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The Response to DNA Damage at Telomeric Repeats and Its Consequences for Telomere Function

IFOM, The FIRC Institute of Molecular Oncology, via Adamello 16, 20139 Milan, Italy
Genes 2019, 10(4), 318; https://doi.org/10.3390/genes10040318
Received: 26 March 2019 / Revised: 13 April 2019 / Accepted: 18 April 2019 / Published: 24 April 2019
(This article belongs to the Special Issue Chromosome Replication and Genome Integrity)
Telomeric repeats, coated by the shelterin complex, prevent inappropriate activation of the DNA damage response at the ends of linear chromosomes. Shelterin has evolved distinct solutions to protect telomeres from different aspects of the DNA damage response. These solutions include formation of t-loops, which can sequester the chromosome terminus from DNA-end sensors and inhibition of key steps in the DNA damage response. While blocking the DNA damage response at chromosome ends, telomeres make wide use of many of its players to deal with exogenous damage and replication stress. This review focuses on the interplay between the end-protection functions and the response to DNA damage occurring inside the telomeric repeats, as well as on the consequences that telomere damage has on telomere structure and function. View Full-Text
Keywords: telomere maintenance; shelterin complex; end-protection problem; telomere damage; telomeric double strand breaks; telomere replication; alternative lengthening of telomeres telomere maintenance; shelterin complex; end-protection problem; telomere damage; telomeric double strand breaks; telomere replication; alternative lengthening of telomeres
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Doksani, Y. The Response to DNA Damage at Telomeric Repeats and Its Consequences for Telomere Function. Genes 2019, 10, 318.

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