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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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25th Anniversary of IJMS: Updates and Advances in Molecular Pathology, Diagnostics, and Therapeutics

edited by

Francesca Oliviero

and

Anna Lisa Giuliani

submission deadline 30 Jan 2026 | 49 articles | Viewed by 56869 | Submission Open

Keywords: molecular mechanisms of diseases; diagnostic approaches; therapeutic strategies

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Thyroid-Related Diseases: Molecular Pathology, Diagnosis and Treatment: 2nd Edition

edited by

Maurizio Martini

and

Vincenzo Fiorentino

submission deadline 30 Jan 2026 | 6 articles | Viewed by 44655 | Submission Open

Keywords: thyroid disease; thyroid nodules; thyroid cancer; thyroid carcinoma; thyroid radiology; thyroid– gut axis; autoimmune thyroid disorders; thyroid hormone; molecular mechanisms; molecular tests

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Advances in Tomato Breeding and Molecular Research

edited by Silvana Grandillo,

Gianfranco Diretto

and

Maria Cammareri

submission deadline 30 Jan 2026 | 7 articles | Viewed by 19957 | Submission Open

Keywords: tomato; natural and induced variation; genetics; genomics; omics; molecular breeding; physiology and development; fruit quality; biochemistry and metabolism; biotic and abiotic stresses

(This special issue belongs to the Section Molecular Plant Sciences)

The Molecular Basis of Vascular Pathology

edited by

Jolanta Neubauer-Geryk

submission deadline 30 Jan 2026 | 8 articles | Viewed by 18289 | Submission Open

Keywords: vascular pathologies; blood vessels; dysfunction; vascular damage; blood flow; biomarkers; biomolecules; cytokines

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Neuroinflammation and Neurodegeneration: Molecular Mechanism and Novel Therapy

edited by

Chih Hung Lo

submission deadline 30 Jan 2026 | 5 articles | Viewed by 18273 | Submission Open

Keywords: neuroinflammation; neurodegeneration; neuroimmunology; toxic protein aggregates; autolysosomal dysfunction; metabolic defects; aberrant receptor signaling; neuron-glia interactions; glia-immune interactions; omics characterizations; therapeutic development; biomarker discovery

(This special issue belongs to the Section Molecular Neurobiology)

Dopamine, Histamine, Serotonin—Receptors, Ligands and Their Biological Role in Central Nervous System Diseases, 2nd Edition

edited by

Dorota Łażewska

and

Anna Stasiak

submission deadline 30 Jan 2026 | 4 articles | Viewed by 17644 | Submission Open

Keywords: biogenic amines (histamine; dopamine; serotonin); receptors; ligands; antagonist/inverse agonist; affinity; intrinsic activity; multitarget ligands; molecular modeling; CNS diseases; neurodegeneration; psychiatric disorders; pain; in vitro studies; in silico studies; in vivo studies

(This special issue belongs to the Section Molecular Neurobiology)

Versatility of Protein Synthesis in a Test Tube

edited by

Tamás Mészáros

submission deadline 30 Jan 2026 | 5 articles | Viewed by 16755 | Submission Open

Keywords: protein synthesis; synthetic biology; cell-free translation; in vitro translation

(This special issue belongs to the Section Molecular Biology)

Microbial Enzymes for Biotechnological Applications: 2nd Edition

edited by

Salvatore Fusco

submission deadline 30 Jan 2026 | 4 articles | Viewed by 16611 | Submission Open

Keywords: microbial enzymes; whole-cell biocatalysts; extremozyme; enzyme assays; protein engineering

(This special issue belongs to the Section Biochemistry)

The Use of Molecular Markers in Forensic Field as an Element of Scientific Evidence

edited by

Angelo Montana

and

Margherita Neri

submission deadline 30 Jan 2026 | 3 articles | Viewed by 15789 | Submission Open

Keywords: biomarkers; immunohistochemistry; histopathology; forensic pathology; forensic toxicology; forensic biomarkers; toxicological biomarkers; neuropathology; mRNA; post-mortem interval; cerebral damage; in vitro; in vivo; and in silico models; hypoxic– ischemic brain injury; pregnancy biomarkers; vitality

(This special issue belongs to the Section Molecular Biology)

Programmed Cell Death and Oxidative Stress: 3rd Edition

edited by

Takuya Noguchi

submission deadline 30 Jan 2026 | 10 articles | Viewed by 15158 | Submission Open

Keywords: oxidative stress; programmed cell death; cellular stresses; senescence; cytotoxicity; cancer; neurodegenerative disease; inflammatory disease; organelle stress

(This special issue belongs to the Section Biochemistry)

Molecular Precision Medicine: Unraveling Novel Mechanisms and Delivery Strategies in Complex Diseases

edited by

Nuno Vale

submission deadline 30 Jan 2026 | 4 articles | Viewed by 13681 | Submission Open

Keywords: molecular precision therapeutics; disease biomarkers; novel therapeutic molecules; drug delivery strategies; personalized medicine; bioinformatics; nanotechnology; synthetic biology

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Advances in Liposome-Based Drug Delivery Systems

edited by

Shao-Ling Huang

submission deadline 30 Jan 2026 | 4 articles | Viewed by 12618 | Submission Open

Keywords: liposomes; targeted delivery; controlled release; nanotechnology; drug delivery; diagnostics; therapeutics; multifunctional liposomes; phospholipids

(This special issue belongs to the Section Molecular Pharmacology)

Role of Glia in Human Health and Disease

edited by

Daniele Lana

and

Hajime Hirase

submission deadline 30 Jan 2026 | 8 articles | Viewed by 12102 | Submission Open

Keywords: astrocytes; microglia; oligodendrocytes; Schwann cells; neurodegeneration

(This special issue belongs to the Section Molecular Neurobiology)

Molecular Mechanisms and Regulation in Blood-Brain Barrier

edited by Rajkumar Vutukuri

submission deadline 30 Jan 2026 | 3 articles | Viewed by 10826 | Submission Open

Keywords: blood brain barrier (BBB); tight junctions; NVU cell types; neurodegenerative diseases; neuro-inflammation

(This special issue belongs to the Section Molecular Neurobiology)

Advances in Burn Wound Healing and Skin Regeneration: Innovations and Insights

edited by

H. Ibrahim Korkmaz

submission deadline 30 Jan 2026 | 2 articles | Viewed by 10480 | Submission Open

Keywords: burn wound healing; skin regeneration; novel biomaterials; wound dressings; regenerative therapies

(This special issue belongs to the Section Biochemistry)

New Trends in Biologically Active Compounds in Age-Related Diseases

edited by Celia Andrés Juan

submission deadline 30 Jan 2026 | 3 articles | Viewed by 10447 | Submission Open

Keywords: age-related diseases; oxidative stress and inflammation; energy failure; mitochondrial dysfunction; deregulated autophagy

(This special issue belongs to the Section Bioactives and Nutraceuticals)

High Fat Diet Metabolism and Diseases

edited by

Miguel Walter Fornés

and

Luís Fernando Barbisan

submission deadline 30 Jan 2026 | 7 articles | Viewed by 10050 | Submission Open

Keywords: diet; fat; high-fat diets; obesity; NAFLD; metabolism; reproductive system; lungs; pathology

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Engineering in Dental Restorative and Regenerative Materials

edited by

Danijela Marović

submission deadline 30 Jan 2026 | 5 articles | Viewed by 9423 | Submission Open

Keywords: dental composites; ceramics; additive manufacturing; dental adhesives; bioactive; 3D printing; photopolymerization; curing devices; microstructure; degree of conversion; bulk-fill composites; lasers in dentistry; infrared spectroscopy; biocompatibility; bone regeneration; osseointegration; soft tissue regeneration

(This special issue belongs to the Section Materials Science)

Molecular Advances in Combinatorial Therapies for Spinal Cord Injury

edited by

Lingxiao Deng

submission deadline 30 Jan 2026 | 1 articles | Viewed by 9281 | Submission Open

Keywords: molecular; cellular; engineering; spinal cord injury

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

New Molecular Aspects of Colorectal Cancer

edited by

Christos K. Kontos

submission deadline 30 Jan 2026 | 5 articles | Viewed by 9187 | Submission Open

Keywords: colorectal adenocarcinoma; cancer pathobiology; molecular biomarkers; diagnosis and prognosis; prediction of therapy selection; therapeutic targets; RNA molecules; microRNA; long non-coding RNA; circular RNA

(This special issue belongs to the Section Molecular Oncology)

Molecular Mechanisms of Zinc Finger Proteins in Biological Processes and Diseases

edited by

Amelia Casamassimi

and Patrizia Gazzerro

submission deadline 30 Jan 2026 | 4 articles | Viewed by 9023 | Submission Open

Keywords: zinc finger domain; CTCF; PRDM family; nuclear receptors; human diseases; transcriptional regulation; epigenetic modifications

(This special issue belongs to the Section Molecular Biophysics)

Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease

edited by David Rohde

submission deadline 30 Jan 2026 | 6 articles | Viewed by 8881 | Submission Open

Keywords: myocardial infarction; heart failure; atherosclerosis; arterial hypertension; myocarditis; arrhythmia; inflammation; hematopoiesis; myelopoiesis; tissue macrophages; neutrophil biology; lymphocytes; endothelial cells; megakaryocytes; platelet biology; biomarkers

(This special issue belongs to the Section Molecular Immunology)

Advances in Antimicrobial Nanomaterials 2.0

edited by

Irena Maliszewska

submission deadline 30 Jan 2026 | 3 articles | Viewed by 8072 | Submission Open

Keywords: metallic nanoparticles; bimetallic nanoparticles; antimicrobial activity; polymeric nanomaterials; nanoplatforms; nanoparticle functionalization; delivery of antimicrobial agents

(This special issue belongs to the Section Molecular Nanoscience)

The Role of the IGF Axis in Disease, 4th Edition

edited by Claire M. Perks

submission deadline 30 Jan 2026 | 3 articles | Viewed by 8029 | Submission Open

Keywords: IGF axis; cancer; obesity; hallmarks of cancer

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Retinal Diseases: From Molecular Pathology to Therapies—2nd Edition

edited by

Peter Koulen

submission deadline 30 Jan 2026 | 4 articles | Viewed by 6960 | Submission Open

Keywords: diabetic retinopathy; age-related macular degeneration; neuroprotection; retina; diabetic macular edema; therapy development; pathophysiology; retinitis pigmentosa; aging; eye trauma; vitreous; macula; choroideremia; stargardt disease; cone– rod dystrophy

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Toxic Liver Injury: Molecular, Mechanistic, and Medical Challenges 3.0

edited by

Rolf Teschke

submission deadline 30 Jan 2026 | 3 articles | Viewed by 6884 | Submission Open

Keywords: liver injury; nonalcoholic fatty liver disease; nonalcoholic steatonecrosis; nonalcoholic liver cirrhosis; hepatocellular carcinoma

(This special issue belongs to the Section Molecular Endocrinology and Metabolism)

Molecular Studies of Age-Related Diseases: Immunosenescence and Inflammaging

edited by

Lia Ginaldi

submission deadline 30 Jan 2026 | 2 articles | Viewed by 6873 | Submission Open

Keywords: aging; age-related; immunosenescence; immune system; inflammaging

(This special issue belongs to the Section Molecular Immunology)

Novel Treatment Strategies for Head and Neck Cancer

edited by

Francesca Spirito

submission deadline 30 Jan 2026 | 1 articles | Viewed by 6508 | Submission Open

Keywords: head and neck cancer; drug resistance; cancer initiation; biomarker

(This special issue belongs to the Section Molecular Oncology)

From Kidney Disease to Hypertension: Molecular Basis and Pathophysiology

edited by

Alexis A. Gonzalez

submission deadline 30 Jan 2026 | 3 articles | Viewed by 6069 | Submission Open

Keywords: renin-angiotensin-aldosterone system; endothelial cell dysfunction; systemic inflammation; hypertension; oxidative stress; vascular remodeling

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Food Science and Molecular Nutrition

edited by

Hsinjung Ho

submission deadline 30 Jan 2026 | 1 articles | Viewed by 5820 | Submission Open

Keywords: food science; antioxidants; bioactive compounds; mitochondria; nutrigenomics; metabolomics

(This special issue belongs to the Section Biochemistry)

Molecular Aspects of Forensic Toxicology

edited by

Angelo Montana

submission deadline 30 Jan 2026 | 1 articles | Viewed by 5549 | Submission Open

Keywords: forensic toxicology; molecular mechanism; toxicological biomarkers; post-mortem interval; in vitro; in vivo; and in silico models; new psychoactive substances (NPSs); new synthetic opioids; liquid chromatography-high resolution mass spectrometry (LC-HRMS/MS); liquid chromatography-tandem mass spectrometry (LC-MS/MS) and gas chromatography-tandem mass spectrometry (GC-MS/MS)

(This special issue belongs to the Section Molecular Toxicology)

Recent Advances in Crustacean Aquaculture

edited by Tom Levy and

Tomer Ventura

submission deadline 30 Jan 2026 | 3 articles | Viewed by 5456 | Submission Open

Keywords: androgenic gland; aquaculture; crustaceans; disease management; gene silencing; genetic modification; monosex; selective breeding; sex reversal; yield improvement

(This special issue belongs to the Section Molecular Biology)

Novel Biomarkers and Emerging Therapeutic Targets for Breast and Gynecologic Cancers

edited by

Hisham Bahmad

submission deadline 30 Jan 2026 | 4 articles | Viewed by 5346 | Submission Open

Keywords: cancer; uterus; cervix; breast; ovary; endometrial cancer; ovarian cancer; cervical cancer; breast cancer; biomarkers; therapeutic target; personalized medicine; targeted therapy; molecular signatures; diagnosis; prognosis

(This special issue belongs to the Section Molecular Oncology)

New Insights into Autophagy and Retinal Degeneration

edited by

Francesco Fornai

submission deadline 30 Jan 2026 | 1 articles | Viewed by 5179 | Submission Open

Keywords: autophagy; retinal degeneration; retinal inflammation; oxidative stress; retinal alterations; age-related macular degeneration; retinal damage; inflammatory processes

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

The Transcendental World of Plant Toxic Compounds

edited by

Helena Fernández

submission deadline 30 Jan 2026 | 2 articles | Viewed by 5069 | Submission Open

Keywords: alcaloids; biotic stress; defence; phenols; phytotoxins; secondary metabolism; terpenes

(This special issue belongs to the Section Molecular Plant Sciences)

Unraveling Sugar Signaling: Insights into Plant Stress Responses

edited by

Claudia Uhde-Stone

submission deadline 30 Jan 2026 | 2 articles | Viewed by 4800 | Submission Open

Keywords: sugar signaling; glucose signaling; sucrose signaling; signal transduction pathways; plant response to stress; biotic stress; abiotic stress; plant physiology

(This special issue belongs to the Section Molecular Plant Sciences)

New Insights into Hyaluronan in Human Medicine

edited by

Monica Salamone

submission deadline 30 Jan 2026 | 3 articles | Viewed by 4513 | Submission Open

Keywords: hyaluronan; regenerative medicine; inflammation; cancer therapy; metabolomics ; hyaluronidases; cell– matrix interaction; glucose metabolism; pathological processes

(This special issue belongs to the Section Biochemistry)

Design, Synthesis and Applications of the Task-Specific Molecules

edited by

Ye Yuan

and

Yang Yang

submission deadline 30 Jan 2026 | 3 articles | Viewed by 4415 | Submission Open

Keywords: task-specific molecules; molecular design and synthesis; physical/chemical absorption; catalysis (including electrocatalysis; photocatalysis; etc.); mechanism on the molecular level; molecular dynamic simulations; optical materials; optoelectronic devices; photoelectric detection; semiconductors

(This special issue belongs to the Section Physical Chemistry and Chemical Physics)

Drug Development Breakthroughs: From Novel Antimicrobials to Targeted Cancer Drugs

edited by

Christos Papaneophytou

submission deadline 30 Jan 2026 | 2 articles | Viewed by 3274 | Submission Open

Keywords: drug development; molecular science; small-molecule inhibitors; biopharmaceuticals; peptides; cancer therapy

(This special issue belongs to the Section Molecular Pharmacology)

Dietary Components in the Brain–Gut Axis: Exploring Nutrigenetic and Microbiome Interactions

edited by

Piotr Dobrowolski

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2996 | Submission Open

Keywords: dietary components; carbohydrates; proteins; fats; fatty acids; vitamins; minerals; brain– gut axis; nutrigenetics; microbiome interactions; neurodegenerative disorders; metabolic pathways

(This special issue belongs to the Section Bioactives and Nutraceuticals)

Glutamine Metabolism in Cancer

edited by

Andrew R. Green

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2868 | Submission Open

Keywords: glutamine metabolism; cancer; oncometabolism; cancer metabolism; metabolic reprogramming; personalised medicine; therapeutic resistance; drug targets

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Innovations in Synthetic Organic Chemistry

edited by Anand H. Shinde

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2842 | Submission Open

Keywords: organic synthesis; catalysis; material applications; bioactive molecules; active pharmaceutical ingredients; green chemistry

(This special issue belongs to the Section Biochemistry)

From Genes to Medicine: Exploring the Genetic and Biological Bases of Medicinal Plants

edited by Wajid Zaman

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2835 | Submission Open

Keywords: medicinal plants; genetic diversity; biosynthesis pathways; bioactive compounds; genomic technologies; plant breeding; biotechnology; CRISPR; phytochemistry; pharmacology; drug discovery; plant-based therapies

(This special issue belongs to the Section Molecular Biology)

Molecular Mechanisms and Therapeutic Strategies to Overcome Drug Resistance in Cancer

edited by

Inamul Haque

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2829 | Submission Open

Keywords: drug resistance; cancer therapy; targeted therapy; nanotechnology; tumor microenvironment; signaling pathway; immunotherapy

(This special issue belongs to the Section Molecular Oncology)

Endothelial Function and Cardiovascular Disease: Molecular Advances and Challenges

edited by

Elena Grossini

submission deadline 30 Jan 2026 | 2 articles | Viewed by 2700 | Submission Open

Keywords: endothelium; heart; protection; therapeutic strategies; vascular system; vesicles

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Dynamics Simulations of Nanobubble for Different Applications

edited by

Ebrahim Kadivar

submission deadline 30 Jan 2026 | 3 articles | Viewed by 2590 | Submission Open

Keywords: cavitation bubble; nanobubble dynamics; hydrodynamic cavitation; molecular dynamics simulations; laser-induced cavitation bubble; cavitation exploitation

(This special issue belongs to the Section Molecular Nanoscience)

Neuroblastoma: Molecular Pathology, Diagnostics and Therapeutics

edited by

Simona Dedoni

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2544 | Submission Open

Keywords: neuroblastoma; solid cancer; immature nerve cells; molecular mechanism; biomarker; tumor heterogeneity

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Plasma-Based Technologies for Food Safety and Health Enhancement

edited by

Ihn Han

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2376 | Submission Open

Keywords: plasma-based technologies; food safety; microbial pathogens; oxidative stability; nutrient preservation

(This special issue belongs to the Section Biochemistry)

Cancer Immunotherapy Biomarkers

edited by Ilias P. Nikas,

Ioannis Pateras

and

Apostolos Zaravinos

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2351 | Submission Open

Keywords: tumor microenvironment; tumor immunology; cancer biomarkers; immunotherapy; immunohistochemistry; pathology; personalized medicine; omics technologies; prognosis and therapy; bioinformatics

(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)

Molecular Biological Determination of Physical Injury

edited by

Sorin Hostiuc

submission deadline 30 Jan 2026 | 1 articles | Viewed by 2163 | Submission Open

Keywords: molecular markers; physical injury; micro-RNA; dating of traumatic injuries

(This special issue belongs to the Section Molecular Biology)

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