Genetic Testing and Clinical Management of Hereditary Cancer
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Epigenomics".
Deadline for manuscript submissions: 25 January 2026 | Viewed by 10
Special Issue Editor
Special Issue Information
Dear Colleagues,
One in six Americans will die from cancer. Therefore, understanding individual genetic or hereditary predisposition to cancer plays a critical role in reducing both morbidity and mortality by enabling personalized approaches to cancer screening, prevention, and management. Over the past two decades, germline genetic testing has become the cornerstone in the effort to identify high-risk individuals before cancer develops and tailor treatment following a diagnosis. Cascade genetic testing in biological relatives can further accelerate the detection process of at-risk individuals.
With rapid advances in genomic technology and knowledge, our understanding of cancer genetics now spans rare high-risk monogenic, moderate-risk monogenic, and common polygenic etiologies. Yet despite this process, substantial gaps remain between genetic risk prediction and the implementation of personalized strategies for cancer screening, prevention, and treatment. Conversely, genetic etiologies remain elusive for many families with significant histories of cancer, even after standard comprehensive genetic testing.
In this Special Issue of Genes, we invite the submission of original research articles, up-to-date reviews, or significant case series to highlight insights and experience. We especially welcome contributions that address the limitations in current standard clinical practices, highlight underexplored yet significant topics, and offer new directions for the identification, estimation, and clinical translation of genetic cancer risk.
Dr. Xia Wang
Guest Editor
Manuscript Submission Information
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Keywords
- genetic cancer predisposition
- hereditary cancer risk
- polygenic risk
- cancer screening
- genetic testing
- genomic testing
- DNA sequencing
- RNA sequencing
- cascade genetic testing
- precision medicine
- germline genetic testing
- tumor molecular profiling
- paired analysis
- hematological malignancy
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