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Diagnostics
Special Issues
Advances in Diagnosis and Management of Skin Diseases
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Advances in Diagnosis and Management of Skin Diseases

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Clinical Diagnosis and Prognosis".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 313

Special Issue Editor

Dr. Montserrat Fernández-Guarino

E-Mail Website
Guest Editor
Dermatology Department, Hospital Universitario Ramony Cajal, 28034 Madrid, Spain
Interests: dermatology; skin cancer; phototherapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of dermatology has experienced remarkable development in recent years, with advances in diagnostic techniques and therapeutic approaches that improve patient outcomes. Accurate diagnosis is necessary for an effective treatment, particularly as the spectrum of skin diseases continues to be described. 

Today, the integration of diagnostic tools—ranging from molecular techniques to imaging innovations—enables earlier and more precise detection of dermatologic conditions. Simultaneously, the development of novel therapies, including targeted and personalized treatments, is changing the management of chronic and complex skin diseases.

In this Special Issue, entitled “Advances in Diagnosis and Management of Skin Diseases”, we aim to explore the current scenario and future directions in dermatologic care. Through a series of expert contributions and comprehensive reviews, we will highlight key innovations and clinical experiences that reflect the dynamic of modern dermatology.

I warmly invite researchers and clinicians from diverse backgrounds to share their knowledge and findings. By fostering collaboration and disseminating insights, this issue intends to serve as a valuable reference for advancing clinical practice and improving patient care in dermatology.

Dr. Montserrat Fernández-Guarino
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dermatology
  • skin disease
  • molecular diagnostics
  • laboratory test
  • assessment of therapies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

24 pages, 1355 KiB  
Article
A Novel Radiology-Adapted Logistic Model for Non-Invasive Risk Stratification of Pigmented Superficial Skin Lesions: A Methodological Pilot Study
by Betül Tiryaki Baştuğ, Hatice Gencer Başol, Buket Dursun Çoban, Sinan Topuz and Özlem Türelik
Diagnostics 2025, 15(15), 1921; https://doi.org/10.3390/diagnostics15151921 - 30 Jul 2025
Viewed by 239
Abstract
Background: Pigmented superficial skin lesions pose a persistent diagnostic challenge due to overlapping clinical and dermoscopic appearances between benign and malignant entities. While histopathology remains the gold standard, there is growing interest in non-invasive imaging models that can preoperatively stratify malignancy risk. This [...] Read more.
Background: Pigmented superficial skin lesions pose a persistent diagnostic challenge due to overlapping clinical and dermoscopic appearances between benign and malignant entities. While histopathology remains the gold standard, there is growing interest in non-invasive imaging models that can preoperatively stratify malignancy risk. This methodological pilot study was designed to explore the feasibility and initial diagnostic performance of a novel radiology-adapted logistic regression approach. To develop and preliminarily evaluate a new logistic model integrating both structural (lesion size, depth) and vascular (Doppler patterns) ultrasonographic features for non-invasive risk stratification of pigmented superficial skin lesions. Material and Methods: In this prospective single-center pilot investigation, 44 patients underwent standardized high-frequency grayscale and Doppler ultrasound prior to excisional biopsy. Lesion size, depth, and vascularity patterns were systematically recorded. Three logistic regression models were constructed: (1) based on lesion size and depth, (2) based on vascularity patterns alone, and (3) combining all parameters. Model performance was assessed via ROC curve analysis. Intra-observer reliability was determined by repeated measurements on a random subset. Results: The lesion size and depth model yielded an AUC of 0.79, underscoring the role of structural features. The vascularity-only model showed an AUC of 0.76. The combined model demonstrated superior discriminative ability, with an AUC of approximately 0.85. Intra-observer analysis confirmed excellent repeatability (κ > 0.80; ICC > 0.85). Conclusions: This pilot study introduces a novel logistic framework that combines grayscale and Doppler ultrasound parameters to enhance non-invasive malignancy risk assessment in pigmented superficial skin lesions. These encouraging initial results warrant larger multicenter studies to validate and refine this promising approach. Full article
(This article belongs to the Special Issue Advances in Diagnosis and Management of Skin Diseases)
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