Research on Genetics and Breeding of Cattle

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Animal Genetics and Genomics".

Deadline for manuscript submissions: 15 July 2025 | Viewed by 387

Special Issue Editor


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Guest Editor
Hanwoo Research Institute, National Institute of Animal Science, Pyeongchang 25340, Republic of Korea
Interests: reproductive genetics; biotechnology in livestock; genomic selection; genetic diversity conservation; assisted reproductive technologies; molecular genetics; cattle breeding strategies; epigenetics and gene regulation

Special Issue Information

Dear Colleagues,

The genetic improvement of cattle is critical for enhancing productivity, reproductive efficiency, and adaptability to evolving environmental conditions. This Special Issue highlights recent advances in the genetics and breeding of cattle, with an emphasis on cutting-edge innovations in reproductive genetics and biotechnology.

Reproductive genetics is pivotal in understanding the genetic basis of fertility, embryonic development, and maternal traits, offering insights into improving reproductive efficiency and success rates. Advances in genetic technologies now allow for the identification of key genetic markers associated with reproductive traits, enabling the development of targeted breeding strategies. Furthermore, biotechnology has emerged as a powerful tool for accelerating genetic progress, with techniques such as in vitro fertilization, somatic cell nuclear transfer, and CRISPR-based gene editing providing unprecedented control over genetic improvement.

We welcome submissions exploring diverse topics, including genomic selection, reproductive genetics, assisted reproductive technologies, genetic diversity conservation, and the integration of biotechnology into breeding programs. Studies investigating the molecular mechanisms underlying fertility and reproductive health, as well as the application of biotechnologies to address emerging challenges in cattle production, are strongly encouraged.

This Special Issue aims to foster a deeper understanding of the intersection between genetics, reproduction, and biotechnology, advancing sustainable and efficient cattle breeding practices.

Dr. Borhan Shokrollahi
Guest Editor

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Keywords

  • reproductive genetics and biotechnology
  • biotechnology in cattle
  • genomic selection
  • marker-assisted breeding
  • genetic diversity
  • assisted reproductive technologies
  • molecular genetics
  • fertility and reproduction
  • cattle breeding strategies
  • epigenetics

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Published Papers (1 paper)

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Research

22 pages, 1186 KiB  
Article
Establishment and Validation of a Method for the Identification of Recessive Mastitis Resistance Genes in Dairy Cows
by Wei Zheng, Pei Wu, Mengting Zhu, Yaseen Ullah, Zongsheng Zhao, Shaoqi Cao, Guang Li, Sihai Ou, Kaibing He and Ye Xu
Genes 2025, 16(5), 485; https://doi.org/10.3390/genes16050485 - 25 Apr 2025
Viewed by 253
Abstract
Background/Objectives: The resistance to occult mastitis in dairy cows is a multifaceted trait influenced by a variety of genetic and environmental factors, posing significant challenges to its prevention and treatment. Methods: In this study, a cohort of 389 Holstein dairy cows was selected [...] Read more.
Background/Objectives: The resistance to occult mastitis in dairy cows is a multifaceted trait influenced by a variety of genetic and environmental factors, posing significant challenges to its prevention and treatment. Methods: In this study, a cohort of 389 Holstein dairy cows was selected for investigation. The genes NOD2, CXCR1, SPP1 and LF, which are implicated in resistance to occult mastitis, were genotyped utilizing the efficient and cost-effective Kompetitive Allele-Specific PCR (KASP) technology. Additionally, the study analyzed the association between various single nucleotide polymorphisms (SNPs) and the somatic cell score in Holstein dairy cows. Multi-locus penetrance variance analysis (MPVA) analysis was also conducted to assess the resistance of different genotypic combinations to recessive mastitis in dairy cows. A genotyping kit for occult mastitis resistance was developed. Subsequently, 300 Holstein cows were randomly selected to evaluate the accuracy of the kit’s classification and resistance detection. Results: The findings revealed that the most effective genotype combination was SPP1(AA)-CXCR1(CC)-NOD2(CA)-LF(GA). Upon verification, the genotyping kit for recessive mastitis resistance in dairy cows exhibited an accuracy rate of 100% for individual genotyping and 95.90% for resistance detection. Conclusions: From the perspective of disease resistance genetics, this study lays a foundation for the precise management of dairy cow herds. It enables the early identification and removal of individuals susceptible to subclinical mastitis, thereby improving the overall quality of the cattle population. Full article
(This article belongs to the Special Issue Research on Genetics and Breeding of Cattle)
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