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Open AccessArticle

HDL Triglycerides: A New Marker of Metabolic and Cardiovascular Risk

1
Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, Sant Joan University Hospital, Universitat Rovira i Virgili, IISPV, 43201 Reus, Spain
2
Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28029 Madrid, Spain
3
Biosfer Teslab, 43204 Reus, Spain
4
Department of Electronic Engineering, Universitat Rovira i Virgili, IISPV, 430007 Tarragona, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(13), 3151; https://doi.org/10.3390/ijms20133151
Received: 31 May 2019 / Revised: 25 June 2019 / Accepted: 26 June 2019 / Published: 27 June 2019
While cholesterol content in high-density lipoproteins (HDLs) is a well-established inverse marker of cardiovascular risk, the importance of HDL–triglyceride (HDL-TG) concentration is not well known. We aim to examine plasma HDL-TG concentrations, assessed by 1H-NMR, in patients with metabolic diseases and their association with classical biomarkers. In this cross-sectional study, we included 502 patients with type 2 diabetes or metabolic syndrome attending the lipid unit of our University Hospital. The presence of arteriosclerotic plaques was assessed by ultrasonography. A complete lipoprotein profile was performed by 1H-NMR (Liposcale test). HDL-TG was strongly positively correlated with total triglycerides, glycerol, and fatty liver index, while a strong negative correlation was observed with HDL-cholesterol (HDL-C) and HDL-particle number (HDL-P). HDL-TG was associated with all triglyceride-rich lipoprotein parameters and had an opposite association with HDL-C and HDL-P. It was also significantly correlated with circulating cholesterol ester transfer protein (CETP). HDL-TG concentrations were higher as metabolic syndrome components increased. HDL-TG was also higher with worsening glucose metabolism. Patients with carotid plaques also showed higher HDL-TG. In contrast to HDL-C, HDL-TG is directly associated with metabolism and arteriosclerotic vascular alterations. HDL-TG should be considered a biomarker of metabolic and cardiovascular risk and could be a marker of HDL dysfunction. View Full-Text
Keywords: HDL triglycerides; HDL cholesterol; HDL particle number; 1H-NMR; cardiovascular risk HDL triglycerides; HDL cholesterol; HDL particle number; 1H-NMR; cardiovascular risk
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Girona, J.; Amigó, N.; Ibarretxe, D.; Plana, N.; Rodríguez-Borjabad, C.; Heras, M.; Ferré, R.; Gil, M.; Correig, X.; Masana, L. HDL Triglycerides: A New Marker of Metabolic and Cardiovascular Risk. Int. J. Mol. Sci. 2019, 20, 3151.

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