Special Issue "The Metabolism and Health Benefits of Bioactive Compounds in Foods"

A special issue of Foods (ISSN 2304-8158). This special issue belongs to the section "Food Nutrition".

Deadline for manuscript submissions: 10 January 2021.

Special Issue Editors

Prof. Dr. José Manuel Moreno-Rojas
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Guest Editor
Food Science and Health Department, Andalusian Institute of Agricultural and Fisheries Research and Training (IFAPA) Alameda del Obispo, Córdoba, Spain
Interests: food quality and traceability; specifically on the characterization of sensory; bioactive compounds of different food matrixes using several techniques (e.g., GC-MS/GC-FID, UHPLC-HRMS and EA(GC)-C-IRMS)
Special Issues and Collections in MDPI journals
Prof. Dr. Gema Pereira Caro
Website
Guest Editor
Department of Food Science and Health, Andalusian Institute of Agricultural and Fisheries Research and Training (IFAPA), Alameda del Obispo, Avda. Menéndez Pidal, SN, Córdoba 14004, Spain
Interests: bioactive compounds in food; polyphenols; organosulfur compounds; LC-MS and GC-MS techniques; metabolomics; bioavailability; bioactivity; effect of processing on bioactive compounds
Special Issues and Collections in MDPI journals
Dr. Raquel Rodríguez Solana
Website
Guest Editor
Food Science and Health Department, Andalusian Institute of Agricultural and Fisheries Research and Training (IFAPA) Alameda del Obispo, Córdoba, Spain
Interests: My principal research interest is the study of the chemical composition and in vitro biological capacities of foods and alcoholic beverages, through the mineral characterization by techniques such as ICP-MS and AAS/AES; the volatile and phenolic profiles by gas (GC-MS/GC-FID) and liquid (HPLC-MS/HPLC-DAD) chromatographic techniques, respectively; and the antioxidant capacity and the inhibition of enzymes involved in neurodegenerative diseases and type 2 diabetes using different spectrophotometric methods.

Special Issue Information

There is growing evidence that plant-derived bioactives, including polyphenols, carotenoids and organosulfur compounds, may have several health benefits by reducing or delaying the incidence of non-communicable diseases such as cancer, cardiovascular disorders and diabetes. Those positive effects are dependent, in the first instance, on the bioavailability, absorption and metabolism of bioactives. In this context, the microbiota play an important role since they transform ingested bioactives that reach the colon into low-molecular-weight phenolic and aromatic metabolites which are absorbed into the circulatory system and, further, are subjected to phase II metabolism by mammalian enzymes, producing metabolites with potential biological activities.

The study of the bioactive metabolites in vivo and the evaluation of their activity against several diseases is challenging, not only because of the diversity of chemical structures and their low and varied concentrations, but also because of the variability in the production of specific metabolites by the population.

This Special Issue welcomes manuscripts on i) the reliable phytochemical characterization of fruit- and vegetable-derived product extracts; ii) in vivo and in vitro studies on the absorption and metabolism of food bioactives using targeted and non-targeted approaches; iii) studies dealing with the potential benefits of the consumption of bioactives using cell-based experiments.

Dr. José Manuel Moreno-Rojas
Dr. Gema Pereira Caro
Dr. Raquel Rodríguez Solana
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Foods is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polyphenols
  • organosulfur compounds
  • carotenoids
  • bioavailability
  • gut microbiota
  • bioactivity
  • metabolomics
  • cancer
  • cardiovascular diseases

Published Papers (5 papers)

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Research

Open AccessArticle
Characterization of Andean Blueberry in Bioactive Compounds, Evaluation of Biological Properties, and In Vitro Bioaccessibility
Foods 2020, 9(10), 1483; https://doi.org/10.3390/foods9101483 - 17 Oct 2020
Abstract
The aim of this study was to evaluate Andean blueberries (Vaccinium floribundum Kunth) from Ecuador as a potential functional ingredient for the food and pharmaceutical industries. The analysis of bioactive compounds by HPLC–DAD–MSn determined a high content of (poly)phenols, mainly anthocyanins, [...] Read more.
The aim of this study was to evaluate Andean blueberries (Vaccinium floribundum Kunth) from Ecuador as a potential functional ingredient for the food and pharmaceutical industries. The analysis of bioactive compounds by HPLC–DAD–MSn determined a high content of (poly)phenols, mainly anthocyanins, and the presence of the carotenoid lutein. Regarding its biological properties, Andean blueberry did not show toxicity by the zebrafish embryogenesis test, showing also a lack of the antinutrients lectins. Moreover, the results of in vitro and in vivo antioxidant capacity evaluation suggested its possibility to be used as natural antioxidant. This fruit also exhibited antimicrobial activity toward Staphylococcus aureus and Escherichia coli in low doses. Finally, in vitro gastrointestinal (GI) digestion showed a partial bioaccessibility of (poly) phenols (~50% at the final step), showing high antioxidant capacity in the different GI phases. These results revealed Andean blueberry as an interesting candidate for being used as a functional ingredient and the development of further in vivo and clinical assays. Full article
(This article belongs to the Special Issue The Metabolism and Health Benefits of Bioactive Compounds in Foods)
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Open AccessArticle
Vitamin D Intake in a Population-Based Sample of Young Polish Women, Its Major Sources and the Possibility of Meeting the Recommendations
Foods 2020, 9(10), 1482; https://doi.org/10.3390/foods9101482 - 17 Oct 2020
Abstract
The recommendations of vitamin D intake are commonly not met, which results from the fact that fish, being its major sources, are commonly rarely consumed. Consequently, a reliable estimation of its habitual intake is also difficult, as its daily intake is highly variable. [...] Read more.
The recommendations of vitamin D intake are commonly not met, which results from the fact that fish, being its major sources, are commonly rarely consumed. Consequently, a reliable estimation of its habitual intake is also difficult, as its daily intake is highly variable. The aim of the study was to analyze vitamin D intake from food, its major sources and the possibility to meet its recommendations in a population-based sample of young Polish women. The study was conducted in a sample of Polish women aged 15–30 years, recruited in cooperation with local students’ and youth organizations from all regions of Poland (convenience sampling with the snowball effect), while the stratified sampling procedure was applied with a random quota sampling for voivodeships (an administrative subdivision), to obtain an adequate distribution regarding the general population of young Polish women (n = 1,032). The vitamin D intake was assessed while using the validated Vitamin D Estimation Only—Food Frequency Questionnaire (VIDEO-FFQ) and was compared with the recommended 10 µg. The median vitamin D intake in the study group was 3.09 µg (0.00–24.52 µg) and in 95% of participants was lower than recommended, while the highest vitamin D intake was observed for the following sources: eggs (0.50 µg), meat and meat products (0.49 µg), herring, sardine and tuna products (0.41 µg) and dairy products (0.40 µg). The correlation between total vitamin D intake and its intake from its sources was strongest for eggs (p < 0.0001; R = 0.5989) and for herring, sardine and tuna products (p < 0.0001; R = 0.5314), while the correlation between total vitamin D intake and the number of servings was strongest for herring, sardine and tuna products (p < 0.0001; R = 0.5314). At the same time, while compared with other fish species, consuming herring was the strongest predictor of meeting the recommended vitamin D level of 10 µg (p = 0.0292; odds ratio (OR) = 1.94; 95% confidence interval (CI) 1.07–3.52), but also of 5 µg (p < 0.0001; OR = 2.54; 95% CI 1.85–3.47). Therefore, taking into account the relatively low prices of herring, its high vitamin D content, as well as its influence on total vitamin D intake, it could be beneficial to recommend young women to increase herring intake in order to increase dietary vitamin D intake and to meet its recommendations. Full article
(This article belongs to the Special Issue The Metabolism and Health Benefits of Bioactive Compounds in Foods)
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Open AccessArticle
Tangerines Cultivated on Madeira Island—A High Throughput Natural Source of Bioactive Compounds
Foods 2020, 9(10), 1470; https://doi.org/10.3390/foods9101470 - 15 Oct 2020
Abstract
Tangerines (Citrus reticulata) are popular fruits worldwide, being rich in many bioactive metabolites. The setubalense variety cultivated on Madeira Island has an intense aroma easily distinguishable from other tangerines, being traditionally used to enrich several foods and beverages. Nonetheless, setubalense volatile [...] Read more.
Tangerines (Citrus reticulata) are popular fruits worldwide, being rich in many bioactive metabolites. The setubalense variety cultivated on Madeira Island has an intense aroma easily distinguishable from other tangerines, being traditionally used to enrich several foods and beverages. Nonetheless, setubalense volatile composition has never been characterized, and we aimed to unveil the bioactive potential of peels and juices of setubalense tangerines and compare them with the murcott variety grown in Portugal mainland. Using headspace solid-phase microextraction coupled to gas chromatography mass spectrometry (HS-SPME/GC-MS), we identified a total of 128 volatile organic metabolites (VOMs) in the juice and peels, with d-limonene, γ-terpinene, β-myrcene, α- and β-pinene, o-cymene, and terpinolene, the most dominant in both cultivars. In contrast, setubalense juices are richer in terpenes, many of them associated with health protection. Discriminant analysis revealed a pool of VOMs, including β-caryophyllene and E-ocimene, with bioactive properties able to differentiate among tangerines according to variety and sample type (peel vs. juice). This is the first report on the volatile composition of setubalense tangerines grown on Madeira Island revealing that its pungent aroma is constituted by secondary metabolites with specific aroma notes and health properties. This is strong evidence of the higher nutraceutical value of such fruit for the human diet. Full article
(This article belongs to the Special Issue The Metabolism and Health Benefits of Bioactive Compounds in Foods)
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Open AccessArticle
Green/Roasted Coffee May Reduce Cardiovascular Risk in Hypercholesterolemic Subjects by Decreasing Body Weight, Abdominal Adiposity and Blood Pressure
Foods 2020, 9(9), 1191; https://doi.org/10.3390/foods9091191 - 28 Aug 2020
Abstract
In previous studies, after regularly consuming a green/roasted coffee blend, body weight, body fat%, glucose, plasminogen activator inhibitor-1 (PAI-1), resistin, leptin, ghrelin, diastolic (DBP) and systolic blood pressure (SBP) significantly changed in healthy and hypercholesterolemic subjects. However, glucagon, total-cholesterol (T-C), triglycerides (TG), LDL-cholesterol [...] Read more.
In previous studies, after regularly consuming a green/roasted coffee blend, body weight, body fat%, glucose, plasminogen activator inhibitor-1 (PAI-1), resistin, leptin, ghrelin, diastolic (DBP) and systolic blood pressure (SBP) significantly changed in healthy and hypercholesterolemic subjects. However, glucagon, total-cholesterol (T-C), triglycerides (TG), LDL-cholesterol (LDL-C) and Homeostasis Model Assessment index to estimate insulin resistance (HOMA-IR) only changed in the hypercholesterolemics. This work looks into the antiobesity effects of coffee blend and into the relationship of antiobesity with the aforementioned cardiometabolic modifications in hypercholesterolemics. (1) Methods: Tricipital and subscapular skinfolds, hip, thigh, arm and waist circumference (WC) were measured in normocholesterolemic and hypercholesterolemics. To understand the relationship between cardiometabolic and antiobesity results in hypercholesterolemics, factor analysis was carried out using baseline values of the variables that changed. (2) Results: WC, WC/hip and WC/height showed significant coffee×group interaction, and in hypercholesterolemics tended to decrease. After factor analysis, three factors emerged, accounting for 29.46, 13.13 and 11.79% of variance. Only factor 1 (main loadings: WC, DBP and SBP, body weight, WC/hip and WC/height ratios, TG and ghrelin, inversely) decreased after coffee intake. (3) Conclusion: Regularly consuming green/roasted coffee may help to control body weight, and in hypercholesterolemics, may reduce cardiovascular risk by reducing abdominal adiposity and blood pressure. Full article
(This article belongs to the Special Issue The Metabolism and Health Benefits of Bioactive Compounds in Foods)
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Open AccessArticle
The Human Microbial Metabolism of Quercetin in Different Formulations: An In Vitro Evaluation
Foods 2020, 9(8), 1121; https://doi.org/10.3390/foods9081121 - 14 Aug 2020
Abstract
Quercetin is one of the main dietary flavonols, but its beneficial properties in disease prevention may be limited due to its scarce bioavailability. For this purpose, delivery systems have been designed to enhance both stability and bioavailability of bioactive compounds. This study aimed [...] Read more.
Quercetin is one of the main dietary flavonols, but its beneficial properties in disease prevention may be limited due to its scarce bioavailability. For this purpose, delivery systems have been designed to enhance both stability and bioavailability of bioactive compounds. This study aimed at investigating the human microbial metabolism of quercetin derived from unformulated and phytosome-formulated quercetin through an in vitro model. Both ingredients were firstly characterized for their profile in native (poly)phenols, and then fermented with human fecal microbiota for 24 h. Quantification of microbial metabolites was performed by ultra-high performance liquid chromatography coupled to mass spectrometry (uHPLC-MSn) analyses. Native quercetin, the main compound in both products, appeared less prone to microbial degradation in the phytosome-formulated version compared to the unformulated one during fecal incubation. Quercetin of both products was bioaccessible to colonic microbiota, resulting in the production of phenylpropanoic acid, phenylacetic acid and benzoic acid derivatives. The extent of the microbial metabolism of quercetin was higher in the unformulated ingredient, in a time-dependent manner. This study opened new perspectives to investigate the role of delivery systems on influencing the microbial metabolism of flavonols in the colonic environment, a pivotal step in the presumed bioactivity associated to their intake. Full article
(This article belongs to the Special Issue The Metabolism and Health Benefits of Bioactive Compounds in Foods)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Functional components, antioxidant activity and enzyme inhibitory ability following in vitro simulated gastrointestinal digestion of date (Phoenix dactylifera L.) fruit and seed extracts of different cultivars
Authors: Ouarda Djaoudene
Affiliation: Laboratoire de Biochimie Appliquée, Faculté des Sciences de la Nature et de la Vie, Université de Bejaia, Bejaia, Algeria

Title: Bioaccesibility of bioactive compounds of “garlic” and “black garlic” through simulated gastrointestinal digestion.
Authors: José Manuel Moreno Rojas
Affiliation: Food Science and Health Department, Andalusian Institute of Agricultural and Fisheries Research and Training (IFAPA) Alameda del Obispo, Córdoba, Spain

Title: Factors influencing the nutritional quality parameters and the bioaccesibility of black carrot (Daucus carota ssp. Sativus var. atrorubens Alef.)
Authors: Gema Pereira Caro
Affiliation: Food Science and Health Department, Andalusian Institute of Agricultural and Fisheries Research and Training (IFAPA) Alameda del Obispo, Córdoba, Spain

Title: Cruciferous sprouts produced under LED ligthing - Biomass production and Phytochemical Contents
Authors: Diego Moreno
Affiliation: Phytochemistry and Healthy Foods Lab, Department of Food Science Technol- ogy, CEBAS-CSIC, Murcia, Spain

Title: Green/roasted coffee may reduce cardiovascular risk in hypercholesterolemic subjects by decreasing body weight, abdominal adiposity and blood pressure
Authors: Beatriz Sarriá; José Luis Sierra-Cinos; Luis García-Diz; Sara Martínez-López; Raquel Mateos; Laura Bravo
Affiliation: Department of Metabolism and Nutrition Institute of Food Science, Technology and Nutrition (ICTAN-CSIC) Spanish National Research Council (CSIC), José Antonio Nováis 10, 28040 Madrid, Spain
Abstract: Background Effects of regularly consuming a green/roasted coffee blend were studied in normocholesterolemic and hypercholesterolemic subjects. After coffee intake, in both groups, body weight, body fat percentage, glucose, plasminogen activator inhibitor-1, resistin, leptin, ghrelin, diastolic (DBP) and systolic blood pressure (SBP) significantly changed. However, glucagon, total-cholesterol (T-C), triglycerides (TG), LDL-C and HOMA-IR only changed in the hypercholesterolemics. This work looks into the relationship between the aforementioned cardiometabolic and antiobesity coffee effects in hypercholesterolemics. Methods Tricipital and subscapular skinfolds, WC, hip, thigh and arm circumferences were measured in both normocholesterolemics and hypercholesterolemics. To further understand the relationship between cardiometabolic and antiobesity results in the hypercholesterolemics, factor analysis was carried out using baseline values of the variables that changed. Results WC, WC/hip and WC/height showed significant coffee × group interaction, and in the hypercholesterolemics tended to decrease. Three factors emerged (F1, F2, F3), accounting for 29.46, 13.13 and 11.79% of variance, respectively. Only F1 (main loadings: WC, DBP and SBP, body weight, WC/hip and WC/height ratios, TG and ghrelin, inversely) significantly decreased after coffee intake. Conclusion Regularly consuming green/roasted coffee may help to control weight, and in hypercholesterolemics it may reduce cardiovascular risk through reducing abdominal adiposity, blood pressure and body weight.

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