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Control of Eukaryotic DNA Replication Initiation—Mechanisms to Ensure Smooth Transitions

Max Planck Institute of Biochemistry, DNA Replication and Genome Integrity, 82152 Martinsried, Germany
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Genes 2019, 10(2), 99; https://doi.org/10.3390/genes10020099
Received: 31 December 2018 / Revised: 25 January 2019 / Accepted: 25 January 2019 / Published: 29 January 2019
(This article belongs to the Special Issue Chromosome Replication and Genome Integrity)
DNA replication differs from most other processes in biology in that any error will irreversibly change the nature of the cellular progeny. DNA replication initiation, therefore, is exquisitely controlled. Deregulation of this control can result in over-replication characterized by repeated initiation events at the same replication origin. Over-replication induces DNA damage and causes genomic instability. The principal mechanism counteracting over-replication in eukaryotes is a division of replication initiation into two steps—licensing and firing—which are temporally separated and occur at distinct cell cycle phases. Here, we review this temporal replication control with a specific focus on mechanisms ensuring the faultless transition between licensing and firing phases. View Full-Text
Keywords: DNA replication; DNA replication initiation; cell cycle; post-translational protein modification; protein degradation; cell cycle transitions DNA replication; DNA replication initiation; cell cycle; post-translational protein modification; protein degradation; cell cycle transitions
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MDPI and ACS Style

Reusswig, K.-U.; Pfander, B. Control of Eukaryotic DNA Replication Initiation—Mechanisms to Ensure Smooth Transitions. Genes 2019, 10, 99. https://doi.org/10.3390/genes10020099

AMA Style

Reusswig K-U, Pfander B. Control of Eukaryotic DNA Replication Initiation—Mechanisms to Ensure Smooth Transitions. Genes. 2019; 10(2):99. https://doi.org/10.3390/genes10020099

Chicago/Turabian Style

Reusswig, Karl-Uwe, and Boris Pfander. 2019. "Control of Eukaryotic DNA Replication Initiation—Mechanisms to Ensure Smooth Transitions" Genes 10, no. 2: 99. https://doi.org/10.3390/genes10020099

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