Cytotoxicity on Pharmaceutical Interactions in Chemotherapy

Dear Colleagues,

A wide variety of anticancer drugs are used for chemotherapy depending on the type of cancer. Many of these anticancer agents have cytotoxic effects on tumor cells as a major mechanism for their anticancer effects. However, insufficient tumor cell selectivity may result in a risk of comorbid side effects, including hematotoxicity due to myelosuppression. Because chemotherapy is often achieved using a combination of drugs, the relationship between these antitumor effects and side effects and anticancer drugs is complex.

The purpose of this Special Issue is to integrate knowledge, including mechanisms of clinically and biochemically useful expression of pharmacological interactions. In other words, it is expected that findings relevant to this topic will be based on the results of biochemical studies through in vivo and in vitro experiments and data accumulated in a variety of clinical studies, including database studies. This combined knowledge allows molecular interpretations of chemotherapy and may contribute to improved clinical outcomes of anticancer therapy.

Prof. Dr. Yoshihiro Uesawa
Guest Editor

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