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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Unraveling Immune Dynamics and Novel Therapeutic Strategies in the Tumor Microenvironment
edited by Shahidul M. Islam
submission deadline 30 Oct 2026 | Viewed by 46 | Submission Open
Keywords: tumor microenvironment; immune dynamics; tumor heterogeneity; immune checkpoints; CAR T; cancer immunology; adoptive cell transfer; resistance; biomarkers; combination therapy; machine learning; molecular modeling
(This special issue belongs to the Section Tumor Microenvironment)
Gastrointestinal Tumors: Screening and Prevention
edited by
submission deadline 30 Oct 2026 | Viewed by 45 | Submission Open
Keywords: cancer; early detection; esophageal; gastric; pancreatic; hepatocellular; colorectal; risk stratification; endoscopy; liquid biopsy
Solid Tumors, with a Focus on Urological Cancers: From Molecular Mechanisms to Predictive Biomarkers
edited by and
submission deadline 30 Oct 2026 | Viewed by 39 | Submission Open
Keywords: solid tumors; urological cancers; tumor microenvironment; molecular mechanisms; predictive biomarkers
(This special issue belongs to the Section Cancer Biomarkers)
Epigenetic Modifiers in Cancer Treatment: Molecular Mechanisms and Clinical Applications
edited by and Umamaheswari Natarajan
submission deadline 30 Oct 2026 | Viewed by 37 | Submission Open
Keywords: epigenetics; histones; DNA methylation; histone acetylations; chromatin remodeling; DNMTs (DNMT1; DNMT3A; DNMT3B); PRMTs; HDACs; miRNA; ncRNAs; lncRNA
(This special issue belongs to the Section Molecular Cancer Biology)
Clinical Research of Brachytherapy in Cancer
edited by Ludmiła Grzybowska-Szatkowska, and Aleksandra Kozłowska
submission deadline 30 Oct 2026 | Viewed by 36 | Submission Open
Keywords: brachytherapy; LDR; HDR; genitourinary cancers; breast cancer; skin cancer; gastrointestinal cancers; oligometastatic disease; personalized treatment and neoplasm
(This special issue belongs to the Section Clinical Research of Cancer)
Pathological Diagnosis and Surgical Treatment of Cholangiocarcinoma: Current Status and Novel Perspectives
edited by
submission deadline 30 Oct 2026 | Viewed by 30 | Submission Open
Keywords: cholangiocarcinoma; intrahepatic cholangiocarcinoma; small-duct type; large-duct type; immune checkpoint inhibitor; conversion surgery
Combination Therapies for Brain Tumors
edited by Jason H. Huang and Ekokobe Fonkem
submission deadline 31 Oct 2026 | 6 articles | Viewed by 14064 | Submission Open
Keywords: novel diagnostics; therapies; glioblastoma; meningioma; astrocytoma
(This special issue belongs to the Section Cancer Therapy)
Oncologic Pathology: Diagnostic Challenges, Molecular Advances, and Clinical Correlations submission deadline 31 Oct 2026 | 1 articles | Viewed by 901 | Submission Open
Keywords: solid neoplasia; predictive and prognostic biomarkers; target therapy; tumor microenvironment; molecular biology
(This special issue belongs to the Section Cancer Pathophysiology)
The Role of Nutrients in Cancer Progression
edited by
submission deadline 31 Oct 2026 | Viewed by 318 | Submission Open
Keywords: vitamins; phytochemicals; trace minerals; ketogenic diet; cancer recurrence; cancer metastasis; treatment response; radiotherapy; chemotherapy; immunotherapy
(This special issue belongs to the Section Cancer Pathophysiology)
Overcoming Drug Resistance: Precision Medicine Drug Therapy
edited by , Yuting Huang and Raveena Manem
submission deadline 31 Oct 2026 | Viewed by 163 | Submission Open
Keywords: drug resistance; precision medicine; molecular and cellular mechanisms; biomarker-guided therapy; genomic profiling; combination treatment; novel drug delivery system
(This special issue belongs to the Section Cancer Drug Development)
Molecular Targets and Therapeutic Pathways in Cancer
edited by Ashish H. Shah and Deepa Seetharam
submission deadline 31 Oct 2026 | Viewed by 146 | Submission Open
Keywords: cancer therapeutics; molecular targets; signal transduction pathways; targeted therapy; drug resistance; precision oncology; tumor microenvironment; immunotherapy; kinase inhibitors; translational cancer research
(This special issue belongs to the Section Cancer Drug Development)
Omics Data for Cancer Therapies: From Molecular Profiling to Clinical Applications
edited by
submission deadline 31 Oct 2026 | Viewed by 144 | Submission Open
Keywords: multi-omics integration; precision oncology; biomarker discovery; computational oncology; translational cancer research
(This special issue belongs to the Section Cancer Informatics and Big Data)
Artificial Intelligence-Driven Multi-Omics Integration for Precision Oncology and Complex Disease Research
edited by and
submission deadline 31 Oct 2026 | Viewed by 127 | Submission Open
Keywords: artificial intelligence; multi-omics; precision medicine; biomarker; deep learning
(This special issue belongs to the Section Cancer Informatics and Big Data)
Role of Pathology in Detection, Prognosis and Treatment of Gastrointestinal Cancers
edited by and Luís Ortega-Medina
submission deadline 31 Oct 2026 | Viewed by 120 | Submission Open
Keywords: gastrointestinal cancer; pathology; histopathology; molecular pathology; biomarkers; prognosis; precision medicine; digital pathology; cancer detection; targeted therapy
(This special issue belongs to the Section Cancer Pathophysiology)
Current Research in Pediatric Hematological Oncology submission deadline 31 Oct 2026 | Viewed by 95 | Submission Open
Keywords: pediatric hematology; childhood leukemia; acute myeloid leukemia (AML); juvenile myelomonocytic leukemia (JMML); acute lymphoblastic leukemia (ALL); immunotherapy; CAR-T cell therapy; targeted therapies; translational research; survivorship; pediatric oncology models
(This special issue belongs to the Section Pediatric Oncology)
Artificial Intelligence in Urological Oncology: Applications in Imaging, Prognostics, and Precision Disease Management
edited by
submission deadline 31 Oct 2026 | Viewed by 89 | Submission Open
Keywords: artificial intelligence; machine learning; urological oncology; imaging; precision medicine; digital pathology; therapeutic decision-making
(This special issue belongs to the Section Cancer Therapy)
Oral Cancer and Precancerous Lesions: Advances in Diagnosis, Prognosis, and Therapy submission deadline 31 Oct 2026 | Viewed by 87 | Submission Open
Keywords: potentially malignant oral disorders (PMODs); malignant transformation; oral cancer and precancerous lesions
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Signaling Networks and Systems Biology in Cancer submission deadline 31 Oct 2026 | Viewed by 68 | Submission Open
Keywords: cancer signaling; immuno-oncology; cancer nanotechnology; AI/ML in cancer; systems oncology
(This special issue belongs to the Section Molecular Cancer Biology)
Radiotherapy and the Tumor Microenvironment: From Basic Mechanisms to Clinical Translation
edited by Eleanor J. Cheadle and
submission deadline 31 Oct 2026 | Viewed by 68 | Submission Open
Keywords: radiotherapy; tumor microenvironment; immune response; biomarkers; stroma; immunogenic cell death
The Tumor Microenvironment and Its Role in Tumor Growth and Angiogenesis—2nd Edition
edited by
submission deadline 31 Oct 2026 | Viewed by 65 | Submission Open
Keywords: tumor microenvironment; tumor angiogenesis; tumor targeted therapies; inflammation; immunotherapies
(This special issue belongs to the Section Tumor Microenvironment)
Molecular Imaging in Oncology: Recent Advances (2nd Edition) submission deadline 31 Oct 2026 | Viewed by 63 | Submission Open
Keywords: nuclear medicine; molecular imaging; PET; oncology; cancer; SPECT; precision medicine; personalized medicine; biomarker; targeted radionuclide therapies; personalized dosimetry
(This special issue belongs to the Section Cancer Therapy)
Synergistic Radiotherapy and Immunotherapy in Cancer Treatment
edited by
submission deadline 31 Oct 2026 | Viewed by 62 | Submission Open
Keywords: radiotherapy; immunotherapy; combination therapy; nanomedicine; immunogenic cell death; tumor microenvironment; immune checkpoint inhibitors; abscopal effect; systemic immunity; clinical trials
(This special issue belongs to the Section Cancer Therapy)
Circulating Tumor Cells (CTCs) for Cancer Diagnosis and Prognosis
edited by
submission deadline 31 Oct 2026 | Viewed by 56 | Submission Open
Keywords: CTCs; liquid biopsy; metastasis; biomarkers
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Exploring the Genetic and Epigenetic Factors in Leukemia and Lymphoma (2nd Edition) submission deadline 31 Oct 2026 | Viewed by 52 | Submission Open
Keywords: hematology; leukemia; lymphoma; epigenetics; bioinformatics; gene expression; chromatin conformation
(This special issue belongs to the Section Cancer Therapy)
The Role of Lifestyle Choices in Cancer Risk
edited by Itunu O. Sokale, Aaron P. Thrift and
submission deadline 31 Oct 2026 | Viewed by 52 | Submission Open
Keywords: cancer risk; lifestyle; behavioral factors; outcome; cancer prevention
Decoding the Tumor Microenvironment: From Mechanisms to Therapeutic Opportunities
edited by , Giacomo Miserocchi and
submission deadline 31 Oct 2026 | Viewed by 49 | Submission Open
Keywords: tumor microenvironment (TME); cancer immunology; tumor– stroma interactions Immune; evasion; therapy resistance; spatial and single-cell omics; biomarker discovery; translational oncology; 3D models
(This special issue belongs to the Section Tumor Microenvironment)
Oxidative Stress in Cancer: From Mechanisms to Therapeutic Strategies submission deadline 31 Oct 2026 | Viewed by 46 | Submission Open
Keywords: redox signaling; tumor microenvironment; senolytics; immunometabolism; gut microbiome; preventive oncology; drug delivery
(This special issue belongs to the Section Cancer Therapy)
Metabolism and Precision Oncology
edited by Rays H.Y. Jiang and Gloria C. Ferreira
submission deadline 31 Oct 2026 | Viewed by 46 | Submission Open
Keywords: cancer metabolism; precision oncology; tumor microenvironment; immunometabolism; metabolic reprogramming; redox biology; metabolomics; lipid metabolism; mitochondrial function; therapeutic targeting
(This special issue belongs to the Section Cancer Pathophysiology)
Opportunities and Challenges in Cancer Immunotherapies
edited by
submission deadline 31 Oct 2026 | Viewed by 38 | Submission Open
Keywords: cancer immunotherapy; immune checkpoint inhibitors; cellular therapy; tumor microenvironment; therapeutic resistance
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Innovations in Surgical and Management Strategies for Complex and Advanced Gastric Cancer submission deadline 31 Oct 2026 | Viewed by 38 | Submission Open
Keywords: advanced gastric cancer; surgical innovation; multimodal therapy; minimally invasive gastrectomy (robotic/laparoscopic); perioperative management; immunotherapy; precision medicine; peritoneal metastasis
(This special issue belongs to the Section Clinical Research of Cancer)
AI-Driven Advanced Radiotherapy: Towards Personalized, Predictive, and Adaptive Cancer Treatment
edited by Zhen Tian and Chaoqiong Ma
submission deadline 31 Oct 2026 | Viewed by 37 | Submission Open
Keywords: radiotherapy; artificial intelligence; machine learning; deep learning; outcome prediction; treatment planning; adaptive RT; personalized RT; radiomics
(This special issue belongs to the Section Methods and Technologies Development)
Pituitary Tumors: Molecular Insights, Diagnosis, and Targeted Therapy—Third Edition submission deadline 31 Oct 2026 | Viewed by 33 | Submission Open
Keywords: acromegaly; adrenocorticotropic hormone; Cushing’ s disease; diagnosis; growth hormone; pituitary tumor; proliferation; transcriptional factor; treatment
Advances in Imaging Techniques of Molecular Oncology (2nd Edition)
edited by
submission deadline 31 Oct 2026 | Viewed by 30 | Submission Open
Keywords: cancer; oncological imaging; molecular imaging; SPECT/TC; PET/CT; PET/MRI; DWI; DCE-MRI; nanotheranostics; artificial intelligence; radiomics; theranostics
(This special issue belongs to the Section Methods and Technologies Development)
Local, Systemic and Combined Therapy for Hepatocellular Carcinoma
edited by Xiaoqun Dong
submission deadline 31 Oct 2026 | Viewed by 26 | Submission Open
Keywords: hepatocellular carcinoma; immunotherapy; cell therapy; targeted therapy; local therapy; combination therapy; oncolytic virus; precision oncology; drug resistance; translational research
(This special issue belongs to the Section Cancer Therapy)
Skin and Hair Side Effects of Cancer Treatment
edited by Ian W. Tattersall
submission deadline 31 Oct 2026 | Viewed by 4 | Submission Open
Keywords: oncodermatology; toxicity management; supportive oncology
(This special issue belongs to the Section Cancer Therapy)
Evaluating the Clinical Impact of Robotic Surgery in the Management of Colorectal Cancer
edited by and Miguel Leon-Arellano
submission deadline 15 Nov 2026 | Viewed by 102 | Submission Open
Keywords: robotic surgery; colorectal cancer; oncological outcomes; surgical technique; laparoscopic comparison; margin status; postoperative recovery; quality of life; intraoperative imaging; surgical navigation; learning curve; complications; cost-effectiveness; surgical training; technological innovation
(This special issue belongs to the Section Clinical Research of Cancer)
Recent Advances in Endoscopic, Metabolomic, and Ultrasound Approaches to Gastrointestinal, Hepatic, and Pancreatic Tumors
edited by Ciprian Brisc and Nadim Al Hajjar
submission deadline 15 Nov 2026 | Viewed by 28 | Submission Open
Keywords: gastrointestinal; hepatic and pancreatic tumors; metabolomics; endoscopy; ultrasound; elastography; molecular investigations and treatment; robotic surgery; laparoscopic surgery; early lesions; radiofrequency and microwave ablation; irreversible electroporation; cryoablation; targeted chemo- or radio-embolization
(This special issue belongs to the Section Cancer Therapy)
The Pathologic Diagnosis and Clinical Therapy of Neuroendocrine Tumors: 2nd Edition submission deadline 20 Nov 2026 | Viewed by 39 | Submission Open
Keywords: neuroendocrine neoplasms; molecular mechanisms; cancer pathogenesis; tumorigenesis; diagnosis; molecular and cellular heterogeneity; predictive biomarkers; animal models and of neuroendocrine cancer; diagnostic clinical oncology; genomic characterization; clinical biomarkers; biomarkers of drug response; epigenetic biomarkers; targeted therapy; tumor immunity; molecular oncology; clinical therapy
Infectious Pathogens and Cancer
edited by
submission deadline 25 Nov 2026 | Viewed by 9 | Submission Open
Keywords: infectious cancer pathogens; related topics in immunology; virology; epidemiology; (therapeutic) vaccines; oncogenesis; screening; therapy
(This special issue belongs to the Section Infectious Agents and Cancer)
Treatment and Prognosis of Pediatric Medulloblastoma
edited by Marwa Ismail
submission deadline 25 Nov 2026 | Viewed by 3 | Submission Open
Keywords: pediatric medulloblastoma; proteomics; radiogenomics
(This special issue belongs to the Section Pediatric Oncology)
New Findings in Targeting Cancer Proteins (Second Edition) submission deadline 30 Nov 2026 | 1 articles | Viewed by 2081 | Submission Open
Keywords: monoclonal antibodies; protein target; immunotherapy; signaling blockade; targeted therapy
(This special issue belongs to the Section Cancer Therapy)
Artificial Intelligence and Machine Learning in Lung Cancer Screening: Current Applications and Future Directions submission deadline 30 Nov 2026 | 1 articles | Viewed by 937 | Submission Open
Keywords: artificial intelligence; machine learning; lung cancer screening; low-dose CT; early detection
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Advances in Nanoparticle and Exosome Technology for Delivery of Payloads in CNS Tumors
edited by
submission deadline 30 Nov 2026 | Viewed by 136 | Submission Open
Keywords: glioblastoma; brain metastasis; nanoparticles; exosomes; viral therapy; delivery of payload; imaging probes
(This special issue belongs to the Section Cancer Drug Development)
In Vitro and In Vivo Pharmacology for Glioma Drug Discovery submission deadline 30 Nov 2026 | Viewed by 134 | Submission Open
Keywords: pre-clinical modern in vitro /in vivo glioma models; complementary glioma therapy; immunotherapy in glioma; inhibition of glioma recurrence
(This special issue belongs to the Section Cancer Drug Development)
New Approaches to Surgical Treatment and Care for Urological Cancer
edited by and Bente Thoft Jensen
submission deadline 30 Nov 2026 | Viewed by 96 | Submission Open
Keywords: bladder cancer; prostate cancer; kidney cancer; penile cancer; patient perspective; patient education; enhanced recovery after surgery (ERAS) protocols; prehabilitation rehabilitation; sexual health
(This special issue belongs to the Section Clinical Research of Cancer)
New Clinical Insights into Gastrointestinal Cancers
edited by Dai Shida
submission deadline 30 Nov 2026 | Viewed by 53 | Submission Open
(This special issue belongs to the Section Clinical Research of Cancer)
Advances in the Management of Pelvic Tumors: 2nd Edition
edited by Giorgia Gaia and
submission deadline 30 Nov 2026 | Viewed by 52 | Submission Open
Keywords: pelvic cancer; prostate cancer; bladder cancer; uterine cancer; ovarian cancer; rectal cancer; anal cancer
(This special issue belongs to the Section Cancer Therapy)
Acute Myeloid Leukemia: Novel Therapeutic Agents and Clinical Trials
edited by Wieslaw W. Jedrzejczak
submission deadline 30 Nov 2026 | Viewed by 52 | Submission Open
Keywords: acute leukemia; targeted therapy; antibody– drug conjugates
(This special issue belongs to the Section Clinical Research of Cancer)
After Cancer Remission: Tracking Minimal Residual Disease and Relapse submission deadline 30 Nov 2026 | Viewed by 50 | Submission Open
Keywords: minimal residual disease (MRD); cancer relapse; liquid biopsy; circulating tumor DNA (ctDNA); biomarkers; molecular monitoring; post-remission surveillance; translational oncology; multi-omics; personalized cancer care; precision medicine
Intraoperative Radiotherapy in Cancer Treatment
edited by
submission deadline 30 Nov 2026 | Viewed by 30 | Submission Open
Keywords: intraoperative radiation therapy; image-guided IORT; IOERT; kV-IORT; HDR-IORT; FLASH
(This special issue belongs to the Section Cancer Therapy)
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