul 2025 | 2 articles | Viewed by 1212
Keywords: diagnostic; prognostic and predictive biomarkers of glioblastoma; ways to target glioma stem cells; targeting glioblastoma-related signaling pathways; epigenetics of glioblastoma; treatment resistance mechanisms; novel treatment options for glioblastoma; combinatorial therapies; immunotherapy; nanotherapy; the application of CRISPR/Cas9 in glioma research; molecular testing of long-term glioblastoma survivors
(This special issue belongs to the Section Molecular Neurobiology)
Applications of Mass Spectrometry in the Analysis of Bioactive and Plant Organic Compounds
edited by
submission deadline 31 Jul 2025 | 1 articles | Viewed by 1022
Keywords: mass spectrometry; VOCs; bioactive compounds; plant organic compounds; pharmaceutical research; metabolites
(This special issue belongs to the Section Biochemistry)
Mechanisms and Effects of Endocrine Disruptors and Environmental Contaminants on Cardiovascular Health
edited by
submission deadline 31 Jul 2025 | 1 articles | Viewed by 1011
Keywords: environmental exposure; emerging compounds; human health; risk assessment; adverse outcome pathway; new approach methodologies; one health
(This special issue belongs to the Section Molecular Toxicology)
Biomechanics of Cardiovascular Remodeling
edited by and Maximilian Doldi Philipp
submission deadline 31 Jul 2025 | 1 articles | Viewed by 954
Keywords: cardiovascular remodeling; cardiac imaging; cardiovascular intervention; cardiovascular pathways; cardiovascular research; structural heart disease; cellular signaling
(This special issue belongs to the Section Molecular Biophysics)
Cardiovascular Disease: Molecular Advances on Pathophysiology and Therapies—2nd Edition
edited by
submission deadline 31 Jul 2025 | 1 articles | Viewed by 877
Keywords: cardiovascular disease; heart failure; biomarkers; pathophysiology; ischemic heart disease; atherosclerosis; coronary microvascular dysfunction; pharmacology
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Selected Papers from the 13th International Conference on Carbonic Anhydrases and Other Research submission deadline 31 Jul 2025 | 1 articles | Viewed by 790
Keywords: metalloenzymes; carbonic anhydrase; inhibitors; activators; pharmacology; SLC-0111; anticancer agents
(This special issue belongs to the Section Biochemistry)
Recent Advances in Soybean Molecular Breeding
edited by Dong Cao
submission deadline 31 Jul 2025 | 1 articles | Viewed by 752
Keywords: soybean; plant architecture; adaptation; yield improvement; molecular breeding; nutritional quality traits; stress tolerance
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research on Advanced Optical Materials 2.0: From Materials to Applications
edited by and Won Yeop Rho
submission deadline 31 Jul 2025 | 1 articles | Viewed by 642
Keywords: metal materials; plasmonic materials; SERS substrates; fluorescence materials; dye-doped materials; quantum dots; up-conversion materials; carbon materials; meta materials; bioapplications; energy applications; LED applications; bioimaging; molecules; molecular dynamic simulations; molecular materials
(This special issue belongs to the Section Materials Science)
The Impact of Biomolecules on the Pathogenesis of Oral and Periodontal Diseases
edited by
submission deadline 31 Jul 2025 | 1 articles | Viewed by 617
Keywords: biomolecules; inflammatory mediators; enzymes; cytokines; dysbiosis; microbiome; genetic and epigenetic factors; oral and periodontal diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Insights in Metabolomics: Chromatography and Mass Spectrometry Applications in Cancer Research submission deadline 31 Jul 2025 | 1 articles | Viewed by 453
Keywords: metabolomics; chromatography; mass spectrometry; molecular oncology; cancer pathways; precision medicine
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Peptide and Protein Metalation submission deadline 31 Jul 2025 | 1 articles | Viewed by 416
Keywords: metallodrugs; metal ions; metal complexes; metal– protein interaction; metal– peptide interaction
(This special issue belongs to the Section Biochemistry)
Nerve Growth Factor (NGF): Molecular Functions and Therapeutic Implications
edited by and Pamela Rosso
submission deadline 31 Jul 2025 | Viewed by 366
Keywords: nerve growth factor; neurotrophic therapy; biomolecules; neurotrophic molecular pathways; neuroprotection; preclinical research; clinical research
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Pharmacology of Protein Kinase Inhibitor
edited by
submission deadline 31 Jul 2025 | Viewed by 306
Keywords: protein kinase inhibitor; molecular pharmacology; signaling pathway; preclinical/clinical evaluation; computational modeling; toxicity
(This special issue belongs to the Section Molecular Pharmacology)
Novel Insights into the Molecular Mechanisms of Pancreatitis
edited by
submission deadline 31 Jul 2025 | Viewed by 294
Keywords: acute pancreatitis; chronic pancreatitis; pancreatic fibrosis; mechanisms; digestive enzymes; inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Bioinformatics of Peptides and Proteins
edited by
submission deadline 31 Jul 2025 | Viewed by 281
Keywords: bioinformatics; peptides; proteins; computational modeling; peptide– protein interactions; multi-omics; peptide and protein design; comparative proteomics; molecular dynamics
(This special issue belongs to the Section Molecular Informatics)
Gut Microbiome Stability in Health and Disease
edited by and Yoshitohi Ogura
submission deadline 31 Jul 2025 | Viewed by 234
Keywords: gut microbiome stability; immune system; epithelial cell; mucous layer; antibiotics; diet; inflammatory bowel disease; gut microbial metabolites
(This special issue belongs to the Section Molecular Microbiology)
Molecular Genetics, Genomics and Breeding in Field Crops
edited by
submission deadline 31 Jul 2025 | 1 articles | Viewed by 198
Keywords: field crop; genomics; molecular genetics; breeding technologies; germplasm utilization
(This special issue belongs to the Section Molecular Plant Sciences)
Cell Death, Inflammation and Oxidative Stress in Neurodegenerative Diseases: 4th Edition
edited by
submission deadline 31 Jul 2025 | Viewed by 197
Keywords: apoptosis; autophagy; necrosis; reticulum stress; natural molecules; oxidative stress; therapeutic; signalling pathways
(This special issue belongs to the Section Molecular Neurobiology)
The Immune Regulation of Osteoclasts
edited by
submission deadline 31 Jul 2025 | Viewed by 182
Keywords: hematopoietic stem cells; osteoclasts; osteoblasts; osteocytes; stromal cells; T cells; B cells; macrophages; dendritic cells; interleukins; cytokines
(This special issue belongs to the Section Molecular Immunology)
Genomics and Epigenomics in Molecular Neurobiology
edited by
submission deadline 31 Jul 2025 | Viewed by 167
Keywords: genomics of brain disorders; neuroepigenetics; neurodegenerative disorders; Alzheimer’ s disease; Parkinson’ s disease
(This special issue belongs to the Section Molecular Neurobiology)
New Research on the Biological Activities of Natural Components and Their Application submission deadline 31 Jul 2025 | Viewed by 162
Keywords: natural compounds; traditional and medicinal plants; biological activities
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Metabolic Dynamics and Immune Surveillance in the Tumor Microenvironment
edited by
submission deadline 31 Jul 2025 | Viewed by 158
Keywords: cancer; TME; metabolism; immune cells; signaling pathway; therapy
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
The Neurotoxicity of Amyloid β-Protein
edited by
submission deadline 31 Jul 2025 | Viewed by 153
Keywords: alzheimer’ s disease; amyloid-β ; oligomer; phosphorylated tau; neurotoxicity; oxidative stress; biomarker; early diagnosis; Aβ -targeted therapy
(This special issue belongs to the Section Molecular Neurobiology)
Leukemias: Molecular Pathogenesis and Influence of the Microenvironment submission deadline 31 Jul 2025 | Viewed by 153
Keywords: acute myeloid leukemia; bone marrow microenvironment; cell– cell communication; drug resistance; leukemic stem cell; myelodysplastic syndrome; therapeutic strategy
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Synthesis and Transformations of Bioactive Cyclic Imides
edited by
submission deadline 31 Jul 2025 | Viewed by 151
Keywords: PROTAC; phthalimides; maleimides; cyclic imides; targeted protein degradation; protein labeling; antibody–drug conjugates; drug design and synthesis; drug conjugation
(This special issue belongs to the Section Biochemistry)
The Interaction Between Cell and Virus, 3rd Edition
edited by
submission deadline 31 Jul 2025 | Viewed by 140
Keywords: viral replication; gene expression; lytic infection; viral structure; viral assembly; cell signaling pathway; post-translational modification; immune evasion; viral tumorigenesis; antiviral medication
(This special issue belongs to the Section Molecular Microbiology)
Synthesis, Biosynthesis and Implications of Chalcones
edited by
submission deadline 31 Jul 2025 | Viewed by 139
Keywords: chalcones; biosynthesis; biochemistry
(This special issue belongs to the Section Biochemistry)
Peptide and Protein Drugs Against Infectious Diseases and Allergic Diseases
edited by
submission deadline 31 Jul 2025 | Viewed by 137
Keywords: peptide and protein drugs; infectious diseases; allergic diseases; hormones; antimicrobial peptides; neuropeptides; cell-penetrating peptides; enzyme inhibitors; vaccines; antibodies
(This special issue belongs to the Section Molecular Pharmacology)
Nanotechnology for Food Science—Innovations and Sustainable Solutions
edited by
submission deadline 31 Jul 2025 | Viewed by 134
Keywords: nanotechnology; nanomaterial synthesis; food safety; food science; nano-engineered food additives; nano-sensors
(This special issue belongs to the Section Molecular Nanoscience)
The Application of Large Language Model and Agents in Molecular Medicine and Molecular Biology
edited by and Hao Lv
submission deadline 31 Jul 2025 | Viewed by 133
Keywords: large language models; artificial intelligence; agents; biological data; medical data
(This special issue belongs to the Section Molecular Informatics)
Molecular Mechanisms of Plant Adaptation to Stress
edited by Yuanchun Ma
submission deadline 31 Jul 2025 | Viewed by 126
Keywords: plant; environmental stresses; signaling pathways; stress-responsive genes; transcription factors; phytohormones; crop resilience; breeding; genetic engineering
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular, Cellular and Systems Research on Neuroanatomy, Brain Function and Its Impact on Human Behavior
edited by
submission deadline 31 Jul 2025 | Viewed by 118
Keywords: central nervous system; neuroanatomy; human behavior; nuclei; neuronal circuits; connectivity channels
(This special issue belongs to the Section Molecular Neurobiology)
The Interaction Between Tumor Microenvironment and Cancer Stem Cell
edited by
submission deadline 31 Jul 2025 | Viewed by 117
Keywords: tumor microenvironment; cancer stem cells; innate and adaptive immunity; mesenchymal stromal cells
(This special issue belongs to the Section Molecular Oncology)
Emerging Therapeutic Potential of Organic Compound in Diseases submission deadline 31 Jul 2025 | Viewed by 114
Keywords: organic compounds; chemical analysis; medicinal chemistry; organic chemistry; organic synthesis; characterization techniques; cancers; chronic diseases; civilization diseases; degenerative and neurodegenerative diseases
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Extracellular Vesicles as Biomarkers in Personalized Medicine
edited by Thi Thuy Nguyen Dao
submission deadline 31 Jul 2025 | Viewed by 113
Keywords: extracellular vesicles; biomarkers; cancer; cardiovascular diseases; neurodegenerative diseases; personalized medicineg
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Age-Dependence of Neuroimmune Reactions
edited by
submission deadline 31 Jul 2025 | Viewed by 111
Keywords: age; neuroimmune dynamics; neuroimmune interaction; immune system; the central nervous system; age-related neuroinflammation; neurodegenerative diseases
(This special issue belongs to the Section Molecular Immunology)
NURR1 Biology in Neurological Disorders and Other Diseases submission deadline 31 Jul 2025 | Viewed by 110
Keywords: NURR1; regulation; chronic diseases; inflammation; neurodegenerative diseases; neurological diseases; cancer; inflammatory diseases
(This special issue belongs to the Section Molecular Biology)
DNA Methylation and Histone Modifications in Cellular Homeostasis
edited by
submission deadline 31 Jul 2025 | Viewed by 110
Keywords: chromatin modification; DNA methylation; histone post-translational modifications; transcriptional regulation; epigenetic landscapes; cellular homeostasis; epigenome analysis; eukaryotic evolution
(This special issue belongs to the Section Molecular Genetics and Genomics)
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