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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Mechanisms of Plant-Pathogen Interactions: The Role of Effectors and Host Targets

edited by

Muhammad Asif

submission deadline 30 Apr 2026 | Viewed by 90 | Submission Open

Keywords: plant immunity; effector proteins; pattern-triggered immunity (PTI); effector-triggered immunity (ETI); NLR receptors; plant-microbe interactions; susceptibility; secreted virulence factors; signal transduction; host manipulation

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Allergy and Asthma: 4th Edition

edited by

Daniel P. Potaczek

submission deadline 30 Apr 2026 | Viewed by 90 | Submission Open

Keywords: allergy; asthma; epigenetics/epigenomics; genetics/genomics; inflammation; molecular biology

(This special issue belongs to the Section Molecular Biology)

Involvement of Connexin-, Pannexin-, and Innexin-Based Hemichannels in Physiological Functions of Diverse Tissues

edited by

Juan Carlos Saéz

submission deadline 30 Apr 2026 | Viewed by 89 | Submission Open

Keywords: connexin; pannexin; innexin; hemichannel; permeant ions

(This special issue belongs to the Section Molecular Biology)

Progress in Photobiomodulation Therapy

edited by

Amílcar Sabino Damazo

submission deadline 30 Apr 2026 | Viewed by 88 | Submission Open

Keywords: photobiomodulation (PBM); low-level light therapy (LLLT); light-emitting diodes (LEDs); mitochondrial photostimulation; anti-inflammatory effects; tissue regeneration; neuromodulation; biostimulation; clinical applications; pain management

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Preservation of Testicular Function: From Andrological Pathologies to Testis Cancer

edited by

Elisa Dalla Pozza

and

Ilaria Dando

submission deadline 30 Apr 2026 | Viewed by 87 | Submission Open

Keywords: testicular function; male infertility; fertility preservation; spermatogenesis; oxidative stress; cell death; testicular cancer; testosterone

(This special issue belongs to the Section Molecular Pharmacology)

Machine Learning Applications in Bioinformatics and Biomedicine: 4th Edition

edited by Hao Lv

submission deadline 30 Apr 2026 | Viewed by 87 | Submission Open

Keywords: genome; transcriptome; proteome; metabolome; drug target; machine learning; prediction of drug side effects; epigenetic marker discovery for diseases; molecular network marker; early screening of diseases

(This special issue belongs to the Section Molecular Informatics)

Application of Germplasm Innovation Technology in Aquactic Genetic Breeding

edited by

Hui Qiao

submission deadline 30 Apr 2026 | Viewed by 87 | Submission Open

Keywords: aquaculture; biotechnology; germplasm improvement; genetic breeding; gene function; genomics; gene editing

(This special issue belongs to the Section Molecular Genetics and Genomics)

Molecular Insights and Therapeutic Innovations in Neuromuscular Diseases

edited by

Virginia Arechavala Gomeza

submission deadline 30 Apr 2026 | Viewed by 87 | Submission Open

Keywords: neuromuscular disorders; molecular mechanisms; gene therapies; RNA therapies; small molecules

(This special issue belongs to the Section Molecular Neurobiology)

Novel Diagnostic and Theragnostic Strategies in Brain Tumors

edited by Andrea Cimini and Laura Travascio

submission deadline 30 Apr 2026 | Viewed by 86 | Submission Open

Keywords: brain tumor; novel diagnostic and theragnostic approaches; neuro-oncology; precision medicine

(This special issue belongs to the Section Molecular Oncology)

The Structure, Function, and Application of Zinc Finger Proteins

edited by

Sabrina Esposito

submission deadline 30 Apr 2026 | Viewed by 84 | Submission Open

Keywords: zinc finger proteins: structure; function and properties; applications; protein folding and dynamics; environmental contaminants and metal ions exposure; uptake; toxicity; molecular recognition and signal transduction; mechanisms of action and effects of abnormal zinc finger proteins on human health; zinc finger proteins as drug targets

(This special issue belongs to the Section Molecular Biology)

Endometrial Cancer: From Molecular Mechanisms to Treatment

edited by Ursula Catena

submission deadline 30 Apr 2026 | Viewed by 83 | Submission Open

Keywords: endometrial cancer; molecular mechanisms; biomarkers; targeted therapy; immunotherapy; genomics; precision medicine

(This special issue belongs to the Section Molecular Oncology)

Advanced Composite Materials: Innovative Molecular Design, Cross-Scale Materials Characterization and Integrated Engineering Applications

edited by

Zhengzhi Mu

submission deadline 30 Apr 2026 | Viewed by 83 | Submission Open

Keywords: composite materials; molecular design; cross-scale characterization; advanced synthesis; integrated applications

(This special issue belongs to the Section Materials Science)

Emerging Metabolomics Techniques and Applications

edited by Jun Han

submission deadline 30 Apr 2026 | Viewed by 83 | Submission Open

Keywords: metabolomics; lipidomics; bioinformatics; micro-extraction; chemical derivatization; liquid chromatography-mass spectrometry (LC-MS); matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS); gas chromatography-mass spectrometry (GC-MS); metabolic profiling; biomarker assay

(This special issue belongs to the Section Molecular Informatics)

Multi-Omic Data Integration in Oncology

edited by Hung-Yu Lin and

Hsing-Ju Wu

submission deadline 30 Apr 2026 | Viewed by 82 | Submission Open

Keywords: bioinformatics; multi-omics at bulk level; single-cell omics; spatial multi-omics; metabolomics; proteomics; pharmacogenomics; tumor microenvironment; tumor molecular profiling; therapy resistance

(This special issue belongs to the Section Molecular Informatics)

New Insight into Pathogen Stress Effects on Plant Structure and Metabolism

edited by

Edmund Kozieł

and

Katarzyna Otulak-Kozieł

submission deadline 30 Apr 2026 | Viewed by 81 | Submission Open

Keywords: plant– pathogen interaction; innate immunity; ultrastructure; plant defense systems; plant physiology; signal transduction; resistance genes

(This special issue belongs to the Section Molecular Plant Sciences)

Application of Natural Products in Biomedicine and Pharmacotherapy: 3rd Edition

edited by

George Miloshev

submission deadline 30 Apr 2026 | Viewed by 78 | Submission Open

Keywords: natural products; biomedicine; genotoxicity; epigenetics; aging

(This special issue belongs to the Section Molecular Pharmacology)

Mechanisms of Genotoxicity Induced by Environmental Mutagens—Focus on Nanoparticles and Micro/Nanoplastics

edited by

Ricard Marcos

and Susana Pastor

submission deadline 30 Apr 2026 | Viewed by 78 | Submission Open

Keywords: genotoxicity; DNA damage; chromosome damage; DNA repair; comet assay; micronucleus assay; mechanisms; environmental pollutants; micro/nanoplastics; nanoparticles

(This special issue belongs to the Section Molecular Toxicology)

3D Printing and Biomaterials for Hearing and Balance Restoration

edited by

Chenkai Dai

submission deadline 30 Apr 2026 | Viewed by 75 | Submission Open

Keywords: hearing; balancing; 3D printing; biomaterial

(This special issue belongs to the Section Materials Science)

Breast Cancer and Hormone Receptors: Molecular Insights

edited by

Alkistis Papatheodoridi

and

Antonella Muscella

submission deadline 30 Apr 2026 | Viewed by 74 | Submission Open

Keywords: hormone receptor-positive breast cancer; estrogen receptor (ER); progesterone receptor (PR); endocrine therapy resistance; breast cancer genomics; molecular biomarkers; transcriptomic profiling; targeted therapies

(This special issue belongs to the Section Molecular Oncology)

Molecular Advances in Zoonoses and Vector-Borne Diseases

edited by Ravi Durvasula

submission deadline 30 Apr 2026 | Viewed by 72 | Submission Open

Keywords: malaria; leishmaniasis; soil-transmitted helminths; one health; cryptosporidiosis; trypanosomiasis; mosquito-borne infections; arboviral diseases; paratransgenesis; drug discovery; biomarkers

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Research on New Targets and New Drugs for Dementia

edited by

Jianrong Xu

submission deadline 30 Apr 2026 | Viewed by 71 | Submission Open

Keywords: Alzheimer’ s disease; disease-modifying therapy; neuroinflammation; monoclonal antibodies; natural products

(This special issue belongs to the Section Molecular Neurobiology)

Micro- and Nanoplastics: Molecular Insights from the One Health Perspective

edited by

Magdalena Zemelka-Wiacek

submission deadline 30 Apr 2026 | Viewed by 67 | Submission Open

Keywords: microplastics; nanoplastics; One Health; molecular toxicology; oxidative stress; inflammation; microbiome; bioaccumulation; environmental exposure

(This special issue belongs to the Section Molecular Toxicology)

mRNA Vaccines Against Viral Infectious Diseases: Progress and Prospects

edited by

Barbara Ridolfi

, Maria Teresa Maggiorella and

Ivan Schietroma

submission deadline 30 Apr 2026 | Viewed by 67 | Submission Open

Keywords: viruses; mRNA vaccines; mRNA structure; mRNA platform technologies; lipid nanoparticle (LNP) delivery; immunization strategies; adjuvants; preclinical trials; clinical trials; germline-targeting; broadly neutralizing antibodies; humoral immune response; cellular immune response; host– vaccine interactions

(This special issue belongs to the Section Molecular Microbiology)

Molecular Pathology, Diagnosis and Therapeutic Strategies of Thrombotic Diseases

edited by Emanuele Valeriani

submission deadline 30 Apr 2026 | Viewed by 67 | Submission Open

Keywords: anticoagulants; cardiovascular diseases; diagnosis; platelet aggregation inhibitors; venous thromboembolism

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Natural Compounds: Impact on Health and Diseases

edited by

Charles Benneh

submission deadline 30 Apr 2026 | Viewed by 65 | Submission Open

Keywords: natural compounds; bioactive compounds; efficacy; toxicity; mechanism; compound isolation; chemical characterisation

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Modern Synthetic Pathways for Anticancer Drug Discovery

edited by

Łukasz Struk

submission deadline 30 Apr 2026 | Viewed by 64 | Submission Open

Keywords: new anticancer agents; bioactive molecules; drug design; drug synthesis; cancer therapy; medicinal chemistry

(This special issue belongs to the Section Molecular Oncology)

The Tumor Microenvironment in Hepatocellular Carcinoma: Mechanistic Insights and Future Therapeutic Approaches

edited by

Agnes Chan

submission deadline 30 Apr 2026 | Viewed by 64 | Submission Open

Keywords: advance or metastatic hepatocellular carcinoma; liver disease; radiotherapy; transarterial chemoembolization (TACE) or SBRT; immune checkpoint inhibitors; tumor microenvironment

(This special issue belongs to the Section Molecular Oncology)

Toxicology of Cyanobacterial Toxins

edited by

Carlos García

submission deadline 30 Apr 2026 | Viewed by 63 | Submission Open

Keywords: toxicology; cyanotoxins; cyanobacteria; harmful effects; health risk

(This special issue belongs to the Section Molecular Toxicology)

Exploring the Gut-Brain Axis: Mechanisms and Implications for Health and Disease

edited by

Martina Vincenzi

submission deadline 30 Apr 2026 | Viewed by 63 | Submission Open

Keywords: gut– brain axis; enteric nervous system; dysbiosis; gut microbiota; neuroinflammation; one health; microbiota– immune crosstalk; metabolic syndromes; cardiovascular diseases; neurodegenerative diseases; cancer

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Insights into Medicinal Fungi and Plants: From Bioactive Compounds to Therapeutic Mechanisms

edited by

Jasmina Glamočlija

and

Ana Ćirić

submission deadline 30 Apr 2026 | Viewed by 63 | Submission Open

Keywords: medicinal fungi; medicinal plants; molecular mechanisms; bioactive compounds; metabolomics; phytochemistry; natural products; network pharmacology; molecular docking; functional foods; therapeutic development

(This special issue belongs to the Section Bioactives and Nutraceuticals)

State-of-the-Art Immunotherapy for Non-Small-Cell Lung Cancer

edited by

Haris Charalambous

submission deadline 30 Apr 2026 | Viewed by 61 | Submission Open

Keywords: immunotherapy; checkpoint inhibitors; vaccines; cellular therapies; predictive biomarkers; chemotherapy; angiogenesis inhibitors; radiotherapy; modulation microbiome

(This special issue belongs to the Section Molecular Oncology)

Advanced Silica-Based Materials: From Molecular Design to Sustainable Applications

edited by Marius Rǎdulescu

submission deadline 30 Apr 2026 | Viewed by 60 | Submission Open

Keywords: silica-based materials; molecular design; hybrid nanomaterials; surface chemistry; structure– property relationships; functionalized silica; sol– gel processes; molecular interactions; green synthesis; sustainable applications; nanostructured systems; catalysis and adsorption; biomedical interfaces; energy and environmental materials; molecular modeling

(This special issue belongs to the Section Molecular Nanoscience)

Effects of Natural Bioactive Compounds on Cellular Responses

edited by

Amélia M. Silva

submission deadline 30 Apr 2026 | Viewed by 59 | Submission Open

Keywords: cellular targets; cell proliferation; cell death mechanisms; cell signalling; cytokines; vitamins; phytochemicals; venoms; peptides; pharmacological effect

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Integrative Regenerative Medicine: Bridging Molecular Mechanisms and Therapeutic Applications

edited by

Jerran Santos

submission deadline 30 Apr 2026 | Viewed by 59 | Submission Open

Keywords: regenerative medicine; stem cells; molecular mechanisms; tissue engineering; organoids; biomaterials; biofabrication; clinical translation; cell therapy; integrative biology

(This special issue belongs to the Section Molecular Biology)

Molecular Research in Orofacial Pain and Headache

edited by Adriana Elena Bulboaca

submission deadline 30 Apr 2026 | Viewed by 58 | Submission Open

Keywords: neuropathic pain; trigeminal neuralgia; temporomandibular joint disorders; headache; migraine; neuroplasticity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Smart Biomolecular Nanocarriers for Precision Cancer Therapy and Diagnosis

edited by

Atul Garkal

submission deadline 30 Apr 2026 | Viewed by 58 | Submission Open

Keywords: nanobiotechnology; anti-cancer agents; nanocarrier; targeted drug delivery

(This special issue belongs to the Section Molecular Nanoscience)

Molecular and Physiological Effects of Exercise in Cachexia

edited by

Marilia Seelaender

and

Fábio Santos Lira

submission deadline 30 Apr 2026 | Viewed by 57 | Submission Open

Keywords: cachexia; skeletal muscle mass; skeletal muscle strength; exercise; muscle metabolism

(This special issue belongs to the Section Molecular Biology)

KRAS-Associated Cancer Signaling

edited by Sang Hun Lee

submission deadline 30 Apr 2026 | Viewed by 55 | Submission Open

Keywords: KRAS signaling; receptor tyrosine kinases; EGFR; c-MET; PI3K– MAPK pathways; tumor microenvironment; drug resistance and adaptive rewiring; combination therapy; biomarker stratification; prion protein (PrPC)

(This special issue belongs to the Section Molecular Oncology)

Molecular Basis of Plant Traits Associated with Responses to Biotic and Abiotic Stress

edited by Nobuhiro Suzuki

submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open

Keywords: molecular mechanisms ; biotic and abiotic stress ; plant trait ; signaling

(This special issue belongs to the Section Molecular Plant Sciences)

Molecular Mechanisms of Assisted Reproductive Technology

edited by Nuria Marti-Gutierrez

submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open

Keywords: cytoplasm maternal factors; mitochondrial replication; meiosis; chromosome pairing; recombination; gene editors

(This special issue belongs to the Section Molecular Biology)

Molecular Advances in Brucella Research

edited by

Angel Oñate

submission deadline 30 Apr 2026 | Viewed by 53 | Submission Open

Keywords: Brucella abortus; molecular pathogenesis; host– pathogen interaction; virulence factors; oxidative stress response; intracellular survival; immune evasion; exosomes; vaccine development

(This special issue belongs to the Section Molecular Microbiology)

Biomass as Feedstock for the Production of High Value-Added Chemicals by Heterogeneous Catalysis

edited by

Cristina García-Sancho

submission deadline 30 Apr 2026 | Viewed by 52 | Submission Open

Keywords: biomass; heterogeneous catalysts; biofuels; bioproducts; platform molecules

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Metabolomics as a Window into Human Disease Mechanisms

edited by

Paolo Iadarola

submission deadline 30 Apr 2026 | Viewed by 52 | Submission Open

Keywords: biomarker discovery; metabolomics; disease mechanisms

(This special issue belongs to the Section Molecular Informatics)

New Advance in Xenobiotic Toxicology

edited by Marcelo Arbo

submission deadline 30 Apr 2026 | Viewed by 51 | Submission Open

Keywords: xenobiotics; toxicity tests; biotransformation; drug effects; signal transduction; environmental pollutants; chemically induced- injury; toxicogenomics; biomarkers; risk assessment

(This special issue belongs to the Section Molecular Toxicology)

Advances in Lupus Erythematosus and Lupus Nephritis: Pathogenesis, Biomarkers and Treatments, 2nd Edition

edited by

Chi Chiu Mok

submission deadline 30 Apr 2026 | Viewed by 49 | Submission Open

Keywords: lupus erythematosus; lupus nephritis; SLE; LN; organ damage; pathogenesis; biomarkers; genomic; transcriptomic; metabolomic; treatments; therapeutic

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Insight in Reproductive Immunology

edited by Ruben Motrich

submission deadline 30 Apr 2026 | Viewed by 47 | Submission Open

Keywords: reproductive immunology; immune tolerance; male reproductive tract; female reproductive tract; fertility disorders; inflammation; pregnancy complications; immunoregulation

(This special issue belongs to the Section Molecular Immunology)

Molecular Mechanisms and Treatment Strategies in Diabetic Kidney Disease

edited by

Érika Bevilaqua Rangel

submission deadline 30 Apr 2026 | Viewed by 47 | Submission Open

Keywords: diabetic kidney disease; oxidative stress; autophagy; inflammation; fibrosis; cell therapy; SGLT2 inhibitors and GLP-1 agonists; mesenchymal stem cells; gene therapy; translational nephrology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Artificial Intelligence, Machine Learning, and Bioinformatics in Molecular Mechanisms of Human Health and Disease

edited by

Santosh Anand

submission deadline 30 Apr 2026 | Viewed by 46 | Submission Open

Keywords: artificial intelligence; machine learning; bioinformatics; molecular mechanisms; human health; human disease; multi-omics data; molecular pathways; personalized medicine; disease biomarkers

(This special issue belongs to the Section Molecular Informatics)

Regenerative Medicine: Biomaterials and Stem Cell Research: 2nd Edition

edited by Silvia María Díaz-Prado

submission deadline 30 Apr 2026 | Viewed by 45 | Submission Open

Keywords: regenerative medicine; stem cell; biomaterial; bioprinting; tissue engineering; tissue and organ transplant; organ scarcity

(This special issue belongs to the Section Materials Science)

Inflammatory Bowel Disease: Molecular Advances in Pathogenesis and Therapies, 2nd Edition

edited by

Rafał Filip

submission deadline 30 Apr 2026 | Viewed by 45 | Submission Open

Keywords: Crohn’ s disease; inflammatory bowel disease; immunologic and molecular mechanisms; therapies in IBD; ulcerative colitis

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Displaying special issue 2501-2550 on page 51 of 68.

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