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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Radiobiology: New Challenges and Advances

edited by Lorenzo Manti and

Pavel Bláha

submission deadline 30 Apr 2026 | Viewed by 44 | Submission Open

Keywords: strategies for overcoming cancer radioresistance and normal-tissue damage mitigation; combined approaches: BNCT; proton– boron capture therapy; radioimmunotherapy; emerging technologies and novel temporal regimes: FLASH RT mechanisms and radiobiology of laser-accelerated particles; radiobiology of new ions and of novel dose-delivery modalities in particle radiotherapy; limphopoenia in radiotherapy and biomarkers of radiation response; three-dimensional models; microdosimetry: standardising measurements; DNA damage/repair; tumour microenvironment: autophagy; ferroptosis; fibroblast activation protein; non-cancer effects and non-targeted effects

(This special issue belongs to the Section Molecular Biology)

Emerging Targeted Therapies and Evolving Treatment Paradigms in Non-Small Cell Lung Cancer

edited by Luis E. Raez

submission deadline 30 Apr 2026 | Viewed by 43 | Submission Open

Keywords: non-small cell lung cancer (NSCLC); targeted therapies; human epidermal growth factor receptor 2 (HER2); mesenchymal-epithelial transition factor (MET); anaplastic lymphoma kinase (ALK); C-ROS oncogene 1 receptor tyrosine kinase (ROS1); rearranged during transfection (RET); neurotrophic tyrosine receptor kinase (NTRK); B-Raf proto-oncogene serine/threonine kinase V600 mutation (BRAFv600); Kirsten rat sarcoma viral oncogene homolog (KRAS); epidermal growth factor receptor (EGFR)

(This special issue belongs to the Section Molecular Oncology)

From Molecule to Mind: Neuropharmacology of Psychoactive Alkaloids and Next-Generation Neuroactives

edited by Kyoko Koshibu

submission deadline 30 Apr 2026 | Viewed by 43 | Submission Open

Keywords: psychoactive alkaloids; neuropharmacology; bioactive compounds; performance enhancement; addiction; translational research; cognitive modulation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Role of Complement Regulation in Kidney Disease

edited by Jasmina Marković Lipkovski

submission deadline 30 Apr 2026 | Viewed by 42 | Submission Open

Keywords: complement system; kidney disease; glomerulonephritis; C3 glomerulopathy; membranous nephropathy; complement regulation; innate immunity; molecular pathology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Mechanistic Insights into the Ubiquitin System’s Role in Cellular Signal Transduction and Homeostasis

edited by Michael Massiah

submission deadline 30 Apr 2026 | Viewed by 41 | Submission Open

Keywords: ubiquitination; protein homeostasis; deubiquitinases; E3-associated diseases; autophagy; ubiquitin dysregulation; proteasome-targeting; protac

(This special issue belongs to the Section Molecular Biology)

Cutting Edge Advances in Wound Healing

edited by Fui Ping Lim

submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open

Keywords: wound repair; molecular pathways; regenerative biology; tissue remodelling; inflammation modulation

(This special issue belongs to the Section Molecular Biology)

Dietary Interventions for Type 2 Diabetes: Current Evidence and Emerging Perspectives on Underlying Molecular Mechanisms

edited by Caterina Formichi

submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open

Keywords: type 2 diabetes; nutritional intervention; dietary strategies; nutrients; personalized nutrition; diet; metabolic health

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Bioactive Phenolic Compounds in Human Health and Disease: Second Edition

edited by

Andrei Lobiuc

submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open

Keywords: novel sources; synthesis; biological activity; molecular interactions; pharmacodynamics; pharmacokinetics; assay development; microbiota; sources and intake

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Genomic and Epigenetic Determinants of Circulating Cell-Free DNA Release in Cancer

edited by

Federica Maione

submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open

Keywords: genomic alterations; epigenetic modifications; chromosomal instability; aneuploidy and DNA fragmentation; tumor cell-derived cell-free DNA release; chromosome methylation; liquid biopsy; gene-gene interactions; cell death

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances on Gut Microbiota in Human Health

edited by

Sanda Cretoiu

submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open

Keywords: gut microbiota; dysbiosis; metabolomics; host– microbe interaction; molecular pathways; inflammation; personalized medicine

(This special issue belongs to the Section Molecular Microbiology)

Bioactive Food Components in Human Health

edited by

Kamila Rachwał

and Klaudia Gustaw

submission deadline 30 Apr 2026 | Viewed by 36 | Submission Open

Keywords: bioactive compounds; functional food; phytochemicals; bioactive peptides; health-promoting foods; food chemistry; polyphenols; natural products; human health; prebiotic compounds; bioavailability; nutraceuticals; bioaccessibility

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Nanoscale Materials for Advanced Electrocatalysts

edited by

Safia Khan

submission deadline 30 Apr 2026 | Viewed by 36 | Submission Open

Keywords: nanomaterials; electrocatalysis; electrocatalysts; energy conversion; fuel cells

(This special issue belongs to the Section Molecular Nanoscience)

Electrochemical Detection: A Molecular-Level Perspective

edited by Katarzyna Fendrych and

Joanna Smajdor-Baran

submission deadline 30 Apr 2026 | Viewed by 34 | Submission Open

Keywords: electrochemical detection; molecular sensing; biosensors; nanostructured electrodes; biomolecular interactions; electroanalytical chemistry; molecular electrochemistry

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Interdisciplinary Molecular Design: Catalysis, Therapeutics, and Biomaterials

edited by

Zhiwei Yang

submission deadline 30 Apr 2026 | Viewed by 34 | Submission Open

Keywords: intelligent molecular design; computational catalysis; antibody and protein engineering; biomaterials design; molecular dynamics simulations; AI in drug discovery

(This special issue belongs to the Section Molecular Biophysics)

Recent Advances in Sperm Physiology and Genetics

edited by Jordi Ribas-Maynou and Ariadna Delgado Bermudez

submission deadline 30 Apr 2026 | Viewed by 33 | Submission Open

Keywords: sperm; DNA; chromatin; physiology; reproduction

(This special issue belongs to the Section Molecular Genetics and Genomics)

New Perspectives in Cardiovascular Disease: From Molecular Mechanisms to Clinical Innovations

edited by

Yunglung Chen

submission deadline 30 Apr 2026 | Viewed by 33 | Submission Open

Keywords: cardiovascular disease; molecular mechanisms; biomarkers; atrial fibrillation; translational medicine

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Composites of Cellulose and Cellulose Derivatives: Engineering and Applications

edited by

Omar A. El Seoud

submission deadline 30 Apr 2026 | Viewed by 31 | Submission Open

Keywords: cellulose composites: engineering and applications; composites of cellulose esters: engineering and applications; composites of cellulose ethers: engineering and applications; molecular interactions within cellulose and its derivatives; molecular interactions within composites of cellulose and its derivatives

(This special issue belongs to the Section Macromolecules)

Emerging Biological Markers and Molecular Targets in Bladder Cancer

edited by Stanislav Žiaran

submission deadline 30 Apr 2026 | Viewed by 31 | Submission Open

Keywords: bladder cancer; biomarkers; urothelial carcinoma; molecular pathways; liquid biopsy; extracellular matrix; omics profiling; precision medicine; tissue engineering; translational urology

(This special issue belongs to the Section Molecular Oncology)

Stem Cells for Biomedical Applications

edited by

Sorina Dinescu

submission deadline 30 Apr 2026 | Viewed by 30 | Submission Open

Keywords: stem cells biology; stem cells differentiation; stem cell-based regenerative therapies; stem cells exosomes; personalized medicine; stem cell-based 3D models

(This special issue belongs to the Section Molecular Biology)

Design, Synthesis and Development of Anticancer Drugs Targeting the Tumor Microenvironment

edited by

Yoshihiro Uto

submission deadline 30 Apr 2026 | Viewed by 29 | Submission Open

Keywords: anticancer drugs; tumor microenvironment; in vivo model; cancer-associated fibroblast; tumor-associated macrophage; tumor hypoxia; tumor endothelial cells

(This special issue belongs to the Section Molecular Oncology)

Research Advances in Plant Interactions with Bacteria and Fungi: From Molecular to Ecological Perspectives

edited by

Jessie Fernandez

submission deadline 30 Apr 2026 | Viewed by 28 | Submission Open

Keywords: plant-microbe interactions; plant-bacteria interactions; plant-fungi interactions; biocontrol; beneficial microbes; endophytes; microbiome; plant growth-promoting microbes; synthetic microbial communities

(This special issue belongs to the Section Molecular Plant Sciences)

Insulin Resistance Mechanisms: From Epigenetics to Receptor-Mediated Signaling Pathways

edited by

Angélica Rueda

and

Jesús Alberto Olivares-Reyes

submission deadline 30 Apr 2026 | Viewed by 27 | Submission Open

Keywords: epigenetics; insulin receptor; insulin resistance; inflammation; metabolic syndrome; protein phosphorylation; cardiometabolic syndrome

(This special issue belongs to the Section Molecular Genetics and Genomics)

Advances on Viral Immunology and Pathogenesis of Viral Infections

edited by Yeong-Bin Baek

submission deadline 30 Apr 2026 | Viewed by 24 | Submission Open

Keywords: viral immunology; viral pathogenesis; innate sensing and interferon; cytokine networks and inflammasomes; adaptive immunity (T- and B-cell quality); immunometabolism and lipid signaling; host-directed antiviral strategies; transcriptomics and spatial omics; mechanism of action and target engagement; complex bioactive modulators

(This special issue belongs to the Section Molecular Microbiology)

Molecular Crosstalk Between Allergens, Microbes, and the Mucosal Immune System

edited by Stefanie Gilles

submission deadline 30 Apr 2026 | Viewed by 24 | Submission Open

Keywords: allergens and innate immunity; mucosal immune signaling; epithelial barrier and inflammation; pathogen-allergen crosstalk; bioaerosol exposure; allergen recognition mechanisms; environmental immunology

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms of Dysfunctional Neural Circuits in Brain Disorders

edited by

Yun Li

submission deadline 30 Apr 2026 | Viewed by 23 | Submission Open

Keywords: dynamic wiring; brain network; brain connectivity; neuropathology; neuromodulation; neuroplasticity; circuit mapping

(This special issue belongs to the Section Molecular Neurobiology)

Applications of Polysaccharides in Biomedicine and Agriculture

edited by

Artur Valente

and

Edvani C. Muniz

submission deadline 30 Apr 2026 | Viewed by 3 | Submission Open

Keywords: polysaccharides; carbohydrates; oligosaccharides; biomedical applications; pharmaceutical applications; drugs

(This special issue belongs to the Section Macromolecules)

From Molecular Insights to Novel Therapies: Neurological Diseases

edited by

Margarita Neganova

submission deadline 20 May 2026 | 17 articles | Viewed by 69044 | Submission Open

Keywords: neurological diseases; neurodegenerative diseases; epilepsy; mental illness; transgenic animal models; molecular pathways; metabolism disabilities; mitochondrial dysfunction; oxidative stress; disturbances in epigenetic regulation

(This special issue belongs to the Section Molecular Neurobiology)

Targeted Therapy for Immune Diseases

edited by

Alexey Sarapultsev

submission deadline 20 May 2026 | 15 articles | Viewed by 48719 | Submission Open

Keywords: targeted therapy; immune diseases; biologics; immunotherapy; precision medicine; nanoparticles; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Fascial Anatomy and Histology: Advances in Molecular Biology

edited by

Carla Stecco

submission deadline 20 May 2026 | 4 articles | Viewed by 30320 | Submission Open

Keywords: fascia; connective tissue; myofascial pain; collagen; hyaluronan

(This special issue belongs to the Section Molecular Biology)

Plant Responses to Biotic and Abiotic Stresses

edited by

Shu Yuan

submission deadline 20 May 2026 | 21 articles | Viewed by 27602 | Submission Open

Keywords: plant enzymes and metabolites; abiotic stress; stress response; phytohormones; secondary metabolism; gene regulation network; developmental and environmental adaptation; microbial interactions; biotic stress; pathogen response

(This special issue belongs to the Section Molecular Plant Sciences)

Natural Compounds in Cancer Therapy and Prevention, 2nd Edition

edited by

Federica Finetti

and

Lorenza Trabalzini

submission deadline 20 May 2026 | 6 articles | Viewed by 25367 | Submission Open

Keywords: cancer therapy cancer prevention; natural compounds; metastasis; immunomodulation; adjuvant therapy; preventive therapy; drug discovery; natural drugs

(This special issue belongs to the Section Molecular Pharmacology)

Advances in Anti-Inflammatory Activity of Natural Products of Plant Origin

edited by Radoslaw Zajdel

submission deadline 20 May 2026 | 2 articles | Viewed by 24768 | Submission Open

Keywords: anti-inflammatory; phytochemicals; natural products; medicinal plants; inflammation; cytokines; NF-κ B pathway; cyclooxygenase inhibitors; flavonoids; terpenoids; polyphenols; molecular mechanisms; drug discovery; ethnopharmacology; metabolomics

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Rare Genetic Diseases: From Molecular Mechanisms to Therapeutic Strategies

edited by

Maria Arnedo

submission deadline 20 May 2026 | 6 articles | Viewed by 22071 | Submission Open

Keywords: rare genetic disease; innate metabolic errors; neurodegenerative diseases; therapeutic; molecular diagnosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Innovative Nanomaterials from Functional Molecules

edited by Xiaoming Zhang and

Yi Jia

submission deadline 20 May 2026 | 5 articles | Viewed by 20734 | Submission Open

Keywords: functional materials; molecular design; molecular assembly; medicine; catalysis; battery; supercapacitor; sensing

(This special issue belongs to the Section Molecular Nanoscience)

Omics Science and Research in Human Health and Disease

edited by Elisa De Paolis

submission deadline 20 May 2026 | 7 articles | Viewed by 19057 | Submission Open

Keywords: genomics; transcriptomics; proteomics; metabolomics; single-cell analysis; spatial transcriptomics; bioinformatics; multi-omics

(This special issue belongs to the Section Molecular Biology)

Skeletal Muscle Function and Metabolism: Molecular Mechanisms and Treatment—2nd Edition

edited by

Andrea Telek

submission deadline 20 May 2026 | 5 articles | Viewed by 15146 | Submission Open

Keywords: skeletal muscle; metabolism; mitochondria; epigenetics; exercise; signalization

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

102nd Anniversary of Neurotransmitter Discovery: Cholinergic Pathways in Physiology and Pathophysiology

edited by

Sumonto Mitra

submission deadline 20 May 2026 | 4 articles | Viewed by 14091 | Submission Open

Keywords: acetylcholine; physiological functions; pathological alterations; cholinergic pathways

(This special issue belongs to the Section Biochemistry)

Advances in Melanoma and Skin Cancers: 2nd Edition

edited by

Domenico Mallardo

Debora Basile

and Maria Grazia Vitale

submission deadline 20 May 2026 | 6 articles | Viewed by 13853 | Submission Open

Keywords: melanoma; immunotherapy; biomarkers; translational research; drug repurposing; clinical outcome; prognostic markers; predictive markers; combination immunotherapy

(This special issue belongs to the Section Molecular Oncology)

The Role of Oxidative Stress and Antioxidants in Human Disease

edited by

Federica Mannino

submission deadline 20 May 2026 | 7 articles | Viewed by 12691 | Submission Open

Keywords: oxidative stress; free radicals; antioxidants; reactive oxygen species (ROS); polyphenols

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Liver Fibrosis: Molecular Pathogenesis, Diagnosis and Treatment

edited by Manuel Morales-Ruiz

submission deadline 20 May 2026 | 6 articles | Viewed by 12356 | Submission Open

Keywords: liver fibrosis; cirrhosis; hepatic stellate cells; collagen; fibrogenic pathways; diagnosis of fibrosis; therapeutic strategies for liver disease; extracellular matrix remodeling; cell-to-cell interactions; fibrosis complications

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plant-Derived Bioactives: Antioxidant Mechanisms and Preventive Health Strategies

edited by

Charles Manful

submission deadline 20 May 2026 | 4 articles | Viewed by 12263 | Submission Open

Keywords: antioxidant; plant-derived bioactive compounds; flavonoids; oxidative stress; mechanisms of action

(This special issue belongs to the Section Bioactives and Nutraceuticals)

The Roles of Photodynamic Therapy in Tumors and Cancers

edited by Jianyong Liu

submission deadline 20 May 2026 | 4 articles | Viewed by 11568 | Submission Open

Keywords: photodynamic therapy; PDT; photodetection; photosensitizers; photosensitizing agents; reactive oxygen species; molecular mechanisms; cell necrosis; apoptosis; singlet oxygen; synergetic therapy; combination therapy; delivery vehicles; immunophototherapy; nano-photosensitizer

(This special issue belongs to the Section Molecular Oncology)

The Role of Mesenchymal Stem Cells in Organ Repair and Tissue Regeneration

edited by

Sara Cruciani

submission deadline 20 May 2026 | 6 articles | Viewed by 11072 | Submission Open

Keywords: stem cells; differentiation; cell therapy; tissue regeneration; cell mechanisms; regenerative medicine; immunomodulation

(This special issue belongs to the Section Molecular Biology)

Pathogenesis and Novel Therapeutic Approaches for Sarcomas

edited by Francisco Giner

submission deadline 20 May 2026 | 4 articles | Viewed by 10980 | Submission Open

Keywords: soft tissue tumors; bone tumors; molecular biology; target therapies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights in Antivirals and Vaccines

edited by

Gergana Zahmanova

Ivan Minkov

and

Yoana Dimitrova Kiselova-Kaneva

submission deadline 20 May 2026 | 2 articles | Viewed by 10835 | Submission Open

Keywords: new vaccine platforms; cell cultures; plant molecular farming; vaccines and VLPs; nanoparticle vaccines; emerging viral diseases; novel therapeutics; biologics; antibodies; receptor modulators; plant-based compounds with antiviral activity; medicinal plant-derived products; bioactive proteins from plants

(This special issue belongs to the Section Molecular Microbiology)

Molecular Mechanisms and Therapies of Colorectal Cancer: 4th Edition

edited by

Donatella Delle Cave

submission deadline 20 May 2026 | 7 articles | Viewed by 10696 | Submission Open

Keywords: transforming growth factor beta (TGF-β ) signaling; genetic alterations; molecular targeted therapy precision medicine

(This special issue belongs to the Section Molecular Oncology)

New Cardiovascular Risk Factors: 2nd Edition

edited by

Antonio Barbato

submission deadline 20 May 2026 | 4 articles | Viewed by 10547 | Submission Open

Keywords: atherosclerosis; cardiovascular risk; arterial stiffness; blood pressure; vitamin D; miRNA; inflammation

(This special issue belongs to the Section Molecular Biology)

Applications of Stem Cells and Extracellular Vesicles in Regenerative Medicine

edited by

Ramya Lakshmi Rajendran

and

Prakash Gangadaran

submission deadline 20 May 2026 | 3 articles | Viewed by 10546 | Submission Open

Keywords: regenerative medicine; pluripotent stem cells; cell differentiation; tissue engineering; gene editing; therapeutic potential; clinical applications; neurodegenerative disorders; disease modeling

(This special issue belongs to the Section Molecular Biology)

The Impact of Mitochondria on Human Disease and Health

edited by

Martina Semenzato

submission deadline 20 May 2026 | 5 articles | Viewed by 10158 | Submission Open

Keywords: mitochondrial dysfunction; mitochondrial bioenergetics; mitochondrial dynamics; mitophagy; oxidative stress; mitochondrial DNA (mtDNA) mutations; neurodegenerative diseases; cardiovascular diseases; metabolic disorders; aging and mitochondria; cancer

(This special issue belongs to the Section Biochemistry)

Exploring the Molecular Mechanisms of Chronic Kidney Disease

edited by

Juan Miguel Diaz-Tocados

submission deadline 20 May 2026 | 5 articles | Viewed by 10095 | Submission Open

Keywords: chronic kidney disease; hereditary renal disease; renal hypertension; diabetic nephropathy; secondary hyperparathyroidism; cardiovascular disease; renal osteodystrophy; peritoneal dialysis; hemodialysis; anemia; metabolic acidosis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 2551-2600 on page 52 of 68.

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