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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Hormone Receptors in Cancer
edited by Rajeshwar R. Tekmal
submission deadline 20 Jan 2026 | Viewed by 459 | Submission Open
Keywords: hormone recptors; hormone-mediated therapies; agonists and antgonists of hormone ligands; coactivators; corepressors  
(This special issue belongs to the Section Molecular Oncology)
Insights into How Electromagnetic Fields Affect Human Immunity and Metabolic Activity
edited by Jolanta Kaszuba-Zwoińska
submission deadline 20 Jan 2026 | Viewed by 444 | Submission Open
Keywords: electromagnetic fields; metabolism; innate and acquired immunity; cell viability; cell secretory activity; cell death types; pathogenesis of diseases
(This special issue belongs to the Section Molecular Biology)
Drug Discovery and Development for Renal Disease Treatment
edited by
submission deadline 20 Jan 2026 | Viewed by 442 | Submission Open
Keywords: kidney disease; medicinal chemistry; drug discovery; computer-assisted drug design; drug targets; in vitro assays; epigenetic targets; multi-targeting compounds; biophysical methods; target engagement studies
(This special issue belongs to the Section Molecular Pharmacology)
Synthesis and Application of Organic Antibacterial Agents
edited by
submission deadline 20 Jan 2026 | Viewed by 435 | Submission Open
Keywords: organic antibacterial compounds; synthesis; natural organic compounds; biological activity; active compounds; biological applications
(This special issue belongs to the Section Biochemistry)
Cognitive Aging: Molecular Perspectives
edited by
submission deadline 20 Jan 2026 | Viewed by 426 | Submission Open
Keywords: brain; neuron; aging; neurodegeneration; cognitive neuroscience; inflammation; regeneration; behavioral neuroscience; pharmacology; brain disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Metabolomics Research of Environmental Stress in Plants
edited by and Sonika Pandey
submission deadline 20 Jan 2026 | Viewed by 423 | Submission Open
Keywords: agricultural applications of primary and secondary metabolite; ; crop improvement; integration of metabolomics with genomics and transcriptomics; medicinal plants; natural products in agriculture; plant metabolomics; plant biochemistry; primary metabolites; secondary metabolites; tools and techniques of plant metabolites in agriculture research
(This special issue belongs to the Section Molecular Plant Sciences)
The Plant Phenotyping and Phenomics for Breeding
edited by
submission deadline 20 Jan 2026 | Viewed by 422 | Submission Open
Keywords: plant phenomics; high-throughput phenotyping (HTP); genotype– phenotype association; non-invasive imag-ing; functional genomics; environmental interactions
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Mechanisms of Animal Reproduction and Development
edited by
submission deadline 20 Jan 2026 | Viewed by 407 | Submission Open
Keywords: spermatogenesis; oogenesis; fertilization; embryogenesis; cell division; cell differentiation; stem cell; abnormal development; obesity; cancer
(This special issue belongs to the Section Molecular Biology)
Cellular and Molecular Mechanisms of Cardiovascular and Metabolic Diseases, 3rd Edition
edited by
submission deadline 20 Jan 2026 | Viewed by 386 | Submission Open
Keywords: cardiovascular diseases; metabolic diseases; cellular and molecular mechanisms
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Innovations in Organic Framework Materials: Expanding the Horizons of COFs, MOFs, and HOFs for Advanced Applications
edited by Bhausaheb Dhokale
submission deadline 20 Jan 2026 | Viewed by 379 | Submission Open
Keywords: COF; MOF; HOF; synthesis; molecular applications; porous materials; molecular engineering; membranes; theoretical studies; energy
(This special issue belongs to the Section Materials Science)
Molecular Biology and Diagnosis on Biliary and Pancreatic Cancers
edited by Francesco Vasuri and Luca Saragoni
submission deadline 20 Jan 2026 | Viewed by 361 | Submission Open
Keywords: biliary cancer; pancreatic cancer; histological diagnoses; cytological diagnoses; chromosome aneuploidy; specific genetic mutations
(This special issue belongs to the Section Molecular Oncology)
DNA and RNA Nanostructures for the Assembly of Functional Molecules
edited by and
submission deadline 20 Jan 2026 | Viewed by 358 | Submission Open
Keywords: DNA nanotechnology; RNA nanotechnology; biomolecular engineering; biomimetics
(This special issue belongs to the Section Molecular Nanoscience)
Advancements and Trends in Plant Genomics
edited by Rongbin Hu
submission deadline 20 Jan 2026 | Viewed by 358 | Submission Open
Keywords: plant; genomics; next-generation sequencing; third-generation sequencing; CRISPR-Cas
(This special issue belongs to the Section Molecular Plant Sciences)
Advances in Plant Cell Dynamics
edited by
submission deadline 20 Jan 2026 | Viewed by 356 | Submission Open
Keywords: organelles; cellular polarity; cytoskeleton; vesicle trafficking; cell wall synthesis; signalling; differentiation
(This special issue belongs to the Section Molecular Plant Sciences)
Molecular Research on Autophagy, 2nd Edition
edited by
submission deadline 20 Jan 2026 | Viewed by 351 | Submission Open
Keywords: ATG molecules; transcriptional and post translational modification; selective pathways; secretory pathways; complexes diseases; degenerative processes; inflammatory diseases; tumorigenesis; metabolism; proteostasis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
New Insight into Bacteriophage and Their Potential Applications
edited by Wilfried Moreira
submission deadline 20 Jan 2026 | Viewed by 339 | Submission Open
Keywords: bacteriophage; phage biology; phage-host interactions; antimicrobial resistance
(This special issue belongs to the Section Molecular Microbiology)
Advances in Sepsis: Molecular and Biochemical Perspectives submission deadline 20 Jan 2026 | Viewed by 337 | Submission Open
Keywords: sepsis; outcome; molecular diagnosis; machine learning; biochemical biomarkers; targeted immunotherapy; personalized medicine; sepsis inflammatory endotypes
(This special issue belongs to the Section Biochemistry)
Liver Transplantation: Pathogenesis, Therapeutic Strategies and Future Challenges
edited by
submission deadline 20 Jan 2026 | Viewed by 329 | Submission Open
Keywords: MASLD; transplant oncology; machine perfusion; extended-criteria donors; donors after cardiac death
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
The Latest Molecular and Psycho-Physiological Insights on “Brain Fatigue” submission deadline 20 Jan 2026 | Viewed by 316 | Submission Open
Keywords: epigenetics; neurotransmitter including dopamine; mitochondria dysfunction; neuroinflammation; lipidomics including plasmalogen; proteomics including neuropeptide; neural network; cognition abilities; decline in attention; judgement capacity; depressive state
(This special issue belongs to the Section Molecular Neurobiology)
Recent Applications of Programmable Nanobiomaterials in Cancer Targeting and Therapy
edited by Wensheng Xie
submission deadline 20 Jan 2026 | Viewed by 315 | Submission Open
Keywords: programmable nanobiomaterials; cancer targeting; cancer combined therapy; tumor imaging; field-responsive nanomaterials
(This special issue belongs to the Section Molecular Biophysics)
New Optical, Electrical, and Thermal Materials: Recent Advances and Challenges
edited by Luyi Zou
submission deadline 20 Jan 2026 | Viewed by 314 | Submission Open
Keywords: optical materials; electrical materials; thermal materials; molecular structure; molecular composition; structural performance
(This special issue belongs to the Section Materials Science)
Cutting-Edge Advances in Transcriptional Therapy and Nucleic Acid-Based Therapeutics
edited by
submission deadline 20 Jan 2026 | Viewed by 313 | Submission Open
Keywords: antisense oligonucleotides (ASOs); siRNAs; peptide nucleic acids (PNAs); aptamers; transcriptional therapy; nanocarriers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Single-Atom Catalysts for Small Molecule Transformation
edited by Aijuan Han
submission deadline 20 Jan 2026 | Viewed by 289 | Submission Open
Keywords: single-atom catalyst; small molecule transformation; rational design; applications
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
The Role of Extracellular Vesicles in Drug Delivery submission deadline 20 Jan 2026 | Viewed by 288 | Submission Open
Keywords: red blood cells; red blood cell-extracellular vesicles; drug delivery systems; RNA therapies; EV engineering
(This special issue belongs to the Section Molecular Biology)
Exploring the New Cancer Biomarkers: Progress and Prospects submission deadline 20 Jan 2026 | Viewed by 276 | Submission Open
Keywords: prevention; diagnostic; prognostic; response; liquid biopsy; image biomarkers; clinicopathological biomarkers
(This special issue belongs to the Section Molecular Oncology)
Recent Advances in Coagulation Proteins
edited by
submission deadline 20 Jan 2026 | Viewed by 273 | Submission Open
Keywords: coagulation proteins; hemostasis; thrombosis; structural biology; Cryo-EM; inherited coagulation disorders
(This special issue belongs to the Section Molecular Biology)
Environmental and Human Adverse Effects of Micro and Nanoplastics: 2nd Edition
edited by
submission deadline 20 Jan 2026 | Viewed by 267 | Submission Open
Keywords: micro and nanoplastics; environmental pollution; micro and nanoplastic toxicity; human health
(This special issue belongs to the Section Molecular Toxicology)
Molecular Insights into Environmental Toxicology in Cancer
edited by
submission deadline 20 Jan 2026 | Viewed by 267 | Submission Open
Keywords: environmental carcinogenesis; toxic exposure; exposome; occupational cancer risk; biomarkers of exposure; new approach methodologies (NAMs)
(This special issue belongs to the Section Molecular Oncology)
Polymer Materials Related to Food Packaging
edited by
submission deadline 20 Jan 2026 | Viewed by 266 | Submission Open
Keywords: polymeric materials; food packaging; biodegradable polymers; active packaging; intelligent packaging; nanocomposites; sustainability; circular economy; barrier properties; life cycle assessment
(This special issue belongs to the Section Macromolecules)
Advancements in Cytopathology: Challenges and Changes
edited by Panagiota Mikou
submission deadline 20 Jan 2026 | Viewed by 260 | Submission Open
Keywords: cytopathology; cancer diagnosis; cytology; early cancer detection; exfoliative cytology
(This special issue belongs to the Section Molecular Biology)
Photosynthesis and Stress Signaling
edited by
submission deadline 20 Jan 2026 | Viewed by 255 | Submission Open
Keywords: photosynthesis; chloroplasts; stress; signaling
(This special issue belongs to the Section Molecular Plant Sciences)
Psoriasis and Associated Complications: Pathogenic Mechanisms, Gene Biomarkers and Treatments submission deadline 20 Jan 2026 | Viewed by 246 | Submission Open
Keywords: psoriasis; autoimmune disease; autoinflammatory disease; psoriatic arthritis; diabetes; hypertension; lipid disorders; obesity; cardiovascular diseases (CVDs); immunological biomarkers; genetic biomarkers; epigenetic biomarkers
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Neurohormones in Cardiac Fibrosis and Heart Failure
edited by
submission deadline 20 Jan 2026 | Viewed by 246 | Submission Open
Keywords: heart failure; neurohormones; cardiac fibrosis; angiotensin II; aldosterone; endothelin; catecholamines
(This special issue belongs to the Section Molecular Biology)
Density Functional Theory and Its Application in Atomic Collision Models
edited by
submission deadline 20 Jan 2026 | Viewed by 240 | Submission Open
Keywords: density functional theory; time-dependent density functional theory; finite-temperature density functional theory; ensemble density functional theory; atom collision models; electron stopping power
(This special issue belongs to the Section Physical Chemistry and Chemical Physics)
Effects of Co-Exposure of Pollutants on Animal Models
edited by
submission deadline 20 Jan 2026 | Viewed by 230 | Submission Open
Keywords: environmental health; biological systems; toxic exposure; co-exposure; physiological mechanisms; behavioral responses; gene expression; epigenetic effects; molecular research
(This special issue belongs to the Section Molecular Toxicology)
Novel Insights into Mitochondrial Signaling and Homeostasis in Metabolic Diseases
edited by Ching-Yi Chen
submission deadline 20 Jan 2026 | Viewed by 223 | Submission Open
Keywords: diabetes mellitus; cardiovascular disease; fatty liver; chronic kidney disease; mitochondrial homeostasis
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Mechanism of Immune Response
edited by Marisa Mariel Fernández
submission deadline 20 Jan 2026 | Viewed by 207 | Submission Open
Keywords: training of the innate immune response; antigen recognition; cell migration; autoimmune processes; cell differentiation; tolerance; molecular responses of epithelial cells to foreign stimuli; alterations in immune checkpoints; modulation of immune responses; mechanisms of hypersensitivity
(This special issue belongs to the Section Molecular Immunology)
Nanomedicine for Diagnostic and Therapeutic Application
edited by and Antonella Barone
submission deadline 20 Jan 2026 | Viewed by 197 | Submission Open
Keywords: polymeric nanoparticles; lipid nanoparticles; diagnostic; theranostic; targeted drug delivery; nonovesicles; prescion medicine
(This special issue belongs to the Section Molecular Nanoscience)
Synthetic RNA Biology: Designing Function Through Structure submission deadline 20 Jan 2026 | Viewed by 183 | Submission Open
Keywords: structural biology of RNA; rational design of RNA; RNA structure– function relationships; RNA-based molecular devices and switches; functional RNAs
(This special issue belongs to the Section Biochemistry)
Molecular Research on Porous Polymers for Advanced Separation and Analytical Applications
edited by
submission deadline 20 Jan 2026 | Viewed by 182 | Submission Open
Keywords: microporous polymers; molecular imprinting; ion imprinting; separation; porous surfaces; spectroscopy; chromatography
(This special issue belongs to the Section Macromolecules)
Advances in Targeted Therapy and Immunotherapy for Lung Cancer
edited by
submission deadline 20 Jan 2026 | Viewed by 157 | Submission Open
Keywords: lung cancer; small-cell lung cancer; non-small-cell lung cancer; targeted therapy; immunotherapy
(This special issue belongs to the Section Molecular Oncology)
Molecular Mechanisms and Therapeutic Potential of Natural Compounds
edited by and Adrianna Sławińska-Brych
submission deadline 20 Jan 2026 | Viewed by 147 | Submission Open
Keywords: natural products; biological activity; bioactive compounds; mechanistic study; mechanism of action; drug discovery; pharmacological activity; synergism
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Pathogenesis and Molecular Therapy of Inflammatory Bowel Disease
edited by
submission deadline 20 Jan 2026 | Viewed by 146 | Submission Open
Keywords: intestinal epithelial barrier; gut microbiota; tight junctions; inflammatory bowel disease; mucosal immunity; autophagy; epithelial restitution; host– microbe interaction; barrier dysfunction; gastrointestinal inflammation
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Cellulose and Its Applications, 2nd Edition
edited by and Ce Sun
submission deadline 20 Jan 2026 | Viewed by 145 | Submission Open
Keywords: cellulose; biomedical applications; nanocomposites; biodegradable polymers; water purification; nanocellulose
(This special issue belongs to the Section Macromolecules)
Molecular Mechanisms of Tumor Progression and New Therapeutic Strategies for Urological Cancers, 3rd Edition submission deadline 20 Jan 2026 | Viewed by 110 | Submission Open
Keywords: prostate cancer; bladder cancer; renal cell carcinoma; upper urinary tract tumors; testicular cancer; predictive and prognostic biomarkers; tumor progression; novel treatment strategies; chemotherapy; immunotherapy; target therapies; drug resistance mechanisms; tumor microenvironment; precision medicine
(This special issue belongs to the Section Molecular Oncology)
Colorectal Cancer—Emerging Trends and Treatment Strategies
edited by Victor Strambu
submission deadline 20 Jan 2026 | Viewed by 104 | Submission Open
Keywords: innovative therapies; colorectal cancer; new therapeutic approach; synchronous tumors
(This special issue belongs to the Section Molecular Oncology)
Mechanisms of Heavy Metal Toxicity: 3rd Edition
edited by
submission deadline 25 Jan 2026 | 9 articles | Viewed by 16612 | Submission Open
Keywords: heavy metal; metal compound; metallothionein; cellular defense mechanism; metal transporter
(This special issue belongs to the Section Molecular Toxicology)
Cardiovascular Diseases: Molecular Mechanisms and Potential Therapy (2nd Edition)
edited by
submission deadline 25 Jan 2026 | 1 articles | Viewed by 766 | Submission Open
Keywords: cardiovascular diseases; pathogenic mechanisms; genetics; cardiomyopathy; myocardial infarction; cardiac fibrosis; pharmacogenomics; drug discovery
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Mechanisms of Hematologic Disorders
edited by
submission deadline 25 Jan 2026 | Viewed by 690 | Submission Open
Keywords: solid tumors; hematologic disorders; hematology; bone marrow failure; leukemia; myeloma
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mitochondrial Dysfunction in Disease: Mechanisms, Biomarkers and Emerging Therapies submission deadline 25 Jan 2026 | Viewed by 223 | Submission Open
Keywords: mitochondria; bioenergetic homeostasis; calcium homeostasis; redox homeostasis; oxidative stress; biogenesis; mitophagy; dynamics
(This special issue belongs to the Section Biochemistry)
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