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SMC5/6: Multifunctional Player in Replication

1
National Centre for Biomolecular Research, Faculty of Science, Masaryk University, Kotlarska 2, 61137 Brno, Czech Republic
2
Mendel Centre for Plant Genomics and Proteomics, Central European Institute of Technology, Masaryk University, Kamenice 5, 62500 Brno, Czech Republic
Received: 3 December 2018 / Revised: 18 December 2018 / Accepted: 19 December 2018 / Published: 22 December 2018
(This article belongs to the Special Issue Chromosome Replication and Genome Integrity)
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Abstract

The genome replication process is challenged at many levels. Replication must proceed through different problematic sites and obstacles, some of which can pause or even reverse the replication fork (RF). In addition, replication of DNA within chromosomes must deal with their topological constraints and spatial organization. One of the most important factors organizing DNA into higher-order structures are Structural Maintenance of Chromosome (SMC) complexes. In prokaryotes, SMC complexes ensure proper chromosomal partitioning during replication. In eukaryotes, cohesin and SMC5/6 complexes assist in replication. Interestingly, the SMC5/6 complexes seem to be involved in replication in many ways. They stabilize stalled RFs, restrain RF regression, participate in the restart of collapsed RFs, and buffer topological constraints during RF progression. In this (mini) review, I present an overview of these replication-related functions of SMC5/6. View Full-Text
Keywords: SMC complexes; SMC5/6; chromatin structure; loop extrusion; stalled replication fork; replication fork regression; collapsed replication fork; homologous recombination SMC complexes; SMC5/6; chromatin structure; loop extrusion; stalled replication fork; replication fork regression; collapsed replication fork; homologous recombination
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Palecek, J.J. SMC5/6: Multifunctional Player in Replication. Genes 2019, 10, 7.

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