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HDL Cholesterol as a Marker of Disease Severity and Prognosis in Patients with Pulmonary Arterial Hypertension

Department of Cardiac and Vascular Diseases, Jagiellonian University Medical College, John Paul II Hospital, 31-202 Krakow, Poland
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Int. J. Mol. Sci. 2019, 20(14), 3514; https://doi.org/10.3390/ijms20143514
Received: 27 June 2019 / Revised: 15 July 2019 / Accepted: 16 July 2019 / Published: 18 July 2019
The impact of high-density lipoprotein (HDL) cholesterol on the development of atherosclerosis and diseases of systemic circulation has been well documented both in experimental and registry studies. Recent discoveries in pulmonary arterial hypertension (PAH) revealed a significant impact of HDL on pulmonary artery vasoreactivity and patients’ prognosis. The vasoprotective activity of HDL primarily involves vascular endothelium that also plays a central role in pulmonary arterial hypertension (PAH) pathobiology. However, the exact mechanism in which this lipoprotein fraction exerts its effect in pulmonary circulation is still under investigation. This paper reviews potential vasoprotective mechanisms of HDL in pulmonary circulation and presents current clinical reports on the role of HDL in PAH patients. View Full-Text
Keywords: lipoprotein metabolism; inflammation; endothelium; microRNA lipoprotein metabolism; inflammation; endothelium; microRNA
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MDPI and ACS Style

Jonas, K.; Kopeć, G. HDL Cholesterol as a Marker of Disease Severity and Prognosis in Patients with Pulmonary Arterial Hypertension. Int. J. Mol. Sci. 2019, 20, 3514.

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