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Diagnostics publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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AI-Powered Biomedical Imaging and Diagnostics

edited by

Leandro Donisi

and Fabrizio Esposito

submission deadline 30 Nov 2026 | Viewed by 1054 | Submission Open

Keywords: non-invasive diagnostics; biomarker quantification; early diagnosis; personalized diagnostics; synthetic data; radiomics; multimodal data integration; predictive diagnostics

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in Breast Imaging: Improving Detection and Diagnosis

edited by

Graziella Di Grezia

submission deadline 30 Nov 2026 | 1 articles | Viewed by 822 | Submission Open

Keywords: breast cancer screening; digital breast tomosynthesis (DBT); contrast-enhanced mammography (CEM); breast MRI; artificial intelligence; radiomics; automated breast ultrasound (ABUS)

(This special issue belongs to the Section Medical Imaging and Theranostics)

Pediatric Neurological Disorders: Diagnostic and Management Innovations

edited by Hui Xiong

submission deadline 30 Nov 2026 | 1 articles | Viewed by 766 | Submission Open

Keywords: pediatric neurological disorders; diagnostic and Management Innovations; biomarkers; neuroimaging techniques; genetic test; artificial intelligence-assisted; personalized treatment

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Innovations in Diagnosis and Clinical Practice of Corneal Disorders

edited by Lei Tian

submission deadline 30 Nov 2026 | 2 articles | Viewed by 658 | Submission Open

Keywords: corneal diseases; corneal biomechanics; diagnostic innovation; in vivo corneal imaging; ocular biomarkers; artificial intelligence in ophthalmology; clinical ophthalmology

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Artificial Intelligence in Hearing Diseases

edited by

Mehdi Abouzari

submission deadline 30 Nov 2026 | Viewed by 531 | Submission Open

Keywords: artificial intelligence; hearing loss; diagnosis; machine learning; auditory neuroscience; speech recognition; cochlear implants; data science; computational algorithm

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

New Advances in Artificial Intelligence for Clinical Diagnostic Decision Making

edited by

Md Mohaimenul Islam

and

Ming-Chin Lin

submission deadline 30 Nov 2026 | 1 articles | Viewed by 513 | Submission Open

Keywords: artificial intelligence; machine learning; clinical decision support systems; health disparity; medical imaging; disease diagnosis; medical errors; patient safety

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Large Vision–Language Models (LVLMs) in Medical Imaging: Methods, Evaluation, and Clinical Translation

edited by

Tim Duong

submission deadline 30 Nov 2026 | Viewed by 438 | Submission Open

Keywords: large vision–language models (LVLMs); medical imaging; diagnostics; AI; radiology and pathology

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Imaging-Driven Virtual and Augmented Reality for Surgical Diagnosis and Intervention

edited by

Maki Sugimoto

submission deadline 30 Nov 2026 | Viewed by 429 | Submission Open

Keywords: imaging; three-dimensional reconstruction; virtual; augmented; mixed; extended reality; hologram; polygon modeling; spatial computing; image guided; surgical diagnosis; minimally invasive surgery; endoscopic surgery; robot; MRI; CT; ultrasound

(This special issue belongs to the Section Medical Imaging and Theranostics)

Wearable Sensors and Artificial Intelligence for Real-Time Disease Monitoring

edited by

Wei-Chih Lien

submission deadline 30 Nov 2026 | Viewed by 359 | Submission Open

Keywords: wearable sensors; artificial intelligence; real-time monitoring; digital health; biosensors; machine learning

(This special issue belongs to the Section Point-of-Care Diagnostics and Devices)

Novel Advances in Allergy Diagnosis, 2nd Edition

edited by

Zenon Brzoza

submission deadline 30 Nov 2026 | Viewed by 332 | Submission Open

Keywords: allergic diseases; diagnostic tools and techniques; artificial intelligence; biomarkers; point-of-care testing and wearable devices

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Rheumatic Diseases: From Macroscopic Diagnosis to Molecular Mechanisms

edited by

Cristina Pamfil

submission deadline 30 Nov 2026 | Viewed by 292 | Submission Open

Keywords: rheumatology diagnostics; imaging and radiomics; autoantibodies and biomarkers; multi-omics (proteomics/metabolomics/genomics); machine learning/artificial intelligence; disease activity and prognosis; precision medicine; interstitial lung disease in rheumatology; vasculitis and connective tissue diseases; diagnostic pathways

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Heart Failure and Cardiomyopathies: From Accurate Diagnosis to Novel Therapies

edited by Christos A. Papanastasiou

submission deadline 30 Nov 2026 | Viewed by 289 | Submission Open

Keywords: heart failure; cardiomyopathy; diagnosis; prognosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Multimodal Diagnostics Using Medical Imaging and Liquid Biopsy: Clinical Translation and Implementation

edited by Yoshihisa Shimada

submission deadline 30 Nov 2026 | Viewed by 280 | Submission Open

Keywords: medical imaging; liquid biopsy; multimodal diagnostics; clinical translation; precision medicine; biomarkers; real-world clinical application

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

New Generation Radiology: Towards a New Standard of Diagnostic Accuracy

edited by

Emanuele David

submission deadline 30 Nov 2026 | Viewed by 273 | Submission Open

Keywords: radiology; medical imaging; precision medicine; diagnosis; artificial intelligence

(This special issue belongs to the Section Medical Imaging and Theranostics)

Oncology Imaging and Radiotherapy: From Diagnosis to Personalized Management

edited by Gokoulakrichenane Loganadane and

Mattia Falchetto Osti

submission deadline 30 Nov 2026 | Viewed by 264 | Submission Open

Keywords: oncology imaging; radiotherapy; MR-guided radiotherapy; MR-LINAC; radiomics; artificial intelligence; image-guided radiotherapy (IGRT); multiparametric MRI

(This special issue belongs to the Section Medical Imaging and Theranostics)

Recent Advances in Echocardiography, 3rd Edition

edited by

Giulia Elena Mandoli

and Antonio Capolongo

submission deadline 30 Nov 2026 | Viewed by 246 | Submission Open

Keywords: standard echocardiography; speckle tracking echocardiography; strain; myocardial deformation; 3D echocardiography; valvular reconstruction; differential diagnosis; artificial intelligence

(This special issue belongs to the Section Medical Imaging and Theranostics)

Recent Advances in the Diagnosis and Management of Head and Neck Cancers

edited by Jessica Lyn Geiger

submission deadline 30 Nov 2026 | Viewed by 244 | Submission Open

Keywords: head and neck squamous cell carcinoma (HNSCC); advanced thyroid carcinoma; diagnosis and detection; salivary gland malignancies; radiotherapy; neoadjuvant immunotherapy

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in the Diagnosis and Phenotyping of Metabolic Disorders

edited by

Zhiguang Su

submission deadline 30 Nov 2026 | Viewed by 228 | Submission Open

Keywords: metabolic disorders; precision diagnosis; biomarker discovery; multi-omics; artificial intelligence (AI); disease phenotyping; diagnostic technologies; clinical decision support

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Modern Diagnosis and Management in Abdominal Surgical Oncology

edited by Spiros G. Delis

submission deadline 30 Nov 2026 | Viewed by 227 | Submission Open

Keywords: gastrointestinal, hepatobiliary, and pancreatic cancers; abdominal surgical oncology; surgical techniques; diagnosis; medical imaging

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Precision Medicine in Valvular Heart Disease: Diagnosis and Management

edited by Roney Orismar Sampaio

submission deadline 30 Nov 2026 | Viewed by 172 | Submission Open

Keywords: precision medicine; valvular heart disease; biomarkers; aortic stenosis; mitral regurgitation; cardiovascular imaging

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Advances in Diagnostic Approaches and Biomarkers of Polycystic Ovary Syndrome

edited by Enrico Carmina

submission deadline 30 Dec 2026 | Viewed by 228 | Submission Open

Keywords: polycystic ovary syndrome (PCOS); anti-müllerian hormone (AMH); rotterdam criteria; metabolic phenotypes; adolescent PCOS diagnosis

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Novel Methods and Devices for Monitoring and Diagnosing in Critical Care

edited by

Zhongheng Zhang

submission deadline 31 Dec 2026 | 7 articles | Viewed by 19674 | Submission Open

Keywords: hemodynamic monitoring; perfusion; heart-lung interactions; novel biomarkers; machine learning; ultrasound; therapeutic drug monitoring; wearable sensors

(This special issue belongs to the Section Point-of-Care Diagnostics and Devices)

Lung Cancer: Screening, Diagnosis and Management: 2nd Edition

edited by

Fu-Zong Wu

submission deadline 31 Dec 2026 | 6 articles | Viewed by 18998 | Submission Open

Keywords: lung cancer; LDCT; overdiagnosis; artificial intelligence; deep learning; prognosis; radiomics; texture analysis; thoracic surgery

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Diagnostic Methods in Forensic Pathology, Third Edition

edited by

Gennaro Baldino

and

Elvira Ventura Spagnolo

submission deadline 31 Dec 2026 | 7 articles | Viewed by 16487 | Submission Open

Keywords: multidisciplinary approach; forensic pathology; sudden/unexpected death; sepsis and health infections; suicide; gender violence; post-mortem immunohistochemistry; post-mortem CT; virtopsy

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Pathology and Diagnosis of Head and Neck Diseases

edited by

Eliano Cascardi

submission deadline 31 Dec 2026 | 7 articles | Viewed by 14393 | Submission Open

Keywords: head and neck disease; histopathology; oral tumors; cancer; biomarkers; digital pathology; AI applications; personalized medicine

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Insights into Perinatal Medicine and Fetal Medicine—2nd Edition

edited by Paola Quaresima and Ilaria Fantasia

submission deadline 31 Dec 2026 | 6 articles | Viewed by 13128 | Submission Open

Keywords: fetal malformations; hypertensive disorders of pregnancy; gestational diabetes; fetal growth; in utero surgery; first-trimester screening; fetal aneuploidies

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Recent Advances in Pathology 2026

edited by

Francesca Sanguedolce

and

Roberta Mazzucchelli

submission deadline 31 Dec 2026 | 4 articles | Viewed by 11058 | Submission Open

Keywords: pathology innovations; molecular diagnostics; biomarkers and precision medicine; digital pathology; artificial intelligence in pathology; translational pathology

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Progress in Chronic Pain: Bridging Basic and Clinical Research

edited by

Helder Cardoso-Cruz

and

Clara Monteiro

submission deadline 31 Dec 2026 | 3 articles | Viewed by 9850 | Submission Open

Keywords: chronic pain; pain prevention; new biomarkers in chronic pain; personalized treatment approaches; sensory and cognitive dimensions; neuropathic pain; inflammatory pain

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Clinical Diagnosis and Management in Pediatric Surgery

edited by Ioannis A. Valioulis

submission deadline 31 Dec 2026 | 5 articles | Viewed by 9165 | Submission Open

Keywords: pediatric surgery; neonatal surgery; pediatric urology; pediatric oncology; laparoscopy in children; robotic surgery for children; organ transplantation; diagnostic biomarkers

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Molecular Techniques in Infectious Disease Diagnosis: Advances and Applications

edited by

Peisong Chen

submission deadline 31 Dec 2026 | 7 articles | Viewed by 8801 | Submission Open

Keywords: molecular diagnostics; PCR; NGS; CRISPR; antimicrobial resistance; point-of-care testing; metagenomics; pathogen detection

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Cardiovascular Diseases: Advances in Diagnosis and Management

edited by

Thien Tan Tri Tai Truyen

submission deadline 31 Dec 2026 | 5 articles | Viewed by 7967 | Submission Open

Keywords: cardiovascular diseases; predictive risk score; mortality; prognosis; artificial intelligence; machine learning; large language models

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Artificial Intelligence for Health and Medicine—2nd Edition

edited by

Daniele Giansanti

submission deadline 31 Dec 2026 | 11 articles | Viewed by 7737 | Submission Open

Keywords: artificial intelligence; deep learning; healthcare; image segmentation; disease prediction; monitoring

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Recent Advances in the Diagnosis and Management of Respiratory Disease: From Biomarkers to Treatment Decisions

edited by

Konstantinos Kostikas

and

Athena Gogali

submission deadline 31 Dec 2026 | 3 articles | Viewed by 7464 | Submission Open

Keywords: respiratory biologics; bronchoscopy; airways disease; exhaled biomarkers; artificial intelligence

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Artificial Intelligence in Cardiovascular and Stroke Imaging

edited by

Jasjit S. Suri

submission deadline 31 Dec 2026 | 5 articles | Viewed by 7058 | Submission Open

Keywords: artificial intelligence; cardiovascular; stroke imaging; diagnosis; prognosis

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in Non-Invasive Diagnostic Technologies for Heart Diseases

edited by Dentamaro Ilaria

submission deadline 31 Dec 2026 | 5 articles | Viewed by 6496 | Submission Open

Keywords: transthoracic echocardiography; cardiac magnetic resonance; multimodality cardiovascular imaging; cardiac CT; transesophageal echocardiography; cardiovascular disease

(This special issue belongs to the Section Medical Imaging and Theranostics)

Recent Advances in AI and Hyperspectral Techniques for Medical Imaging

edited by

Hsianmin Chen

submission deadline 31 Dec 2026 | 2 articles | Viewed by 6204 | Submission Open

Keywords: AI in medical imaging; hyperspectral medical imaging; biomedical image processing; deep learning; image segmentation and classification; multimodal imaging; intelligent diagnostic systems; tissue characterization; spectral imaging in medicine; clinical applications of AI and HSI

(This special issue belongs to the Section Medical Imaging and Theranostics)

Advances in Diagnosis and Management of Skin Diseases

edited by

Montserrat Fernández-Guarino

submission deadline 31 Dec 2026 | 6 articles | Viewed by 6048 | Submission Open

Keywords: dermatology; skin disease; molecular diagnostics; laboratory test; assessment of therapies

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Innovative Approaches to Tuberculosis Screening and Diagnosis

edited by

Nguyen Nhat Linh

, Dennis Falzon and

Alexei Korobitsyn

submission deadline 31 Dec 2026 | 4 articles | Viewed by 5556 | Submission Open

Keywords: tuberculosis; diagnosis; screening; genomics; biomarkers; artificial intelligence; linkage to care

(This special issue belongs to the Section Diagnostic Microbiology and Infectious Disease)

Multimodal Cardiac Imaging: Diagnostic and Prognostic Advances

edited by

Lucia La Mura

and Ciro Santoro

submission deadline 31 Dec 2026 | 4 articles | Viewed by 4778 | Submission Open

Keywords: cardiovascular imaging; cardiac CT; cardiac magnetic resonance; cardiac MRI; echocardiography; multimodality cardiovascular imaging; advanced echocardiography

(This special issue belongs to the Section Medical Imaging and Theranostics)

Current Diagnosis and Management of Metabolic Bone Diseases

edited by Liming Xiong

submission deadline 31 Dec 2026 | 3 articles | Viewed by 4740 | Submission Open

Keywords: metabolic bone disease; bone turnover markers; maintenance of bone homeostasis; multiorgan–bone axis; fracture risk assessment; diabetic osteopathy; precision management

(This special issue belongs to the Section Pathology and Molecular Diagnostics)

Biochemical Testing Applications in Clinical Diagnosis—2nd Edition

edited by

Donatella Coradduzza

submission deadline 31 Dec 2026 | 5 articles | Viewed by 4607 | Submission Open

Keywords: biochemical testing; clinical diagnosis; biomarkers; point-of-care tests; innovative analytical techniques

(This special issue belongs to the Section Clinical Laboratory Medicine)

Ultrasound Imaging in Medicine in 2026

edited by

Michael Bachmann Nielsen

submission deadline 31 Dec 2026 | 3 articles | Viewed by 4525 | Submission Open

Keywords: 3D ultrasound; blood flow velocity; ultrasonography; contrast-enhanced ultrasound; elasticity imaging; endoscopic ultrasound; intervention

(This special issue belongs to the Section Medical Imaging and Theranostics)

Pathological Speech Classification and Processing for Advanced Medical Diagnosis

edited by

Juan Rafael Orozco-Arroyave

submission deadline 31 Dec 2026 | 2 articles | Viewed by 4499 | Submission Open

Keywords: pathological speech; medical diagnosis; classification and processing; Parkinson's disease; hypokinetic dysarthria; dysarthria; aphasia; voice disorders; dysphonia; AI

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Diagnostics in Maxillofacial Oncology and Trauma

edited by

Ioanna Kalaitsidou

and

Benoît Schaller

submission deadline 31 Dec 2026 | 2 articles | Viewed by 4396 | Submission Open

Keywords: maxillofacial diagnostics; craniofacial trauma; oral and maxillofacial oncology; artificial intelligence in imaging; photon-counting CT (PCCT); molecular biomarkers; histopathology; radiomics; multimodal imaging; preoperative planning

(This special issue belongs to the Section Medical Imaging and Theranostics)

Artificial Intelligence in Medical Image Analysis and Clinical Decision Support

edited by Zahid Ullah and Tahir Mahmood

submission deadline 31 Dec 2026 | 7 articles | Viewed by 4208 | Submission Open

Keywords: medical image analysis; deep learning; vision transformers; medical image segmentation; clinical decision support; multimodal learning; explainable AI; continual learning; federated learning; healthcare AI

(This special issue belongs to the Section Machine Learning and Artificial Intelligence in Diagnostics)

Advances in Diagnostic Imaging and Interpretation in Pediatric Radiology

edited by

André Lollert

submission deadline 31 Dec 2026 | 6 articles | Viewed by 4176 | Submission Open

Keywords: pediatric radiology; pediatric MRI; pediatric CT; photon-counting CT; pediatric ultrasound; clinico-radiologic diagnostics; rare diseases; quantitative imaging; artificial intelligence; nuclear medicine

(This special issue belongs to the Section Medical Imaging and Theranostics)

Clinical and Laboratory Diagnosis of Inherited Metabolic Diseases in Children

edited by

Patryk Lipiński

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3943 | Submission Open

Keywords: newborn screening; selective screening; inherited metabolic disease; biochemical diagnostics; biomarkers; molecular analysis; next-generation sequencing

(This special issue belongs to the Section Clinical Laboratory Medicine)

Artificial Intelligence in Diagnostic Imaging

edited by Arthur Rodriguez Gonzalez Cortes

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3673 | Submission Open

Keywords: artificial intelligence; deep learning; large language models; convolutional neural networks; radiology

(This special issue belongs to the Section Medical Imaging and Theranostics)

Diagnosis and Prognosis of Pulmonary Diseases

edited by

Fabio Perrotta

and

Filippo Scialò

submission deadline 31 Dec 2026 | 2 articles | Viewed by 3672 | Submission Open

Keywords: interstitial lung disease; pulmonology; airway obstruction; pulmonary medicine; respiration disorders

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

Interdisciplinary Approaches to Improve Cardiovascular Outcomes

edited by

Mihaela Hostiuc

submission deadline 31 Dec 2026 | 4 articles | Viewed by 3573 | Submission Open

Keywords: cardiovascular disease; prevention; risk factors; cardiovascular outcomes; interdisciplinarity; burden of disease

(This special issue belongs to the Section Clinical Diagnosis and Prognosis)

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