New Challenges and Advances in the Treatment of Lung Cancer: From Predictive Biomarkers to Minimally Invasive Techniques

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Thoracic Oncology".

Deadline for manuscript submissions: closed (15 January 2025) | Viewed by 1204

Special Issue Editors


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Guest Editor
Department of Cardiothoracic Surgery, General University Hospital of Patras, 16673 Athens, Greece
Interests: thoracic surgery

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Guest Editor
Laboratory of Experimental Surgery & Surgical Research, Democritus University of Thrace Medical School, Dragana, 68100 Alexandroupolis, Greece
Interests: experimental surgery; gastrointestinal cancer; breast cancer; lung cancer; transplantation; gastrointestinal surgery; general surgery

Special Issue Information

Dear Colleagues,

Lung cancer is the leading cause of cancer-related death, with non-small-cell (NSCLC) coming out on top according to the 2020 global cancer statistics; this type represents 80–85% of all lung cancers globally. Despite advances in treatment, the five-year survival rate for NSCLC patients is below 18%, primarily because about 70% of patients present with advanced disease at diagnosis. The treatment of patients with lung cancer includes multidisciplinary approaches that are based on surgical practice, such as chemotherapy, radiotherapy, targeted therapies, and immunotherapy, which largely improve quality of life and survival rates.

We invite potential contributors to submit their work on the current challenges in lung cancer and the newest advances in, as well as updated role of, minimally invasive techniques. In particular, are interested in survival predictors, including the newest neoadjuvant chemoradiation regimens. Original articles, narrative reviews, and systematic reviews will be considered for publication.

We look forward to receiving your contributions.

Dr. Efstratios Koletsis
Prof. Dr. Alexandra Tsaroucha
Guest Editors

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Keywords

  • lung cancer
  • immunotherapy
  • lung disease
  • targeted therapy
  • video-assisted thoracoscopic surgery (VATS)

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Published Papers (1 paper)

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9 pages, 3967 KiB  
Case Report
Metabolic Complete Response of Metastatic Oncogene-Negative, PDL1-Negative Non-Small Cell Lung Cancer After Chemo-Immunotherapy and Radiotherapy: A Case Report
by Alessia Surgo, Valerio Davì, Maria Paola Ciliberti, Roberta Carbonara, Morena Caliandro, Fiorella Cristina Di Guglielmo, Nicola Sasso, Roberto Calbi, Maria Annunziata Gentile, Tiziana Talienti, Isabella Bruno, Michele Troia, Ilaria Bonaparte, Giuseppe Mario Ludovico, Giammarco Surico and Alba Fiorentino
Curr. Oncol. 2024, 31(12), 8118-8126; https://doi.org/10.3390/curroncol31120598 - 23 Dec 2024
Viewed by 781
Abstract
A 71-year-old male ex-smoker presented in October 2021 to our department with a brain and bone metastatic adenocarcinoma NSCLC. PDL1, ROS, EGFR, and ALK were negative. He underwent stereotactic radiotherapy for brain metastases. In November 2021, he started a chemotherapy (CHT) regimen with [...] Read more.
A 71-year-old male ex-smoker presented in October 2021 to our department with a brain and bone metastatic adenocarcinoma NSCLC. PDL1, ROS, EGFR, and ALK were negative. He underwent stereotactic radiotherapy for brain metastases. In November 2021, he started a chemotherapy (CHT) regimen with cisplatin (75 mg/m2 every 21 days) and pemetrexed (500 mg/m2 every 21 days), and ICI with Atezolizumab (1200 mg every 21 days). In July 2022, RT to the lung tumor and mediastinal nodal was performed with a total dose of 45 Gy in 15 fractions. He continued with immunotherapy until December 2022, when a grade 3–4 toxicity from immunotherapy was observed (hypothyroidism, psoriasis, and cystitis). He achieved a complete clinical response to the therapy. To date, the patient is alive, with a complete metabolic response, without treatment at 37 months from diagnosis. Full article
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