Neuroinflammation in Neurodegenerative Diseases—a Target for Novel CNS-Permeable Anti-inflammatory Drugs?

Dear Colleagues, 

Multiple sclerosis has long been recognized as the “classical” neuroinflammatory disease. More recently, the term ‘neuroinflammation’ has been applied to chronic, CNS-specific, inflammation-like glial responses that do not reproduce the classic characteristics of inflammation but cause neurodegeneration. For example, Chronic microglial activation (T-cell independent neuroinflammation) has been described in many neurodegenerative diseases such as chronic traumatic encephalopathy (CTE), amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD) and Alzheimer’s disease (AD). In summary, the progression of many neurodegenerative diseases is driven by a cycle of self-perpetuating inflammatory neurotoxicity. Consequently, targeting chronic neuroinflammation with brain permeable anti-inflammatory drugs has been suggested as a disease-modifying treatment for many neurodegenerative diseases including AD. This special issue will invite manuscript providing more evidence for this hypothesis, and also explore the beneficial effect of potential novel and repurposed anti-inflammatory and neuroprotective drugs from cell culture models through to human clinical trials.

Prof. Dr. Gerald Muench
Guest Editor

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• inflammation
• microglia
• brain
• cytokines
• chemokines