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Diagnostics
Special Issues
Current Diagnosis and Management of Metabolic Bone Disease
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Current Diagnosis and Management of Metabolic Bone Disease

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 651

Special Issue Editor

Prof. Dr. Liming Xiong

E-Mail Website
Guest Editor
Department of Orthopaedics, Huazhong University of Science and Technology Tongji Medical College Union Hospital, Wuhan 430022, China
Interests: fractures; osteoporosis; bone infection and defects; diabetic foot; bone regeneration

Special Issue Information

Dear Colleagues,

Metabolic bone diseases (MBDs), including osteoporosis, diabetic osteopathy, and hepatic osteodystrophy, pose a mounting global burden exacerbated by aging and metabolic disorders. This Special Issue addresses critical gaps in the early detection and personalized management of MBDs, frequently undiagnosed until fracture. We invite cutting-edge research on the following areas:

  • How novel biomarkers (bone turnover markers, metabolites, and endocrine/immune factors) enhance diagnostic precision and fracture risk prediction;
  • Imaging innovations, including photon-counting DXA and AI-enhanced bone microarchitecture analysis, which surpass BMD limitations for fracture risk stratification;
  • Pharmacotherapy innovations, including GLP-1 receptor agonists, improving BMD/fracture risk in diabetes and the skeletal safety of anti-diabetic drugs;
  • Multiorgan–bone axis mechanisms wherein bone acts as an endocrine/metabolic hub, dynamically interacting with the liver, brain, kidneys, and so on via osteokines to fine-tune systemic homeostasis.

This Special Issue bridges translational research and clinical practice to advance risk stratification, treatment monitoring, and precision interventions. Submissions on genomic/proteomic studies, AI-driven diagnostics, and multidisciplinary approaches are encouraged.

Prof. Dr. Liming Xiong
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolic bone disease
  • bone turnover markers
  • maintenance of bone homeostasis
  • multiorgan–bone axis
  • fracture risk assessment
  • diabetic osteopathy
  • precision management

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Published Papers (1 paper)

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Research

14 pages, 1488 KB  
Article
Association of Hemoglobin to Red Blood Cell Distribution Width Ratio and Total Bone Mineral Density in U.S. Adolescents: The NHANES 2011–2018
by Tianhao Guo, Jiheng Xiao, Xinjun Yao, Jiangbo Bai and Yadong Yu
Diagnostics 2025, 15(20), 2567; https://doi.org/10.3390/diagnostics15202567 - 12 Oct 2025
Viewed by 522
Abstract
Background: The hemoglobin-to-red-cell distribution width ratio has emerged as a novel prognostic marker in various clinical settings. However, its association with total bone mineral density in adolescents remains inadequately explored. Methods: This cross-sectional study was based on data from the 2011–2018 [...] Read more.
Background: The hemoglobin-to-red-cell distribution width ratio has emerged as a novel prognostic marker in various clinical settings. However, its association with total bone mineral density in adolescents remains inadequately explored. Methods: This cross-sectional study was based on data from the 2011–2018 National Health and Nutrition Examination Survey, including adolescents aged 12–19 years with complete data on hemoglobin, red cell distribution width, and total bone mineral density. Weighted multivariable linear regression models and generalized additive models were used to evaluate the association between hemoglobin-to-red-cell distribution width and total bone mineral density. A two-piecewise linear regression model was applied to assess potential threshold effects, with log-likelihood ratio tests used to determine the significance of inflection points. Subgroup and interaction analyses were further conducted to examine whether age, sex, race, and milk product consumption modified this association. Results: A total of 3789 adolescents were included. Participants in the highest hemoglobin-to-red-blood-cell distribution width ratio quartile had significantly higher hemoglobin levels, lower red blood cell distribution width, greater total bone mineral density, higher total calcium and blood urea nitrogen levels, and lower body mass index, high-density lipoprotein cholesterol, and serum 25OHD levels compared to lower quartiles. The hemoglobin-to-red-blood-cell distribution width ratio was positively associated with total bone mineral density (fully adjusted β = 0.078, 95% CI: 0.053, 0.104, p < 0.0001). A two-piecewise linear regression model identified an inflection point at the hemoglobin-to-red-cell distribution width ratio = 1.055; the positive association became stronger above this threshold (β = 0.143 vs. β = 0.039 below the threshold, p = 0.003 for nonlinearity). Subgroup analysis revealed significant gender interactions (p < 0.0001). A higher HRR was significantly associated with greater total BMD in males (β = 0.130, 95% CI: 0.089–0.171, p < 0.0001), whereas no significant association was observed in females (β = −0.009, 95% CI: −0.043–0.025, p = 0.604). Positive associations were also observed among participants aged 12–15 years, non-Hispanic Whites, non-Hispanic Blacks, other Hispanics, Mexican Americans, and frequent milk consumers. Conclusions: Our results indicate that the hemoglobin-to-red-cell distribution width ratio shows a potential association with bone mineral density in male adolescents, which may offer supportive value for bone health assessment but requires further validation. Full article
(This article belongs to the Special Issue Current Diagnosis and Management of Metabolic Bone Disease)
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