Advanced Enzyme-Based Sensors

Dear Colleagues,

The development of enzyme-based sensors has attracted much interest in the fields of biosensing, environmental monitoring, food analysis, disease diagnosis, and so on, showing great promise as important tools. These sensors are usually designed based on necessary principles for target recognition, signal amplification, signal transduction, and signal output.

In particular, enzyme-based reactions play a critical part in signal procurement, catalyzing a chemical reaction that produces a measurable change, such as a colorimetric, fluorescent, or electrochemical signal. They are widely used because many enzymes are well-characterized and readily available with good specificity, selectivity, and high efficiency. However, they always suffer from stability issues, as enzymes may denature over time or in certain conditions, requiring careful storage and handling. Thus, it is of great significance to optimize enzyme conformations and enhance enzyme activities, including promising enzyme hosts, interface or volume compartments, and so on. In addition, as an ideal alternative, nanozyme-based sensors also show great potential in analysis areas benefiting from the sufficient catalytic activity, stability, and high signal transduction capability of nanozymes.

In this Special Issue, we aim to attract outstanding researchers from diverse backgrounds focused on advanced enzyme-based sensors to share the latest research and insights. It also serves as a platform for discussing current challenges and advancements in the development of enzyme-based sensors as well as the characterization and application of traditional or emerging sensors. All kinds of research are welcomed in the Special Issue, including original articles, reviews, and perspectives that cover the following topics: enzyme-based sensor development, the integration of enzyme-based sensors with novel analytical technology, and the applications of enzyme-based sensors.

Dr. Nuanfei Zhu
Guest Editor

Dr. Jinyu Zhu
Dr. Dali Wei
Guest Editor Assistants

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