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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Driving Progress in Urological Cancer Outcomes: Predictive Factors and Treatment Innovations
edited by Juan Gómez Rivas
submission deadline 31 Jan 2027 | 1 articles | Viewed by 639 | Submission Open
Keywords: urological cancers; prostate cancer; bladder cancer; kidney cancer; prognostic factors; treatment outcomes
Updates in Cancer Imaging: PET/CT, MRI and Beyond
edited by
submission deadline 31 Jan 2027 | 1 articles | Viewed by 638 | Submission Open
Keywords: positron emission tomography/computed tomography; computed tomography; MR; conventional imaging; positron emission tomography; neoplasm; cancer
(This special issue belongs to the Section Methods and Technologies Development)
Epigenetic Dysregulation in Hematological Malignancies: Mechanisms and Therapeutic Implications submission deadline 31 Jan 2027 | Viewed by 532 | Submission Open
Keywords: epigenetic dysregulation; hematologic malignancies; epigenetic therapy; DNA methylation; histone modification; non-coding RNAs; exosomes
(This special issue belongs to the Section Cancer Therapy)
Artificial Intelligence in Radiation Therapy for Head and Neck Cancers: Prediction, Personalization, and Precision
edited by Meysam Tavakoli
submission deadline 31 Jan 2027 | Viewed by 454 | Submission Open
Keywords: head and neck cancer; radiation therapy; artificial intelligence ; machine learning ; deep learning ; toxicity prediction ; radiomics ; dosiomics ; outcome modeling ; personalized radiotherapy
(This special issue belongs to the Section Methods and Technologies Development)
Multimodal Management of Bone Metastases: From Microenvironment Crosstalk to Precision Interventional Therapy
edited by and Zhiyu Chen
submission deadline 31 Jan 2027 | 1 articles | Viewed by 446 | Submission Open
Keywords: bone metastases; tumor microenvironment; precision therapy; molecular mechanisms; multimodal treatment; therapeutic targets
(This special issue belongs to the Section Cancer Metastasis)
Clinical Trials for Hepatobiliary and Pancreatic Cancer Diagnosis and Treatment (2nd Edition)
edited by
submission deadline 31 Jan 2027 | Viewed by 411 | Submission Open
Keywords: biliary cancer; liver cancer; pancreatic cancer; clinical trial; diagnosis; surgery; neoadjuvant therapy; adjuvant therapy; radiotherapy; chemotherapy; targeted therapy; precision medicine; immunotherapy; biliary and duodenal stent; psycho-oncology; palliative and supportive care
(This special issue belongs to the Section Clinical Research in Cancer)
Digital Health and Patient-Reported Outcomes in Cancer Care
edited by Joanne Droney
submission deadline 31 Jan 2027 | Viewed by 390 | Submission Open
Keywords: patient-reported outcome measures; digital health; remote symptom monitoring; outcome-based healthcare; health-related quality of life (HRQoL); shared decision-making; real-world data collection; data standardization; health equity in digital health
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Microsatellite Instability in Colorectal Cancer
edited by and Vicente Alonso-Orduña
submission deadline 31 Jan 2027 | Viewed by 380 | Submission Open
Keywords: microsatellite instability; colorectal cancer; immune checkpoint inhibitors; immune signatures
(This special issue belongs to the Section Tumor Microenvironment)
Blood Stem Cell and Hematological Malignancies (Second Edition)
edited by Dirk Loeffler
submission deadline 31 Jan 2027 | 1 articles | Viewed by 378 | Submission Open
Keywords: hematopoietic stem cells; hematological malignancies; clonal hematopoiesis; clonal evolution; preleukemia and leukemia; self-renewal and differentiation; asymmetric cell division; cell polarity; therapy resistance; transformation
(This special issue belongs to the Section Molecular Cancer Biology)
Redefining Cancer Through Its Microenvironment: Mechanisms, Modeling, and Targeting Strategies
edited by Leandro Marcelo Martinez
submission deadline 31 Jan 2027 | Viewed by 369 | Submission Open
Keywords: tumor microenvironment; solid cancer; hematologic malignancies; tumor initiation; tumor progression; therapeutic resistance; in-vitro models; personalized therapy
(This special issue belongs to the Section Tumor Microenvironment)
Nanomedicine for Cancer Treatment
edited by Youssef Wahib Naguib
submission deadline 31 Jan 2027 | Viewed by 334 | Submission Open
Keywords: cancer nanomedicine; CRISPR/CAS9 nanomedicine; immune checkpoint inhibitors; cancer immunotherapy; targeted therapeutics; targeted nanoparticles; cell-penetrating peptides
(This special issue belongs to the Section Cancer Drug Development)
The TGF-β Pathway in Hepatocellular Carcinoma
edited by Dan Feng
submission deadline 31 Jan 2027 | Viewed by 295 | Submission Open
Keywords: hepatocellular carcinoma; HCC; TGF-β
(This special issue belongs to the Section Cancer Pathophysiology)
Advances in Exosomes and Cancer Therapy
edited by and
submission deadline 31 Jan 2027 | Viewed by 292 | Submission Open
Keywords: exosomes; extracellular vesicles; isolation of exosomes; cancer therapy; tumor microenvironment; exosome engineering; drug delivery systems; cancer biomarkers; immunomodulation; precision oncology
(This special issue belongs to the Section Cancer Therapy)
Thoracic Surgical Oncology—Current Landscape and Future Directions
edited by Piergiorgio Solli and Alessia Stanzi
submission deadline 31 Jan 2027 | Viewed by 272 | Submission Open
Keywords: minimally invasive thoracic surgery; immunotherapy; liquid biopsy; lung cancer; mesothelioma; esophageal cancer; precision oncology
(This special issue belongs to the Section Clinical Research in Cancer)
Advances and Challenges in Charged Particle Therapy: Protons and Beyond
edited by Annie W. Chan
submission deadline 31 Jan 2027 | Viewed by 241 | Submission Open
Keywords: proton therapy; carbon ion therapy; helium ion therapy; charged particle therapy; relative biological effectiveness
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Molecular Biology and Genetics of Prostate Cancer submission deadline 31 Jan 2027 | Viewed by 236 | Submission Open
Keywords: prostate cancer; treatment resistance; tumor microenvironment; genomic alterations; therapy progression mechanisms
(This special issue belongs to the Section Molecular Cancer Biology)
Paradigm Shifts and Patient-Centered Outcomes of Breast Cancer Surgery
edited by Rakhshanda Layeequr Rahman, Cathy Graham and Jaime Alberty
submission deadline 31 Jan 2027 | Viewed by 225 | Submission Open
Keywords: shared decision-making; precision medicine; surgical de-escalation; minimally invasive surgery; clinical approaches with modern technologies; quality of life after breast surgery; economic impact of breast cancer surgery; financial toxicity
(This special issue belongs to the Section Methods and Technologies Development)
Molecular and Genetic Drivers of Cancer: Organelle Dysfunction, Cancer Stem Cells, and Tumor Progression
edited by and Maziar Ashrafian-Bonab
submission deadline 31 Jan 2027 | Viewed by 180 | Submission Open
Keywords: cancer progression; organelle dysfunction; cancer stem cells; mitochondria; microtubules; organelle crosstalk; tumor metabolism; therapeutic resistance
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Anticancer Drugs and Pharmacotherapy of Cancer
edited by
submission deadline 31 Jan 2027 | Viewed by 145 | Submission Open
Keywords: anticancer; therapeutics; target therapy; immune-oncology; mode of action; molecular mechanisms; targeted protein degradation; antibody-drug conjugates; cell therapy; cancer parmacology
(This special issue belongs to the Section Cancer Drug Development)
Role of Cancer Biomarkers for Diagnosis, Prognosis and Targeted Therapy in Gastrointestinal Cancers: 2nd Edition
edited by and Neda Dadgar
submission deadline 31 Jan 2027 | Viewed by 124 | Submission Open
Keywords: liquid biopsy; esophageal cancer; gastric cancer; colorectal cancer; pancreatic cancer; hepatocellular cancer; appendiceal cancer; cancer biomarker; DNA sequencing; transcriptomics; proteomics; immunohistochemistry
(This special issue belongs to the Section Cancer Biomarkers)
Precision Oncology and Immunotherapy in Bone and Soft Tissue Sarcomas submission deadline 31 Jan 2027 | Viewed by 109 | Submission Open
Keywords: soft tissue sarcoma (STS); immunotherapy; precision medicine; cellular signaling; biomarkers; translational research; molecular profiling; survivorship; supportive care
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
The Future Is Now: Novel Technologies in Use in Head and Neck Cancer Surgery
edited by Peter T. Dziegielewski, Daniel A. Benito, Austin S. Lam and Dustin Conrad
submission deadline 31 Jan 2027 | Viewed by 101 | Submission Open
Keywords: head and neck cancer; surgery; reconstruction
(This special issue belongs to the Section Cancer Therapy)
Endoscopic and Minimally Invasive Approaches in Neuro-Oncology
edited by Michael Karsy and
submission deadline 31 Jan 2027 | Viewed by 98 | Submission Open
Keywords: endoscopic neurosurgery; minimally invasive neuro-oncology; skull base tumors; surgical robotics and navigation; translational neuro-oncology
Advances in PET/CT-Guided Diagnosis and Treatment of Hematologic Malignancies
edited by
submission deadline 31 Jan 2027 | Viewed by 97 | Submission Open
Keywords: PET/CT; nuclear medicine; lymphoma; multiple myeloma; leukemia; hybrid imaging
Focal Adhesion Kinase Signaling in Cancers
edited by
submission deadline 31 Jan 2027 | Viewed by 96 | Submission Open
Keywords: focal adhesion kinase (FAK); tumor microenvironment (TME); fibrosis; chemoresistance; immunotherapy; KRAS; BRAF; epithelial–mesenchymal transition (EMT) homologous repair deficiency; FAK inhibitor; ifebemtinib; defactinib; narmafotinib; integrin; metastasis; mechanotransduction
(This special issue belongs to the Section Molecular Cancer Biology)
Diagnosis and Management of Diffuse Glioma
edited by Francesco Bruno
submission deadline 31 Jan 2027 | Viewed by 77 | Submission Open
Keywords: diffuse glioma; IDH-mutant glioma; molecular classification; advanced MRI; amino acid PET; radiomics; artificial intelligence; targeted therapy; brain tumour-related epilepsy; neurocognition; quality of life; neurosurgery; liquid biopsy
Psycho-Oncology and Supportive Care in Women with Cancer Across the Lifespan
edited by Michelle Peate and Zobaida Edib
submission deadline 31 Jan 2027 | Viewed by 27 | Submission Open
Keywords: survivorship; infertility; menopause; primary ovarian insufficiency; treatment-induced amenorrhoea; quality of life; supportive care; women with cancer
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Progress and Precision in Surgical Treatment for Hepatobiliary and Pancreatic Cancers
edited by Ajith K. Siriwardena, Samik Kumar Bandyopadhyay and Louise M. Finch
submission deadline 1 Feb 2027 | 1 articles | Viewed by 522 | Submission Open
Keywords: liver surgery; pancreas surgery; robotic surgery; ablation; irreversible electroporation; liver tumours
Targeted Therapies in Sarcomas: Overcoming Resistance and Improving Outcomes
edited by and Mohammed M. Milhem
submission deadline 8 Feb 2027 | Viewed by 456 | Submission Open
Keywords: sarcoma; targeted therapy; resistance mechanisms; combination therapy; biomarkers; precision oncology; translational research; clinical trials
(This special issue belongs to the Section Tumor Microenvironment)
Bridging Translational and Clinical Oncology in Gastrointestinal Cancers: Molecular Mechanisms to Therapeutic Advances submission deadline 10 Feb 2027 | Viewed by 571 | Submission Open
Keywords: gastrointestinal cancers; translational oncology; molecular mechanisms; biomarkers; immunotherapy; radiomics; precision medicine; therapeutic advances
(This special issue belongs to the Section Methods and Technologies Development)
Cytoreduction in Gynecologic Oncology
edited by Sabrina Piedimonte
submission deadline 13 Feb 2027 | Viewed by 341 | Submission Open
Keywords: cytoreduction; ovarian cancer; endometrial cancer; minimally invasive surgery; AI
(This special issue belongs to the Section Cancer Therapy)
Minimally Invasive Therapies in Urologic Cancers
edited by Eric M. Walser and
submission deadline 15 Feb 2027 | 5 articles | Viewed by 7713 | Submission Open
Keywords: laparoscopic surgery; robotic-assisted surgery; ablation; high-intensity focused ultrasound; partial nephrectomy; minimally invasive procedures; urologic cancers
(This special issue belongs to the Section Methods and Technologies Development)
Molecular Signatures of Therapy: Biomarkers Predicting Response and Relapse in Cancer
edited by
submission deadline 15 Feb 2027 | 5 articles | Viewed by 6637 | Submission Open
Keywords: molecular biomarkers; therapeutic response; disease relapse; precision oncology; liquid biopsy; predictive biomarkers; multi-omics integration; minimal residual disease; translational oncology
(This special issue belongs to the Section Cancer Biomarkers)
Utilizing the DNA Damage Response Mechanism for Cancer Treatments submission deadline 15 Feb 2027 | 2 articles | Viewed by 1250 | Submission Open
Keywords: DNA damage response; synthetic lethality; replication stress; DDR-targeted therapy; cancer metabolism; drug resistance; combination therapy
(This special issue belongs to the Section Cancer Therapy)
Neuroimaging of Adult-Type Diffuse Gliomas
edited by
submission deadline 15 Feb 2027 | 1 articles | Viewed by 765 | Submission Open
Keywords: glioma; image diagnosis; molecular diagnosis; MRI; MRS; SPECT; PET
(This special issue belongs to the Section Methods and Technologies Development)
Immunotherapy for Hematologic Malignancies
edited by Rajesh Ramakrishnan Nair
submission deadline 15 Feb 2027 | Viewed by 450 | Submission Open
Keywords: immune evasion; immunotherapy; CAR-T cell therapy; BiTEs; immunomodulators; checkpoint; inhibitors; bone marrow microenvironment; refractory/relapsed; drug resistance; gene editing
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Pancreaticoduodenectomy in the Treatment of Pancreatic Cancer
edited by Piero Chirletti and Roberto L. Meniconi
submission deadline 15 Feb 2027 | Viewed by 291 | Submission Open
Keywords: pancreatic ductal adenocarcinoma (PDAC); surgical treatment; R0 exeresis; mesopancreas; lymphadenectomy; reconstruction technique
(This special issue belongs to the Section Clinical Research in Cancer)
Novel Advances in the Molecular Understanding of Myeloproliferative Neoplasms (MPNs): 2nd Edition
edited by Wei Chen, Fei Li and
submission deadline 15 Feb 2027 | Viewed by 84 | Submission Open
Keywords: MPNs; ET; PV; PMF; post-PV-MF; post-ET-MF; MDS/MPN; JAK2
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Stereotactic Body Radiation Therapy for Thoracic and Abdominopelvic Tumors
edited by and
submission deadline 19 Feb 2027 | 2 articles | Viewed by 2305 | Submission Open
Keywords: stereotactic body radiation therapy (SBRT); adaptive radiation therapy (ART); image-guided radiation therapy (IGRT); motion management; thoracic tumors; abdominopelvic tumors
(This special issue belongs to the Section Methods and Technologies Development)
Sarcoma Management in Orthopaedic Oncology
edited by and Jendrik Hardes
submission deadline 20 Feb 2027 | 5 articles | Viewed by 8511 | Submission Open
Keywords: orthopaedic surgical oncology; sarcoma; orthopaedic surgery; bone and soft tissue sarcoma; diagnose; neoadjuvant therapy; targeted therapy; immunotherapy
(This special issue belongs to the Section Methods and Technologies Development)
Advances in Surgery for Endocrine Cancers
edited by and Eren Berber
submission deadline 20 Feb 2027 | 1 articles | Viewed by 2246 | Submission Open
Keywords: thyroid cancer; thyroid surgery; hyperparathyroidism; adrenal tumors; adrenal surgery; pancreatic neuroendocrine tumors; fluorescence guided surgery; intraoperative imaging; surgical navigation; technological innovation
(This special issue belongs to the Section Methods and Technologies Development)
Advances in the Immunotherapy of Metastatic Cancer
edited by
submission deadline 20 Feb 2027 | 1 articles | Viewed by 1649 | Submission Open
Keywords: metastatic cancer; immunotherapy; immune checkpoint inhibitors; CAR-T cells; tumor microenvironment; immune-related adverse events; biomarkers; combination therapy; resistance mechanisms
(This special issue belongs to the Section Cancer Immunology and Immunotherapy)
Novel Strategies in the Prevention/Treatment of Colorectal Cancer: 2nd Edition
edited by
submission deadline 20 Feb 2027 | 1 articles | Viewed by 1384 | Submission Open
Keywords: colorectal cancer; chemotherapy; chemoprevention; targeted therapy; kinase inhibitor; immunotherapy
Advanced Immunotherapeutic Strategies and Clinical Developments in Hepatocellular Carcinoma and Gastrointestinal Cancers
edited by Kaushik Banerjee, Shayanki Lahiri and Lei Yang
submission deadline 20 Feb 2027 | 1 articles | Viewed by 1290 | Submission Open
Keywords: hepatocellular carcinoma; gastrointestinal cancers; clinical immunotherapy; immune checkpoint inhibitors; tumor immune microenvironment; biomarkers and precision oncology; immunotherapy resistance; immune-related adverse events; combination therapy; CAR-T and adoptive cell therapy; cancer vaccines; translational and clinical research; clinical trials; real-world evidence
HIV-Associated Lymphoid Neoplasms (2nd Edition) submission deadline 20 Feb 2027 | 1 articles | Viewed by 1203 | Submission Open
Keywords: B-cell lymphoma; HIV; AIDS; Epstein–Barr virus; epidemiology; pathogenesis; prognosis
(This special issue belongs to the Section Infectious Agents and Cancer)
Cellular Plasticity, Metabolic Adaptations and Therapeutic Strategies in Breast Cancer submission deadline 20 Feb 2027 | Viewed by 533 | Submission Open
Keywords: breast cancer; cellular plasticity; metabolic reprogramming; tumor microenvironment; therapy resistance; epithelial–mesenchymal transition (EMT); cancer stem cells; redox metabolism; mitochondrial pathways; targeted therapy
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Targeted Therapies and Pharmacogenomics of Leukemia
edited by
submission deadline 20 Feb 2027 | Viewed by 467 | Submission Open
Keywords: blood cancer; targeted therapy; immunotherapy; primary and secondary resistance; pharmacogenetics; combination therapy; tumor microenvironment
(This special issue belongs to the Section Molecular Cancer Biology)
Advances in Surgery of Liver Cancer
edited by Ho-Seong Han and Roberto Ivan Troisi
submission deadline 20 Feb 2027 | 1 articles | Viewed by 281 | Submission Open
Keywords: liver cancer surgery; hepatocellular carcinoma; minimally invasive liver resection; laparoscopic surgery; robotic surgery; anatomical resection; surgical oncology; precision surgery
(This special issue belongs to the Section Methods and Technologies Development)
Treatment Outcomes in Older Adults with Cancer (2nd Edition) submission deadline 25 Feb 2027 | 1 articles | Viewed by 863 | Submission Open
Keywords: older adults with cancer; geriatric oncology; geriatric assessment; supportive care; palliative care; cancer rehabilitation; nutrition; physical activity; functional status; survivorship
(This special issue belongs to the Section Cancer Therapy)
Digital Health Technologies in Oncology: 2nd Edition submission deadline 25 Feb 2027 | Viewed by 631 | Submission Open
Keywords: digital healthcare; digital health technologies; diagnosis; wearable devices; rehabilitation technologies; assistive technologies; robotic surgery; (remote) monitoring; precision medicine; data analytics; healthcare teleassistance; AI-driven diagnostics and monitoring; AI-driven analytics.
(This special issue belongs to the Section Methods and Technologies Development)
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