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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Cellular Senescence in Cancer: Therapeutic Induction, Microenvironmental Crosstalk and Clinical Implications

edited by

Aria Baniahmad

and

Carlo Gaetano

submission deadline 30 Nov 2026 | Viewed by 375 | Submission Open

Keywords: therapy-induced senescence (TIS); TIS resistance; senescence-associated secretory phenotype (SASP); senescence-associated heterochromatin foci (SAHF); immune escape; immune response; immune surveillance; cancer-associated fibroblasts; tumor microenvironment; senolytic therapy; senomorphics; senomodulation; extracellular vesicles; chromatin; imprinting and epigenetic reprogramming; biomarkers

(This special issue belongs to the Section Molecular Cancer Biology)

Acute Myeloid Leukemia: Novel Therapeutic Agents and Clinical Trials

edited by Wieslaw W. Jedrzejczak

submission deadline 30 Nov 2026 | Viewed by 361 | Submission Open

Keywords: acute leukemia; targeted therapy; antibody–drug conjugates

(This special issue belongs to the Section Clinical Research in Cancer)

Intraoperative Radiotherapy in Cancer Treatment

edited by

Falk Roeder

submission deadline 30 Nov 2026 | Viewed by 360 | Submission Open

Keywords: intraoperative radiation therapy; image-guided IORT; IOERT; kV-IORT; HDR-IORT; FLASH

(This special issue belongs to the Section Cancer Therapy)

HMGA Oncoproteins in Cancer

edited by

Monica Fedele

and

Sabrina Battista

submission deadline 30 Nov 2026 | Viewed by 357 | Submission Open

Keywords: HMGA1; HMGA2; chromatin architecture; oncogenic signaling; tumor progression; biomarkers; therapeutic targeting

(This special issue belongs to the Section Molecular Cancer Biology)

Epigenetic Alterations in Human Tumors

edited by Michail Panagiotidis and

Young Kyung Park

submission deadline 30 Nov 2026 | Viewed by 352 | Submission Open

Keywords: cancer; DNA methylation; post-translational histone modifications; miRNAs; genome reorganization; multi-omics; experimental/translational therapeutics

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Minimally Invasive Surgery in Gastrointestinal Cancers

edited by

Giovanni Domenico Tebala

and Fabio Rondelli

submission deadline 30 Nov 2026 | Viewed by 345 | Submission Open

Keywords: laparoscopic surgery; robotic surgery; gastrointestinal cancer; colorectal surgery; hepatobiliary surgery; pancreatic surgery; oesophagogastric surgery; peritoneal surface malignancies

(This special issue belongs to the Section Cancer Therapy)

Biomarkers in Liquid Biopsy: Circulating Tumor DNA (ctDNA), Circulating Tumor Cells (CTCs) and Exosomes

edited by George Zarkavelis

submission deadline 30 Nov 2026 | Viewed by 331 | Submission Open

Keywords: liquid biopsy; circulating tumor DNA; circulating tumor cells; early cancer detection; assessment of minimal residual disease (MRD); monitoring treatment response; identifying resistance to therapy

(This special issue belongs to the Section Methods and Technologies Development)

Novel Approaches to Management of Therapy and Prevention of Pancreatic Cancer

edited by

Carmen Guerra

and Vasiliki Liaki

submission deadline 30 Nov 2026 | Viewed by 323 | Submission Open

Keywords: pancreatic ductal adenocarcinoma (PDAC); targeted therapy; preclinical models; cancer mutiomics; early detection; prevention; precision medicine; biomarkers; drug resistance

(This special issue belongs to the Section Cancer Therapy)

Metabolic Reprogramming and Neuroendocrine Regulation in Cancer: From Pathophysiology to Therapeutic Targets

edited by

Dimiter B. Avtanski

submission deadline 30 Nov 2026 | Viewed by 317 | Submission Open

Keywords: ageing and cancer; breast cancer metabolism; cancer metabolism; inflammation; insulin resistance; metabolic reprogramming; neuroendocrine signaling; obesity and cancer; precision oncology; tumor microenvironment

(This special issue belongs to the Section Cancer Pathophysiology)

Multiple Myeloma: From Molecular Insights to Clinical Treatment

edited by Mikala Gabor

submission deadline 30 Nov 2026 | Viewed by 311 | Submission Open

Keywords: multiple myeloma; novel therapy; bispecific; CelMod; CAR-T; CAR-NK; ADC; CD38; BCMA; GPRC5D; FcRH5; transplantation

Advances in Adoptive Cell Therapy for Cancer

edited by Andrew Furness

submission deadline 30 Nov 2026 | Viewed by 302 | Submission Open

Keywords: CAR-T cells; adoptive cell therapy; tumor microenvironment; immunotherapy; translational oncology

Radiation Therapy for Sarcomas

edited by Peter Chung and Elizabeth H. Baldini

submission deadline 30 Nov 2026 | Viewed by 301 | Submission Open

Keywords: radiation therapy; dose-fractionation; functional outcomes; combination approaches; histology-specific outcomes; toxicity; site-specific

(This special issue belongs to the Section Cancer Therapy)

Mechanism of Action of Novel Anticancer Drugs in Cancer Treatment

edited by

Ruifang Liu

submission deadline 30 Nov 2026 | Viewed by 299 | Submission Open

Keywords: targeted therapy; immunotherapy; tumor-agostic approval; therapy resistence; mechaninsm of action; kinase inhibitor; immune checkpoint inhibitor

(This special issue belongs to the Section Cancer Drug Development)

Mammographic Density in Prevention and Early Detection of Breast Cancer

edited by

Wendy Ingman

submission deadline 30 Nov 2026 | Viewed by 294 | Submission Open

Keywords: mammographic density; breast cancer; risk; prevention; early detection; mammogram; breast cancer screening

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Clinical Studies in Gastrointestinal Malignancies: 2nd Edition

edited by

Ulrich Ronellenfitsch

submission deadline 30 Nov 2026 | Viewed by 280 | Submission Open

Keywords: gastrointestinal cancers; clinical studies; multimodal treatment; study design; outcomes

(This special issue belongs to the Section Clinical Research in Cancer)

Applications of Imaging in Lung Cancer

edited by

Chiara Romei

submission deadline 30 Nov 2026 | Viewed by 277 | Submission Open

Keywords: lung cancer; chest X-ray; computed tomography; magnetic resonance imaging; tumor staging; treatment response; radiomics; artificial intelligence

(This special issue belongs to the Section Methods and Technologies Development)

Advancements in the Science of Endocrine Surgical Oncology

edited by Alessandra L. Moore

submission deadline 30 Nov 2026 | Viewed by 277 | Submission Open

Keywords: endocrine oncology; endocrine surgery; endocrine; cancer; biology; surgery; oncology; science; surgical science

(This special issue belongs to the Section Clinical Research in Cancer)

Optimizing Cancer Healthcare with Clinical Decision Support

edited by

Avishek Choudhury

and

Safa Elkefi

submission deadline 30 Nov 2026 | Viewed by 264 | Submission Open

Keywords: cancer clinical decision support; AI in oncology; human-centered AI; trust, safety and explainability; health informatics; decision analytics; patient safety; digital oncology

Update in Pathology of Gynaecologic Cancer

edited by

Mona El-Bahrawy

submission deadline 30 Nov 2026 | Viewed by 261 | Submission Open

Keywords: gynaecological; cancer; pathology; diagnosis

(This special issue belongs to the Section Cancer Pathophysiology)

External Environmental Factors Inducing Cancer-Related Mutations

edited by

Evgeniya Ostroumova

submission deadline 30 Nov 2026 | Viewed by 260 | Submission Open

Keywords: molecular epidemiology; cancer; environmental exposure; cancer-related mutations; cancer molecular pathways; risk assessment

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Hippo/YAP Signaling Pathways in Cancers

edited by

Chunlin Ou

submission deadline 30 Nov 2026 | Viewed by 254 | Submission Open

Keywords: Hippo signaling pathway; YAP/TAZ; tumorigenesis; tumor microenvironment; targeted therapy

(This special issue belongs to the Section Molecular Cancer Biology)

Health Equity and Clinical Outcomes in Hepatocellular Carcinoma

edited by

Edoardo G. Giannini

and Catherine Mezzacappa

submission deadline 30 Nov 2026 | Viewed by 239 | Submission Open

Keywords: hepatocellular carcinoma; health equity; material deprivation; social determinants of health; clinical outcomes; access to care; cancer staging; liver cancer disparities

(This special issue belongs to the Section Clinical Research in Cancer)

Redefining Breast Cancer Surgery: Emerging Technologies and De-Escalation Strategies

edited by Marco Pellicciaro

submission deadline 30 Nov 2026 | Viewed by 227 | Submission Open

Keywords: breast cancer surgery; surgical innovation; indocyanine green; fluorescence imaging; tumor localization; sentinel lymph node; axillary surgery; de-escalation; precision surgery

(This special issue belongs to the Section Clinical Research in Cancer)

Research Progress of Targeted Therapy for Acute Myeloid Leukemia

edited by Maher Abdul-Hay

submission deadline 30 Nov 2026 | Viewed by 226 | Submission Open

Keywords: acute myeloid leukemia; targeted therapy; chimeric antigen receptor T-cell therapy; menin inhibitors; FLT3; IDH1; IDH2; NPM1; molecular; therapeutic targets

(This special issue belongs to the Section Cancer Therapy)

Surgical Management of Sarcomas

edited by Maniram Ragbir

submission deadline 30 Nov 2026 | Viewed by 208 | Submission Open

Keywords: sarcoma; MDT; surgical management; microsurgery; reconstruction

(This special issue belongs to the Section Cancer Therapy)

Hepatocellular Carcinoma Ablation: Technology, Biology, and Immunologic Synergy

edited by

Robert C.G. Martin

submission deadline 30 Nov 2026 | Viewed by 205 | Submission Open

Keywords: hepatocellular carcinoma; ablation therapy; radiofrequency ablation; microwave ablation; irreversible electroporation; tumor microenvironment; immunogenic cell death; immunotherapy; combination therapy; biomarkers; locoregional therapy; liver cancer

Novel Developments Regarding Pathological Complete Response in Breast Cancer Patients

edited by

Vasiliki Zolota

, Dimitris Goutas and

Nektarios Koufopoulos

submission deadline 30 Nov 2026 | Viewed by 204 | Submission Open

Keywords: neoadjuvant chemotherapy; adjuvant therapy; pathologic complete response; HER2-positive; triple-negative; tumor microenvironment

(This special issue belongs to the Section Cancer Pathophysiology)

Precision Pharmacotherapy for Solid Tumors: Challenges and Opportunities in Optimization and Resistance

edited by Paula Fresco and Joaquim Faria Monteiro

submission deadline 30 Nov 2026 | Viewed by 176 | Submission Open

Keywords: solid tumors; adjuvant therapy; neoadjuvant therapy; precision medicine; tumor heterogeneity; therapeutic drug monitoring; resistance mechanisms

(This special issue belongs to the Section Cancer Therapy)

Innovative Therapeutic Approaches in Acute Myeloid Leukemia (AML): Insights from Recent Clinical Trials

edited by Bhavana Bhatnagar

submission deadline 30 Nov 2026 | Viewed by 161 | Submission Open

Keywords: acute myeloid leukemia; clinical trials; therapy resistance

(This special issue belongs to the Section Clinical Research in Cancer)

Insights into Molecular Pathology of Hematological Malignancies

edited by

Mingyi Chen

and Jing Xu

submission deadline 30 Nov 2026 | Viewed by 161 | Submission Open

Keywords: hematological malignancies; molecular pathology; precision medicine; translational oncology; spatial omics; computational pathology; diagnostics

(This special issue belongs to the Section Cancer Pathophysiology)

Tumor Biomarkers in Precision Oncology: From Non-Coding RNAs to Functional Protein Signatures

edited by

Caiming Xu

, Silei Sui, Kainan Wang and Tikam Chand Dakal

submission deadline 1 Dec 2026 | 1 articles | Viewed by 764 | Submission Open

Keywords: tumor biomarkers; non-coding RNA; protein biomarkers; protein biomarkers; precision oncology

(This special issue belongs to the Section Cancer Biomarkers)

Cannabinoids and Cancer: Novel Mechanisms, Targets, and Therapeutic Horizons

edited by

Sabrina Bimonte

and Arturo Cuomo

submission deadline 1 Dec 2026 | Viewed by 512 | Submission Open

Keywords: cancer treatment; cannabinoid; novel therapeutic strategic; cannabidiol; tetrahydrocannabinol

(This special issue belongs to the Section Cancer Therapy)

The Emerging Role of Extracellular Vesicles and Mitochondria in Cancer

edited by

Anna Kakehashi

submission deadline 1 Dec 2026 | Viewed by 258 | Submission Open

Keywords: extracellular vesicles (EVs); mitochondria; tumor microenvironment and metastasis; cancer diagnosis; drug delivery and cancer treatment

(This special issue belongs to the Section Molecular Cancer Biology)

Integrating Pharmacogenetics and Pharmacogenomics in Cancer Management

edited by Fu Peng,

Xiao-Lu Wei

and

Xudong Zhu

submission deadline 1 Dec 2026 | Viewed by 105 | Submission Open

Keywords: recurrent hepatocellular carcinoma; clonal evolution; multi-omics; biomarkers; surgical resection; local ablation; TACE; systemic therapy; prognosis

(This special issue belongs to the Section Cancer Drug Development)

Precision and Innovation in Urological Cancer Surgery

edited by John Shyi Peng Yuen

submission deadline 4 Dec 2026 | Viewed by 233 | Submission Open

Keywords: urological; precision surgery; laparoscopic; robotic-assisted surgery

(This special issue belongs to the Section Cancer Therapy)

Radiomics in Head and Neck Cancer Care (2nd Edition)

edited by

Aurora Mirabile

submission deadline 5 Dec 2026 | 1 articles | Viewed by 2846 | Submission Open

Keywords: radiomics; personalized therapeutic approach; radiology; improving outcome; head and neck cancer; imaging biomarkers; artificial intelligence

(This special issue belongs to the Section Methods and Technologies Development)

New Advances of Brain Metastasis in Oncology

edited by

Shailendra Kumar Maurya

submission deadline 5 Dec 2026 | 1 articles | Viewed by 779 | Submission Open

Keywords: brain mets; BBB; brain microenvironment; molecular mechanism; immune; cytokines; drugs

(This special issue belongs to the Section Cancer Metastasis)

Factors Modifying Response to Breast Cancer Treatment

edited by

Robert Treat Chatterton

submission deadline 5 Dec 2026 | Viewed by 345 | Submission Open

Keywords: DNA damage; checkpoint inhibitor; retinoid; PARP1; estrogen/estrogen receptors; androgen/androgen receptors; glucocorticoid/glucocorticoid receptors; tumor classification

(This special issue belongs to the Section Cancer Therapy)

Research on New Drugs and Drug Targets in Melanoma: 2nd Edition

edited by

Paula Wróblewska Łuczka

and

Nicolas Dumaz

submission deadline 10 Dec 2026 | 1 articles | Viewed by 903 | Submission Open

Keywords: melanoma; new drugs; drug targets; mechanism of action; substances with anti-melanoma potential

(This special issue belongs to the Section Cancer Drug Development)

Innovative Surgical Strategies for Thoracic Malignancies

edited by

Gregor J. Kocher

and

Fabrizio Minervini

submission deadline 10 Dec 2026 | 1 articles | Viewed by 727 | Submission Open

Keywords: robotic thoracic surgery; RATS; uRATS; NSCLC; thoracic malignancies; video-assisted thoracic surgery; VATS; uVATS

(This special issue belongs to the Section Methods and Technologies Development)

New Approaches in Modulating Transcription Factors for Cancer Therapy: 2nd Edition

edited by

Sarah Walker

submission deadline 10 Dec 2026 | Viewed by 535 | Submission Open

Keywords: transcription factors; cancer treatment; degraders; inhibitors

(This special issue belongs to the Section Cancer Therapy)

HCC Associated with Viral Liver Infections (HBV, HCV, and HDV) and Other Rare Conditions

edited by

Liliana Chemello

and

Luisa Cavalletto

submission deadline 11 Dec 2026 | 2 articles | Viewed by 1560 | Submission Open

Keywords: hepatocellular carcinoma; viral infections; hepatocarcinogenesis; chronic liver damage; epidemiology; etiopathogenesis; diagnostic approaches; therapeutic strategies

(This special issue belongs to the Section Infectious Agents and Cancer)

Clinical Treatment and Prognostic Factors of Urologic Cancer

edited by

Hiroaki Iwamoto

submission deadline 15 Dec 2026 | 16 articles | Viewed by 55754 | Submission Open

Keywords: prostate cancer; bladder cancer; urothelial carcinoma; upper urinary tract tumors; kidney cancer; renal cell carcinoma; testicular tumors; molecular markers; diagnosis; systemic treatment

(This special issue belongs to the Section Cancer Therapy)

Advances in Radiotherapy of Gastrointestinal Cancers

edited by

Sunil Krishnan

submission deadline 15 Dec 2026 | 2 articles | Viewed by 3639 | Submission Open

Keywords: gastrointestinal cancer; radiotherapy; IMRT; SBRT; MR-guided; proton therapy; adaptive radiotherapy; treatment planning; radiomics; artificial intelligence; combination therapy; immunotherapy; toxicity management; quality of life; personalized medicine

(This special issue belongs to the Section Methods and Technologies Development)

Clinical and Translational Research in Head and Neck Cancer—2nd Edition

edited by Young J. Kim

submission deadline 15 Dec 2026 | 3 articles | Viewed by 2303 | Submission Open

Keywords: head and neck cancer; immunotherapy; translation; combinatorial clinical trials; oncologic therapeutics

(This special issue belongs to the Section Clinical Research in Cancer)

Myelodysplastic Neoplasms (MDS) and Myelodysplastic/ Myeloproliferative Neoplasms (MDS/MPN): New Insights into Diagnosis and Targeted Therapy

edited by

Ling Zhang

, David Sallman and Deniz Peker

submission deadline 15 Dec 2026 | 1 articles | Viewed by 1241 | Submission Open

Keywords: myelodysplastic syndromes/myelodysplastic neoplasms (MDS); myelodysplastic/myeloproliferative neoplasm; chronic myelomonocytic leukemia (CMML); diagnosis; mutations; IPSS-R; IPSS-M; hypomethylation agents; targeted therapy; hematopoietic stem cell transplant (HSCT)

(This special issue belongs to the Section Molecular Cancer Biology)

Studies on Molecular Mechanisms in the Tumor Microenvironment

edited by

Danny N. Dhanasekaran

submission deadline 15 Dec 2026 | 2 articles | Viewed by 1133 | Submission Open

Keywords: molecular mechanisms; tumor microenvironment; non-coding RNAs

(This special issue belongs to the Section Tumor Microenvironment)

Treatment-Induced Metabolic and Inflammatory Responses in Cancer

edited by

Anis Ahmad

submission deadline 15 Dec 2026 | 1 articles | Viewed by 1104 | Submission Open

Keywords: radiation therapy; chemotherapy; immunotherapy; normal tissue toxicity; metabolic reprogramming; chronic inflammation; lipid dysregulation; treatment resistance; inflammatory signaling

Deep Learning-Driven Medical Image Analysis for Cancer Screening, Detection, and Early Diagnosis

edited by

Saed Moradi

submission deadline 15 Dec 2026 | 1 articles | Viewed by 986 | Submission Open

Keywords: deep learning; medical image analysis; cancer screening; cancer detection; early diagnosis; artificial intelligence; medical imaging

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Evolving Landscape of Squamous Cell Carcinoma of the Anal Canal: State of the Art, Current Challenges and Future Perspectives

edited by

Alessandra Boccaccino

and Francesco Vasuri

submission deadline 15 Dec 2026 | 1 articles | Viewed by 967 | Submission Open

Keywords: squamous cell anal carcinoma; anal cancer; HIV; HPV

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Displaying special issue 401-450 on page 9 of 21.

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