Special Issues

Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Reviews in Genetic Bioinformatics: Tools and Analyses
edited by
submission deadline 20 Jan 2026 | Viewed by 247 | Submission Open
Keywords: genetics; genomics; machine learning; computational biology; big data; bioinformatics
(This special issue belongs to the Section Bioinformatics)
Application of Bioinformatics in Complex Traits
edited by
submission deadline 20 Jan 2026 | Viewed by 138 | Submission Open
Keywords: complex traits; bioinformatics; multi-omics integration; gene– environment interactions; polygenic risk scores; machine learning; systems biology; network analysis; statistical genetics; causal inference
(This special issue belongs to the Section Bioinformatics)
Molecular Genetics of Neurodevelopmental Disorders: 2nd Edition submission deadline 25 Jan 2026 | 1 articles | Viewed by 1549 | Submission Open
Keywords: neurodevelopmental disorders; attention deficit hyperactivity disorder; intellectual disabilities; autism spectrum disorder; mitochondria; neuroinflammation; epigenetics; transcriptomics; genetic syndromes; polygenetic interactions
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
5Gs in Crop Genetic and Genomic Improvement: 2025–2026
edited by
submission deadline 25 Jan 2026 | 2 articles | Viewed by 762 | Submission Open
Keywords: crop gene functional analysis; crop protemics; crop metabonomics; new crop breeding methods; crop GWAS analysis; crop gene edit technology; crop gene epigenetic modification
(This special issue belongs to the Section Plant Genetics and Genomics)
Genetic Testing and Clinical Management of Hereditary Cancer
edited by
submission deadline 25 Jan 2026 | Viewed by 306 | Submission Open
Keywords: genetic cancer predisposition; hereditary cancer risk; polygenic risk; cancer screening; genetic testing; genomic testing; DNA sequencing; RNA sequencing; cascade genetic testing; precision medicine; germline genetic testing; tumor molecular profiling; paired analysis; hematological malignancy
(This special issue belongs to the Section Epigenomics)
Genomics and Proteomics-Based Molecular Diagnostics and Targeted Therapies in Cancer
edited by
submission deadline 25 Jan 2026 | Viewed by 262 | Submission Open
Keywords: molecular diagnostics; targeted therapies; biomarkers; precision medicine oncology; chemotherapy; small-molecule drugs; monoclonal antibodies; cancer immunotherapy
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Unraveling Genomic Mechanisms of Stress Tolerance and Antimicrobial Resistance in Foodborne Pathogens submission deadline 25 Jan 2026 | Viewed by 236 | Submission Open
Keywords: foodborne pathogens; AMR; survivability; thermal resistance; in silico analysis; DNA sequencing; RNA sequencing; environmental stress condition
(This special issue belongs to the Section Microbial Genetics and Genomics)
Genetic Epidemiology of Multifactorial Diseases
edited by and Ioannis Stefanidis
submission deadline 25 Jan 2026 | Viewed by 219 | Submission Open
Keywords: genetic association studies; polygenic risk scores; functional genomics; causal inference; mendelian randomization; translational applications
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genetics and Environmental Factors in Psychiatric Disorders
edited by
submission deadline 25 Jan 2026 | Viewed by 113 | Submission Open
Keywords: PGS; environmental factors; epigenetics; prenatal environmental exposures; GWAS; GxE interactions
(This special issue belongs to the Section Genes & Environments)
Genetics and Physiology of Multiple-Stress Tolerance in Plants
edited by Jin Wang
submission deadline 25 Jan 2026 | Viewed by 72 | Submission Open
Keywords: plant; genetics; genomics; physiology; biotic stress; abiotic stress; genetic breeding; molecular biology
(This special issue belongs to the Section Plant Genetics and Genomics)
Novel Insights into Forensic Genetics submission deadline 31 Jan 2026 | 2 articles | Viewed by 1074 | Submission Open
Keywords: forenscic genetics; molecular autopsy; forensic omics; post-mortem genetic testing; legal medicine
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genetics and Treatment in Neurodegenerative Diseases
edited by Valentino Rački and
submission deadline 5 Feb 2026 | 3 articles | Viewed by 3104 | Submission Open
Keywords: neurodegeneration; genetics; Alzheimer’ s disease; Parkinson’ s disease; gene therapy; pharmacogenomics; precision medicine
(This special issue belongs to the Section Neurogenomics)
Molecular Genetics Reviews: Current Understanding and Future Directions submission deadline 5 Feb 2026 | Viewed by 522 | Submission Open
Keywords: molecular genetics; gene expression regulation; genome structure and function; epigenetics; mutation and DNA repair; genomic technologies; functional genomics; human genetics; multi-omics integration; future directions in genomics
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genetics, Diversity and Evolution of Molluscs
edited by Marianna Soroka
submission deadline 5 Feb 2026 | Viewed by 248 | Submission Open
Keywords: molluscs; genetics; DNA; genomes; Barcode DNA; DNA sequencing; DUI; diversity; evolution; native; alien and invasive species; hybridisation zones
(This special issue belongs to the Section Animal Genetics and Genomics)
Inherited Retinal Diseases: Genetic Research and Novel Therapeutic Prospects
edited by
submission deadline 10 Feb 2026 | 2 articles | Viewed by 2118 | Submission Open
Keywords: inherited retinal degeneration; ophthalmogenetics; genotype– phenotype correlations; gene therapy; optogenetics; stem cell therapy; neuroprotection; clinical studies
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Decoding the Plant Epigenome: Interactions Between Genomics, Transcription, and Epigenetic Regulation
edited by Zaifeng Li
submission deadline 10 Feb 2026 | 1 articles | Viewed by 409 | Submission Open
Keywords: integration of multi-omics; functional genomics; gene mining and expression; phenotype prediction; plant epigenomics  
(This special issue belongs to the Section Plant Genetics and Genomics)
Molecular Diagnostics of Adrenal Tumors
edited by Piotr Glinicki
submission deadline 10 Feb 2026 | Viewed by 271 | Submission Open
Keywords: adrenal tumors; pheochromocytoma; paraganglioma; Cushing syndrome; primary aldosteronism; adrenocortical cancer; molecular testing; biomarkers
(This special issue belongs to the Section Genetic Diagnosis)
Genetics and Genomics of Pancreatitis
edited by
submission deadline 10 Feb 2026 | Viewed by 265 | Submission Open
Keywords: recurrent acute pancreatitis; chronic pancreatitis; gene– environment interaction; genetics; genomics; pharmacogenomics; personalized medicine
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Identifying Fertility Biomarkers Using Omics Approach submission deadline 10 Feb 2026 | Viewed by 203 | Submission Open
Keywords: fertility; infertility; biomarker; omics; multi-omics; genomics; transcriptomics; proteomics; metabolomics; epigenomics; lipidomic; microbiomics
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Molecular Breeding and Genetics of Plant Drought Resistance
edited by and Miroslav Bukan
submission deadline 15 Feb 2026 | 3 articles | Viewed by 2011 | Submission Open
Keywords: climate change; abiotic stress; drought assessment; plant phenotyping; drought resistance; molecular breeding; marker assisted selection
(This special issue belongs to the Section Molecular Genetics and Genomics)
Abiotic Stress in Plant: Molecular Genetics and Genomics
edited by Weicong Qi and
submission deadline 15 Feb 2026 | 2 articles | Viewed by 1522 | Submission Open
Keywords: abiotic stress; molecular genetics; genomics; plant stress response; epigenetics; crop improvement; sustainable agriculture
(This special issue belongs to the Section Plant Genetics and Genomics)
Genomics and Breeding of Wheat
edited by and Jiajia Zhao
submission deadline 15 Feb 2026 | Viewed by 462 | Submission Open
Keywords: wheat; disease resistance; gene; gene editing; genome analysis; genomic diversity; functional analysis
(This special issue belongs to the Section Plant Genetics and Genomics)
Batch Effects in High Dimensional Biological Data—Detection, Correction and Challenges
edited by and Maximilian Sprang
submission deadline 15 Feb 2026 | Viewed by 338 | Submission Open
Keywords: batch effects; artifacts; RNA seq; omics; quality control; single cell; bioinformatics
(This special issue belongs to the Section Technologies and Resources for Genetics)
Genetics of Pediatric Neuro-Oncology
edited by Yiran Guo
submission deadline 15 Feb 2026 | Viewed by 312 | Submission Open
Keywords: pediatric neuro-oncology; central nervous system tumors; brain tumors; genetics; transcriptomics; artificial intelligence; multi-modal datasets
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Molecular Basis and Therapeutics of Neurodegenerative Diseases submission deadline 15 Feb 2026 | Viewed by 284 | Submission Open
Keywords: Alzheimer’ s disease; Parkinson’ s disease; amyotrophic lateral sclerosis (ALS); molecular mechanisms; protein misfolding and aggregation; mitochondrial dysfunction; neuroinflammation; extracellular vesicles (EVs); gene therapy
(This special issue belongs to the Section Molecular Genetics and Genomics)
Unraveling the Genetic Landscape of Colorectal Cancer: The Latest Breakthroughs and Insights
edited by Nadia Saoudi Gonzalez
submission deadline 15 Feb 2026 | Viewed by 182 | Submission Open
Keywords: personalized medicine; target therapy; metastatic colorectal cancer; precision oncology; biomarker discovery
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetic and Morphological Diversity in Plants
edited by
submission deadline 16 Feb 2026 | 2 articles | Viewed by 1496 | Submission Open
Keywords: biodiversity; conservation; genetic structure; genetics; genotype; germplasm; haplotype; high-throughput sequencing; invasive species; microsatellites; molecular markers; morphological characters; morphology; morphometrics; morphotype; next-generation sequencing; phenotype; systematics; taxonomy; variation
(This special issue belongs to the Section Plant Genetics and Genomics)
Genetic Insights into Diseases Related to Mitochondrial Dysfunction: From Diagnosis to Treatment
edited by Luigi Citrigno and Annamaria Cerantonio
submission deadline 16 Feb 2026 | Viewed by 196 | Submission Open
Keywords: mitochondrial dysfunction; mtDNA mutations; genetic diagnosis; next-generation sequencing; neurodegeneration; metabolic disorders; mitochondrial therapeutics
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Pediatric Rare Diseases: Genetics and Diagnosis
edited by Antonio F. Martínez‐Monseny
submission deadline 20 Feb 2026 | 2 articles | Viewed by 4956 | Submission Open
Keywords: rare diseases; genetics; pediatrics; dysmorphology; molecular diagnosis; genetic syndromes; genome; precision medicine; phenotype
(This special issue belongs to the Section Molecular Genetics and Genomics)
Computational Genomics and Bioinformatics of Cancer
edited by
submission deadline 20 Feb 2026 | 2 articles | Viewed by 3249 | Submission Open
Keywords: cancer; data analysis; bioinformatics; complex diseases; dimensionality reduction; genetics; epigenetics; gene regulation; molecular mechanism; environmental factors
(This special issue belongs to the Section Bioinformatics)
Roles of RNAs in Biology
edited by
submission deadline 20 Feb 2026 | 1 articles | Viewed by 1176 | Submission Open
Keywords: regulatory RNAs; non-coding RNAs; RNA in disease and therapy; RNA modifications including editing; RNA-RNA interaction including microRNAs; RNA in transcriptional and post-transcriptional regulation; non-coding RNA in epigenetic regulation
(This special issue belongs to the Section RNA)
Genetic and Molecular Mechanisms of Crop Resistance
edited by
submission deadline 20 Feb 2026 | Viewed by 254 | Submission Open
Keywords: abiotic and biotic stress; crop resilience; molecular mechanism; molecular breeding; resilient crops
(This special issue belongs to the Section Plant Genetics and Genomics)
Extracellular Vesicles in Genetic Diseases: Emerging Biomarkers and Clinical Applications
edited by Benedetta Niccolini and
submission deadline 20 Feb 2026 | Viewed by 59 | Submission Open
Keywords: extracellular vesicles; inherited diseases; EV-derived microRNAs; biomarkers; genetic disorders; patient stratification; therapeutic monitoring; disease progression; intercellular communication; molecular diagnostics
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Advanced Research in Forensic Genetics
edited by
submission deadline 25 Feb 2026 | 4 articles | Viewed by 4316 | Submission Open
Keywords: forensic genetics; massive parallel sequencing (MPS); DNA quantification methods; DNA extraction methods; sudden cardiac death; post-mortem interval; microRNA; DNA phenotyping; individual identification; genetic markers; short tandem repeats (STRs); single-nucleotide polymorphism (SNP); mitochondrial DNA (mtDNA); microhaplotype; forensic statistics; artificial intelligence; activity level in forensics
(This special issue belongs to the Section Molecular Genetics and Genomics)
DNA Repair, Genomic Instability and Cancer
edited by
submission deadline 25 Feb 2026 | 1 articles | Viewed by 1256 | Submission Open
Keywords: DNA structure; DNA damage; DNA repair; genomic instability; mutagenesis
(This special issue belongs to the Section Molecular Genetics and Genomics)
Genetic and Genomic Mechanisms of Heat Stress in Disease Modulation: From Molecular Pathways to Clinical Manifestations submission deadline 25 Feb 2026 | 1 articles | Viewed by 773 | Submission Open
Keywords: heatstroke; global warming; heat stress; neurodegenerative diseases; molecular pathogenesis; gene– environment interactions
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Advancing Nephrogenetics: Diagnosis, Genetic Testing, and Treatment Innovations
edited by , Anita Racetin and
submission deadline 25 Feb 2026 | Viewed by 363 | Submission Open
Keywords: nephrogenetics; hereditary kidney disease; genetic testing; next-generation sequencing; renal genomics; precision nephrology; gene therapy; targeted treatment; personalized medicine
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Host Genetics Shapes the Gut Microbiome: From Genes to Microbiota
edited by
submission deadline 25 Feb 2026 | Viewed by 248 | Submission Open
Keywords: gut microbiome; host genetics; microbiota; multi-omics; host– microbe interaction; genetic variation; 16S rRNA sequencing; bioinformatics; personalized medicine
(This special issue belongs to the Section Microbial Genetics and Genomics)
Genetics in Headache and Neurogenic Pain
edited by Yohannes W. Woldeamanuel and Xianghong Arakaki
submission deadline 25 Feb 2026 | Viewed by 184 | Submission Open
Keywords: genetics; headache; neurogenic pain; migraine; genomics; epigenetics; polygenic risk; biomarkers; precision medicine; CRISPR; neuropathic pain; gene– environment interactions; translational research; molecular mechanisms; therapeutic targets
(This special issue belongs to the Section Neurogenomics)
Genetics of Ehlers–Danlos Syndrome and Related Connective Tissue Disorders
edited by Irman Forghani
submission deadline 25 Feb 2026 | Viewed by 179 | Submission Open
Keywords: Ehlers– Danlos  syndrome; Marfan syndrome; connective tissue disorders; extracellular matrix; Loeys– Dietz syndrome; genotype– phenotype correlation; aortopathies; hypermobility syndromes
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Unraveling the Genetic Tapestry of Human Populations: New Insights from Population Genetics and Identification in Anthropology submission deadline 25 Feb 2026 | Viewed by 132 | Submission Open
Keywords: human genetic diversity; population genetics; migration patterns; admixture; isolated populations; ancestry reconstruction; anthropological genomics; biomedical relevance; forensic identification
(This special issue belongs to the Section Population and Evolutionary Genetics and Genomics)
Genomics and Gene Expression of the Oral Microbiome submission deadline 25 Feb 2026 | Viewed by 127 | Submission Open
Keywords: oral microbiome; gene expression regulation; metagenomics; transcriptome; horizontal gene transfer; antimicrobial resistance; biofilms; bacteriophages; virulence factors
(This special issue belongs to the Section Microbial Genetics and Genomics)
Driver Genes in Prostate Carcinogenesis and Resistance to Treatment
edited by
submission deadline 25 Feb 2026 | Viewed by 73 | Submission Open
Keywords: genomic instability; driver genes; prostate cancer prevention; castration therapy; drug resistance
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetics and Breeding of Tea Tree and Tea Plant
edited by Lianyu Yuan
submission deadline 25 Feb 2026 | Viewed by 62 | Submission Open
Keywords: gene function analysis; genome analysis; biotechnological breeding; genetic diversity; breeding technology; multi-omics analysis; tea plant
(This special issue belongs to the Section Plant Genetics and Genomics)
Research on Genetics and Breeding of Cattle
edited by
submission deadline 5 Mar 2026 | 3 articles | Viewed by 2480 | Submission Open
Keywords: reproductive genetics and biotechnology; biotechnology in cattle; genomic selection; marker-assisted breeding; genetic diversity; assisted reproductive technologies; molecular genetics; fertility and reproduction; cattle breeding strategies; epigenetics
(This special issue belongs to the Section Animal Genetics and Genomics)
AI and Neurogenomics: Innovations in Precision Medicine for Brain Disorders submission deadline 5 Mar 2026 | 1 articles | Viewed by 1460 | Submission Open
Keywords: neurogenetics; genomics; artificial intelligence; brain disorders; neurodegenerative disease
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetic Profiling and Molecular Analysis in Autism Spectrum Disorders
edited by John Jay Gargus
submission deadline 5 Mar 2026 | Viewed by 154 | Submission Open
Keywords: whole-exome and genome sequencing in ASD; functional genomics of high-confidence ASD risk genes; transcriptomics and splicing variants in the autistic brain; calcium signaling and ion channelopathies; chromatin and epigenetic dysregulation in ASD; mitochondrial dysfunction and oxidative stress; immune– neural signaling cross-talk; systemic extracerebral traits associated with ASD; stratification of ASD subtypes; sex-biased molecular mechanisms in ASD; integrative omics for therapeutic target discovery
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Genetics and Genomics of Endocrine Diseases in Children and Adolescents submission deadline 10 Mar 2026 | 2 articles | Viewed by 2920 | Submission Open
Keywords: endocrine disease; endocrine gland; genetic syndrome; genetic polymorphism; genetic pathomechanism
(This special issue belongs to the Section Human Genomics and Genetic Diseases)
Advances in Prenatal and Postnatal Genetic Testing: Precision Diagnosis for Genetic Disorders
edited by and Eirini Louizou
submission deadline 10 Mar 2026 | Viewed by 386 | Submission Open
Keywords: genetic testing; prenatal diagnosis; postnatal diagnosis; precision medicine
(This special issue belongs to the Section Genetic Diagnosis)
Reviews in RNA: Mechanisms and Roles submission deadline 10 Mar 2026 | Viewed by 279 | Submission Open
Keywords: gene regulation; non-coding RNA; RNA world; RNA-related metabolism
(This special issue belongs to the Section RNA)
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