Molecular Insights into Sphingolipids
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: 30 November 2024 | Viewed by 7278
Special Issue Editor
Interests: antioxidants; vegetable-derived compounds; vitamins; skeletal muscle; chronic diseases; aging; signalling pathway effectors; subcellular compartments; mitochondria; cytoskeleton
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Dear Colleagues,
A strong case is emerging that bioactive sphingolipids, although only a minor constituent of the global lipid milieu in cells and tissues, play a central role in regulating metabolic functions. Specific bioactive sphingolipids have been identified as physiological and pathogenic mediators in metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD), diabetes, or cardiovascular dysfunctions, as well as multifactorial disease such as cancer. Circulating mediators that are released from adipose tissue (e.g., adipokines, inflammatory cytokines) specifically modulate enzymes that are involved in sphingolipid synthesis and degradation. The accumulation of specific sphingolipid species in tissues, such as the liver, muscle, heart, pancreas, and vasculature, may contribute to the onset and development of metabolic diseases, including insulin resistance, pancreatic β-cell failure, liver dysfunction, neuro-muscolar degeneration, cardiomyopathy, and vascular and microenviromental dysfunction. Striking progress has been made over the last few years in elucidating the complex crosstalk between sphingolipids, especially sphingosine 1-phosphate (S1P) and its specific receptors, and the development of several diseases, as scientists have discerned that pharmacological intervention (or the genetic ablation of enzymes controlling sphingolipid synthesis or degradation) and S1P signalling have beneficial effects on these disorders.
Prof. Dr. Elisabetta Meacci
Guest Editor
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Keywords
- sphingolipids
- ceramide
- sphingosine
- sphingosine 1-phosphate
- ceramide 1-phosphate
- glycosphingolipids
- diabetes
- insulin resistance
- beta-cell failure
- NAFLD
- cardiovascular disease
- metabolic dysfunction
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