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Genes publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Immunotherapy in Glioblastoma: Genetic Insights and Innovations

edited by

Richard J. Tancredi

submission deadline 15 Jan 2026 | Viewed by 275 | Submission Open

Keywords: glioblastoma; treatment strategy; genetic mutations; immunotherapies; checkpoint inhibitors

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Integrating Traditional and Modern Technology for Cattle Genetic Improvement

edited by

Xibi Fang

and

Tianyu Deng

submission deadline 15 Jan 2026 | Viewed by 240 | Submission Open

Keywords: cattle breeding; animal genetics; genomic selection; functional genomics; epigenetics and epigenomics; functional genes; Quantitative Trait Loci (QTL)

(This special issue belongs to the Section Animal Genetics and Genomics)

Animal Virus Immunology and Genomics

edited by

Huijun Lu

and

Changzhan Xie

submission deadline 15 Jan 2026 | Viewed by 240 | Submission Open

Keywords: epidemiology; gene editing; genome; transcriptome; and proteome; synthetic biology; high-throughput sequencing; multi-omics; transcription factor; immunology

(This special issue belongs to the Section Animal Genetics and Genomics)

Next-Generation Diagnosis and Treatment of Hematologic Diseases

edited by

Thomas David Daniel Kazmirchuk

and

Ashkan Golshani

submission deadline 15 Jan 2026 | Viewed by 218 | Submission Open

Keywords: hematologic disease; hematology; thrombosis and hemostasis; bleeding disorders; artificial intelligence; next-generation theranostics; therapeutics; diagnostics; peptide design; precision medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic and Epigenetic Mechanisms Underlying Cancer Stem Cells and Their Implications for Novel Therapeutic Approaches

edited by

Fumihiko Kakizaki

and

Frank Buchholz

submission deadline 15 Jan 2026 | Viewed by 217 | Submission Open

Keywords: cancer stem cell; metastasis; cancer-associated gene; model organism for cancer research; therapeutics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic Insights into Aortic Aneurysm Disease

edited by

John Alex Elefteriades

and Bulat A. Ziganshin

submission deadline 15 Jan 2026 | Viewed by 205 | Submission Open

Keywords: aneurysm; thoracic aortic aneurysm; abdominal aortic aneurysm; aorta; thoracic aorta; genetics; aortic syndromes; Marfan; Loeys– Dietz; Ehlers– Danlos; aortopathy; medial degeneration; aneurysm genes

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Next-Gen Omics in Animal and Microbial Science

edited by Loan To Nguyen

submission deadline 15 Jan 2026 | Viewed by 134 | Submission Open

Keywords: Oxford nanopore technologies; genomics; transcriptomics; metagenomics; microbiome

(This special issue belongs to the Section Animal Genetics and Genomics)

Molecular and Genetic Mechanisms of Floral Development

edited by Kaifeng Ma

submission deadline 16 Jan 2026 | Viewed by 117 | Submission Open

Keywords: floral induction and differentiation; flower bud formation and dormancy; floral organ; flower pattern; flower color and fragrance; blooming period; molecular and genetic mechanism

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Studies on Cotton Stress Resistance, Quality Traits, and Drought Response Mechanisms

edited by Xueyuan Li, Juyun Zheng,

Jie Sun

and Fenglei Sun

submission deadline 20 Jan 2026 | 1 articles | Viewed by 929 | Submission Open

Keywords: cotton; drought stress; growth and development; gene editing; molecular marker-assisted selection

(This special issue belongs to the Section Plant Genetics and Genomics)

Advances in Molecular Genetics of Psychiatric Diseases

edited by Fotis Tsetsos

submission deadline 20 Jan 2026 | 1 articles | Viewed by 832 | Submission Open

Keywords: psychiatric genetics; molecular psychiatry; GWAS; rare variants; transcriptomics; epigenetics; gene-environment interactions; precision psychiatry; schizophrenia; bipolar disorder; depression; autism spectrum disorder; anxiety; functional genomics; neurodevelopmental disorders

(This special issue belongs to the Section Molecular Genetics and Genomics)

Cytogenetics/Cytogenomics and Functional Genomics in Human Health and Disease

edited by

Patrick R. Gonzales

submission deadline 20 Jan 2026 | Viewed by 322 | Submission Open

Keywords: functional genomics; cytogenetics; cytogenomics; microarray; optical genome mapping (OGM); Hi-C; genomic proximity mapping (GPM); intergenic; topologically associating domains (TAD); expression

(This special issue belongs to the Section Cytogenomics)

New Insight into the Genetic and Molecular Aspects of Yeast Nutrient Metabolism

edited by Roman Maslanka and

Renata Zadrag-Tecza

submission deadline 20 Jan 2026 | Viewed by 297 | Submission Open

Keywords: yeasts as a model organism; yeast metabolism; nutrient sensing; sugar/hexose transport; central carbon metabolism; catabolite repression; nutrient availability; resource allocation; calorie restriction; cAMP-PKA signaling; metabolic flux; metabolic adaptation; genetic and transcriptional regulation; cellular homeostasis; molecular biology of yeast

(This special issue belongs to the Section Molecular Genetics and Genomics)

Reviews in Genetic Bioinformatics: Tools and Analyses

edited by

Hongyan Xu

submission deadline 20 Jan 2026 | Viewed by 273 | Submission Open

Keywords: genetics; genomics; machine learning; computational biology; big data; bioinformatics

(This special issue belongs to the Section Bioinformatics)

Application of Bioinformatics in Complex Traits

edited by

Xiang-Yang Lou

submission deadline 20 Jan 2026 | Viewed by 170 | Submission Open

Keywords: complex traits; bioinformatics; multi-omics integration; gene– environment interactions; polygenic risk scores; machine learning; systems biology; network analysis; statistical genetics; causal inference

(This special issue belongs to the Section Bioinformatics)

Molecular Genetics of Neurodevelopmental Disorders: 2nd Edition

edited by

Richard Eugene Frye

and

Richard Boles

submission deadline 25 Jan 2026 | 1 articles | Viewed by 1817 | Submission Open

Keywords: neurodevelopmental disorders; attention deficit hyperactivity disorder; intellectual disabilities; autism spectrum disorder; mitochondria; neuroinflammation; epigenetics; transcriptomics; genetic syndromes; polygenetic interactions

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

5Gs in Crop Genetic and Genomic Improvement: 2025–2026

edited by

Xinjie Shen

submission deadline 25 Jan 2026 | 3 articles | Viewed by 1254 | Submission Open

Keywords: crop gene functional analysis; crop protemics; crop metabonomics; new crop breeding methods; crop GWAS analysis; crop gene edit technology; crop gene epigenetic modification

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Epidemiology of Multifactorial Diseases

edited by

Maria Tziastoudi

and Ioannis Stefanidis

submission deadline 25 Jan 2026 | 1 articles | Viewed by 725 | Submission Open

Keywords: genetic association studies; polygenic risk scores; functional genomics; causal inference; mendelian randomization; translational applications

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic Testing and Clinical Management of Hereditary Cancer

edited by

Xia Wang

submission deadline 25 Jan 2026 | Viewed by 325 | Submission Open

Keywords: genetic cancer predisposition; hereditary cancer risk; polygenic risk; cancer screening; genetic testing; genomic testing; DNA sequencing; RNA sequencing; cascade genetic testing; precision medicine; germline genetic testing; tumor molecular profiling; paired analysis; hematological malignancy

(This special issue belongs to the Section Epigenomics)

Genomics and Proteomics-Based Molecular Diagnostics and Targeted Therapies in Cancer

edited by

Hilal Arnouk

submission deadline 25 Jan 2026 | Viewed by 316 | Submission Open

Keywords: molecular diagnostics; targeted therapies; biomarkers; precision medicine oncology; chemotherapy; small-molecule drugs; monoclonal antibodies; cancer immunotherapy

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Unraveling Genomic Mechanisms of Stress Tolerance and Antimicrobial Resistance in Foodborne Pathogens

edited by

Eduardo Eustáquio de Souza Figueiredo

and

Vinicius Silva Castro

submission deadline 25 Jan 2026 | Viewed by 273 | Submission Open

Keywords: foodborne pathogens; AMR; survivability; thermal resistance; in silico analysis; DNA sequencing; RNA sequencing; environmental stress condition

(This special issue belongs to the Section Microbial Genetics and Genomics)

Genetics and Environmental Factors in Psychiatric Disorders

edited by

Sarah Tosato

submission deadline 25 Jan 2026 | Viewed by 125 | Submission Open

Keywords: PGS; environmental factors; epigenetics; prenatal environmental exposures; GWAS; GxE interactions

(This special issue belongs to the Section Genes & Environments)

Genetics and Physiology of Multiple-Stress Tolerance in Plants

edited by Jin Wang

submission deadline 25 Jan 2026 | Viewed by 96 | Submission Open

Keywords: plant; genetics; genomics; physiology; biotic stress; abiotic stress; genetic breeding; molecular biology

(This special issue belongs to the Section Plant Genetics and Genomics)

Novel Insights into Forensic Genetics

edited by

Simone Grassi

Sarah Gino

and

Paola A. Magni

submission deadline 31 Jan 2026 | 2 articles | Viewed by 1928 | Submission Open

Keywords: forenscic genetics; molecular autopsy; forensic omics; post-mortem genetic testing; legal medicine

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetics and Treatment in Neurodegenerative Diseases

edited by Valentino Rački and

Gaber Bergant

submission deadline 5 Feb 2026 | 3 articles | Viewed by 3629 | Submission Open

Keywords: neurodegeneration; genetics; Alzheimer’ s disease; Parkinson’ s disease; gene therapy; pharmacogenomics; precision medicine

(This special issue belongs to the Section Neurogenomics)

Molecular Genetics Reviews: Current Understanding and Future Directions

edited by

Valeria D’Argenio

and

Orazio Palumbo

submission deadline 5 Feb 2026 | Viewed by 564 | Submission Open

Keywords: molecular genetics; gene expression regulation; genome structure and function; epigenetics; mutation and DNA repair; genomic technologies; functional genomics; human genetics; multi-omics integration; future directions in genomics

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetics, Diversity and Evolution of Molluscs

edited by Marianna Soroka

submission deadline 5 Feb 2026 | Viewed by 273 | Submission Open

Keywords: molluscs; genetics; DNA; genomes; Barcode DNA; DNA sequencing; DUI; diversity; evolution; native; alien and invasive species; hybridisation zones

(This special issue belongs to the Section Animal Genetics and Genomics)

Inherited Retinal Diseases: Genetic Research and Novel Therapeutic Prospects

edited by

Ditta Zobor

submission deadline 10 Feb 2026 | 2 articles | Viewed by 2787 | Submission Open

Keywords: inherited retinal degeneration; ophthalmogenetics; genotype– phenotype correlations; gene therapy; optogenetics; stem cell therapy; neuroprotection; clinical studies

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Decoding the Plant Epigenome: Interactions Between Genomics, Transcription, and Epigenetic Regulation

edited by Zaifeng Li

submission deadline 10 Feb 2026 | 1 articles | Viewed by 511 | Submission Open

Keywords: integration of multi-omics; functional genomics; gene mining and expression; phenotype prediction; plant epigenomics

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetics and Genomics of Pancreatitis

edited by

Jian-Min Chen

submission deadline 10 Feb 2026 | Viewed by 293 | Submission Open

Keywords: recurrent acute pancreatitis; chronic pancreatitis; gene– environment interaction; genetics; genomics; pharmacogenomics; personalized medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Molecular Diagnostics of Adrenal Tumors

edited by Piotr Glinicki

submission deadline 10 Feb 2026 | Viewed by 288 | Submission Open

Keywords: adrenal tumors; pheochromocytoma; paraganglioma; Cushing syndrome; primary aldosteronism; adrenocortical cancer; molecular testing; biomarkers

(This special issue belongs to the Section Genetic Diagnosis)

Identifying Fertility Biomarkers Using Omics Approach

edited by

Muhammet Rasit Ugur

submission deadline 10 Feb 2026 | Viewed by 228 | Submission Open

Keywords: fertility; infertility; biomarker; omics; multi-omics; genomics; transcriptomics; proteomics; metabolomics; epigenomics; lipidomic; microbiomics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Molecular Breeding and Genetics of Plant Drought Resistance

edited by

Ivan Pejić

and Miroslav Bukan

submission deadline 15 Feb 2026 | 3 articles | Viewed by 2430 | Submission Open

Keywords: climate change; abiotic stress; drought assessment; plant phenotyping; drought resistance; molecular breeding; marker assisted selection

(This special issue belongs to the Section Molecular Genetics and Genomics)

Abiotic Stress in Plant: Molecular Genetics and Genomics

edited by Weicong Qi and

Hongyan Wang

submission deadline 15 Feb 2026 | 2 articles | Viewed by 1826 | Submission Open

Keywords: abiotic stress; molecular genetics; genomics; plant stress response; epigenetics; crop improvement; sustainable agriculture

(This special issue belongs to the Section Plant Genetics and Genomics)

Genomics and Breeding of Wheat

edited by

Shuaifeng Geng

and Jiajia Zhao

submission deadline 15 Feb 2026 | Viewed by 479 | Submission Open

Keywords: wheat; disease resistance; gene; gene editing; genome analysis; genomic diversity; functional analysis

(This special issue belongs to the Section Plant Genetics and Genomics)

Batch Effects in High Dimensional Biological Data—Detection, Correction and Challenges

edited by

Miguel Andrade

and Maximilian Sprang

submission deadline 15 Feb 2026 | Viewed by 378 | Submission Open

Keywords: batch effects; artifacts; RNA seq; omics; quality control; single cell; bioinformatics

(This special issue belongs to the Section Technologies and Resources for Genetics)

Genetics of Pediatric Neuro-Oncology

edited by Yiran Guo

submission deadline 15 Feb 2026 | Viewed by 324 | Submission Open

Keywords: pediatric neuro-oncology; central nervous system tumors; brain tumors; genetics; transcriptomics; artificial intelligence; multi-modal datasets

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Molecular Basis and Therapeutics of Neurodegenerative Diseases

edited by

Tânia Soares Martins

submission deadline 15 Feb 2026 | Viewed by 317 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; amyotrophic lateral sclerosis (ALS); molecular mechanisms; protein misfolding and aggregation; mitochondrial dysfunction; neuroinflammation; extracellular vesicles (EVs); gene therapy

(This special issue belongs to the Section Molecular Genetics and Genomics)

Unraveling the Genetic Landscape of Colorectal Cancer: The Latest Breakthroughs and Insights

edited by Nadia Saoudi Gonzalez

submission deadline 15 Feb 2026 | Viewed by 194 | Submission Open

Keywords: personalized medicine; target therapy; metastatic colorectal cancer; precision oncology; biomarker discovery

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Genetic and Morphological Diversity in Plants

edited by

P. Roxanne Kellar

submission deadline 16 Feb 2026 | 2 articles | Viewed by 1731 | Submission Open

Keywords: biodiversity; conservation; genetic structure; genetics; genotype; germplasm; haplotype; high-throughput sequencing; invasive species; microsatellites; molecular markers; morphological characters; morphology; morphometrics; morphotype; next-generation sequencing; phenotype; systematics; taxonomy; variation

(This special issue belongs to the Section Plant Genetics and Genomics)

Genetic Insights into Diseases Related to Mitochondrial Dysfunction: From Diagnosis to Treatment

edited by Luigi Citrigno and Annamaria Cerantonio

submission deadline 16 Feb 2026 | Viewed by 221 | Submission Open

Keywords: mitochondrial dysfunction; mtDNA mutations; genetic diagnosis; next-generation sequencing; neurodegeneration; metabolic disorders; mitochondrial therapeutics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Pediatric Rare Diseases: Genetics and Diagnosis

edited by Antonio F. Martínez‐Monseny

submission deadline 20 Feb 2026 | 2 articles | Viewed by 5819 | Submission Open

Keywords: rare diseases; genetics; pediatrics; dysmorphology; molecular diagnosis; genetic syndromes; genome; precision medicine; phenotype

(This special issue belongs to the Section Molecular Genetics and Genomics)

Computational Genomics and Bioinformatics of Cancer

edited by

Ilya Ioshikhes

submission deadline 20 Feb 2026 | 2 articles | Viewed by 4550 | Submission Open

Keywords: cancer; data analysis; bioinformatics; complex diseases; dimensionality reduction; genetics; epigenetics; gene regulation; molecular mechanism; environmental factors

(This special issue belongs to the Section Bioinformatics)

Roles of RNAs in Biology

edited by

Zihua Hu

submission deadline 20 Feb 2026 | 2 articles | Viewed by 1868 | Submission Open

Keywords: regulatory RNAs; non-coding RNAs; RNA in disease and therapy; RNA modifications including editing; RNA-RNA interaction including microRNAs; RNA in transcriptional and post-transcriptional regulation; non-coding RNA in epigenetic regulation

(This special issue belongs to the Section RNA)

Genetic and Molecular Mechanisms of Crop Resistance

edited by

Quanle Xu

submission deadline 20 Feb 2026 | Viewed by 278 | Submission Open

Keywords: abiotic and biotic stress; crop resilience; molecular mechanism; molecular breeding; resilient crops

(This special issue belongs to the Section Plant Genetics and Genomics)

Extracellular Vesicles in Genetic Diseases: Emerging Biomarkers and Clinical Applications

edited by Benedetta Niccolini and

Elisabetta Tabolacci

submission deadline 20 Feb 2026 | Viewed by 79 | Submission Open

Keywords: extracellular vesicles; inherited diseases; EV-derived microRNAs; biomarkers; genetic disorders; patient stratification; therapeutic monitoring; disease progression; intercellular communication; molecular diagnostics

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advanced Research in Forensic Genetics

edited by

Mauro Pesaresi

submission deadline 25 Feb 2026 | 4 articles | Viewed by 5302 | Submission Open

Keywords: forensic genetics; massive parallel sequencing (MPS); DNA quantification methods; DNA extraction methods; sudden cardiac death; post-mortem interval; microRNA; DNA phenotyping; individual identification; genetic markers; short tandem repeats (STRs); single-nucleotide polymorphism (SNP); mitochondrial DNA (mtDNA); microhaplotype; forensic statistics; artificial intelligence; activity level in forensics

(This special issue belongs to the Section Molecular Genetics and Genomics)

DNA Repair, Genomic Instability and Cancer

edited by

Karen M. Vasquez

submission deadline 25 Feb 2026 | 1 articles | Viewed by 1432 | Submission Open

Keywords: DNA structure; DNA damage; DNA repair; genomic instability; mutagenesis

(This special issue belongs to the Section Molecular Genetics and Genomics)

Genetic and Genomic Mechanisms of Heat Stress in Disease Modulation: From Molecular Pathways to Clinical Manifestations

edited by

Hisahide Nishio

and

Hiroyuki Awano

submission deadline 25 Feb 2026 | 1 articles | Viewed by 1116 | Submission Open

Keywords: heatstroke; global warming; heat stress; neurodegenerative diseases; molecular pathogenesis; gene– environment interactions

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Advancing Nephrogenetics: Diagnosis, Genetic Testing, and Treatment Innovations

edited by

Katarina Vukojević

, Anita Racetin and

Nela Kelam

submission deadline 25 Feb 2026 | Viewed by 377 | Submission Open

Keywords: nephrogenetics; hereditary kidney disease; genetic testing; next-generation sequencing; renal genomics; precision nephrology; gene therapy; targeted treatment; personalized medicine

(This special issue belongs to the Section Human Genomics and Genetic Diseases)

Host Genetics Shapes the Gut Microbiome: From Genes to Microbiota

edited by

Shaoqiu Chen

submission deadline 25 Feb 2026 | Viewed by 270 | Submission Open

Keywords: gut microbiome; host genetics; microbiota; multi-omics; host– microbe interaction; genetic variation; 16S rRNA sequencing; bioinformatics; personalized medicine

(This special issue belongs to the Section Microbial Genetics and Genomics)

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