Synthesis and Transformations of Bioactive Cyclic Imides
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Biochemistry".
Deadline for manuscript submissions: closed (20 February 2026) | Viewed by 703
Special Issue Editor
Interests: indole derivatives; 8-hydroxyquinolines; 4-hydroxyquinoline-2-carboxylic acid (KYNA) derivatives; β-carbolines; drug design and synthesis; ortho-quinone methides; modified Mannich reaction; modified aza-Friedel–Crafts reaction
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Special Issue Information
Dear Colleagues,
We are delighted to announce a call for submissions to this Special Issue of the International Journal of Molecular Sciences, entitled “Synthesis and Transformations of Bioactive Cyclic Imides”.
Molecules bearing imide fragments are widely known for their versatile biological activities; thus, these compounds show great prospects within novel bioactive agents.
Glutarimide and thalidomide derivatives are essential fragments for the synthesis of various proteolysis targeting chimera (PROTAC) compounds in the field of proximity-driven drug degradation. As these compounds readily bind to the protein Cereblon, the targeted degradation of various proteins becomes possible via utilizing the ubiquitin–proteasome system, making valuable assets in the fight against a broad range of diseases, e.g., different types of malignancies.
Digressing further from protein degradation, compounds bearing maleimide moiety, on the other hand, are valuable tools for targeted protein conjugation, essential for the synthesis of novel antibody–drug conjugates (ADCs) and the labeling of various proteins.
Phthalimides could be mentioned as a third valuable group of imides. These compounds have various biological properties, such as anticancer, antibacterial, and antiviral properties, along with benign effects on various neurological diseases.
Lead by Prof. Dr. István Szatmáriand and assisted by Dr. Péter Simon (University of Szeged), we encourage submissions of both original research articles and topical reviews on all aspects of synthesis and pharmacological studies on different imide derivatives to this Special Issue. All submitted articles will be subject to peer review.
Prof. Dr. István Szatmári
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- PROTAC
- phthalimides
- maleimides
- cyclic imides
- targeted protein degradation
- protein labeling
- antibody–drug conjugates
- drug design and synthesis
- drug conjugation
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