Recent Trend in Chromatography for Pharmaceutical Analysis

Dear colleagues,

Pharmaceuticals are synthetic or natural chemicals that can be found in prescription medicines, over-the-counter therapeutic drugs, and veterinary drugs. Nevertheless, due to their biological properties, use of off-label pharmaceuticals and their misuse is widespread (e.g., in aquaculture, agriculture, doping in sport). Therefore, the separation, detection, and quantification of pharmaceuticals is required in different areas. Further, many pharmaceuticals are chiral and, thus, enantiomeric analysis is required in many fields and for different purposes.

Chromatography is the elected methodology for routine and research laboratories for the analysis of pharmaceuticals and their metabolites using both non-enantioselective and enantioselective methods. It is among the most advanced and versatile methodology concerning equipment, stationary phases, and chromatographic elution modes allowing good selectivity/specificity, short analysis time, and beyond accurate and precise data.

A variety of chromatographic techniques coupled with different detectors have been developed for both preparation and analysis of pharmaceuticals. For example, in manufacturing processes to assess the stability of drugs and test for impurities and degradation products as well as in clinical analysis for pharmacokinetic studies or therapeutic monitoring. However, chromatographic methods for the analysis of pharmaceuticals have also been reported in other fields such as forensic toxicology and food and environmental analysis.

Therefore, this Topical Collection aims to focus on recent and innovative preparative and analytical chromatographic methods used for the analysis of pharmaceuticals in different areas covering industry, clinical and medical purposes, forensic toxicology, and food and environmental analysis.

Prof. Dr. Cláudia Maria Rosa Ribeiro
Prof. Dr. Maria Elizabeth Tiritan
Collection Editors

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