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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Molecular Biomarkers in Cancer Diagnosis, Prognosis and Therapy

edited by

Antonis Giakountis

submission deadline 25 Jan 2027 | Viewed by 114 | Submission Open

Keywords: molecular biomarkers; cancer diagnosis and prognosis; precision oncology; next-generation sequencing (NGS); liquid biopsy; circulating tumor cells (CTCs)

(This special issue belongs to the Section Genetic Diagnosis)

Advances in Insect Mitochondrial Genomics and Molecular Phylogenetics

edited by Nan Song

submission deadline 10 Feb 2027 | Viewed by 165 | Submission Open

Keywords: mitogenome; insects; gene rearrangement; gene order; phylogeny; evolution; taxonomy; systematics; next-generation sequencing

(This special issue belongs to the Section Animal Genetics and Genomics)

Evolutionary Cytogenetics and Phylogenetics of Insects

edited by

Pedro Lorite Martínez

and

Sebastian Pita

submission deadline 15 Feb 2027 | 1 articles | Viewed by 549 | Submission Open

Keywords: evolutionary cytogenetics; insect phylogenetics; cytogenomics; chromosome evolution; sex chromosomes; B chromosomes; repetitive DNA; chromosomal rearrangements; comparative cytogenetics; genome evolution

(This special issue belongs to the Section Animal Genetics and Genomics)

Population Studies on the Genetic Diversity and Evolutionary Adaptability of Amphibian and Reptile Genomes

edited by

Wei Chen

Jie Wang

and Buddhi Dayananda

submission deadline 15 Feb 2027 | Viewed by 245 | Submission Open

Keywords: amphibians; reptiles; population genomics; genetic diversity; evolutionary adaptability; conservation genetics; local adaptation; gene flow; demographic history; climate change

(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)

Innovative Biotechnological Strategies in Molecular Microbiology and Genomic Technologies to Overcome Multi-Drug Resistance in a One Health Perspective

edited by

Pedro Panzenhagen

Carlos Adam Conte Júnior

and

Anamaria M. P. dos Santos

submission deadline 15 Feb 2027 | Viewed by 169 | Submission Open

Keywords: One Health; pathogen genomics; whole genome sequencing (WGS); CRISPR technology; infectious disease outbreaks; antimicrobial resistance; genomic epidemiology; public health surveillance; bioinformatics in pathogen research

(This special issue belongs to the Section Microbial Genetics and Genomics)

Molecular Genetics and Genomics of Plant Metabolism and Development

edited by Quanle Xu,

Lei Wang

and

Yaoyao Song

submission deadline 15 Feb 2027 | Viewed by 149 | Submission Open

Keywords: plant metabolic regulation; genetic; metabolism and development; genome-wide association studies; crop yield and quality

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics and Genomics of Thyroid Function and Benign and Malignant Thyroid Disorders

edited by

Tatjana Bogovic Crncic

and Tomislav Jukić

submission deadline 15 Feb 2027 | Viewed by 97 | Submission Open

Keywords: thyroid diseases; thyroid cancer; benign thyroid nodules; autoimmune thyroid diseases; genomic alterations; molecular diagnostics; genetic susceptibility; thyroid tumorigenesis; personalized medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Molecular Pathology and Genomic Analytics: Bioinformatics Innovations in Cancer Research

edited by

Massimiliano Chetta

submission deadline 20 Feb 2027 | 1 articles | Viewed by 338 | Submission Open

Keywords: molecular pathology; genomic analytics; cancer research; bioinformatics innovations; tumor evolution; clonal evolution; tumor heterogeneity

(This special issue belongs to the Section Bioinformatics)

Genetic and Molecular Insights into Cardiovascular Disease: From Mechanisms to Precision Medicine

edited by

Lingfeng Luo

and

Laurent Metzinger

submission deadline 25 Feb 2027 | 13 articles | Viewed by 12087 | Submission Open

Keywords: cardiovascular disease; genetic variants; precision medicine; epigenetics; non-coding RNAs; polygenic risk scores; mendelian randomization; biomarkers; genome-wide association studies (GWASs); molecular mechanisms

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Molecular Genetics of Psychiatric Diseases

edited by Fotis Tsetsos

submission deadline 25 Feb 2027 | 2 articles | Viewed by 3137 | Submission Open

Keywords: psychiatric genetics; molecular psychiatry; GWAS; rare variants; transcriptomics; epigenetics; gene-environment interactions; precision psychiatry; schizophrenia; bipolar disorder; depression; autism spectrum disorder; anxiety; functional genomics; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Genetics and Genomics)

Structural and Evolutionary Perspectives on Immunogenetic Variation in Autoimmune and Related Disorders

edited by Athena Andreou and Catriona Kelly

submission deadline 25 Feb 2027 | 1 articles | Viewed by 2811 | Submission Open

Keywords: gene polymorphisms; exonic and intronic variants; structural biology; biophysical analysis; structural evolution; protein molecular function and evolution; immunological biomarkers; human genetic diseases; evolutionary genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Monogenic Diabetes—from Basic Scientific Insights to Precision Care and Beyond

edited by Kathy HC Wu

submission deadline 25 Feb 2027 | Viewed by 357 | Submission Open

Keywords: MODY; precision; implementation; diversity; equity; bioinformatics; functional genomics; genotype; phenotype; high throughput

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Animal Genomics and Transcriptome Analysis

edited by Mengxun Li

submission deadline 25 Feb 2027 | Viewed by 143 | Submission Open

Keywords: animal genomics; transcriptome profiling; next-generation sequencing; molecular breeding; bioinformatic analysis

(This special issue belongs to the Section Animal Genetics and Genomics)

Plant Peptides: Genetics and Function

edited by

Yanping Jing

and

Huawei Xu

submission deadline 25 Feb 2027 | Viewed by 120 | Submission Open

Keywords: plant peptides; peptidomics; peptide maturation; peptide evolution; peptide–receptor interactions; peptide signaling networks; synthetic peptide engineering; peptide-based crop protection

(This special issue belongs to the Section Plant Genetics and Genomics)

Sheep Genomics: Present and Future

edited by

Hangxing Ren

Caiye Zhu

and Huihua Wang

submission deadline 10 Mar 2027 | Viewed by 56 | Submission Open

Keywords: sheep; genome; epigenomics; single-cell sequencing; spatial transcriptome; quantitative genetics; functional validation

(This special issue belongs to the Section Animal Genetics and Genomics)

Advancements in Pharmacogenomics for Precision Medicine

edited by

Óscar Teijido Hermida

submission deadline 15 Mar 2027 | 2 articles | Viewed by 1736 | Submission Open

Keywords: pharmacogenomics; precision medicine; pharmacoepigenomics; epidrugs; genomic biomarkers; drug response variability; personalized therapy; multi-omics integration; pharmacogenetic testing; clinical implementation; artificial intelligence in pharmacogenomics; genetic polymorphisms; translational genomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Selected Papers from the 3rd International Online Conference on Genes (IOCGE 2026)

edited by

Silvia Turroni

and

Selvarangan Ponnazhagan

submission deadline 15 Mar 2027 | Viewed by 597 | Submission Open

Keywords: non-coding RNAs in health and disease; advances in the diagnosis, treatment, and prevention of genetic disorders; microbial genetics and metagenomics; epigenetics and chromatin remodeling; cancer genetics; applications of machine learning and bioinformatics; population genetics and genetic epidemiology; pharmacogenomics

Genomics and Functional Genetics of Marine Shrimp Adaptation and Breeding

edited by Jiajia Wang

submission deadline 15 Mar 2027 | Viewed by 328 | Submission Open

Keywords: shrimp; aquaculture; genomics; functional genetics; environmental adaptation; disease resistance; genetic breeding; stress response; molecular mechanisms; genomic selection

(This special issue belongs to the Section Animal Genetics and Genomics)

Genetic Regulation of Neurons and Behavioral Genetics

edited by

Gülcan Akgül

submission deadline 15 Mar 2027 | Viewed by 289 | Submission Open

Keywords: gene regulatory networks; functional genomics; epigenomics; transcriptomics; neuronal development; behavioral tracking; genome editing; organoids

(This special issue belongs to the Section Neurogenomics)

Molecular Basis and Gene Therapy of Cystic Fibrosis

edited by

Beate Illek

submission deadline 15 Mar 2027 | Viewed by 174 | Submission Open

Keywords: genomic medicine & cystic fibrosis; CFTR gene therapy; CRISPR-based editing (HDR/base/prime); mRNA & antisense oligonucleotide (ASO) therapeutics; NMD & miRNA inhibitors; viral vectors; SORT-LNPs (selective ORgan targeting); inhaled & systemic targeted delivery; vascularized & CF cell/animal models; inflammatory gene therapy barriers

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

From Pediatrics to Late-Onset Phenotypes: Closing the Diagnostic Gap in Rare Diseases Through Advanced Molecular Testing

edited by

Lǎcrǎmioara Ionela Butnariu

submission deadline 15 Mar 2027 | Viewed by 151 | Submission Open

Keywords: pediatric genetics; late-onset phenotypes; genetic diagnostic gap; Whole-Exome Sequencing (WES); Whole-Genome Sequencing (WGS); RNA-seq; variants of uncertain significance (VUSs); long-read sequencing; diagnostic odyssey; multi-omics integration

(This special issue belongs to the Section Genetic Diagnosis)

Application of Bioinformatics in Crop Genetic Improvement

edited by Jin Wang and Tongkun Liu

submission deadline 15 Mar 2027 | Viewed by 107 | Submission Open

Keywords: bioinformatics; genomics; crop genetic improvement; crop breeding; biotechnology

(This special issue belongs to the Section Plant Genetics and Genomics)

Molecular Genetics and Breeding Strategies in Crops

edited by Guanghui Guo

submission deadline 15 Mar 2027 | Viewed by 79 | Submission Open

Keywords: marker-assisted selection; genomic selection; genome editing; transgenic; stress; speed breeding

(This special issue belongs to the Section Plant Genetics and Genomics)

Environmental Genomics and Low-Dose Induced Adaptive Response: Underlying Mechanisms from Cells to Organisms

edited by

Stephka Chankova

, Michaela Beltcheva and

Teodora Todorova

submission deadline 20 Mar 2027 | 3 articles | Viewed by 2931 | Submission Open

Keywords: environmental genomics; ecotoxicology; low-dose induced adaptive response; low-dose radiation; genomic instability; environmental mutagenesis; DNA repair; radio-protection; stress response; toxicogenomics; antioxidant system; chaperone system

(This special issue belongs to the Section Genes & Environments)

Advances in Molecular Genetics of Rare Disorders

edited by Miriam Lucia Carriero

submission deadline 20 Mar 2027 | 4 articles | Viewed by 2627 | Submission Open

Keywords: rare diseases; molecular genetics; gene–disease associations; genotype–phenotype correlation; targeted gene therapy; next-generation sequencing; whole-genome sequencing; genome-wide association studies; functional genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Fetal Genetic Disorders: Diagnosis and Therapy

edited by Gianluca Campobasso

submission deadline 20 Mar 2027 | 2 articles | Viewed by 1414 | Submission Open

Keywords: fetal medicine; malformations,; genetic anomalies,; genomic sequencing,; syndromes; artificial intelligence

(This special issue belongs to the Section Genetic Diagnosis)

Genomics and Computational Biology in Human Leukemia

edited by Veronique Voisin

submission deadline 20 Mar 2027 | Viewed by 143 | Submission Open

Keywords: leukemia genomics; single-cell transcriptomics; computational oncology; multi-omics integration; precision medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Decoding Male Infertility: Genomics, Non-Coding RNAs and Multi-Omics Approaches

edited by

Zissis Mamuris

and

Maria-Anna Kyrgiafini

submission deadline 20 Mar 2027 | Viewed by 137 | Submission Open

Keywords: male infertility; non-coding RNAs; genomics; multi-omics; precision reproductive medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advances in Fungal Pathogen Genetics

edited by

Shuaishuai Huang

and

Víctor J. Cid

submission deadline 20 Mar 2027 | Viewed by 109 | Submission Open

Keywords: fungal pathogen; host–pathogen interaction; transcriptomics; genomics; epigenetics; multi-omics; evolution; stress response; development

(This special issue belongs to the Section Microbial Genetics and Genomics)

Integrative Multi-Omics Approaches in Disease Mapping: From Genetic Variation to Protein Regulation and Post-Translational Modifications

edited by

Shrabanti Chowdhury

submission deadline 20 Mar 2027 | Viewed by 82 | Submission Open

Keywords: proteogenomics; post-translational modifications; multi-omics integration; disease mapping; causal inference; machine learning in omics; biomarker discovery

(This special issue belongs to the Section Bioinformatics)

Forest Tree Genetics: Genetic Improvement and Breeding

edited by

Hanbo Yang

and

Wenquan Bao

submission deadline 20 Mar 2027 | Viewed by 68 | Submission Open

Keywords: forest genetics; genetic improvement; tree breeding; germplasm resources; molecular markers; genomic selection; stress-resistance breeding; wood property improvement; genetic diversity; functional genomics

(This special issue belongs to the Section Plant Genetics and Genomics)

Advances in Genetics and Genomics of Medical Plants

edited by

Mingcheng Wang

submission deadline 25 Mar 2027 | 3 articles | Viewed by 2034 | Submission Open

Keywords: medicinal plant genomics; medicinal plant genetics; high-throughput sequencing; functional genomics; multi-omics integration

(This special issue belongs to the Section Plant Genetics and Genomics)

Forage Crop Genetics Improvement and Breeding

edited by Enjun Xu

submission deadline 25 Mar 2027 | Viewed by 102 | Submission Open

Keywords: forage crops; forage genomics; biomass yield; abiotic stress tolerance; forage quality/nutritional quality; genetic transformation; genome editing/gene editing; germplasm innovation

(This special issue belongs to the Section Plant Genetics and Genomics)

Innovations in Aquaculture Breeding via Genetic Technologies

edited by

Lei Liu

submission deadline 5 Apr 2027 | 2 articles | Viewed by 2203 | Submission Open

Keywords: aquaculture species; molecular breeding; genomic; behavioral traits; reproduction and development; genome editing; whole-genome sequencing

(This special issue belongs to the Section Animal Genetics and Genomics)

Abiotic Stress in Plant: Molecular Genetics and Genomics

edited by Weicong Qi and

Hongyan Wang

submission deadline 10 Apr 2027 | 10 articles | Viewed by 9337 | Submission Open

Keywords: abiotic stress; molecular genetics; genomics; plant stress response; epigenetics; crop improvement; sustainable agriculture

(This special issue belongs to the Section Plant Genetics and Genomics)

Molecular Evolution and Mitochondrial Genomics in Animals

edited by

Jiayong Zhang

submission deadline 10 Apr 2027 | 2 articles | Viewed by 1413 | Submission Open

Keywords: mitochondrial genome; gene arrangement; phylogenetic relationship; mitochondrial gene expression; molecular evolution

(This special issue belongs to the Section Animal Genetics and Genomics)

Epigenetic Regulation of Transcription in Eukaryotes

edited by Ralph Grand

submission deadline 10 Apr 2027 | Viewed by 329 | Submission Open

Keywords: epigenetics; nucleosomes; chromatin; transcription; development; disease

(This special issue belongs to the Section Epigenomics)

Computational Genomics and Bioinformatics of Cancer

edited by

Ilya Ioshikhes

submission deadline 15 Apr 2027 | 14 articles | Viewed by 23171 | Submission Open

Keywords: cancer; data analysis; bioinformatics; complex diseases; dimensionality reduction; genetics; epigenetics; gene regulation; molecular mechanism; environmental factors

(This special issue belongs to the Section Bioinformatics)

Genetic and Genomic Mechanisms of Heat Stress in Disease Modulation: From Molecular Pathways to Clinical Manifestations

edited by

Hisahide Nishio

and

Hiroyuki Awano

submission deadline 15 Apr 2027 | 1 articles | Viewed by 2484 | Submission Open

Keywords: heatstroke; global warming; heat stress; neurodegenerative diseases; molecular pathogenesis; gene–environment interactions

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Systems Biology of Single Cells: Bridging Genomics and Functional Insights

edited by

Guilherme Targino Valente

submission deadline 15 Apr 2027 | 2 articles | Viewed by 2227 | Submission Open

Keywords: systems biology; graph theory; single-cell RNA-Seq; spatial transcriptomics; molecular networks; complex networks

(This special issue belongs to the Section Bioinformatics)

Genetics and Breeding of Tea Tree and Tea Plant

edited by Lianyu Yuan

submission deadline 15 Apr 2027 | 2 articles | Viewed by 1501 | Submission Open

Keywords: gene function analysis; genome analysis; biotechnological breeding; genetic diversity; breeding technology; multi-omics analysis; tea plant

(This special issue belongs to the Section Plant Genetics and Genomics)

Gene Regulatory Networks in Hematologic Malignancies and Cancer

edited by Renee M. Demarest

submission deadline 15 Apr 2027 | 1 articles | Viewed by 597 | Submission Open

Keywords: gene regulatory networks; hematologic malignancies; cancer genomics; transcriptional regulation; epigenetic regulation; hematopoiesis; single-cell sequencing; systems biology

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Telomere Biology: From Mechanisms of Genome Stability to Cancer

edited by Marta Dratwa-Kuzmin and Katarzyna Bogunia-Kubik

submission deadline 15 Apr 2027 | Viewed by 172 | Submission Open

Keywords: telomeres; genome stability; chromosomal instability; telomerase; alternative lengthening of telomeres (ALT); DNA damage response; DNA repair; replication stress; cellular senescence; cancer biology; tumor progression; ageing; chromatin organization; telomere dysfunction; cancer therapeutics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Decoding the Epigenomic Basis of Gene Regulation in Cancer

edited by Alireza Lorzadeh

submission deadline 15 Apr 2027 | Viewed by 45 | Submission Open

Keywords: epigenetic enhancer dynamics; epigenetic stem cell plasticity; epigenetic single-cell multi-omics; epigenetic disease heterogeneity; epigenetic gene regulatory networks; AI-driven epigenetic analysis; epigenetic precision medicine

(This special issue belongs to the Section Epigenomics)

Molecular and Genomic Testing in Hematology: From Diagnosis to Disease Monitoring

edited by

Rina Kansal

submission deadline 15 Apr 2027 | Viewed by 33 | Submission Open

Keywords: hematology; pathology; genomics; next-generation sequencing; hematologic malignancies; anemia; measurable residual disease; circulating tumor DNA; machine learning

(This special issue belongs to the Section Genetic Diagnosis)

Epigenomic and Genomic Studies of Cancers

edited by Yuxiang Wang

submission deadline 20 Apr 2027 | Viewed by 289 | Submission Open

Keywords: cancer; mutation; amplification; deletion; epigenetics; 3D epigenetics; next-generation sequencing; ChIP-seq; Hi-C; DamID; sequential FISH; SPRITE; GAM

(This special issue belongs to the Section Epigenomics)

Genomics, Climate Adaptation and Precision Breeding in Animals

edited by

Themistoklis Giannoulis

submission deadline 20 Apr 2027 | 1 articles | Viewed by 63 | Submission Open

Keywords: climate adaptation; genomic selection; livestock genomics; heat stress; precision breeding; sustainability

(This special issue belongs to the Section Animal Genetics and Genomics)

Advances in Genetic Insights into Cardiovascular Diseases

edited by

John Alex Elefteriades

submission deadline 25 Apr 2027 | Viewed by 50 | Submission Open

Keywords: cardiovascular genetics; causative genes; whole exome sequencing; genotype–phenotype correlation; precision therapy; pharmacogenetics in CVD; gender medicine in CVD

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

DNA Replication Fidelity and Dynamics in Cancer

edited by

Francesca Citron

submission deadline 25 Apr 2027 | Viewed by 37 | Submission Open

Keywords: DNA replication; DNA damage and repair; epigenetics; genomic instability; immune response; immunotherapy; tumor evolution

(This special issue belongs to the Section Molecular Genetics and Genomics)

Bioinformatics of Genome Regulation

edited by

Kenta Nakai

Hongyan Xu

and

Martin Loza

submission deadline 25 Apr 2027 | Viewed by 35 | Submission Open

Keywords: epigenomics; transcriptional regulation; single-cell multi-omics; deep learning; gene regulatory networks; chromatin architecture; genome grammar

(This special issue belongs to the Section Bioinformatics)

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