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Special Issue "Inflammation in Health and Disease: New Insights and Therapeutic Avenues"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 30 November 2020.

Special Issue Editors

Dr. Javier Conde Aranda

Guest Editor
Health Research Institute of Santiago de Compostela, Molecular and Cellular Gastroenterology, Santiago de Compostela, Spain
Interests: inflammation; autoimmune diseases; inflammatory bowel disease; colorectal cancer
Dr. Morena Scotece

Guest Editor
Health Research Institute of A Coruña; Inflammation, Aging and Regenerative medicine unit, A Coruña, Spain
Interests: inflammation, fibrotic diseases, autoimmune diseases, rheumatology, drug discovery, natural molecules

Special Issue Information

Dear Colleagues,

The inflammatory response is a highly evolved and complex process that allows the mobilization of leukocytes from circulation to injured tissues, where they remove pathogens and repair the tissue for its functional recovery. Under normal conditions, the inflammatory response is a self-limiting process that ends with the resolution of the inflammation and the restoration of tissue homeostasis. However, alterations in the mechanisms that regulate the promotion or the resolution of the inflammatory response cause the development of chronic inflammatory diseases, such as inflammatory bowel disease, rheumatoid arthritis, and diabetes. Moreover, it is well-described that inflammation is involved in the onset and progression of many other disorders not typically classified as autoimmune diseases, e.g., cancer, obesity, cardiovascular diseases, liver diseases, and fibrotic diseases. For that reason, the study and the understanding of the specific mechanisms that lead to aberrant inflammatory responses is crucial for the development of novel therapies for many different pathologies.

This Special Issue seeks basic and translational original and review articles focused on inflammation in health and disease. Potential topics include, but are not limited to, acute inflammation, chronic inflammation, resolution of inflammation, immunotherapy, and immune system regulation or infection.

Dr. Javier Conde Aranda
Dr. Morena Scotece
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • inflammation
  • inflammation resolution
  • autoimmune disease
  • cancer
  • immunotherapy
  • obesity
  • cardiovascular diseases
  • neurological disorders
  • respiratory diseases
  • liver diseases
  • fibrotic diseases

Published Papers (1 paper)

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Open AccessReview
Adipokines and Inflammation: Focus on Cardiovascular Diseases
Int. J. Mol. Sci. 2020, 21(20), 7711; https://doi.org/10.3390/ijms21207711 - 18 Oct 2020
It is well established that adipose tissue, apart from its energy storage function, acts as an endocrine organ that produces and secretes a number of bioactive substances, including hormones commonly known as adipokines. Obesity is a major risk factor for the development of [...] Read more.
It is well established that adipose tissue, apart from its energy storage function, acts as an endocrine organ that produces and secretes a number of bioactive substances, including hormones commonly known as adipokines. Obesity is a major risk factor for the development of cardiovascular diseases, mainly due to a low grade of inflammation and the excessive fat accumulation produced in this state. The adipose tissue dysfunction in obesity leads to an aberrant release of adipokines, some of them with direct cardiovascular and inflammatory regulatory functions. Inflammation is a common link between obesity and cardiovascular diseases, so this review will summarise the role of the main adipokines implicated in the regulation of the inflammatory processes occurring under the scenario of cardiovascular diseases. Full article
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