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Genes 2018, 9(12), 603; https://doi.org/10.3390/genes9120603

Homologous Recombination: To Fork and Beyond

Department of Genome Biology, Andalusian Molecular Biology and Regenerative Medicine Center (CABIMER), CSIC-University of Seville-University Pablo de Olavide, 41092 Seville, Spain
Received: 9 November 2018 / Revised: 29 November 2018 / Accepted: 29 November 2018 / Published: 4 December 2018
(This article belongs to the Special Issue Chromosome Replication and Genome Integrity)
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Abstract

Accurate completion of genome duplication is threatened by multiple factors that hamper the advance and stability of the replication forks. Cells need to tolerate many of these blocking lesions to timely complete DNA replication, postponing their repair for later. This process of lesion bypass during DNA damage tolerance can lead to the accumulation of single-strand DNA (ssDNA) fragments behind the fork, which have to be filled in before chromosome segregation. Homologous recombination plays essential roles both at and behind the fork, through fork protection/lesion bypass and post-replicative ssDNA filling processes, respectively. I review here our current knowledge about the recombination mechanisms that operate at and behind the fork in eukaryotes, and how these mechanisms are controlled to prevent unscheduled and toxic recombination intermediates. A unifying model to integrate these mechanisms in a dynamic, replication fork-associated process is proposed from yeast results. View Full-Text
Keywords: homologous recombination; replication stress; DNA damage tolerance; fork stability; single-strand DNA gap filling homologous recombination; replication stress; DNA damage tolerance; fork stability; single-strand DNA gap filling
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Prado, F. Homologous Recombination: To Fork and Beyond. Genes 2018, 9, 603.

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