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Open AccessArticle

Compositional Features of HDL Particles Interact with Albuminuria to Modulate Cardiovascular Disease Risk

1
Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
2
Department of Nephrology, University of Groningen and University Medical Center Groningen, 9700 RB Groningen, The Netherlands
3
Department of Endocrinology, University of Groningen and University Medical Center Groningen, 9700 RB Groningen, The Netherlands
4
Laboratory Corporation of America Holdings (LabCorp), Morrisville, NC 27560, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(4), 977; https://doi.org/10.3390/ijms20040977
Received: 25 January 2019 / Revised: 17 February 2019 / Accepted: 19 February 2019 / Published: 23 February 2019
Lipoproteins containing apolipoprotein B modify associations of elevated urinary albumin excretion (UAE) with cardiovascular disease (CVD). Additionally, it is known that elevated UAE alters high-density lipoprotein functionality. Accordingly, we examined whether HDL features might also modify UAE-associated CVD. Multivariable Cox proportional-hazards modeling was performed on participants of the PREVEND (Prevention of Renal and Vascular Endstage Disease) study at the baseline screening with standard lipid/lipoprotein analyses and, three-to-four years later (second screen), with nuclear magnetic resonance lipoprotein analyses focusing on HDL parameters including HDL particle (HDL-P) and apolipoprotein A-I concentrations. These were used with UAE and derived measures of HDL apoA-I content (apoA-I/HDL-C and apoA-I/HDL-P) in risk models adjusted for gender, age, apoB, diabetes, past CVD history, CRP and GFR. Interaction analysis was also performed. Baseline screening revealed significant associations inverse for HDL-C and apoA-I and direct for apoA-I/HDL-C. The second screening demonstrated associations inverse for HDL-P, large HDL-P, medium HDL-P, HDL size, and apoA-I/HDL-P. Significant interactions with UAE included apoA-I/HDL-C at the baseline screening, and apoA-I/HDL-P and medium HDL-P but not apoA-I/HDL-C at the second screening. We conclude that features of HDL particles including apoA-I/HDL-P, indicative of HDL apoA-I content, and medium HDL-P modify associations of elevated UAE with CVD risk. View Full-Text
Keywords: albuminuria; urinary albumin excretion; HDL; apolipoprotein A-I; HDL subfractions albuminuria; urinary albumin excretion; HDL; apolipoprotein A-I; HDL subfractions
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Corsetti, J.P.; Bakker, S.J.L.; Gansevoort, R.T.; Gruppen, E.G.; Connelly, M.A.; Sparks, C.E.; Dullaart, R.P.F. Compositional Features of HDL Particles Interact with Albuminuria to Modulate Cardiovascular Disease Risk. Int. J. Mol. Sci. 2019, 20, 977.

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