The Role of Genetic Variation on Transcription Factor Binding Sites in Evolution and Disease

Dear Colleagues,

The genetic bases of many human diseases and phenotypic evolutionary changes most frequently implicate regulatory elements, and one important type of functional element among those are transcription factor binding sites (TFBSs). The study of disease susceptibility or evolutionary changes derived from variation in TFBSs is of great interest but challenging, as it requires the extracting of inferences from very short and sometimes intrinsically degenerated transcription factor motifs.

This Special Issue will highlight in silico and experimental approaches to study the contribution of genetic polymorphisms that create or disrupt TFBSs in disease and in evolution. This includes topics related to molecular evolution, regulatory sequences and both in silico and experimental analyses on transcription factor binding sites.

Dr. Gabriel Santpere
Guest Editor

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