Treatment of Bone Tumors in Children

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Bone and Soft Tissue Oncology".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 1980

Special Issue Editor


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Guest Editor
Department of Orthopedic Oncology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
Interests: bone and soft tissue sarcomas; pediatric orthopedics; surgical treatment; limb reconstruction
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Special Issue Information

Dear Colleagues,

We cordially invite researchers, surgeons, and medical professionals worldwide to submit their papers on “Treatment of Bone Tumors in Children” for an upcoming Special Issue of Current Oncology. This Special Issue aims to bring together papers that explore groundbreaking advancements in sarcoma surgery and medical treatment.

Sarcoma, a highly aggressive form of cancer, poses significant challenges to patients and medical practitioners alike. We believe that the key to improving outcomes is continually exploring and implementing innovative surgical approaches. By fostering collaboration and knowledge sharing, we aim to accelerate progress in this field and to offer renewed hope to those affected by this devastating disease, often at a very young age.

We encourage researchers and practitioners to submit papers that cover a wide range of topics relating to surgical innovations for sarcoma surgery in children and adolescents. Potential areas of interest include but are not limited to the following:

  • Limb-salvage surgery techniques: novel approaches and advancements in pre-serving limb functionality while effectively removing the tumor, e.g., use of growing prostheses, biological reconstructions, and 3D printing;
  • Customized implant solutions: the application of 3D printing and advanced imaging technologies to create personalized implants for improved surgical outcomes;
  • Integrating navigation and fluorescence-guided surgery systems: utilizing (computer-assisted) navigation systems to enhance precision, to optimize surgical planning, and to minimize complications;
  • Adjuvant therapies: investigations into the role of adjuvant therapies, such as radiotherapy and targeted therapies or immunotherapies, in conjunction with surgical interventions to enhance treatment efficacy;
  • Rehabilitation and functional outcomes: evaluation of rehabilitation strategies and long-term functional outcomes following surgical interventions for sarcoma surgery.

Prof. Dr. Michiel A. J. Van de Sande
Guest Editor

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Keywords

  • pediatric cancer
  • sarcoma
  • adolecents and young adults (AYA)
  • limb salvage
  • biological reconstruction
  • prothesis
  • non-invasive growing prosthesis
  • amputation
  • shared decision-making
  • quality of life
  • PROM
  • complications
  • lung metastasis
  • fluorescence/navigation-guided surgery
  • 3D printing
  • saw guides
  • medical treatment

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Published Papers (1 paper)

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13 pages, 382 KiB  
Article
Dynamic Prediction of Overall Survival for Patients with Osteosarcoma: A Retrospective Analysis of the EURAMOS-1 Clinical Trial Data
by Marta Spreafico, Audinga-Dea Hazewinkel, Hans Gelderblom and Marta Fiocco
Curr. Oncol. 2024, 31(7), 3630-3642; https://doi.org/10.3390/curroncol31070267 - 22 Jun 2024
Cited by 2 | Viewed by 1542
Abstract
Current prediction models for patients with ostosarcoma are restricted to predictions from a single, static point in time, such as diagnosis or surgery. These approaches discard information which becomes available during follow-up and may have an impact on patient’s prognosis. This study aims [...] Read more.
Current prediction models for patients with ostosarcoma are restricted to predictions from a single, static point in time, such as diagnosis or surgery. These approaches discard information which becomes available during follow-up and may have an impact on patient’s prognosis. This study aims at developing a dynamic prediction model providing 5-year overall survival (OS) predictions from different time points during follow-up. The developed model considers relevant baseline prognostic factors, accounting for where appropriate time-varying effects and time-varying intermediate events such as local recurrence (LR) and new metastatic disease (NM). A landmarking approach is applied to 1965 patients with high-grade resectable osteosarcoma from the EURAMOS-1 trial (NCT00143030). Results show that LR and NM negatively affected 5-year OS (HRs: 2.634, 95% CI 1.845–3.761; 8.558, 95% CI 7.367–9.942, respectively). Baseline factors with strong prognostic value (HRs > 2) included poor histological response (≥10% viable tumor), axial tumor location, and the presence of lung metastases. The effect of poor versus good histological response changed over time, becoming non-significant from 3.25 years post-surgery onwards. This time-varying effect, as well as the strong impact of disease-related time-varying variables, show the importance of including updated information collected during follow-up in the model to provide more accurate survival predictions. Full article
(This article belongs to the Special Issue Treatment of Bone Tumors in Children)
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