Synthetic RNA Biology: Designing Function Through Structure

Dear Colleagues,

In recent years, breakthroughs in rational RNA design and RNA nanotechnology have dramatically expanded our ability to engineer RNAs with novel functions. From precision-designed riboswitches and aptamers to powerful non-coding RNAs, the field is witnessing an unprecedented “RNA renaissance” as the repertoire of functional RNAs continues to grow. This Special Issue aims to capture this excitement and showcase cutting-edge studies that leverage these advances to push the frontiers of RNA science.

RNA’s unique ability to fold into complex three-dimensional structures enables it to act as both a carrier of information and an active molecular device. Insights into RNA folding pathways, structural motifs, and dynamic conformations are increasingly guiding the design of synthetic RNAs that can sense, regulate, and actuate within biological systems. These developments are transforming RNA into a versatile platform for applications ranging from therapeutic interventions to smart biosensors and programmable cellular circuits.

We invite contributions that explore the mechanistic, structural, and applied dimensions of synthetic RNA biology, including, but not limited to, the following:

• Structural biology of RNA (novel motifs, RNA–ligand interactions, and cryo-EM/NMR advances).
• Rational design of RNA molecules for new structures and catalytic as well as regulatory functions.
• Mechanistic insights into RNA structure–function relationships and folding dynamics.
• RNA-based molecular devices and switches (aptamers, riboswitches, ribozymes, and logic gates) in synthetic biology.
• Applications of functional RNAs in therapeutics, biosensing, diagnostics, and biotechnology.

We welcome original research articles and comprehensive reviews.

Dr. Michael T. Wolfinger
Guest Editor

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