Next Article in Journal
The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer
Next Article in Special Issue
HDL Cholesterol as a Marker of Disease Severity and Prognosis in Patients with Pulmonary Arterial Hypertension
Previous Article in Journal
Marek’s Disease Virus Infection Induced Mitochondria Changes in Chickens
Previous Article in Special Issue
Lipoprotein Lipase Inhibitor, Nordihydroguaiaretic Acid, Aggravates Metabolic Phenotypes and Alters HDL Particle Size in the Western Diet-Fed db/db Mice
Open AccessArticle

HDL Triglycerides: A New Marker of Metabolic and Cardiovascular Risk

Vascular Medicine and Metabolism Unit, Research Unit on Lipids and Atherosclerosis, Sant Joan University Hospital, Universitat Rovira i Virgili, IISPV, 43201 Reus, Spain
Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), 28029 Madrid, Spain
Biosfer Teslab, 43204 Reus, Spain
Department of Electronic Engineering, Universitat Rovira i Virgili, IISPV, 430007 Tarragona, Spain
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(13), 3151;
Received: 31 May 2019 / Revised: 25 June 2019 / Accepted: 26 June 2019 / Published: 27 June 2019
While cholesterol content in high-density lipoproteins (HDLs) is a well-established inverse marker of cardiovascular risk, the importance of HDL–triglyceride (HDL-TG) concentration is not well known. We aim to examine plasma HDL-TG concentrations, assessed by 1H-NMR, in patients with metabolic diseases and their association with classical biomarkers. In this cross-sectional study, we included 502 patients with type 2 diabetes or metabolic syndrome attending the lipid unit of our University Hospital. The presence of arteriosclerotic plaques was assessed by ultrasonography. A complete lipoprotein profile was performed by 1H-NMR (Liposcale test). HDL-TG was strongly positively correlated with total triglycerides, glycerol, and fatty liver index, while a strong negative correlation was observed with HDL-cholesterol (HDL-C) and HDL-particle number (HDL-P). HDL-TG was associated with all triglyceride-rich lipoprotein parameters and had an opposite association with HDL-C and HDL-P. It was also significantly correlated with circulating cholesterol ester transfer protein (CETP). HDL-TG concentrations were higher as metabolic syndrome components increased. HDL-TG was also higher with worsening glucose metabolism. Patients with carotid plaques also showed higher HDL-TG. In contrast to HDL-C, HDL-TG is directly associated with metabolism and arteriosclerotic vascular alterations. HDL-TG should be considered a biomarker of metabolic and cardiovascular risk and could be a marker of HDL dysfunction. View Full-Text
Keywords: HDL triglycerides; HDL cholesterol; HDL particle number; 1H-NMR; cardiovascular risk HDL triglycerides; HDL cholesterol; HDL particle number; 1H-NMR; cardiovascular risk
Show Figures

Figure 1

MDPI and ACS Style

Girona, J.; Amigó, N.; Ibarretxe, D.; Plana, N.; Rodríguez-Borjabad, C.; Heras, M.; Ferré, R.; Gil, M.; Correig, X.; Masana, L. HDL Triglycerides: A New Marker of Metabolic and Cardiovascular Risk. Int. J. Mol. Sci. 2019, 20, 3151.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop