Liver Fibrosis: Molecular Pathogenesis, Diagnosis and Treatment
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 20 October 2025 | Viewed by 1481
Special Issue Editor
2. Biomedicine Department, School of Medicine and Biomedical Sciences, University of Barcelona, 08036 Barcelona, Spain
3. Network Biomedical Research Center for Liver and Digestive Diseases (CIBERehd), 28222 Madrid, Spain
Interests: liver disease; fibrosis; clinical laboratory; vascular dysfunction; liver cancer; angiogenesis; lymphangiogenesis; endocrynology; nanotechnology
Special Issue Information
Dear Colleagues,
Advanced liver fibrosis and cirrhosis represent a significant global health concern, affecting more than 200 million people and often leading to severe complications such as hepatocellular carcinoma (HCC). Despite its broad impact, treatment options are still limited. Liver fibro-sis results from a variety of etiologies, including chronic viral hepatitis, steatotic liver disease (SLD), and alcoholic liver disease. Collagen deposition, a hallmark of fibrosis, is driven by the activation of hepatic stellate cells (HSCs) and their complex crosstalk with other cell types, such as myofibroblasts, endothelial cells, and immune cells. However, the exact pathological mechanisms are not yet fully understood.
This Special Issue aims to shed light on the molecular pathways involved in liver fibrosis, including fibrogenic signaling, extracellular matrix dynamics, and intercellular communication. We invite submissions that explore novel diagnostic and therapeutic strategies that target the molecular mechanism and address the unmet clinical needs for more effective diagnosis and treatment.
Dr. Manuel Morales-Ruiz
Guest Editor
Manuscript Submission Information
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Keywords
- liver fibrosis
- cirrhosis
- hepatic stellate cells
- collagen
- fibrogenic pathways
- diagnosis of fibrosis
- therapeutic strategies for liver disease
- extracellular matrix remodeling
- cell-to-cell interactions
- fibrosis complications
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