Molecular Mechanisms of Skeletal Muscle Metabolism
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".
Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 1166
Special Issue Editor
Interests: antioxidants; vegetable-derived compounds; vitamins; skeletal muscle; chronic diseases; aging; signalling pathway effectors; subcellular compartments; mitochondria; cytoskeleton
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Skeletal muscle (SkM) is critical for the generation of mechanical force and the support of bodily posture and movement. However, in recent years, the relevance of SkM functions as a regulator of whole-body metabolism, especially carbohydrate and lipid metabolism, has been studied. Although this interest is mainly due to its contribution to resting energy expenditure, insulin-mediated glucose disposal and body mass, the role of SkM in lipid metabolism is underestimated. Interestingly, SkM metabolic capacity is correlated with the types of fibers and acute and chronic contraction. In fact, in response to exercise, leading to an increase in energy turnover, changes even greater than 100-fold can occur.
In addition, SkM acts also as an endocrine organ releasing peptides, known as exokines, that act in a paracrine manner; thus, SkM can also modulate the functions and metabolism in other organs.
In this Special Issue, high-quality original research and reviews are welcome, as they could help us to better understand the cellular mechanisms underlying glucose and lipid metabolism inside SkM and the potential crosstalk between SkM modulators and the effects of released myokines on other organs during exercise, as well as in patients with obesity and other pathological conditions. Reporting advances in SkM metabolic capacity in aging and sex differences is also encouraged.
Prof. Dr. Elisabetta Meacci
Guest Editor
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Keywords
- skeletal muscle
- metabolism
- aging
- skeletal muscle atrophy
- bioactive lipids
- oxidative stress
- biomarkers
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