DNA Repair, Genomic Instability and Cancer

Dear Colleagues,

The maintenance of genome integrity is essential for proper cellular function and organismal survival. To protect the genome from endogenous and exogenous sources of DNA damage, cells have evolved a variety of DNA repair mechanisms. Paradoxically, in some cases, DNA repair proteins can promote genetic instability via error-prone processing, thereby contributing to the etiology and progression of diseases such as cancer. A notable example includes the processing of alternative (i.e., non-B) DNA structures, which can form repetitive DNA sequences and are abundant across genomes. In this Special Issue, we will highlight both canonical and aberrant DNA repair mechanisms, providing insights into their roles in genome integrity.

Prof. Dr. Karen M. Vasquez
Guest Editor

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