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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Toll-Like Receptors (TLRs) and Cancer Immunology: Mechanisms, Biomarkers, and Therapeutic Perspectives
edited by
submission deadline 28 Feb 2027 | Viewed by 56 | Submission Open
Keywords: toll-like receptors; innate immune sensing; cancer immunology; tumor microenvironment; immune evasion; immune checkpoints; biomarkers; cancer immunotherapy; epigenetic regulation; non-coding RNAs
Innovative Approaches in Minimally Invasive and Robotic Surgery for Gastrointestinal Oncology
edited by Maximos Frountzas, Efstathia Liatsou and Dimitrios Katsarelias
submission deadline 28 Feb 2027 | Viewed by 44 | Submission Open
Keywords: robotic surgery; minimally invasive surgery; gastrointestinal oncology; surgical innovation; oncological outcomes; fluorescence-guided surgery
(This special issue belongs to the Section Methods and Technologies Development)
Feature Papers in Section “Methods and Technologies Development” in 2026 submission deadline 1 Mar 2027 | 5 articles | Viewed by 4210 | Submission Open
Keywords: artificial intelligence (AI); medical imaging; clinical diagnostics; oncology biomarkers; precision medicine; big data integration; early cancer detection; radiomics; therapy response prediction; translational technology
(This special issue belongs to the Section Methods and Technologies Development)
New Advances and Approaches in Thyroid Cancer
edited by and José Manuel Rodríguez
submission deadline 1 Mar 2027 | 2 articles | Viewed by 3297 | Submission Open
Keywords: thyroid cancer; medullary thyroid cancer; papillary thyroid cancer; follicular thyroid cancer; poorly differentiated thyroid tumours; novel approaches; prognostic biomarkers; risk stratification
(This special issue belongs to the Section Cancer Therapy)
Novel Developments in Invasive Lobular Breast Cancer: Diagnosis, Prognosis and Therapy (2nd Edition) submission deadline 1 Mar 2027 | 1 articles | Viewed by 1532 | Submission Open
Keywords: invasive lobular carcinoma; imaging; diagnosis; pathology; tumor microenvironment; treatment; metastasis
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
Advances in Endoscopic Management of Esophageal Cancer
edited by Hugo Uchima and
submission deadline 1 Mar 2027 | 1 articles | Viewed by 1106 | Submission Open
Keywords: endoscopic submucosal dissection (ESD); esophageal squamous cell carcinoma; Barrett’s esophagus
(This special issue belongs to the Section Cancer Therapy)
Precise and Personalized Radiation Therapy for Cancer Treatment
edited by Thomas Weissmann and
submission deadline 1 Mar 2027 | Viewed by 345 | Submission Open
Keywords: radiation research; artificial intelligence; cancer; adaptive radiotherapy; stereotactic radiotherapy; radiotherapy; (radio)-immunotherapy; (radio)-chemotherapy; precision radiotherapy
(This special issue belongs to the Section Cancer Therapy)
Primary and Recurrent Gynecological Cancer: Epidemiology, Management and New Therapies
edited by Nithya Ratnavelu and Ioannis Biliatis
submission deadline 5 Mar 2027 | 5 articles | Viewed by 21257 | Submission Open
Keywords: ovarian cancer; endometrial cancer; cervical cancer; vulva cancer; vaginal cancer; gynecological cancer
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Symptom Management in Cancer Care
edited by Lena Lee and Joosun Shin
submission deadline 5 Mar 2027 | Viewed by 431 | Submission Open
Keywords: symptom burden; symptom management; health service; palliative care
(This special issue belongs to the Section Cancer Survivorship and Quality of Life)
Ovarian Cancer: Pathogenesis, Molecular Mechanism and Opportunities for Interventions submission deadline 10 Mar 2027 | 2 articles | Viewed by 4073 | Submission Open
Keywords: ovarian cancer; pathogenesis; therapy; biomarkers; molecular
(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)
The Molecular Pathogenesis of Lung Cancer: From Oncogenic Drivers to Tumor Microenvironment
edited by
submission deadline 12 Mar 2027 | Viewed by 340 | Submission Open
Keywords: lung cancer; oncogenic drivers; tumor microenvironment; immune checkpoint inhibitors; immunotherapy resistance; predictive biomarkers
(This special issue belongs to the Section Cancer Pathophysiology)
Extracellular Vesicles in Cancer: Biology, Biomarkers and Therapeutic Applications
edited by
submission deadline 12 Mar 2027 | Viewed by 83 | Submission Open
Keywords: extracellular vesicles; exosomes; biomarker; liquid biopsy; tumor microenvironment
Clinical, Immune, and Microbial Markers of Response to Systemic Therapy in Skin Cancer
edited by
submission deadline 14 Mar 2027 | 1 articles | Viewed by 975 | Submission Open
Keywords: melanoma; cutaneous squamous cell carcinoma; immunotherapy; immune checkpoint inhibitors; tumor microenvironment; microbiome; predictive biomarkers
Contemporary Management of Urologic Cancers
edited by and Hangcheng Fu
submission deadline 14 Mar 2027 | Viewed by 149 | Submission Open
Keywords: urologic oncology; prostate cancer; kidney cancer; bladder cancer; testicular cancer; penile cancer; upper urinary tract cancer; focal therapy; cancer survivorship; robotic surgery
(This special issue belongs to the Section Cancer Therapy)
Proton Therapy of Cancer Treatment
edited by Minglei Kang, Benjamin Durkee and Kuo Men
submission deadline 15 Mar 2027 | 5 articles | Viewed by 9764 | Submission Open
Keywords: proton therapy; FLASH radiotherapy; upright; pediatric cancer; head and neck cancer; affordable proton solutions; adaptive radiation therapy; treatment planning optimization; proton system commissioning
(This special issue belongs to the Section Cancer Therapy)
Advances in Bone Metastasis Research: From Mechanisms to Therapy
edited by Ye Lin
submission deadline 15 Mar 2027 | 1 articles | Viewed by 2544 | Submission Open
Keywords: bone metastasis; tumour microenvironment; biomarker; targeted therapy; detection; palliative care
(This special issue belongs to the Section Cancer Metastasis)
The Clinical, Technological, and Scientific Progress of Boron Neutron Capture Therapy
edited by
submission deadline 15 Mar 2027 | Viewed by 1551 | Submission Open
Keywords: boron neutron capture therapy (BNCT); neutron capture therapy (NCT); accelerator-based neutron source; neutron dosimetry; boron drug development; alternative capture agents; radiobiological effects; radiation oncology; interdisciplinary research; clinical translation
(This special issue belongs to the Section Cancer Therapy)
New Models of Cancer Care to Improve Patient Experiences and Clinical Outcomes
edited by
submission deadline 15 Mar 2027 | 1 articles | Viewed by 1292 | Submission Open
Keywords: patient-centered care; community-based interventions; innovative care models; digital health solutions; patient engagement; clinical outcomes; value-based cancer care
Resistance in Lung Cancer
edited by Mohamed Gadelkarim
submission deadline 15 Mar 2027 | Viewed by 646 | Submission Open
Keywords: lung cancer; SCLC; NSCLC; drug resistance; genetic mutations; tumor microenvironment; EMT; biomarkers; targeted therapy; immunotherapy
(This special issue belongs to the Section Cancer Therapy)
Clinical Update on Lung Cancer: Current Strategies and Outcome
edited by Antonio D'Andrilli
submission deadline 15 Mar 2027 | 2 articles | Viewed by 438 | Submission Open
Keywords: lung cancer; clinical outcomes; diagnosis; treatment
The Critical Intersection of Tobacco Use and Cancer Care
edited by Irene Tamí-Maury
submission deadline 15 Mar 2027 | Viewed by 426 | Submission Open
Keywords: cancer; oncology settings; smoking; tobacco use; prevention; cessation
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Robotic and Laparoscopic Techniques for Urologic Cancers: Innovations in Resection and Reconstruction
edited by
submission deadline 15 Mar 2027 | Viewed by 331 | Submission Open
Keywords: robot-assisted surgery; surgical robotics; minimally invasive surgery; artificial intelligence; complications; prognostic and predictive factors; planning; perioperative care
(This special issue belongs to the Section Methods and Technologies Development)
Aptamers Against Cancer submission deadline 15 Mar 2027 | Viewed by 273 | Submission Open
Keywords: aptamers; cancer theranostics; targeted therapy; biosensors; molecular imaging
(This special issue belongs to the Section Methods and Technologies Development)
Integrative Cancer Genomics: From Classical Cytogenetics to Emerging Molecular Technologies
edited by Ying S. Zou
submission deadline 15 Mar 2027 | Viewed by 231 | Submission Open
Keywords: integrative cancer genomics; cancer cytogenetics; molecular cytogenetics; chromosomal abnormalities; optical genome mapping; next-generation sequencing; nanopore sequencing; 3D/Hi-C technologies; structural variants; AI in cytogenetics; hematological malignancies; FISH; chromosomal microarray; solid tumors
(This special issue belongs to the Section Methods and Technologies Development)
Mesothelioma Environmental Risk Factors and Epidemiological and Biological Insights
edited by Sonja Klebe
submission deadline 20 Mar 2027 | 1 articles | Viewed by 1422 | Submission Open
Keywords: mesothelioma; asbestos; mesothelial proliferation; therapy; marker
Advances in Clinical, Diagnostic and Neurosurgical Management in Pediatric Neuro-Oncology
edited by and Michael Levy
submission deadline 20 Mar 2027 | Viewed by 452 | Submission Open
Keywords: neuro-oncology; brain tumors; neuroradiology; proton therapy; pediatric; neurosurgery; treatment; chemotherapy; targeted agents; molecular subtypes; immunotherapy; late effects; radiation therapy
(This special issue belongs to the Section Pediatric Oncology)
Inflammatory Bowel Disease and Cancers: What Connections Lie Between Them?
edited by
submission deadline 20 Mar 2027 | 1 articles | Viewed by 380 | Submission Open
Keywords: inflammatory bowel disease; Crohn’s disease; ulcerative colitis; cancers
From Bench to Bedside: Systemic Therapy in Renal Cell Carcinoma
edited by Hailiang Zhang
submission deadline 20 Mar 2027 | Viewed by 85 | Submission Open
Keywords: renal cell carcinoma; systemic therapy; immune checkpoint inhibitors; targeted therapy; tumor microenvironment; biomarkers; precision oncology; translational research
(This special issue belongs to the Section Cancer Therapy)
Image Assisted High Precision Radiation Oncology
edited by Christopher Njeh and
submission deadline 25 Mar 2027 | 4 articles | Viewed by 4535 | Submission Open
Keywords: image-guided radiation therapy (IGRT); MR-guided radiation therapy (MRgRT); adaptive radiation therapy (ART); radiomics and AI in imaging; multi-modal imaging (CT, MRI, PET); treatment planning and verification; real-time tracking and motion management; stereotactic radiotherapy (SBRT/SRS); imaging biomarkers; dose accumulation and image registration
(This special issue belongs to the Section Methods and Technologies Development)
Feature Papers in Section “Infectious Agents and Cancer” submission deadline 25 Mar 2027 | 2 articles | Viewed by 1512 | Submission Open
Keywords: infectious agents; microbiota; biomarker; oncology; cancers
(This special issue belongs to the Section Infectious Agents and Cancer)
Imaging-Based Cancer Radiotherapy
edited by and Alberto Traverso
submission deadline 25 Mar 2027 | 1 articles | Viewed by 774 | Submission Open
Keywords: radiotherapy; imaging biomarkers; artificial intelligence; radiomics; toxicity prediction; adaptive radiotherapy; automated treatment planning; image-guided radiotherapy; multimodal learning; precision oncology
(This special issue belongs to the Section Methods and Technologies Development)
Pediatric Surgery in Oncology: Innovations, Challenges, and Future Directions
edited by Abdelhafeez H. Abdelhafeez and Kokila Lakhoo
submission deadline 30 Mar 2027 | 5 articles | Viewed by 3262 | Submission Open
Keywords: pediatric surgical oncology; intraoperative image guidance; minimally invasive surgery; fluorescence guidance; augmented reality; precision cancer surgery
(This special issue belongs to the Section Pediatric Oncology)
Smart Nanotechnology for Drug Delivery in Cancer Therapy
edited by
submission deadline 30 Mar 2027 | 1 articles | Viewed by 2771 | Submission Open
Keywords: nanotechnology; drug delivery; cancer therapy; nanocarriers; nanoparticles; nano-devices; nano-channels
(This special issue belongs to the Section Methods and Technologies Development)
Brachytherapy in the Treatment of Gynaecological Malignancies
edited by
submission deadline 30 Mar 2027 | 2 articles | Viewed by 1793 | Submission Open
Keywords: image-guided brachytherapy; gynecological malignancies; reirradiation using brachytherapy; cervical cancer; endometrial cancer; vulva/vagina cancer; cancer in the elderly; brachy education
(This special issue belongs to the Section Cancer Therapy)
Radiation Therapy for Meningiomas
edited by Helen A. Shih and Lia M. Halasz
submission deadline 30 Mar 2027 | 1 articles | Viewed by 898 | Submission Open
Keywords: radiation therapy; proton radiation; particle therapy; theranostics; brachytherapy; molecular features; advance imaging; late toxicities; quality of life
(This special issue belongs to the Section Cancer Therapy)
New Era of Systemic Therapy for Different Types of Skin Cancer
edited by Magdalena Ciazynska
submission deadline 30 Mar 2027 | 1 articles | Viewed by 593 | Submission Open
Keywords: skin cancer systemic therapy; immunotherapy in skin cancer; targeted therapy in skin malignancies; melanoma and nonmelanoma skin cancer; biomarkers and treatment response; resistance mechanisms; combination therapy; real worldreal-world outcomes; novel therapeutic agents; precision oncology
(This special issue belongs to the Section Cancer Therapy)
Redefining Precision Radiotherapy
edited by Srinivasan Vijayakumar
submission deadline 30 Mar 2027 | Viewed by 397 | Submission Open
Keywords: precision radiotherapy; cancer radiotherapy; PRT; RadioTheronostics
(This special issue belongs to the Section Methods and Technologies Development)
Research on Fluorescence-Guided Surgery in Cancer Treatment (2nd Edition)
edited by
submission deadline 30 Mar 2027 | Viewed by 365 | Submission Open
Keywords: fluorescence-guided surgery; fluorescent agents; tumor fluorescence; tumor margin detection; residual tumor assessment; glioma surgery; fluorescein sodium; 5-aminolevulinic acid; confocal endomicroscopy; Raman spectroscopy
(This special issue belongs to the Section Cancer Therapy)
Genome Instability, Ubiquitin Signaling and Cancer Therapy
edited by and Aftab Alam
submission deadline 30 Mar 2027 | Viewed by 297 | Submission Open
Keywords: DNA damage response; DNA repair; replication stress; ubiquitin–proteasome system; E3 ubiquitin ligases; targeted protein degradation; cell cycle checkpoints; drug resistance
Leukemia Stem Cells: Persistence, Resistance, and Novel Eradication Strategies
edited by Elisa Donato and Darja Karpova
submission deadline 30 Mar 2027 | Viewed by 292 | Submission Open
Keywords: leukemia stem cells (LSCs); acute myeloid leukemia (AML); therapeutic resistance; minimal residual disease (MRD); LSC quiescence; cellular therapy; hematopoietic stem cell transplantation (HSCT); LSC microenvironment
Reproductive and Hormonal Factors in Breast and Gynecological Cancers: Epidemiological, Pathological, Diagnostic, and Therapeutic Perspectives
edited by
submission deadline 30 Mar 2027 | Viewed by 252 | Submission Open
Keywords: breast cancer; gynecological cancers; reproductive factors; hormonal exposure; epidemiology; tumor pathology; molecular subtypes; biomarkers; early diagnosis; risk stratification; endocrine therapy; targeted therapy; treatment resistance; personalized medicine
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Advances in Pancreatic Cancer: Exploring Biomarkers and Prognostic Predictors (2nd Edition)
edited by
submission deadline 30 Mar 2027 | Viewed by 4 | Submission Open
Keywords: pancreatic cancer; biomarkers; diagnosis; prognosis; liquid biopsy; proteomics; metabolomics; tumor microenvironment; genetic aberrations/mutations; inflammatory markers
(This special issue belongs to the Section Cancer Biomarkers)
Advances in Ovarian Cancer Research and Treatment: 2nd Edition
edited by
submission deadline 31 Mar 2027 | 9 articles | Viewed by 15962 | Submission Open
Keywords: ovarian carcinoma metastasis; mechanisms of dissemination; chemotherapy resistance; novel treatments and therapeutic approaches; novel molecular targets
(This special issue belongs to the Section Cancer Therapy)
Clinical Treatment and Prognosis of Breast Cancer
edited by Roxana Popescu and
submission deadline 31 Mar 2027 | 6 articles | Viewed by 14083 | Submission Open
Keywords: breast cancer; targeted therapy; personalized therapy; alternative approach; tumor biology; gynecologic oncology
(This special issue belongs to the Section Clinical Research in Cancer)
Decision-Making Biomarkers in the Treatment of Hepatocellular Carcinoma
edited by and
submission deadline 31 Mar 2027 | 5 articles | Viewed by 12161 | Submission Open
Keywords: hepatocellular carcinoma; borderline resectable; conversion therapy; neoadjuvant therapy; immunotherapy; immune-related adverse event; molecular-targeted agent
(This special issue belongs to the Section Cancer Biomarkers)
Urological Cancer: Epidemiology and Genetics
edited by Ilir Agalliu and Evan Kovac
submission deadline 31 Mar 2027 | 3 articles | Viewed by 7894 | Submission Open
Keywords: environmental factors; lifestyle; genetic susceptibility; biomarkers; prostate cancer; bladder cancer; kidney cancer
(This special issue belongs to the Section Cancer Epidemiology and Prevention)
Acute Myeloid Leukemia in Adults (2nd Edition) submission deadline 31 Mar 2027 | 3 articles | Viewed by 4437 | Submission Open
Keywords: acute myeloid leukemia; molecular biology; treatment landscape; resistance mechanisms
(This special issue belongs to the Section Clinical Research in Cancer)
Hybrid Molecular Imaging Approaches in Cancer: PET/CT, PET/MRI, and Beyond
edited by
submission deadline 31 Mar 2027 | 3 articles | Viewed by 4257 | Submission Open
Keywords: PET/CT; PET/MRI; hybrid molecular imaging; radiomics and artificial intelligence; conventional PET Radiotracers; emerging PET Radiotracers; cancer imaging
(This special issue belongs to the Section Methods and Technologies Development)
Pancreatic Neoplasms in the 21st Century: Challenges and Opportunities in Diagnosis and Management
edited by
submission deadline 31 Mar 2027 | 4 articles | Viewed by 3934 | Submission Open
Keywords: pancreatic ductal adenocarcinoma (PDCA); pancreatic mucinous cystic neoplasm (MCN); pancreatic intraductal papillary mucinous neoplasm (IPMN); pancreatic serous cystic neoplasm (SCN); pancreatic solid pseudopapillary neoplasm (SPN); pancreatic neuroendocrine tumor (PNET); pancreatectomy; pancreatic resection
Advances in Pathogenesis and Pathology Diagnosis of Gynecologic Cancers
edited by
submission deadline 31 Mar 2027 | 4 articles | Viewed by 3803 | Submission Open
Keywords: gynecologic cancers; molecular pathology; tumor pathogenesis; diagnostic biomarkers; precision medicine; endometrial carcinoma; ovarian cancer; cervical cancer; histopathology; translational research
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