Decoding the Plant Epigenome: Interactions Between Genomics, Transcription, and Epigenetic Regulation

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Plant Genetics and Genomics".

Deadline for manuscript submissions: closed (10 February 2026) | Viewed by 945

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College of Plant Protection, Hebei Agricultural University, Baoding 071000, China
Interests: wheat breeding; plant pathology; molecular biology
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Special Issue Information

Dear Colleagues,

Plant genomics denotes the vigorous relationship of genetic, epigenetic, and transcriptional schemes controlling the expression of genes, phenotypic variability, and adaptation. This Special Issue aims to decipher how epigenomic alterations, including methylation of DNA and histone modifications, act as molecular adjustments, modulating the accessibility of gene and transcriptional activity without changing the DNA sequence. This includes analysing the interactions of epigenetic inscriptions with transcription factors and non-coding RNAs to explore genetic pathways through developmental stages, biotic and abiotic stress responses, and environmental resilience. Stress-induced epigenetic variations can activate or de-activate genes. Enhancements in multi-omics, including genomics, epigenomics, and transcriptomics are enabling the regular mapping of these interactions, indicating how genetic variation is linked with epigenetic maintenance, regulating networks of genes. Genomics enhancement further bridges causality, granting pointed manipulation of epigenetic marks to examine their roles in trait regulation. Understanding this is vital for improvements in crops, offering approaches to enhance yield, resilience, and nutrient efficiency via epigenetic breeding. Future innovative research should focus on integrating single-cell epigenomics, genome construction, and machine learning to interpret context-specific regulatory logic. This comprehensive approach will illustrate how plants balance genomics with epigenetic plasticity, revealing novel biological explanations for sustainable agriculture.

In this Special Issue, we welcome (but are not limited to) research articles, timely review perspectives, and step-by-step protocols.

Topics of interest for this Special Issue include, but are not limited to, the following:

  • Integration of multi-omics
  •  Functional genomics
  • Gene mining and expression
  • Phenotype prediction
  • Plant epigenomics

We look forward to receiving your contributions.

Prof. Dr. Zaifeng Li
Guest Editor

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Keywords

  • integration of multi-omics
  • functional genomics
  • gene mining and expression
  • phenotype prediction
  • plant epigenomics
 

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Published Papers (1 paper)

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Research

13 pages, 1885 KB  
Article
The Role of TuACO Gene Family in Response to Biotic and Abiotic Stresses in Triticum urartu
by Min Li, Xiaoting Liu, Shuo Wang, Xinhai Wang, Pu Gao, Takele Weldu Gebrewahid, Peipei Zhang and Zaifeng Li
Genes 2025, 16(11), 1259; https://doi.org/10.3390/genes16111259 - 25 Oct 2025
Viewed by 728
Abstract
Background: Ethylene is one of the most important plant hormones. ACC oxidase (ACO) plays a vital role in ethylene synthesis and responses to biotic and abiotic stresses in plants. However, its function in Triticum urartu remains unclear. This study aims to [...] Read more.
Background: Ethylene is one of the most important plant hormones. ACC oxidase (ACO) plays a vital role in ethylene synthesis and responses to biotic and abiotic stresses in plants. However, its function in Triticum urartu remains unclear. This study aims to systematically identify the members of the TuACO gene family to elucidate its response characteristics and functions under biotic and abiotic stresses. Methods: Through homologous alignment, phylogenetic evolution analysis, and investigations of gene structure and promoter cis-elements, a total of eight TuACO genes were identified in the T. urartu genome based on their homology to OsACO and AtACO protein sequences. Results: These genes were classified into five ACO subfamilies and distributed across chromosomes 1A, 4A, 5A, 6A, and 7A. TuACO gene families contained 0–3 introns and 1–4 exons. The protein sequence contains 10 different conservative motifs. QRT-PCR expression analysis revealed that the transcript levels of TuACO5a, TuACO5b, and TuACO3a were significantly upregulated at 6 and 24 h after infection with powdery mildew, a biotic stress. Under boron deficiency, an abiotic stress, the expression of TuACO6 and TuACO1b increased, whereas the expression of TuACO5b and TuACO3b was markedly induced under high-boron conditions. Conclusions: These results demonstrate that TuACO genes exhibit functional diversification in response to biotic and abiotic stresses, which lays the foundation for elucidating their gene functions. Full article
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