Journal Menu► ▼ Journal Menu
Journal Browser► ▼ Journal Browser
Special Issue "High-Density Lipoproteins and Cardiovascular Disease: The Good, the Bad, and the Future"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 10 December 2019.
Interests: atherosclerosis; cholesterol; genetically-modified mice; HDL; lipoproteins
Special Issues and Collections in MDPI journals
Interests: obesity; diabetes; lipoprotein metabolism; metabolic syndrome; therapeutics
Special Issues and Collections in MDPI journals
Epidemiological, clinical, and experimental studies have shown that low levels of plasma high-density lipoprotein (HDL) cholesterol are associated with increased atherosclerotic cardiovascular disease. Nevertheless, HDL-targeted drugs, such as cholesteryl ester transfer protein inhibitors, fibrates, and niacin, have failed to reduce cardiovascular events in clinical trials, thereby casting doubt on the beneficial effects of raising HDL levels.
Experimental studies have identified several HDL cardioprotective functions, including the enhancement of macrophage reverse cholesterol transport and endothelial function, as well as its antioxidant, anti-inflammatory, and anti-thrombotic properties. HDL is highly heterogeneous and carries a large variety of lipids, proteins, and microRNAs. The different composition of HDL subpopulations is directly related to their cardioprotective functions, but the assignment of specific molecules to HDL functions is not completely understood.
Compelling available data strongly indicate that increased HDL cholesterol levels do not always correlate with enhanced beneficial HDL properties, thus questioning their potential as a biomarker of HDL functionality. In addition, the association between low HDL cholesterol and cardiovascular disease can be further confounded by several factors, including insulin resistance, inflammation, and/or metabolic derangements leading to altered plasma lipids, thereby indicating that low HDL levels could simply be a marker of an underlying pathology. Current research is moving towards both the development of robust HDL function tests and the identification of specific HDL molecules (many of them bioactive) within HDL that can be widely applied in translational and pre-clinical studies. The application of novel HDL-based approaches for therapeutic purposes requires the development of validated and reproducible measures of these key atheroprotective HDL functions.
This Special Issue is jointly organized between IJMS and Biomedicines journals. According to the Aims and Scope of these journals, articles showing basic studies in biochemistry, molecular biology, and molecular medicine can be submitted to IJMS, while articles presenting more clinical content can be submitted to Biomedicines.
Dr. Joan Carles Escolà-Gil
Dr. Josep Julve
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: HDL composition and function is as important as the HDL-cholesterol levels
Authors: Arash Meshkat, DMD; Nasrin Dorreh, MSc; Ana Dorfman, BSc; Pegah Malek, MD; Elnaz Kasiri, MD; Zarina Barseghyan, MD; Samra Vazirian, MD and Anahid Jewett, MPH, PhD
Title: Advances in HDL functions: much more than lipid transporters
Authors: Soumaya Ben-Aicha, Lina Badimon, Gemma Vilahur
Title: The role and function of HDL in patient with chronic kidney disease
Authors: Jacek Rysz, Beata Franczyk, Maciej Banach, Anna Gluba-Brzózka
Title: One-year Clinical Outcomes According to HDL-C levels in Patients Undergoing Percutaneous Coronary Intervention
Authors: Madhav Sharma, MBBS; Usman Baber, MD, MS; Dhrubajyoti Bandyopadhyay, MBBS, MD; Serdar Farhan, MD; Jaya Chandrasekhar, MD, MS; Sabato Sorrentino, MD, PhD; Samantha Sartori, PhD; Bimmer E. Claeessen, MD, PhD; Samuel Zucker, BS; Faride Godoy, MPH; Jason Kovacic, MD; Pedro R. Moreno, MD; Nitin Barman, MD; Joseph Sweeny, MD; Pooja Vijay BS; Srushti Shah, MS; George Dangas, MD, PhD; Roxana Mehran, MD; Annapoorna Kini, MD; Samin K. Sharma, MD
Title: The role of HDL in interstitium and lymph- why we care about HDL trafficking through tissues
Authors: Li-Hao Huang
Title: HDL cholesterol as a marker of disease severity and prognosis in patients with pulmonary arterial hypertension
Authors: Grzegorz Kopec; Kamil Jonas
Title: HDL triglycerides, a new marker of HDL dysfunction and cardiovascular risk
Authors: Girona J, Amigó N, Ibarretxe D, Plana N, Rodriguez-Borjabad C, Ferre R, Masana L.
Title: The mechanism of Bisphenol A atherogenicity involves apolipoprotein AI downregulation through NF-kB activation
Authors: V.G. Trusca, F.I. Tudorache, M. Dumitrescu, I.M. Fenyo, M. Simionescu, A.V. Gafencu
Title: Regulation of macrophage foam cell lipidome by ApoA1 and HDL
Authors: Ryan Hogan, Kiran Jahangir, Antoni Paul, and Young-Hwa Goo
Title: Targeting circulating HDL-associated sphingolipids as mediators of diabetic cardiomyopathy: a role for diagnosis and therapeutics
Authors: Elena M. G. Diarte-Añazco, Karen Alejandra Méndez-Lara, Francisco Blanco-Vaca, Antonio Pérez-Pérez, Núria Alonso and Josep Julve
Title: Acute intake of a turmeric extract and brewer’s yeast increase HDL cholesterol levels and ameliorate atheroprotective ratios in healthy subjects
Authors: Lorena Calderón-Pérez, et al.
Title: Lipoprotein lipase inhibitor, Nordihydroguaiaretic acid, alters lipid metabolism and HDL phenotypes in the western diet fed db/db mice
Author: Inhae Kang, et al.
Title: (r)HDL in theranostics: how do we applied HDL's biology for precision medicine in atherosclerosis management?
Authors: Kepa Belloso Uribe (Uribe KB), Cesar Martín (Martín C), Noemi Rotllan Vila
Title: High Density Lipoprotein (HDL) Inhibits Serum Amyloid A (SAA) Induced Vascular and Renal Dysfunctions in Apolipoprotein E-Deficient Mice
Authors: Xiaoping Cai, Gulfam Ahmad, Farjaneh Hossain, Anna Liu, XiaoSuo Wang, Joanne Dennis, Saul Benedict Freedman, Paul Witting *
Title: Clinical and molecular effects of the diet on HDL function
Authors: Milessa Afonso, etc.