Special Issues

Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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From Fat to Flame: Targeting Adipose Tissue in Chronic Inflammation and Exploring the Therapeutic Strategies
edited by , Elena Dozio and Lucia la Sala
submission deadline 1 Feb 2027 | Viewed by 108 | Submission Open
Keywords: obesity; inflammasomes; immune system; microbiota
(This special issue belongs to the Section Tissues and Organs)
Stem Cells and Beyond: Innovations in Tissue Repair and Regeneration—Second Edition
edited by Aurora Almadori
submission deadline 1 Feb 2027 | Viewed by 93 | Submission Open
Keywords: adipose-derived stem cells; mesenchymal stem cells; induced pluripotent stem cells; stromal vascular fraction; platelet-rich plasma; exosomes; polynucleotides; cytokines; growth factors; extracellular matrix; cell signaling; wound healing; aging; immune response; inflammation; scarring
(This special issue belongs to the Section Stem Cells)
Pathogenesis and Novel Therapies for Epithelial Carcinoma
edited by Jung Wook Park
submission deadline 2 Feb 2027 | Viewed by 36 | Submission Open
Keywords: transformation; malignant; oncogene; tumor suppressor; molecular mechanisms; epigenetic; metabolic; immune; biomarkers; personalized medicine; primary cells; small-molecule inhibitor
(This special issue belongs to the Section Cellular Pathology)
NF-κB Signaling in Inflammation: Molecular Mechanisms and Therapeutic Targets
edited by Gaetano Spinelli and
submission deadline 3 Feb 2027 | Viewed by 442 | Submission Open
Keywords: NF-κB signaling; inflammation; canonical and non-canonical pathways; immune regulation; post-translational modifications; signal transduction; inflammatory diseases; autoimmune disorders; cancer; tumor microenvironment; oncogenesis; metabolic diseases; neuroinflammation; therapeutic targets; drug development
Emerging Mechanisms and Therapeutic Strategies in Head and Neck Cancer submission deadline 10 Feb 2027 | 6 articles | Viewed by 8402 | Submission Open
Keywords: tumor microenvironment; epithelial–mesenchymal transition (EMT); tumor–stroma interaction; treatment resistance; radiotherapy sensitization; targeted therapy; precision oncology
Immune Cell Signaling Networks in Tumor and Regenerative Stem Cell Niches
edited by
submission deadline 10 Feb 2027 | 1 articles | Viewed by 796 | Submission Open
Keywords: tumor microenvironment; stem cell niche; macrophage polarization; T-cell activation; immune checkpoints; targetable signaling pathways; engineered biomaterials; immune signaling in 3D culture; organ-on-chip models; single-cell omics
(This special issue belongs to the Section Stem Cells)
The Power of Small Molecules in Cancer
edited by
submission deadline 10 Feb 2027 | Viewed by 84 | Submission Open
Keywords: small molecule; cancer therapy; kinase inhibitors
(This special issue belongs to the Section Cell and Gene Therapy)
Ischemic Heart Disease: From Cellular Level to Clinical Approaches submission deadline 15 Feb 2027 | 2 articles | Viewed by 5024 | Submission Open
Keywords: ischemic heart disease; myocardial ischemia; reperfusion injury; oxidative stress; mitochondrial dysfunction; cardiomyocyte death; endothelial dysfunction; inflammation; fibrosis; epigenetics; non-coding RNAs; immunometabolism; single-cell transcriptomics; angiogenesis; ischemic preconditioning; nanomedicine; molecular cardiology; targeted therapy
Advances in Adipocyte Biology Research and Their Relevance to Metabolic Health
edited by
submission deadline 15 Feb 2027 | 2 articles | Viewed by 3276 | Submission Open
Keywords: adipose tissue; obesity; inflammation; thermogenesis; adipokines
The Role of Mitochondria in Health, Disease, and Ageing submission deadline 15 Feb 2027 | 2 articles | Viewed by 2158 | Submission Open
Keywords: mitochondrial dysfunction; metabolism; mitochondrial genetics; aging and senescence; bioenergetics; mitophagy; neurodegeneration; cardiomyopathy; metabolic syndrome; ocular diseases
(This special issue belongs to the Section Mitochondria)
NAMs (New Approach Methodologies) and Neural Stem Cells
edited by Tongguang Wang
submission deadline 15 Feb 2027 | 2 articles | Viewed by 1827 | Submission Open
Keywords: neural stem cells (NSCs); brain organoids; neurodevelopmental disorders; human pluripotent stem cells (hPSCs); translational neuroscience; new approach methodologies
(This special issue belongs to the Section Stem Cells)
Remyelination: From Molecular Mechanism to Therapy submission deadline 15 Feb 2027 | 1 articles | Viewed by 1567 | Submission Open
Keywords: demyelination; oligodendroglia differentiation; regenerative therapies; myelin disease; neurodegeneration
Role of Macrophages in Tissue Repair
edited by
submission deadline 15 Feb 2027 | 1 articles | Viewed by 903 | Submission Open
Keywords: macrophages; inflammation; tissue repair; phagocytosis
(This special issue belongs to the Section Tissues and Organs)
Organoids as Next-Generation Preclinical Models of Disease Progression
edited by Ralf Weiskirchen, Anjali A. J. Roeth and
submission deadline 15 Feb 2027 | 1 articles | Viewed by 637 | Submission Open
Keywords: patient-derived organoids; longitudinal disease modelling; neurodegeneration progression; drug resistance; precision medicine; chronic inflammation; tumor evaluation
Harnessing the Immune System: Emerging Therapeutic Strategies in Cancer
edited by Kishan Shamjibhai Italiya
submission deadline 15 Feb 2027 | Viewed by 266 | Submission Open
Keywords: cancer immunotherapy; tumor microenvironment; immune checkpoint inhibitors; adoptive cell therapy; cancer vaccines; T cell therapy; immuno-oncology; tumor immune evasion; immune modulation; antitumor immunity
(This special issue belongs to the Section Cellular Immunology)
Multi-Omics in the Cellular Microenvironment
edited by Emilio S. Rivera and Katerina Djambazova
submission deadline 15 Feb 2027 | Viewed by 258 | Submission Open
Keywords: cellular microenvironment; single-cell analysis; multi-omics; immunofluorescence microscopy; imaging mass spectrometry
(This special issue belongs to the Section Cell Methods)
Oxidative Stress in Disease and Health
edited by Tatsuya Mimura
submission deadline 17 Feb 2027 | Submission Open
Keywords: oxidative stress; reactive oxygen species; redox homeostasis; antioxidant defense; cellular signaling; mitochondrial dysfunction; cellular metabolism; apoptosis; ferroptosis; autophagy; inflammation; cellular senescence; aging; redox biology
(This special issue belongs to the Section Cellular Pathology)
Cellular Immunotherapies and Immune Modulation in Hematologic Cancers
edited by Erden Atilla and Ali Turan
submission deadline 18 Feb 2027 | 1 articles | Viewed by 1017 | Submission Open
Keywords: cellular immunotherapy; CAR T; CAR NK; immune modulation; hematologic malignancies; microenvironment; cytokine biology; immune escape
(This special issue belongs to the Section Cellular Immunology)
Innate-Like T Cells: The Variegated Roles of Semi-Invariant TCRs in Health and Disease
edited by and Akshat Sharma
submission deadline 19 Feb 2027 | 2 articles | Viewed by 6046 | Submission Open
Keywords: innate-like T cells; cancer; autoimmunity; cytokines; immune mechanisms
(This special issue belongs to the Section Cellular Pathology)
Cellular Signaling and Metabolic Adaptations in the Tumor Microenvironment
edited by Shashi Anand
submission deadline 19 Feb 2027 | 1 articles | Viewed by 946 | Submission Open
Keywords: cancer metabolic plasticity; tumor microenvironment; metabolic vulnerabilities; oncogenic signaling pathways; hypoxia and nutrient stress; therapeutic resistance
(This special issue belongs to the Section Cellular Metabolism)
Pathogenic Angiogenic Mechanisms in Alzheimer's Disease submission deadline 19 Feb 2027 | Viewed by 37 | Submission Open
Keywords: pathological angiogenesis; endothelial dysfunction; blood–brain barrier breakdown; cerebral hypoperfusion; Alzheimer’s disease pathogenesis
(This special issue belongs to the Section Cellular Pathology)
Cell and Molecular Mechanisms of Cytogenesis submission deadline 25 Feb 2027 | 1 articles | Viewed by 10138 | Submission Open
Keywords: cytogenesis; central nervous system; neurogenesis; gliogenesis; neuroplasticity; signaling pathways; cell proliferation; differentiation; CNS homeostasis; neuropsychiatric and neurodegenerative disorders
Recent Advances in Vitamin D and K in Cancer submission deadline 25 Feb 2027 | Viewed by 376 | Submission Open
Keywords: vitamin D; vitamin K; VDR signaling; tumor microenvironment; cancer prevention; molecular pathways; apoptosis and proliferation; oxidative stress; immunomodulation; therapeutic resistance
Ion Channels and Transporters—Structure and Function
edited by Tiziano Mazza, Jonathan Paul Lambert and
submission deadline 25 Feb 2027 | Viewed by 104 | Submission Open
Keywords: ion channels; membrane transporters; SLC; ABC; structure-function relationship; Cryo-EM; X-ray crystallography; molecular mechanism; computational biology
Cancer and Immune System Interactions submission deadline 26 Feb 2027 | 4 articles | Viewed by 4173 | Submission Open
Keywords: cancer immunology; tumor microenvironment; immune evasion; immunotherapy; tumor–immune interactions; immune checkpoint regulation; translational oncology
(This special issue belongs to the Section Cell Microenvironment)
Understanding Nasal Inflammation: The Interplay of Diagnosis, Endotypes, and Environmental Shifts
edited by Simonetta Masieri and
submission deadline 26 Feb 2027 | 1 articles | Viewed by 3366 | Submission Open
Keywords: rhinology; allergy; immunology; environment; pollution; microbiome; inflammation; united airway disease; lymphocyte cells; interleukins
(This special issue belongs to the Section Tissues and Organs)
A New Frontier for Cancer Diagnosis and Therapy submission deadline 26 Feb 2027 | 2 articles | Viewed by 3099 | Submission Open
Keywords: cancer diagnosis; precision oncology; liquid biopsy; molecular biomarkers; immunotherapy; targeted therapy; nanomedicine; multi-omics; artificial intelligence; tumor heterogeneity
(This special issue belongs to the Section Cellular Immunology)
Mitochondrial Dynamics in Health and Disease Metabolism: Mechanisms and Functional Consequences
edited by
submission deadline 26 Feb 2027 | 3 articles | Viewed by 2746 | Submission Open
Keywords: mitochondrial fission; mitochondrial fusion; mitophagy; mitochondrial transport; mitochondrial transfer; mitochondrial diseases
(This special issue belongs to the Section Mitochondria)
Kidney and Lung Disorders: The Role of Tubular and Alveolar Epithelia in Health, Disease, Infection, and Organ Crosstalk
edited by Aparna Renigunta and
submission deadline 26 Feb 2027 | 2 articles | Viewed by 2418 | Submission Open
Keywords: renal tubular disorders; alveolar lung diseases; transport mechanism; intracellular signaling; viral infection; crosstalk; dialysis; ventilation
Application of Stem Cells and Cellular Engineering in Musculoskeletal Tissue Regeneration submission deadline 26 Feb 2027 | 2 articles | Viewed by 1950 | Submission Open
Keywords: mesenchymal stem cells (MSCs); tissue specific progenitors; cellular engineering; musculoskeletal tissue regeneration; tissue engineering; biomaterials; 3D culture systems; mechanobiology; extracellular vesicles; translational regenerative medicine
(This special issue belongs to the Section Stem Cells)
Cellular and Molecular Mechanisms in Reproductive Biology and Fertility
edited by and Antonio Malvasi
submission deadline 26 Feb 2027 | 1 articles | Viewed by 1337 | Submission Open
Keywords: gametogenesis; fertilization; fertility; endocrinology; implantation; gametogenesis regulation; embryo–maternal interaction; reproductive signaling; IVF; in vitro fertilization; ovarian stimulation
(This special issue belongs to the Section Reproductive Cells and Development)
Molecular and Cellular Mechanisms of Pheochromocytoma and Paraganglioma
edited by and
submission deadline 26 Feb 2027 | Viewed by 281 | Submission Open
Keywords: pheochromocytoma; paraganglioma; tumor biology; molecular mechanisms; precision medicine
(This special issue belongs to the Section Cellular Pathology)
Genomics and Cellular Mechanisms in Ovarian Cancer
edited by Hao Huang
submission deadline 28 Feb 2027 | 3 articles | Viewed by 5165 | Submission Open
Keywords: ovarian cancer; tumor heterogeneity; genomics and epigenomics; therapy resistance; tumor microenvironment
(This special issue belongs to the Section Tissues and Organs)
Molecular Signatures and Cellular Pathways of Immune Dysfunction in HIV and Tuberculosis
edited by , Pradeep Kumar Sheokand, , Ekta Saini and Prashant Bajpai
submission deadline 28 Feb 2027 | Viewed by 372 | Submission Open
Keywords: immune cell dysfunction; immune persistence; T cell exhaustion; chronic infection; host–pathogen interactions; cellular immunity; molecular immune signaling; single-cell immunology; immune cell plasticity; infection-induced immune remodeling
(This special issue belongs to the Section Cellular Immunology)
Molecular Signal Transduction in Cancer submission deadline 28 Feb 2027 | Viewed by 203 | Submission Open
Keywords: molecular signal transduction; tumor microenvironment; tumor suppressor; kinase signaling; transcriptional and epigenetic regulation; immune signaling; cancer cell communication
(This special issue belongs to the Section Cell Signaling)
Molecular Biomarkers in Tumors: Prognosis and Mechanisms
edited by
submission deadline 28 Feb 2027 | Viewed by 98 | Submission Open
Keywords: molecular biomarkers; tumor prognosis; tumor microenvironment; genomic alterations; therapeutic resistance; liquid biopsy; extracellular vesicles; multi-omics
(This special issue belongs to the Section Cellular Pathology)
Corneal Biology and Pathophysiology: From Homeostasis to Disease
edited by , Anil Tiwari and Gary (Hin-Fai) Yam
submission deadline 28 Feb 2027 | Viewed by 67 | Submission Open
Keywords: corneal regeneration; corneal tissue homeostasis; corneal pathophysiology; corneal therapeutics
(This special issue belongs to the Section Cellular Pathology)
The Role of Oxidative Stress in Cardiovascular Diseases—3rd Edition
edited by and
submission deadline 28 Feb 2027 | Viewed by 61 | Submission Open
Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species
(This special issue belongs to the Section Cells of the Cardiovascular System)
Cellular and Molecular Mechanisms of Vascular-Related Diseases—Second Edition
edited by and
submission deadline 28 Feb 2027 | Viewed by 38 | Submission Open
Keywords: cellular and molecular mechanisms; cardiovascular disease; cerebrovascular disease; vascular signaling; vascular dysfunctions in cns disorders; vascular dysfunctions in diabetes; vascular dysfunction in chronic kidney disease; tumor metastasis via vascular system; drug delivery via vascular system
(This special issue belongs to the Section Cellular Pathology)
Adipose Tissue Functioning in Health and Diseases—Second Edition
edited by
submission deadline 28 Feb 2027 | Viewed by 30 | Submission Open
Keywords: adipose tissue biology; adipogenesis; lipolysis; adipose tissue inflammation; diet-induced obesity; non-coding RNA in metabolism; PPARγ signaling; metabolic health and disease; obesogens; epigenetics and chromatin regulation; transgenerational inheritance
(This special issue belongs to the Section Tissues and Organs)
Recent Advances in Immunology of Asthma submission deadline 28 Feb 2027 | Viewed by 14 | Submission Open
Keywords: asthma; airway inflammation; immunology; cytokines; airway remodeling; biomarkers; type 2 inflammation; eosinophils
(This special issue belongs to the Section Cellular Immunology)
Novel Insights into Amyotrophic Lateral Sclerosis (ALS)
edited by Zane Zeier
submission deadline 1 Mar 2027 | Viewed by 265 | Submission Open
Keywords: TDP-43 proteinopathy; protein aggregation; RNA metabolism; DNA damage; cryptic splicing; nucleocytoplasmic transport; liquid–liquid phase separation; mitochondrial dysfunction; mitophagy; neuroinflammation; microglial activation; astrogliosis; glutamate excitotoxicity; multi-omics; integrative omics
Cellular Stress Responses, Lysosomal Damage and Non-Canonical Autophagy
edited by and Alf Håkon Lystad
submission deadline 1 Mar 2027 | Viewed by 231 | Submission Open
Keywords: lysosomal damage; cellular stress responses; non-canonical autophagy; lysosomal homeostasis
(This special issue belongs to the Section Autophagy)
How Can We Optimise Cancer Therapy? Tumour Microenvironment and Immune Evasion Strategies submission deadline 10 Mar 2027 | 6 articles | Viewed by 19978 | Submission Open
Keywords: immunosurveillance; immune evasion in cancer; tumour microenvironment; immune suppression; immunotherapy; immune checkpoints; cancer immunity; drug intervention
(This special issue belongs to the Section Cell Microenvironment)
Biochemical Interaction and Supramolecular Complexes of Receptors in Cell Membranes submission deadline 15 Mar 2027 | 1 articles | Viewed by 3075 | Submission Open
Keywords: membrane receptors; molecular complex; membrane microdomains
Phytofactories: From Lab to Applications submission deadline 15 Mar 2027 | 2 articles | Viewed by 3024 | Submission Open
Keywords: plant cell suspension cultures; phytofactories; bioprocess; specialty molecules; metabolic engineering; germplasm preservation
(This special issue belongs to the Section Plant, Algae and Fungi Cell Biology)
Aquaporins at the Crossroads of Human Health and Disease
edited by
submission deadline 15 Mar 2027 | 2 articles | Viewed by 1908 | Submission Open
Keywords: aquaporins; membrane molecular transport; channels proteins in health and disease; novel drug targets; cellular biophysics
Uncovering Placental Inflammatory Pathways Affecting the Developing Brain submission deadline 26 Mar 2027 | Viewed by 257 | Submission Open
Keywords: neuroplacentology; neuroinflammation; hypoxia–ischemia; developing brain; ASD; CP; ADHD; learning disabilities; preclinical model; cell culture
(This special issue belongs to the Section Reproductive Cells and Development)
Cellular and Molecular Mechanisms in Gynecological Disorders—Second Edition
edited by
submission deadline 30 Mar 2027 | 3 articles | Viewed by 6541 | Submission Open
Keywords: uterus; ovary; fallopian tubes; cervix; vagina; endometriosis; polycystic ovary syndrome; primary ovarian insufficiency; ovarian cysts; adenomyosis; endometriosis; leiomyoma (uterine fibroids); endometrial cancer; leiomyosarcoma; female infertility; breast cancer; cell atlas; biomarkers; stem cells; pathways; transcriptome; proteomics; epigenome
(This special issue belongs to the Section Cellular Pathology)
Cancer Cytopathology: Structural Features and Intracellular Events in Malignancy submission deadline 30 Mar 2027 | Viewed by 375 | Submission Open
Keywords: cancer cells; cytopathology; tumor microenvironment; cell culture; biopsies
(This special issue belongs to the Section Cellular Pathology)
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