Reproductive and Hormonal Factors in Breast and Gynecological Cancers: Epidemiological, Pathological, Diagnostic, and Therapeutic Perspectives
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".
Deadline for manuscript submissions: 30 March 2027 | Viewed by 97
Special Issue Editor
Interests: gynecologic pathology; breast pathology; placental pathology; oncologic pathology; digital pathology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Breast and gynecological cancers represent a major global health burden, with incidence and mortality influenced by reproductive history and hormonal exposure. Factors such as age at menarche and menopause, parity, pregnancy, breastfeeding, and use of exogenous hormones have been consistently associated with cancer risk and progression. At the same time, advances in tumor pathology have improved the classification of hormone-dependent malignancies, including distinctions based on receptor status and molecular subtypes, which have direct implications for prognosis and therapy management. Nevertheless, challenges remain in integrating epidemiological data with pathological findings and translating them into optimized diagnostic and therapeutic strategies.
Recent developments in imaging, biomarker discovery, and minimally invasive diagnostic techniques have enhanced early detection and risk stratification, while targeted therapies—including endocrine treatments and novel molecular agents—have significantly improved patient outcomes. However, variability in response and resistance mechanisms continues to raise important clinical questions.
In this context, the aim of this Special Issue is to provide a comprehensive overview of reproductive and hormonal factors in breast and gynecological cancers, integrating epidemiological, pathological, diagnostic, and therapeutic perspectives. We welcome original research and review articles that critically address these aspects and contribute to advancing knowledge and clinical practice in this field.
Dr. Raluca Anca Balan
Guest Editor
Manuscript Submission Information
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Keywords
- breast cancer
- gynecological cancers
- reproductive factors
- hormonal exposure
- epidemiology
- tumor pathology
- molecular subtypes
- biomarkers
- early diagnosis
- risk stratification
- endocrine therapy
- targeted therapy
- treatment resistance
- personalized medicine
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