Advanced in Antioxidant Signalling Mediators/Effectors in Skeletal Muscle Disorders

Dear Colleagues,

In the last few decades, many claims have highlighted the potentiality of antioxidants in preventing dysfunction and acute and chronic diseases. Notably, due to the crucial roles played by antioxidants, both favourable and adverse effects have been described for some of these antioxidants, especially considering their effects in specific conditions (i.e., diabetes) and specific tissues.

In fact, it is emerging that particular tissues (such as skeletal muscle) may be strongly affected in humans that present deficiencies of antioxidant factors, highlighting the importance of deeply investigating the role of these molecules in specific tissue and cell compartments.

In addition, antioxidant activity has been described for many of the most well-known “anti-oxidant factors”, but recently, non-antioxidant activities including anti-inflammatory and immunomodulatory activities have been described for some of these factors, such as vitamin E.

Up until recently, knowledge on the effectors and modulators of antioxidant action in skeletal muscle cells has been limited, especially for chronic conditions, aging and chronic diseases, in which a decline in musculoskeletal health, reduced mobility and persistent discomfort have been reported.

In this Special Issue, we focus on obtaining a better understanding of antioxidants in skeletal muscle, especially taking into consideration the similarity and the differences in the molecular mechanisms and signalling pathways involved in antioxidant action, in addition to the direct and indirect effectors and the subcellular compartments in which these forms biologically act (such as intracellular membranes, mitochondria, and cyto-and nucleo-skeleton). Particular attention will also be paid to the peculiarity of the activities when antioxidants are supplemented in combination. For this Special Issue, we encourage the submission of meta-analysis studies and human studies with supplementation of different antioxidant factors alone or together with vitamins and vegetable-derived compounds.

Prof. Dr. Elisabetta Meacci
Guest Editor

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