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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Advances in Laboratory Diagnosis: Biomarker Validation and Diagnostic Performance

edited by

Ivana Lapić

submission deadline 31 Jan 2027 | Viewed by 209 | Submission Open

Keywords: biomarkers; validation; diagnostic accuracy; clinical performance; patient safety

(This special issue belongs to the Section Clinical Laboratory Medicine)

Kidney Disease: Biomarkers, Diagnosis, and Prognosis—4th Edition

edited by

Akito Maeshima

submission deadline 31 Jan 2027 | Viewed by 202 | Submission Open

Keywords: primary/secondary glomerulonephritis; rapidly progressive glomerulonephritis; nephrotic syndrome; acute kidney injury; chronic kidney disease; diabetic nephropathy/diabetic kidney disease; chronic renal failure; kidney transplantation; renal fibrosis; polycystic kidney

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Machine Learning for Computer-Aided Diagnosis in Biomedical Imaging—3rd Edition

edited by

Farhan Akram

submission deadline 31 Jan 2027 | Viewed by 182 | Submission Open

Keywords: cancer diagnosis; medical images; electronic health records; machine learning; deep learning; artificial intelligence; explainable AI models; multi-modal analysis; federated learning; CAD systems

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

AI and Explainable Intelligence for Medical Diagnosis: Emerging Trends and Future Directions

edited by

Olamilekan Shobayo

submission deadline 31 Jan 2027 | Viewed by 177 | Submission Open

Keywords: artificial intelligence; deep learning; vision transformers (ViTs); generative AI (GANs, VAEs, diffusion models); multimodal learning; radiology AI; image segmentation and classification; explainable AI (XAI); clinical decision support; medical image analysis

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in Oral and Maxillofacial Tumors and Salivary Gland Diseases

edited by

Maria Cristofaro

submission deadline 31 Jan 2027 | Viewed by 171 | Submission Open

Keywords: salivary gland tumors; oral squamous cell carcinoma; maxillofacial surgery; intraoperative nerve monitoring; prognostic biomarkers

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Biomarkers and Biodiagnostics in Neurodegenerative Diseases

edited by

Ludmilla Morozova-Roche

submission deadline 31 Jan 2027 | Viewed by 136 | Submission Open

Keywords: neurodegenerative diseases; biomarkers; biodiagnostics; protein misfolding

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Imaging‑Guided Oral and Maxillofacial Diagnosis

edited by Aleksa Janović

submission deadline 31 Jan 2027 | Viewed by 131 | Submission Open

Keywords: cone-beam computed tomography; dental MRI; ultrasound; computed tomography; image-based 3D modeling; artificial intelligence; digital image analysis

(This special issue belongs to the Section Medical Imaging and Theranostics)

Diagnosis and Management of Adverse Drug Reactions in Precision Medicine and Big Data

edited by

Elena Ramírez

submission deadline 28 Feb 2027 | 1 articles | Viewed by 17806 | Submission Open

Keywords: adverse drug reactions; pharmacovigilance; drug safety; risk factors; causality assessment; big data; precision medicine

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Ultrasound Diagnosis and Guided Intervention of Musculoskeletal/Neuromuscular Pathology, Second Edition

edited by

Ke-Vin Chang

submission deadline 28 Feb 2027 | 7 articles | Viewed by 17280 | Submission Open

Keywords: diagnosis; ultrasound; pain; muscle; tendon; nerve; rehabiltation

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advanced Role of Endoscopic Ultrasound in Clinical Medicine

edited by

Germana De Nucci

submission deadline 28 Feb 2027 | 3 articles | Viewed by 7597 | Submission Open

Keywords: endoscopic ultrasound (EUS); diagnostic imaging; fine needle aspiration (FNA); contrast-enhanced EUS; elastography techniques

(This special issue belongs to the Section Medical Imaging and Theranostics)

Artificial Intelligence in Diagnosis and Management of Cardiovascular Diseases

edited by

Corina Maria Vasile

and Xavier Iriart

submission deadline 28 Feb 2027 | 4 articles | Viewed by 7343 | Submission Open

Keywords: cardiovascular diseases; artificial intelligence; deep learning; machine learning; wearable devices; imaging techniques; personalized medicine; risk prediction; telemedicine; remote monitoring; ethical considerations

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Application of Ultrasound Imaging in Clinical Diagnosis

edited by

Jinbum Kang

submission deadline 28 Feb 2027 | 6 articles | Viewed by 6615 | Submission Open

Keywords: diagnostic ultrasound imaging and systems; doppler ultrasound techniques and applications; elastography for tissue characterization; contrast-enhanced ultrasound (CEUS); artificial intelligence in diagnostic ultrasound; point-of-care ultrasound (POCUS); ultrasound-guided interventions

(This special issue belongs to the Section Medical Imaging and Theranostics)

Clinical Anatomy and Diagnosis of Peripheral Nervous System—2nd Edition

edited by

Alexandra Diana Vrapciu

submission deadline 28 Feb 2027 | 2 articles | Viewed by 5635 | Submission Open

Keywords: anatomy; peripheral nervous system; imaging

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Artificial Intelligence in Alzheimer’s Disease Diagnosis—2nd Edition

edited by

Mohammad Shahadat Hossain

submission deadline 28 Feb 2027 | 5 articles | Viewed by 5164 | Submission Open

Keywords: Alzheimer’s disease; artificial intelligence; machine learning; explainable AI; expert systems; computer vision; deep learning; diagnosis; cognition; brain informatics; neurodegenerative disorder

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Endoscopy in Gynecology and Gynecologic Oncology

edited by

Rudolf Lampé

submission deadline 28 Feb 2027 | 1 articles | Viewed by 4499 | Submission Open

Keywords: gynecology; endoscopy; operative gynecology

(This special issue belongs to the Section Medical Imaging and Theranostics)

Fetal Doppler Assessment: From Basic Research to Clinical Practice

edited by Luís Guedes-Martins

submission deadline 28 Feb 2027 | 1 articles | Viewed by 3910 | Submission Open

Keywords: fetal Doppler; fetal growth restriction; preeclampsia; fetal-placental hemodynamics; fetal death; placental abruption; placental circulation; fetal cerebral circulation; fetal hepatic circulation; fetal heart function

(This special issue belongs to the Section Medical Imaging and Theranostics)

Precise Diagnosis, Classification, and Monitoring of Pulmonary Diseases

edited by

Barbara Ruaro

Paola Confalonieri

and

Francesco Salton

submission deadline 28 Feb 2027 | 2 articles | Viewed by 3324 | Submission Open

Keywords: lung diseases; pulmonary diseases; imaging techniques; causal biological pathways; clinical biomarkers

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Artificial Intelligence in Biomedical Signal and Imaging Processing

edited by

Ankush D. Jamthikar

submission deadline 28 Feb 2027 | 2 articles | Viewed by 2313 | Submission Open

Keywords: artificial intelligence; biomedical imaging; signal processing; unsupervised learning; generative artificial intelligence; image reconstruction; image segmentation; data augmentation; physiological signal analysis; personalized medicine; artificial intelligence-driven diagnostics; self-supervised learning

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Diagnostic Imaging in Urologic Disorders

edited by Matteo Droghetti

submission deadline 28 Feb 2027 | 2 articles | Viewed by 2280 | Submission Open

Keywords: diagnostic imaging; urologic disorders; ultrasound; CT; MRI; PET; hybrid imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Inflammation and Infection Imaging: 2nd Edition

edited by

Giorgio Treglia

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1967 | Submission Open

Keywords: imaging; infection; inflammation; radiology; nuclear medicine; molecular imaging; hybrid imaging

(This special issue belongs to the Section Medical Imaging and Theranostics)

Recent Advances in Hearing and Audiology Science: Diagnosis and Management, 2nd Edition

edited by

Yu Sun

submission deadline 28 Feb 2027 | 2 articles | Viewed by 1686 | Submission Open

Keywords: hearing loss; genetic deafness; cochlear implants; hair cell regeneration; central auditory processing; vestibular disorders; tinnitus; intervention

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in the Diagnosis of Skin Disease: 2nd Edition

edited by

Gerardo Cazzato

submission deadline 28 Feb 2027 | 1 articles | Viewed by 824 | Submission Open

Keywords: dermatology; dermatopathology; skin diseases; neoplastic diseases; inflammatory dermatopathology; CTCL; melanoma; squamous cell carcinoma; basal cell carcinoma; infectious diseases

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Imaging of Long-COVID (Post-Acute Sequelae of COVID, PASC) and Post-Infectious Syndromes

edited by

Eric Guedj

submission deadline 28 Feb 2027 | 1 articles | Viewed by 805 | Submission Open

Keywords: long COVID; post-acute sequelae of COVID (PASC); COVID-19; SARS-CoV-2; post-infectious syndromes; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); medical imaging; nuclear medicine; PET; SPECT; MRI; CT; ultrasound; imaging biomarkers; metabolism; neuroinflammation; microvascular dysfunction; multisystem involvement; diagnosis; prognosis; rehabilitation; functional impairment

(This special issue belongs to the Section Medical Imaging and Theranostics)

Recent Advances in Clinical Biochemical Testing: 2nd Edition

edited by

Tar-Choon Aw

submission deadline 28 Feb 2027 | Viewed by 805 | Submission Open

Keywords: clinical chemistry; diagnostic testing; biomarkers; point-of-care testing; mass spectrometry; immunoassays; microfluidics

(This special issue belongs to the Section Clinical Laboratory Medicine)

Multimodal Assessment of Musculoskeletal Conditions

edited by

Stanley K. H. Lam

and Bradley Dean Fullerton

submission deadline 28 Feb 2027 | Viewed by 760 | Submission Open

Keywords: musculoskeletal disorders; multimodal assessment; biotensegrity; diagnostic ultrasound; imaging; biomechanics; rehabilitation monitoring; patient-reported outcomes

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Quantitative Imaging of Respiratory Diseases: Techniques and Clinical Applications

edited by Chenwang Jin and

Yanrong Chen

submission deadline 28 Feb 2027 | Viewed by 661 | Submission Open

Keywords: quantitative imaging; HRCT; radiomics; machine learning; respiratory diseases; imaging biomarkers

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advanced Imaging and Artificial Intelligence in Emergency Body Radiology

edited by

Francesco Verde

and

Francesca Iacobellis

submission deadline 28 Feb 2027 | Viewed by 642 | Submission Open

Keywords: emergency radiology; advanced imaging; artificial intelligence; dual-energy CT; photon-counting CT; MRI acceleration; contrast-enhanced ultrasound; deep learning; radiomics; workflow optimisation; clinical validation

(This special issue belongs to the Section Medical Imaging and Theranostics)

Surgical Diagnosis and Management of Inflammatory Diseases in Hepatobiliary and Pancreatic Systems

edited by

Roberto Cotellese

and

Federico Selvaggi

submission deadline 28 Feb 2027 | 1 articles | Viewed by 604 | Submission Open

Keywords: surgical diagnosis; diagnostic biomarkers; intraoperative imaging; pathology; risk stratification; disease differentiation; prognostic assessment; hepatobiliary inflammation; pancreatic inflammation; minimally invasive biopsy

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Innovative Biomarkers and Diagnostic Strategies in Immune-Mediated Diseases

edited by

Marcos López Hoyos

submission deadline 28 Feb 2027 | Viewed by 529 | Submission Open

Keywords: immune-mediated diseases; innovative biomarkers; diagnostic strategies; classification criteria; laboratory techniques

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Imaging Methods in Obstetrics and Gynecology

edited by

Dan-Bogdan Navolan

Dana Stoian

, Laurenţiu Cornel Pirtea, Adrian Ratiu and Dan Dumitrascu-Biris

submission deadline 28 Feb 2027 | Viewed by 481 | Submission Open

Keywords: obstetric imaging; gynecologic imaging; prenatal ultrasound; fetal MRI; elastography; AI-assisted diagnosis; materno-fetal medicine; breast imaging; fetal lesions

(This special issue belongs to the Section Medical Imaging and Theranostics)

Clinical Diagnosis and Management in Anesthesia and Pain Medicine: 2nd Edition

edited by Jamal Hasoon

submission deadline 28 Feb 2027 | Viewed by 380 | Submission Open

Keywords: anesthesia and pain medicine; interventional pain management; regional anesthesia; neuromodulation; treatment outcomes; clinical practice patterns; diagnosis; management

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Latest Innovations in Interventional Oncology

edited by

Pierleone Lucatelli

and

David C. Madoff

submission deadline 28 Feb 2027 | Viewed by 363 | Submission Open

Keywords: contrast-enhanced ultrasound (CEUS); hybrid PET-MRI oncology imaging; optical coherence tomography (OCT) diagnostics; AI-driven lesion segmentation; radiomics-based tumor profiling; liquid biopsy innovations; endovascular biomarker sampling; molecular imaging specificity; real-time tumor characterization; image-guided diagnostic paradigms

(This special issue belongs to the Section Medical Imaging and Theranostics)

Computational and Functional Diagnostic Approaches in Behavioral and Clinical Neurosciences

edited by

Marco Esposito

Marcella Caputi

Roberta Fadda

and Antonio Cerasa

submission deadline 28 Feb 2027 | Viewed by 353 | Submission Open

Keywords: computational diagnostics; behavioral assessment; multimodal biomarkers; nutritional and metabolic indicators; physiological; neuroimaging

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Insights into Forensic Imaging

edited by

Oguzhan Ekizoglu

submission deadline 28 Feb 2027 | Viewed by 336 | Submission Open

Keywords: forensic imaging; postmortem imaging; artificial intelligence; 3D reconstruction; foren-sic radiology; forensic anthropology

(This special issue belongs to the Section Forensic Diagnostics)

Insights into Placental Pathology

edited by

Vincenzo Arena

and Eleonora Nardi

submission deadline 28 Feb 2027 | 1 articles | Viewed by 319 | Submission Open

Keywords: placental pathology; placental development; gestational diseases; histopathological examination; pregnancy outcomes; forensic issues

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

From Variability to Reliability: Standardization, Interference, and the Future of Laboratory Medicine

edited by

Katarzyna Winsz-Szczotka

submission deadline 28 Feb 2027 | Viewed by 315 | Submission Open

Keywords: laboratory medicine; standardization; diagnostic reliability; sample quality; automation; artificial intelligence

(This special issue belongs to the Section Clinical Laboratory Medicine)

Emerging Diagnostic Technologies in Orthopedics: Advancing Personalized Implant Design and Therapeutics

edited by

Neil Ashwood

submission deadline 28 Feb 2027 | Viewed by 301 | Submission Open

Keywords: patient-specific implant design; advanced diagnostic technologies; computational biomechanics; surgical navigation systems; implant manufacturing; intraoperative monitoring; postoperative evaluation; biomedical engineering; clinical implant optimization; precision medicine

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Diagnosis and Treatment of Digestive System Diseases

edited by

Zhendong Jin

submission deadline 28 Feb 2027 | Viewed by 248 | Submission Open

Keywords: digestive system diseases; endoscopic diagnostic techniques; AI-assisted endoscopy; gastrointestinal malignancy; molecular biomarkers; minimally invasive therapy; precision diagnosis; clinical translational research

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Current Updates in Neuropathology

edited by

Gianluca Marucci

submission deadline 28 Feb 2027 | Viewed by 219 | Submission Open

Keywords: brain tumors; epilepsy surgery; neurovascular diseases; peripheral neuropathy; glioblastoma; CNS metastases; methylation profiling; neuro-oncology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advancing Precision Cardiovascular Imaging: From Metabolic Disorders to Cardiomyopathies and Rare Cardiac Diseases

edited by

Chung Lieh Hung

submission deadline 28 Feb 2027 | 1 articles | Viewed by 187 | Submission Open

Keywords: cardiomyopathy; rare disease; echocardiography; nuclear imaging; cardiac MRI; computed tomograph

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Modern Diabetes Diagnosis and Treatment Technology, Second Edition

edited by

Tomislav Bulum

and

Martina Tomić

submission deadline 28 Feb 2027 | Viewed by 157 | Submission Open

Keywords: diabetes; complications; diagnosis; diabetic retinopathy; diabetic neuropathy; diabetic nephropathy; technology

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Molecular Diagnostics for Solid Tumors

edited by

Thais Maloberti

submission deadline 28 Feb 2027 | Viewed by 148 | Submission Open

Keywords: rare tumors; solid tumors; NGS; artificial intelligence; molecular profiling; precision oncology; epigenetic biomarkers; liquid biopsy

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Recent Developments in the Diagnosis of Gastrointestinal Diseases

edited by

Nikhitha Mantri

and Sridhar S. Chilimuri

submission deadline 28 Feb 2027 | Viewed by 137 | Submission Open

Keywords: endoscopy; biomarkers; non-invasive testing; screening; artificial intelligence; cancer; early detection

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Diagnosis and Treatment of Hematological Diseases

edited by

Mirjana Mitrovic

and

Nikola Pantic

submission deadline 28 Feb 2027 | Viewed by 136 | Submission Open

Keywords: hematology; anemia; thrombocytopenia; bleeding; thrombosis; hemostasis; leukemia; lymphoma; myeloma; diagnosis; therapy

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Advances in Diagnosis and Prognostic Evaluation of Urological Diseases

edited by

Uroš Bumbaširević

submission deadline 28 Feb 2027 | Viewed by 72 | Submission Open

Keywords: urological diseases; diagnosis; prognosis; biomarkers; prostate diseases; benign prostatic hyperplasia; bladder cancer; testicular cancer; urolithiasis; endourology

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Quantum Machine Learning in Medical Image and Signal Processing

edited by Yolanda Vives-Gilabert

submission deadline 28 Feb 2027 | Viewed by 44 | Submission Open

Keywords: quantum machine learning; medical imaging; medical signal processing; variational quantum circuits

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in Endoscopy—A New Era in Gastrointestinal Diagnostics, 2nd Edition

edited by

Ervin Toth

and

Anastasios Koulaouzidis

submission deadline 28 Feb 2027 | Viewed by 43 | Submission Open

Keywords: AI-supported detection, classification, and workflow in endoscopy; innovations in capsule and device-assisted endoscopy; image enhancement technologies and real-time analytics; therapeutic endoscopic advances and new instrumentation; integration of digital tools and automation into clinical practice; perspectives on training, quality, and standardization; ethical and regulatory considerations in emerging technologies

(This special issue belongs to the Section Biomedical Optics)

Brain Injury: Diagnostic and Prognostic Insights

edited by Pál Barzó

submission deadline 28 Feb 2027 | Viewed by 31 | Submission Open

Keywords: traumatic brain injury; TBI; diffuse axonal injury; DAI; diffusion tensor imaging; DTI; probabilistic tractography; functional outcome; prognosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Digital Innovations in Obstetrics and Gynecology: Artificial Intelligence, Diagnostic Advances, and Clinical Decision-Making

edited by

Iason Psilopatis

submission deadline 20 Mar 2027 | Viewed by 122 | Submission Open

Keywords: obstetrics; gynecology; artificial intelligence; diagnostic imaging; digital diagnostics

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Utilization of Liquid Biopsy in Cancer Diagnosis and Management 2025–2026

edited by

Consolato M. Sergi

submission deadline 31 Mar 2027 | 5 articles | Viewed by 13871 | Submission Open

Keywords: liquid biopsy; precision medicine; cancer diagnostics; nanotechnologies; markers

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

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