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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Extracellular Matrix Proteins in Cancer (2nd Edition)

edited by

Dragana Nikitovic

and Aikaterini Berdiaki

submission deadline 30 Sep 2026 | Viewed by 470 | Submission Open

Keywords: extracellular matrix (ECM); tumor microenvironment (TME); stromal remodeling; cancer-associated fibroblasts (CAFs); fibrous proteins; mechanotransduction; interstitial fluid pressure; proteoglycans and glycoproteins; matrix crosslinking; epithelial-to-mesenchymal transition (EMT); angiogenesis; matrikines; therapy resistance

(This special issue belongs to the Section Tumor Microenvironment)

Metastasis in Tumor Immunity: Current Perspectives

edited by

Ulrike Stein

, Sebastian Torke and

Wolfgang Walther

submission deadline 30 Sep 2026 | Viewed by 441 | Submission Open

Keywords: immune escape; immune evasion; immune microenvironment; intervention strategies; senescence on metastasis; anti-tumor immunity; cellular interactions; molecular interactions; immune suppression; immune checkpoints

(This special issue belongs to the Section Cancer Metastasis)

Tumor-Initiating Cells in Cancer: Their Interactions with Other Cell Types, and Prospective Applications

edited by

Spiros Vlahopoulos

submission deadline 30 Sep 2026 | Viewed by 401 | Submission Open

Keywords: cancer stem cells; cancer stem-like cells; leukemia; chromatin; transcription factors; cellular phenotype; microenvironment; immunity; tumor stroma

(This special issue belongs to the Section Tumor Microenvironment)

Medical Image-Based Cervical Cancer Prevention, Diagnosis, and Treatment

edited by Emma R. Allanson and Ming Yin Lin

submission deadline 30 Sep 2026 | Viewed by 390 | Submission Open

Keywords: medical imaging; 3-dimensional imaging; cervical cancer

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Redefining Precision Radiotherapy

edited by Srinivasan Vijayakumar

submission deadline 30 Sep 2026 | Viewed by 386 | Submission Open

Keywords: precision radiotherapy; cancer radiotherapy; PRT; RadioTheronostics

(This special issue belongs to the Section Methods and Technologies Development)

Beyond PEGylation: Next-Generation Nanomedicine for Cancer Therapy

edited by

Soumen Saha

submission deadline 30 Sep 2026 | Viewed by 380 | Submission Open

Keywords: nanomedicine; tumor-targeting mechanisms; cancers

(This special issue belongs to the Section Tumor Microenvironment)

PSMA Targeted Strategies and Radioligand Therapies in Prostate Cancer: From Preclinical Models to Clinical Translation

edited by Neha Vapiwala and John Nikitas

submission deadline 30 Sep 2026 | Viewed by 363 | Submission Open

Keywords: prostate cancer; prostate-specific membrane antigen; radioligand therapy; radiopharmaceutical therapy; radiotherapy; theranostics

(This special issue belongs to the Section Cancer Therapy)

CRLM in the Era of Transplant Oncology: New Hope, New Questions

edited by Brian Davidson and

Khurum Khan

submission deadline 30 Sep 2026 | Viewed by 356 | Submission Open

Keywords: colorectal cancer; liver transplant; transplant oncology; chemotherapy; immunotherapy; immunosuppression; genetic profiling; circulating ccDNA; staging; surveillance

(This special issue belongs to the Section Cancer Therapy)

Advances in Combination Therapy for Lymphoma

edited by

Maria Christina Cox

submission deadline 30 Sep 2026 | Viewed by 351 | Submission Open

Keywords: lymphoma; combination therapies; T-cell engagers; immuno-conjugates; targeted drugs

(This special issue belongs to the Section Cancer Therapy)

Advances in Clinical Trials and Precision Medicine for Neuro-Oncology

edited by Malaka Ameratunga

submission deadline 30 Sep 2026 | Viewed by 347 | Submission Open

Keywords: clinical trials; neuro-oncology; precision oncology; molecular targets; precision medicine

(This special issue belongs to the Section Clinical Research in Cancer)

Next-Generation Cancer Research: AI Approaches for Biomarkers, Therapeutics and Beyond

edited by Wen Zhang

submission deadline 30 Sep 2026 | Viewed by 340 | Submission Open

Keywords: computational genetics; cancer; big data analysis; deep learning; statistical modeling; bioinformatics; AI; biomarkers; therapeutics

(This special issue belongs to the Section Cancer Informatics and Big Data)

New Era of Systemic Therapy for Different Types of Skin Cancer

edited by Magdalena Ciazynska

submission deadline 30 Sep 2026 | Viewed by 331 | Submission Open

Keywords: skin cancer systemic therapy; immunotherapy in skin cancer; targeted therapy in skin malignancies; melanoma and nonmelanoma skin cancer; biomarkers and treatment response; resistance mechanisms; combination therapy; real worldreal-world outcomes; novel therapeutic agents; precision oncology

(This special issue belongs to the Section Cancer Therapy)

New Approaches in the Treatment of Hepatocellular Carcinoma and Liver Tumor: 2nd Edition

edited by Riccardo Inchingolo, Stavros Spiliopoulos and Riccardo Memeo

submission deadline 30 Sep 2026 | Viewed by 322 | Submission Open

Keywords: hepatocellular carcinoma; cirrhosis; liver; interventional oncology; trans-arterial chemo embolization; selective internal radiation therapy; ablation; radiology

(This special issue belongs to the Section Cancer Therapy)

Roles of Circular RNAs (circRNAs) in Cancer Development and Progression

edited by

Qubo Zhu

submission deadline 30 Sep 2026 | Viewed by 320 | Submission Open

Keywords: circular RNAs (circRNAs); cancer development; tumor progression; oncogenesis; gene regulation; metastasis; tumor microenvironment; therapeutic targets; biomarkers; molecular pathways

(This special issue belongs to the Section Molecular Cancer Biology)

Non-Melanoma Skin Cancer: A Growing Problem in the Elderly Population

edited by Jolanta Jaworek and Dariusz Kowalczyk

submission deadline 30 Sep 2026 | 1 articles | Viewed by 320 | Submission Open

Keywords: NMSC; pathomechanism of NMSC; NMSC and gut and/or skin microbiota; NMSC treatment; NMSC diagnosis

(This special issue belongs to the Section Cancer Epidemiology and Prevention)

Metabolomics Approaches in Cancer Diagnosis

edited by

Raj Kumar Sharma

submission deadline 30 Sep 2026 | Viewed by 312 | Submission Open

Keywords: metabolomics; metabolites; NMR metabolomics; mass spectrometry in metabolomics; cancer biomarkers; metabolomics methods

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Evolving Landscape of Endometrial Cancer

edited by Dimitrios Zouzoulas and Dimitrios Tsolakidis

submission deadline 30 Sep 2026 | Viewed by 305 | Submission Open

Keywords: endometrial cancer; patient quality of life; fertility preservation; molecular classification; minimal invasive surgery; emerging therapeutic approaches

(This special issue belongs to the Section Molecular Cancer Biology)

Advanced Multimodal Neuroimaging and Computational Approaches in Brain Tumor Research

edited by

Feng Liu

submission deadline 30 Sep 2026 | Viewed by 294 | Submission Open

Keywords: brain tumors; multimodal neuroimaging; artificial intelligence; radiomics; imaging genomics; diffusion MRI; functional MRI; precision oncology

Pancreatic Cancer Ultrasound: A Problem-Based Approach

edited by

Carla Serra

and Andrea Boccatonda

submission deadline 30 Sep 2026 | Viewed by 285 | Submission Open

Keywords: cancer; ultrasound; pancreas; CEUS; malignancy

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advancements in Cervical Cancer Screening and HPV-Related Disease Management

edited by

Maria Lina Tornesello

submission deadline 30 Sep 2026 | Viewed by 279 | Submission Open

Keywords: cervical cancer; cervical intraepithelial neoplasia; HPV (human papillomavirus); cervical cancer screening; high-resolution colposcopy; DNA methylation; HPV genotyping; HPV vaccination; molecular diagnostics; self-sampling; biomarkers; immune response; Ai-assisted screening; cervical cancer prevention

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Tumor Microenvironment in Hematological Malignancies: Advances in Targeted Therapies and Cellular Mechanisms

edited by Carolina Simioni

submission deadline 30 Sep 2026 | Viewed by 272 | Submission Open

Keywords: hematological malignancies; tumor microenvironment; bone marrow niche; targeted therapy; signal transduction; drug resistance; tumor metabolism; cell plasticity; biomarkers; cell–cell interactions

(This special issue belongs to the Section Tumor Microenvironment)

Advances in Clinical Pharmacology in Lung Cancer—2nd Edition

edited by

Chih-Jen Yang

submission deadline 30 Sep 2026 | Viewed by 271 | Submission Open

Keywords: lung cancer; target therapy; immunotherapy; antiangiogenic agent; chemotherapy; NGS

(This special issue belongs to the Section Cancer Drug Development)

Conventional and AI-Enabled Precision Medicine/Surgery in Oncology

edited by

Georgios Antonios Margonis

and Dimitris Bertsimas

submission deadline 30 Sep 2026 | Viewed by 267 | Submission Open

Keywords: precision medicine; precision surgery; surgical oncology; treatment effect heterogeneity; subgroup discovery; causal inference; real-world evidence; confounding; interpretable AI; clinical decision support

(This special issue belongs to the Section Cancer Informatics and Big Data)

Minimally Invasive Surgery for Gastric Cancer

edited by Steve Kwon

submission deadline 30 Sep 2026 | Viewed by 255 | Submission Open

Keywords: comparison of laparoscopic vs. robotic approaches in long-term oncological and perioperative outcomes; minimally invasive surgery vs. endoscopic resections in treatment of early gastric cancer; minimally invasive surgery vs. open approaches for advanced gastric cancer, including peritoneal carcinomatosis; the role of minimally invasive surgery in D2 lymphadenectomy; minimally invasive emergent gastrectomy for gastric cancer; minimally invasive surgery (or nonoperative management) for gastric cancer in the era of immunotherapy; learning curve of robotic gastrectomy and D2 lymphadenectomy; technical and review papers, e.g., anastomotic techniques and reconstruction methods; minimally invasive total gastrectomy; three-dimensional (3D) imaging in minimally invasive gastric cancer surgery

(This special issue belongs to the Section Methods and Technologies Development)

Advances in Diagnosis and Clinical Trials of Bladder Cancer

edited by Mutsuo Furihata

submission deadline 30 Sep 2026 | Viewed by 248 | Submission Open

Keywords: bladder cancer; pathological diagnosis; tumorigenesis; 5-aminolevulinic acid; photodynamic therapies; robot-assisted radical cystectomy; fluorescence navigation; artificial intelligence

Novel Strategies for Treating Castration-Resistant Prostate Cancer

edited by

Balaji Chandrasekaran

and

Eswar Shankar

submission deadline 30 Sep 2026 | Viewed by 244 | Submission Open

Keywords: androgen receptor; CRPC; drug resistance; combination therapy; small molecules; chemoprevention

(This special issue belongs to the Section Cancer Therapy)

Therapy of Nasopharyngeal Carcinoma: Emphasizing Radiotherapy

edited by Yunfei Xia

submission deadline 30 Sep 2026 | Viewed by 232 | Submission Open

Keywords: nasopharyngeal carcinoma (NPC); radiotherapy; IMRT; adaptive radiotherapy; dose optimization; re-irradiation; radioresistance; radiomics; biomarkers; toxicity mitigation

(This special issue belongs to the Section Cancer Therapy)

Novel Insights into Platelet Cancer Crosstalk

edited by

Azaj Ahmed

submission deadline 30 Sep 2026 | Viewed by 218 | Submission Open

Keywords: platelet–tumor interactions; cancer-associated thrombosis; metastasis; tumor microenvironment; platelets; platelet activation; thromboinflammation; hemostasis

The Central Role of CD8+ T Cells in Cancer Immunotherapy: From Functional Remodeling to Clinical Translation

edited by

Shengjun Wang

submission deadline 30 Sep 2026 | Viewed by 217 | Submission Open

Keywords: CD8+T cells; T cell exhaustiont; metabolic reprogramming; epigenetic regulation; tumor microenvironmen; immune checkpoint blockade

Advancements in Surgical and Multidisciplinary Management of Hepatopancreaticobiliary Cancer

edited by Hideki Takami

submission deadline 30 Sep 2026 | Viewed by 214 | Submission Open

Keywords: hepatopancreaticobiliary cancer; pancreatic cancer; biliary tract cancer; hepatocellular carcinoma; multidisciplinary treatment; systemic therapy; neoadjuvant therapy; conversion surgery; precision medicine

Biomarkers and Targeted Therapy in Malignant Pleural Mesothelioma: 2nd Edition

edited by

Susana Cedrés

submission deadline 30 Sep 2026 | Viewed by 207 | Submission Open

Keywords: malignant mesothelioma; target therapy; biomarkers

Rare Tumors in Children: Trends in Diagnosis, Treatment and Prevention (2nd Edition)

edited by

Antonio Ruggiero

and

Stefano Mastrangelo

submission deadline 1 Oct 2026 | 5 articles | Viewed by 14100 | Submission Open

Keywords: pediatric oncology; pediatric drugs; clinical pharmacology

(This special issue belongs to the Section Pediatric Oncology)

Cervical Cancer Screening: Current Practices and Future Perspectives

edited by Kimon Chatzistamatiou

submission deadline 1 Oct 2026 | 5 articles | Viewed by 6209 | Submission Open

Keywords: cervical cancer screening; cervical carcinogenesis; human papillomavirus; HPV primary screening; self-sampling; triage of HPV-positive; post-conization follow-up; screening for immunocompromised women; screening for vac-cinated women

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

The Role of Surgery in Lung Cancer Treatment

edited by

Francesco Petrella

submission deadline 1 Oct 2026 | 1 articles | Viewed by 1029 | Submission Open

Keywords: lung cancer surgery; thoracic surgery; minimally invasive surgery; robotic surgery; multimodality therapy; perioperative management; surgical outcomes; thoracic oncology

(This special issue belongs to the Section Clinical Research in Cancer)

Cancer Immunotherapy as Part of Precision Clinical Medicine

edited by

Peter Lang

and

Christo Kole

submission deadline 10 Oct 2026 | 4 articles | Viewed by 9285 | Submission Open

Keywords: cancer; immunotherapy; tumor microenvironment; molecular biology and genetics

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Head and Neck Cancer Recurrence: Diagnosis, Treatment and Prognosis (2nd Edition)

edited by

Oreste Gallo

submission deadline 10 Oct 2026 | 2 articles | Viewed by 5667 | Submission Open

Keywords: head and neck cancer; recurrence; squamous cell carcinoma; HPV; larynx; oral cavity; oropharynx

(This special issue belongs to the Section Cancer Therapy)

Advances in Diagnostics and Treatments for Glioblastoma

edited by Sied Kebir and

Manmeet Singh Ahluwalia

submission deadline 10 Oct 2026 | 2 articles | Viewed by 4034 | Submission Open

Keywords: glioblastoma; molecular diagnostics; neuro-oncology; imaging biomarkers; immunotherapy; targeted therapy; tumor-treating fields; radiotherapy; chemotherapy; translational research; machine learning; positron emission tomography

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Mitochondrial Metabolism in Cancer Immune Responses

edited by

Jae Ho Seo

and Kiwon Lee

submission deadline 10 Oct 2026 | 2 articles | Viewed by 2624 | Submission Open

Keywords: mitochondria; cancer metabolism; immune response; tumor microenvironment (TME); immunometabolism; mitochondrial reprogramming; reactive oxygen species (ROS); cancer immunotherapy

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Multidisciplinary Advances and Surgical Impact in Brain and Central Nervous System Tumors: From Molecular Insights to Clinical Outcomes

edited by Paolo Tini, Salvatore Chibbaro and

Mario Ganau

submission deadline 10 Oct 2026 | 1 articles | Viewed by 1972 | Submission Open

Keywords: glioblastoma; low-grade gliomas; ependymomas; PNET; meningiomas; medulloblastomas; other brain tumors

Pioneering Advances in Neurosurgical Oncology: From Innovative Techniques to Better Patient Outcomes

edited by

Oreste de Divitiis

and

Massimiliano Visocchi

submission deadline 10 Oct 2026 | Viewed by 714 | Submission Open

Keywords: endoscope; 3D exoscope; tractography MRI; molecular biomarkers; stem cells; transoral; cordomas; skullbase

(This special issue belongs to the Section Methods and Technologies Development)

The Bone Marrow Microenvironment in Myelodysplastic Syndromes—Pathogenesis, Immune Evasion, and Therapeutic Opportunities

edited by

Ciro Roberto Rinaldi

submission deadline 15 Oct 2026 | 2 articles | Viewed by 7921 | Submission Open

Keywords: myelodysplastic syndromes; bone marrow microenvironment; hematopoietic stem cells; mesenchymal stromal cells; immune evasion; CD47; calreticulin; inflammatory cytokines; clonal hematopoiesis; microenvironment-targeted therapy

(This special issue belongs to the Section Tumor Microenvironment)

Advanced Insights into the Etiology of Lymphoma

edited by Susan L. Slager and James R. Cerhan

submission deadline 15 Oct 2026 | 4 articles | Viewed by 4844 | Submission Open

Keywords: lymphoma etiology; genetic predisposition; clonal hematopoiesis; precursor conditions; risk stratification; viral oncogenesis; non-Hodgkin lymphoma; Hodgkin lymphoma

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Brain Tumors—Related Cognitive Impairment

edited by

Djaina Satoer

and

Anne Marie Buunk

submission deadline 15 Oct 2026 | 2 articles | Viewed by 2038 | Submission Open

Keywords: aphasia; cognition; brain tumor; surgery; adjuvant treatment; rehabilitation

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Outcomes in Glioblastoma Patients: From Diagnosis to Palliation: 2nd Edition

edited by

Alba Scerrati

and Giorgio Mantovani

submission deadline 15 Oct 2026 | 2 articles | Viewed by 1881 | Submission Open

Keywords: high-grade glioma; outcome assessment; prognostic factors; neuro-oncology; glioblastoma

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

New Strategies for the Treatment of Melanoma in Neoadjuvant and Adjuvant Settings

edited by Michele Del Vecchio

submission deadline 15 Oct 2026 | 1 articles | Viewed by 1209 | Submission Open

Keywords: melanoma; adjuvant therapy; neoadjuvant therapy; treatment

(This special issue belongs to the Section Cancer Therapy)

Cancer Rehabilitation and Physical Activity: Advancing Function, Recovery, and Quality of Life Across the Cancer Continuum

edited by Jennifer Michelle Jones

submission deadline 15 Oct 2026 | 1 articles | Viewed by 988 | Submission Open

Keywords: cancer rehabilitation; exercise science; physical activity; prehabilitation; adverse side effects

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Pathological Features and Treatment Strategies of Head and Neck Cancer

edited by

Davide Mattavelli

and

Boštjan Lanišnik

submission deadline 15 Oct 2026 | 1 articles | Viewed by 866 | Submission Open

Keywords: head and neck cancer (HNC); pathological features; treatment strategies; human papillomavirus (HPV); molecular profile; multimodal therapy; immune checkpoint inhibitors; prognostic markers

(This special issue belongs to the Section Clinical Research in Cancer)

Genetic and Molecular Characterization of Lung Cancer

edited by Sk Kayum Alam

submission deadline 15 Oct 2026 | 1 articles | Viewed by 783 | Submission Open

Keywords: lung cancer; molecular subtypes of lung cancer; genetic alterations; next-generation sequencing; biomarker; oncogenic driver mutations; therapeutic landscapes; treatment resistance; metastasis

(This special issue belongs to the Section Molecular Cancer Biology)

World Lung Cancer Awareness Month: 2nd Edition

edited by

Calvin Sze Hang Ng

submission deadline 15 Oct 2026 | 1 articles | Viewed by 774 | Submission Open

Keywords: lung cancer; tumor microenvironment; early detection; therapeutic targets; new therapeutic strategies; surgery; genetics

(This special issue belongs to the Section Cancer Therapy)

RAS Pathways in Cancer Cells

edited by Geoffrey J. Clark

submission deadline 15 Oct 2026 | Viewed by 364 | Submission Open

Keywords: RAS; inhibitor; signaling; cancer

(This special issue belongs to the Section Molecular Cancer Biology)

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