Brain Injury: Diagnostic and Prognostic Insights
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".
Deadline for manuscript submissions: 28 February 2027 | Viewed by 31
Editor
Interests: traumatic brain injury; intracerebral hemorrhage; decompressive craniectomy; skull base tumors; diffuse midline gliomas; human cortical interneurons; synaptic transmis-sion; calcium signaling; neuroinflammation
Special Issue Information
Dear Colleagues,
Traumatic brain injuries represent a substantial public health burden. Epidemiological data identify them as a leading cause of mortality and morbidity across the lifespan, despite the fact that, by their very nature, their true burden is consistently underestimated. In addition to subtypes that frequently present with a space-occupying effect, such as contusional hemorrhages and epidural or subdural hematomas, diffuse axonal injuries—characterized by multiple microscopic lesions affecting axonal integrity—pose considerable diagnostic, therapeutic and rehabilitative challenges. In this entity, cognitive deficits and long-term neuropsychological sequelae are often disproportionately severe relative to what is suggested by initial conventional radiological imaging, such as CT or MRI. It should be noted, however, that with a comprehensive, multidisciplinary approach to care, the majority of patients may achieve a favorable functional outcome. From a diagnostic perspective, imaging modalities capable of assessing axonal integrity provide important additional information. These include diffusion tensor imaging and model-based probabilistic tractography. The latter enables not only the characterization of changes in diffusion parameters within anatomical regions but also the assessment of injury-related alterations in functional white matter tract systems, such as the corticospinal tract, corticobulbar tract and reticular formation. This, in turn, may allow the extraction of prognostically relevant information.
Prof. Dr. Pál Barzó
Guest Editor
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Keywords
- traumatic brain injury
- TBI
- diffuse axonal injury
- DAI
- diffusion tensor imaging
- DTI
- probabilistic tractography
- functional outcome
- prognosis
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