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Open AccessReview

Adipokines and Inflammation: Focus on Cardiovascular Diseases

Cellular and Molecular Cardiology Unit and Department of Cardiology, Institute of Biomedical Research of Santiago de Compostela (IDIS-SERGAS), Travesía Choupana s/n, 15706 Santiago de Compostela, Spain
CIBERCV, Institute of Health Carlos III, C/Monforte de Lemos 3-5, Pabellón 11, Planta 0, 28029 Madrid, Spain
Cardiology Group, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS) and Institute of Biomedical Research of Santiago de Compostela (IDIS-SERGAS), Av. Barcelona, Campus Vida, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain
Cardiocirculatory Unit, Health Research Institute of La Fe University Hospital, Avinguda de Fernando Abril Martorell 106, 46026 Valencia, Spain
SERGAS (Servizo Galego de Saude): Área Sanitaria de Santiago de Compostela e Barbanza. Santiago University Clinical Hospital, Research Laboratory 9, 15706 Santiago de Compostela, Spain and IDIS (Instituto de Investigación Sanitaria de Santiago), The NEIRID Group (NeuroEndocrine Interactions in Rheumatic and Inflammatory Diseases) C027, 15706 Santiago de Compostela, Spain
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(20), 7711;
Received: 15 September 2020 / Revised: 14 October 2020 / Accepted: 16 October 2020 / Published: 18 October 2020
It is well established that adipose tissue, apart from its energy storage function, acts as an endocrine organ that produces and secretes a number of bioactive substances, including hormones commonly known as adipokines. Obesity is a major risk factor for the development of cardiovascular diseases, mainly due to a low grade of inflammation and the excessive fat accumulation produced in this state. The adipose tissue dysfunction in obesity leads to an aberrant release of adipokines, some of them with direct cardiovascular and inflammatory regulatory functions. Inflammation is a common link between obesity and cardiovascular diseases, so this review will summarise the role of the main adipokines implicated in the regulation of the inflammatory processes occurring under the scenario of cardiovascular diseases. View Full-Text
Keywords: adipokines; inflammation; cardiovascular diseases adipokines; inflammation; cardiovascular diseases
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Feijóo-Bandín, S.; Aragón-Herrera, A.; Moraña-Fernández, S.; Anido-Varela, L.; Tarazón, E.; Roselló-Lletí, E.; Portolés, M.; Moscoso, I.; Gualillo, O.; González-Juanatey, J.R.; Lago, F. Adipokines and Inflammation: Focus on Cardiovascular Diseases. Int. J. Mol. Sci. 2020, 21, 7711.

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