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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Developments in the Management of Gastrointestinal Malignancies (2nd Edition)

edited by Zachary J. Brown

submission deadline 31 May 2026 | 4 articles | Viewed by 8646 | Submission Open

Keywords: gastrointestinal malignancies; multimodal therapy; chemotherapy; radiotherapy; immunotherapy; localized and metastatic

(This special issue belongs to the Section Cancer Therapy)

Cancer Biomarkers—Detection and Evaluation of Response to Therapy

edited by

Giulio Francia

and

Jianying Zhang

submission deadline 31 May 2026 | 5 articles | Viewed by 8616 | Submission Open

Keywords: biomarkers; cancer detection; biomarkers of response to antineoplastic drugs; biomarkers of resistance to chemotherapy; biomarkers for targeted therapies

(This special issue belongs to the Section Cancer Biomarkers)

Exploring the Interplay of Glioblastoma Angiogenesis, ROS, and Tumor Microenvironment: Advancements in Combination Therapy and Bioinformatics Approaches

edited by

Md Ataur Rahman

submission deadline 31 May 2026 | 1 articles | Viewed by 6868 | Submission Open

Keywords: glioblastoma; angiogenesis; reactive oxygen species (ROS); hypoxia-inducible factors (HIFs); radiotherapy (RT); bioactive natural compounds; tumor microenvironment (TME); cancer immunotherapy; combination therapy; autophagy; apoptosis; in silico and network pharmacology; bioinformatics

(This special issue belongs to the Section Cancer Metastasis)

Local Management of Breast Cancer: The Evolving Relationship Between Radiotherapy and Surgery

edited by Shengyang Peter Wu

submission deadline 31 May 2026 | 2 articles | Viewed by 6761 | Submission Open

Keywords: biomarker-guided personalized breast treatment; targeted axillary dissection; neoadjuvant therapy; local therapy; radiotherapy reduction; ultrahypofractionated partial breast irradiation

(This special issue belongs to the Section Cancer Therapy)

Advances in Proton Therapy for Head and Neck Cancer: Techniques, Outcomes and Planning Variations

edited by Jun Zhou

submission deadline 31 May 2026 | 2 articles | Viewed by 6658 | Submission Open

Keywords: proton head and neck cancer therapy; protons vs. photons for head and neck cancer treatment; adaptive proton therapy; robustness in proton head and neck cancer therapy; online vs. offline adaptation in proton head and neck cancer therapy

(This special issue belongs to the Section Cancer Therapy)

Gut Microbiome, Diet and Cancer Risk

edited by

Byeongsang Oh

submission deadline 31 May 2026 | 4 articles | Viewed by 6335 | Submission Open

Keywords: gut microbiome; cancer; diet; dysbiosis; immunity; dietary fiber; probiotic; short-chain fatty acids (SCFAs)

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Advances in Treatment of Uveal Melanoma

edited by

Bożena Romanowska-Dixon

and

Michał S. Nowak

submission deadline 31 May 2026 | 2 articles | Viewed by 5201 | Submission Open

Keywords: uveal melanoma; distant metastases; treatment modalities

(This special issue belongs to the Section Cancer Therapy)

Updates on Thyroid Cancer

edited by

Kwangsoon Kim

and

Ja Seong Bae

submission deadline 31 May 2026 | 3 articles | Viewed by 5142 | Submission Open

Keywords: thyroid cancer; surgery; updates; diagnosis; molecular biology; personalized medicine; artificial intelligence; novel therapeutic strategies; patient outcomes

(This special issue belongs to the Section Cancer Therapy)

Prostate Cancer and Inflammation

edited by Takuji Hayashi

submission deadline 31 May 2026 | 1 articles | Viewed by 2666 | Submission Open

Keywords: prostate cancer; inflammation; immune cells; cytokine; chemokine; anti-inflammatory agents; diet; microbiome

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

MicroRNA in Cancer: From Molecular Mechanisms to Therapeutic Applications

edited by Girish Shukla and

Sivakumar Vijayaraghavalu

submission deadline 31 May 2026 | 3 articles | Viewed by 2555 | Submission Open

Keywords: microRNA (miRNA) therapeutics; cancer biomarkers; oncogenic and tumor-suppressive miRNAs; miRNA delivery systems; precision oncology

(This special issue belongs to the Section Cancer Biomarkers)

Focus on Focal Therapy for Prostate Cancer

edited by Abhinav Sidana and Samuel Tremblay

submission deadline 31 May 2026 | 2 articles | Viewed by 2501 | Submission Open

Keywords: focal therapy; prostate cancer treatment; image-guided therapy; oncological outcomes; functional outcome; patient selection; surveillance

(This special issue belongs to the Section Cancer Therapy)

The Role of Circulating Tumor Cells in Colorectal Cancer

edited by

Chiara Nicolazzo

submission deadline 31 May 2026 | 1 articles | Viewed by 2488 | Submission Open

Keywords: circulating tumor cells (CTC); colorectal cancer (CRC); liquid biopsy; biomarkers; tumor progression; personalized medicine; molecular profiling; metastasis; diagnostic techniques; prognostic evaluation

(This special issue belongs to the Section Cancer Biomarkers)

Quality of Life in Patients with Brain Tumors

edited by Priya U. Kumthekar, Akanksha Sharma and Margaret Johnson

submission deadline 31 May 2026 | 1 articles | Viewed by 1773 | Submission Open

Keywords: quality of life; palliative care; patient reported outcomes; survivorship; caregiver distress; symptom management

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Therapeutic Optimization of Anti-Tumor Drugs Based on Pharmacokinetics

edited by Paula Fresco and Joaquim António Faria Monteiro

submission deadline 31 May 2026 | 1 articles | Viewed by 1383 | Submission Open

Keywords: anti-cancer drugs; pharmacokinetics; therapeutic drug monitoring; cancer; populational pharmacokinetics models

(This special issue belongs to the Section Cancer Drug Development)

Primary Central Nervous System Lymphoma: A Challenging Disease

edited by

Roser Velasco

submission deadline 31 May 2026 | 2 articles | Viewed by 1126 | Submission Open

Keywords: primary central nervous system lymphoma (PCNSL); diffuse large B cell lymphoma (DLBCL); advanced imaging; novel therapies; prognostic markers

(This special issue belongs to the Section Clinical Research of Cancer)

Survivorship and Quality of Life in Endometrial Cancer

edited by George Koukourakis,

Antonios Anagnostopoulos

, Georgios Angelopoulos and Anthi Miliadou

submission deadline 31 May 2026 | 1 articles | Viewed by 1035 | Submission Open

Keywords: endometrial cancer; quality of life; survivorship

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Radiotherapy for the Management of Brain Metastases

edited by Alla Gabriella Wernicke

submission deadline 31 May 2026 | 1 articles | Viewed by 900 | Submission Open

Keywords: brain metastases; molecular profiles; imaging advancements; systemic treatment options; radiotherapeutic techniques; primary irradiation; re-irradiation; cutting-edge clinical research

(This special issue belongs to the Section Cancer Metastasis)

Clinical and Translational Research of Urological Cancer

edited by

Mauro Ragonese

and

Luca Di Gianfrancesco

submission deadline 31 May 2026 | 1 articles | Viewed by 876 | Submission Open

Keywords: urological cancer; bladder cancer; surgery; conservative treatment; immunotherapy; radical cystectomy; artifical intelligence

(This special issue belongs to the Section Clinical Research of Cancer)

Nano-Targeting of Cancer

edited by Thomas Ming Swi Chang OC MD CM PhD DSc FRCPC FRSC FCAHS

submission deadline 31 May 2026 | 1 articles | Viewed by 818 | Submission Open

Keywords: drug delivery; artificial intelligence; targeted delivery; nanorobotics; prodrug activation; intracellular action; liposome; PEGylation; nanoparticles; nanocapsules; nanoartificial cells

(This special issue belongs to the Section Cancer Therapy)

Advances in Neoadjuvant Chemotherapy and Radiotherapy for Breast Cancer: Surgical Impact and Clinical Outcomes

edited by Amparo García-Tejedor

submission deadline 31 May 2026 | 1 articles | Viewed by 780 | Submission Open

Keywords: neoadjuvant chemotherapy; radiotherapy; breast cancer; surgical outcomes; tumor downstaging; personalized therapy; breast-conserving surgery; mastectomy; clinical outcomes

(This special issue belongs to the Section Cancer Therapy)

Current Status and Prospects of Multimodal Treatment for Upper Gastrointestinal Cancer

edited by Koichi Okamoto

submission deadline 31 May 2026 | 1 articles | Viewed by 766 | Submission Open

Keywords: upper gastrointestinal cancer; esophageal cancer; gastric cancer; esophagogastric junction cancer; chemotherapy; oncology; endoscopic resection; minimally invasive surgery; robotic surgery

(This special issue belongs to the Section Cancer Therapy)

Lymphoid and Myeloid Leukemias—Current Progress in Biology and Treatment

edited by Ewa Robak and

Tadeusz Robak

submission deadline 31 May 2026 | Viewed by 394 | Submission Open

Keywords: acute myeloid leukemia; promyelocytic leukemia; myelomonocytic leukemia; chronic lymphocytic leukemia; hairy cell leukemia; prolymphocytic leukemia; large granular lymphocyte leukemia; acute lymphoblastic leukemia

(This special issue belongs to the Section Molecular Cancer Biology)

Decoding the Dynamic Matrix Complexity in Cancer

edited by

Nikos Karamanos

Zoi Piperigkou

and

Luisa Bracci

submission deadline 31 May 2026 | Viewed by 302 | Submission Open

Keywords: extracellular matrix; cancer pathobiology; 3D spheroids/organoids; modeling tumor microenvironment complexity; matrix-based bioscaffolds; matrix remodeling; cell surface matrix mediators and effectors; matrix degrading enzymes; proteoglycans/glycosaminoglycans; collagen; matrix (glyco)proteins; molecular targeting

(This special issue belongs to the Section Tumor Microenvironment)

Emerging Nanotechnology and Advanced Materials for Cancer Therapy

edited by

Iraj Alipourfard

submission deadline 31 May 2026 | Viewed by 235 | Submission Open

Keywords: biomaterials; theranostics; cancer therapy; targeted drug delivery; precision oncology

(This special issue belongs to the Section Methods and Technologies Development)

Advances in High-Grade Serous Ovarian Cancer: New Perspectives Promising Hope for Eradicating a Devastating Disease

edited by

Carlos M. Telleria

submission deadline 31 May 2026 | Viewed by 173 | Submission Open

Keywords: high-grade serous ovarian cancer; risk factors; prevention; early detection; symptoms; screening; standard of care; platinum resistant ovarian cancer; novel therapeutic approaches; drug repositioning; artificial intelligence; life expectancy; quality of life; and prognosis

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances in Surgical and Multimodal Treatments of Hepatopancreatobiliary Cancers

edited by

Andrea Belli

, Matteo Serenari and

Benedetto Ielpo

submission deadline 31 May 2026 | Viewed by 160 | Submission Open

Keywords: pancreatic cancer; liver metastases; hepatocellular carcinoma; cholangiocarcinoma; neuroendocrine tumours; intraductal papillary mucinous neoplasms (IPMN); pancreatic cystic tumours; robotic surgery; laparoscopic surgery; 3D reconstruction; liver hypertrophy

(This special issue belongs to the Section Cancer Therapy)

Mutagenesis and DNA Methylation in Aging

edited by Steven S. Smith

submission deadline 31 May 2026 | Viewed by 144 | Submission Open

Keywords: genome structure evolution; epigenetics; aging; tumorigenesis; endogenous mutagenisis; endogenous decay of methylation patterns

(This special issue belongs to the Section Molecular Cancer Biology)

Infectious Agents and Oesophageal Cancer (2nd Edition)

edited by

Shan Rajendra

and Mohammed Rabiei

submission deadline 31 May 2026 | Viewed by 143 | Submission Open

Keywords: oesophageal cancer; human papillomavirus; infection; Barrett’ s oesophagus; cancer; oesophageal adenocarcinoma; oesophageal squamous cell carcinoma

(This special issue belongs to the Section Infectious Agents and Cancer)

The Future of Cancer Immunotherapy: Biomarkers, Tumor Microenvironment, and Precision Medicine

edited by Aftab Alam

submission deadline 31 May 2026 | Viewed by 138 | Submission Open

Keywords: immunotherapy; genomics; proteomics checkpoint; CAR T cells; predictive biomarkers; resistance mechanisms; combination approaches; tumor microenvironment

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Insulin Resistance, Diabetes, and Cancer: An Overview of the Pathogenetic Mechanisms

edited by

Kumar Ganesan

and

Kunka Mohanram Ramkumar

submission deadline 31 May 2026 | Viewed by 128 | Submission Open

Keywords: insulin resistance; type 2 diabetes; hyperinsulinemia; IGF-1 signaling; tumor microenvironment; metabolic inflammation; adipokines; antidiabetic drugs; cancer metabolism; phytocompounds; bioactive molecules; hormone regulation; intracellular signalling pathways

(This special issue belongs to the Section Cancer Pathophysiology)

Head and Neck Cancer: MRI and PET/CT Diagnosis and Surgical Treatment

edited by

Lavinia Manuela Lenghel

submission deadline 31 May 2026 | Viewed by 125 | Submission Open

Keywords: head and neck cancer; MRI; PET/CT; diagnostic imaging; surgical treatment; tumor staging; image-guided surgery; multidisciplinary approach; oncologic outcomes

(This special issue belongs to the Section Cancer Therapy)

Multimodality Management of Sarcomas (2nd Edition)

edited by

Eelco de Bree

submission deadline 31 May 2026 | Viewed by 115 | Submission Open

Keywords: sarcomas; multimodal; pathology; radiology; surgery; chemotherapy; radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Single-Cell and Spatial Data Analytics in Cancers

edited by

Yu Shyr

and Qi Liu

submission deadline 31 May 2026 | Viewed by 113 | Submission Open

Keywords: single-cell and spatial omics; tumor heterogeneity; tumor progression; tumor microenvironment; cancer immunotherapy

(This special issue belongs to the Section Cancer Informatics and Big Data)

Targeted Therapy in Gastrointestinal Cancer (2nd Edition)

edited by

Wei Kang

and

Ka Fai To

submission deadline 31 May 2026 | Viewed by 111 | Submission Open

Keywords: gastrointestinal cancer; tumor microenvironment; gut microbiome; molecular mechanism; cancer treatment; prognostic and predictive biomarker; therapeutic target; cancer prognosis; targeted therapy; targeted drug development

(This special issue belongs to the Section Cancer Therapy)

Role of Cytokines in Cancer (2nd Edition)

edited by

Venkataswarup Tiriveedhi

submission deadline 31 May 2026 | Viewed by 111 | Submission Open

Keywords: inflammation; tumor microenvironment; cytokines

(This special issue belongs to the Section Tumor Microenvironment)

Image-Guided Radiotherapy in Head and Neck Cancer

edited by Petar Suton

submission deadline 31 May 2026 | Viewed by 100 | Submission Open

Keywords: image-guided radiotherapy (IGRT); head and neck cancer; radiation therapy; cone-beam CT (CBCT); adaptive radiotherapy

(This special issue belongs to the Section Cancer Therapy)

Clinical Imaging and Immunotherapy in Cancer Research

edited by

Fabio Sandomenico

submission deadline 31 May 2026 | Viewed by 98 | Submission Open

Keywords: immunotherapy; immune checkpoint inhibitors; molecular imaging; tumor microenvironment; artificial intelligence (AI); radiomics

(This special issue belongs to the Section Clinical Research of Cancer)

Reducing the Risk of Hepatitis B-Associated Chronic Liver Disease and Hepatocellular Carcinoma

edited by

Mark A. Feitelson

submission deadline 31 May 2026 | Viewed by 97 | Submission Open

Keywords: HBsAg loss; prolonged nucleoside therapy; autoimmune diseases; gut dysbiosis; hepatitis delta coinfection; HIV coinfection; functional cure; immunomodulation; HBV integration; immune-mediated CLD; combination therapies

(This special issue belongs to the Section Clinical Research of Cancer)

Tumor Microenvironment in Ovarian Cancer Progression, Dissemination, Recurrence: Biology and Therapeutic Opportunities

edited by

Ralf-Peter Czekay

Paul J. Higgins

and

Dong-Joo Cheon

submission deadline 31 May 2026 | Viewed by 85 | Submission Open

Keywords: transperitoneal carcinomatosis; malignant ascites; chemoresistance; metabolic adaptations; regulation of immune response; tumor– stroma interaction; tumor– peritoneal interaction

(This special issue belongs to the Section Tumor Microenvironment)

Three-Dimensional In Vitro Modeling for the Study of Epithelial Cancers

edited by

Sherif M. Karam

and George Wai Cheong Yip

submission deadline 31 May 2026 | Viewed by 82 | Submission Open

Keywords: 3D cancer model; 3D cancer stem cell culture; 3D tumor invasion model; cancer-on-a-chip; cancer spheroids; carcinogenesis organoid model; bioprinted cancer tissue; microfluidic platform for cancer; scaffold-based cancer model

(This special issue belongs to the Section Methods and Technologies Development)

The Pathogenesis and Treatment of Diffuse Midline Glioma

edited by

Amanda Muhs Saratsis

submission deadline 31 May 2026 | Viewed by 79 | Submission Open

Keywords: pediatric brain tumors; diffuse midline glioma; high-grade glioma; H3K27M mutant glioma; liquid biopsy; diffuse intrinsic pontine glioma

(This special issue belongs to the Section Cancer Therapy)

Role of Protein and Metabolite in Cancers

edited by

Md. Wasim Khan

submission deadline 31 May 2026 | Viewed by 49 | Submission Open

Keywords: cancer progression; cancer cells; proteins; metabolites; signaling pathway; metabolic dysregulations

(This special issue belongs to the Section Tumor Microenvironment)

Cellular Senescence, Aging and the Tumor Microenvironment in Cancer

edited by Jabed Iqbal and Jeremy Wee Kiat Ng

submission deadline 31 May 2026 | Viewed by 39 | Submission Open

Keywords: aging; senescence; immunosenescence; SASP; tumor microenvironment; immunotherapy

(This special issue belongs to the Section Tumor Microenvironment)

Innovative Approaches of Multimodal Imaging of Cancer Characteristics in Nuclear Medicine

edited by

Daniel Gündel

and

Sophie Stotz

submission deadline 31 May 2026 | Viewed by 29 | Submission Open

Keywords: multimodal imaging; molecular imaging; PET; SPECT; MRI; CT; ultrasound; optical imaging; cancer

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Primary and Secondary Bone and Soft Tissue Tumors

edited by

Frank Traub

submission deadline 31 May 2026 | Viewed by 28 | Submission Open

Keywords: primary bone tumors; soft tissue sarcomas; metastatic bone disease; molecular diagnostics including liquid biopsy; surgical management including reconstruction; immunotherapy; tumor microenvironment; biomarkers and prognostic factors; cancer surveillance; translational oncology

Toxicities of Antineoplastic Therapies

edited by Ysabella Van Sebille,

Hannah Wardill

and

Connor Williams

submission deadline 31 May 2026 | Viewed by 25 | Submission Open

Keywords: antineoplastic therpay; cancer treatment-related toxicities; cancer treatment adverse events; chemotherapy toxicity; targeted therapy toxicities; immunotherapy toxicity; hormonal therapy toxicity; radiation-induced toxicity; cellular and gene therapy toxicity; supportive cancer care; survivorship; patient-reported outcomes; toxicity management

(This special issue belongs to the Section Cancer Therapy)

Advances in Urological Cancer: Innovative Therapies and Biomarkers

edited by Hiroshi Yaegashi

submission deadline 31 May 2026 | Viewed by 18 | Submission Open

Keywords: urological oncology; urothelial cancer; prostate cancer; renal cancer; biomarkers; immunotherapy

Neuroimaging Biomarkers of Cancer Therapy-Related CNS Complications

edited by Jasmina Boban

submission deadline 31 May 2026 | Viewed by 17 | Submission Open

Keywords: neuroimaging; multimodal imaging; chemotherapy; immunotherapy; chemotherapy-related cognitive dysfunction; drug- related side effects and adverse reactions

The Evolving Role of CDK4/6 Inhibitors in Early and Recurrent Breast Cancer: Clinical and Translational Findings and Work in Progress

edited by Hans-Christian Kolberg

submission deadline 31 May 2026 | Viewed by 16 | Submission Open

Keywords: CDK4/6 inhibitors; breast cancer; treatment resistance; combination therapy; biomarkers

Clinical Treatment and Translational Advances in Myelodysplastic Syndromes and Acute Myeloid Leukemia

edited by