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Cancers publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Empowered by Next-Generation AI: Paradigm Transformation in Cancer Radiotherapy

edited by

Jian-Rong Dai

and Kuo Men

submission deadline 31 Dec 2026 | 1 articles | Viewed by 755 | Submission Open

Keywords: radiotherapy; next-generation AI; LLM; RL; auto-segmentation; auto-planning; treatment adaptation; treatment outcome

(This special issue belongs to the Section Cancer Therapy)

Pharmacogenetics and Pharmacogenomics in Oncology

edited by

Cheryl D. Cropp

submission deadline 31 Dec 2026 | 1 articles | Viewed by 750 | Submission Open

Keywords: pharmacogenetics; pharmacogenomics; precision oncology; cancer care

(This special issue belongs to the Section Cancer Therapy)

Surgical Perspectives in Lung Cancer: From Technique to Outcome

edited by Takahiro Homma and Hyun Koo Kim

submission deadline 31 Dec 2026 | Viewed by 748 | Submission Open

Keywords: minimally invasive surgery; enhanced recovery after surgery (ERAS); uniportal VATS; robotic-assisted thoracic surgery (RATS); surgical education; perioperative management; energy devices; lung cancer surgery

(This special issue belongs to the Section Cancer Therapy)

Cancer Patient Cognitive Disorders: Causes, Prevention and Management

edited by

Jeffrey Jianhong Huang

submission deadline 31 Dec 2026 | Viewed by 731 | Submission Open

Keywords: delirium; brain health; cognitive impairment; cancer; etiology; risk stratification; screening tool; biomarkers; postoperative delirium; pain management; delirium prevention; management; outcomes

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Molecular Markers and Targets in Modern Gynecologic Oncology

edited by

Stamatios Petousis

and Chrysoula Margioula-Siarkou

submission deadline 31 Dec 2026 | 1 articles | Viewed by 724 | Submission Open

Keywords: endometrial cancer; ovarian cancer; cervical cancer; vulvar cancer; biomarker; molecular classification; targeted therapy

Advances in Targeted Radiopharmaceuticals: Imaging, Therapy, and Clinical Perspectives

edited by

Kondapa Naidu Bobba

and

Roberto Passera

submission deadline 31 Dec 2026 | 1 articles | Viewed by 717 | Submission Open

Keywords: PET/SPECT radiotracers for cancer diagnosis and staging; targeted beta- and alpha-emitting radionuclide therapy and theranostics; radiochemistry innovation, chelator, and isotope development; dosimetry modeling, radiobiology, and treatment optimization; preclinical and translational studies; clinical case studies and emerging therapeutic indications; combinational therapies integrating radiopharmaceuticals with systemic therapy, immunotherapy, or external-beam radiation; artificial intelligence (AI) integration for imaging analysis, dosimetry, and therapy planning

Risk Stratification and Predictive Biomarkers in Blood Cancers: Enabling Precision Oncology with Data-Driven Insights

edited by

Chung Hoow Kok

submission deadline 31 Dec 2026 | 1 articles | Viewed by 708 | Submission Open

Keywords: leukemia; biomarkers; ML; AI; agentic; deep learning; risk stratification; risk prediction; survival; progression; relapse; treatment resistance

BRCA1 and BRCA2 Pathogenic Variants: Cancer Risk and Genetic Testing

edited by

Daniele Fanale

submission deadline 31 Dec 2026 | Viewed by 601 | Submission Open

Keywords: BRCA1; BRCA2; pathogenic variants; hereditary cancer; genetic testing; PARP inhibitors

(This special issue belongs to the Section Molecular Cancer Biology)

Tumor Microenvironment: Cellular Dynamics, Molecular Players, and Mechanisms of Therapy Resistance

edited by

Teresa Gagliano

, Angeliki Ditsiou and

Viviana Vella

submission deadline 31 Dec 2026 | Viewed by 598 | Submission Open

Keywords: tumor microenvironment (TME); cellular interactions; molecular mechanisms; resistance mechanisms; signaling pathways; translational cancer therapy

(This special issue belongs to the Section Tumor Microenvironment)

Current Advances and Challenges in Skin Cancers

edited by

Syril Keena T. Que

submission deadline 31 Dec 2026 | 1 articles | Viewed by 579 | Submission Open

Keywords: skin cancer; melanoma; basal cell carcinoma; squamous cell carcinoma; artificial intelligence; immunotherapy; biomarkers

New Insights in Parotid Tumors

edited by Chiara Gaudino and Stefan Rohde

submission deadline 31 Dec 2026 | Viewed by 570 | Submission Open

Keywords: advanced imaging in parotid tumors; artificial intelligence tools; parotid gland surgery; facial nerve preservation and reconstruction; chemotherapy in parotid gland malignant tumors; radiotherapy and proton therapy in malignant parotid gland tumors

(This special issue belongs to the Section Cancer Therapy)

Cancer Immunotherapy in Clinical and Translational Research (2nd Edition)

edited by Sofia Genta

submission deadline 31 Dec 2026 | 1 articles | Viewed by 565 | Submission Open

Keywords: cancer immunotherapy; clinical research; immune checkpoint inhibitor; cancer vaccines; biomarker; translational research

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Minimally Invasive Surgery in Gynecologic Cancers

edited by Pawel Sadlecki

submission deadline 31 Dec 2026 | Viewed by 531 | Submission Open

Keywords: minimally invasive surgery; gynecologic oncology; laparoscopy; robotic-assisted surgery; surgical outcomes; endometrial cancer; cervical cancer; ovarian cancer; surgical innovation

(This special issue belongs to the Section Cancer Therapy)

Psycho-Social Pathways in Cancer Care: From Fear of Recurrence to Resilience and Quality of Life

edited by

Romeo Patini

Gioele Gioco

and

Cosimo Rupe

submission deadline 31 Dec 2026 | Viewed by 506 | Submission Open

Keywords: fear of cancer recurrence; oncology; cancer survivorship; quality of life; psychological and behavioral interventions

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Roles of Urokinase Receptors in Cell Biology: Modulating Tumor Cell Migration and Invasion

edited by

Agata Kabała-Dzik

submission deadline 31 Dec 2026 | Viewed by 464 | Submission Open

Keywords: urokinase-type plasminogen receptor; uPAR; inflammation; cancer; migration; invasion

(This special issue belongs to the Section Molecular Cancer Biology)

The Next Cutting-Edge Technologies in Abdominal Solid Tumor Treatment

edited by Jerome Canady, Saravana R.K. Murthy, Aviram Nissan and

Michael Keidar

submission deadline 31 Dec 2026 | Viewed by 458 | Submission Open

Keywords: multi-visceral surgical resection for complex advanced gastrointestinal tumors; cytoreductive surgery; colon and gynecological cancers; pancreatic cancer; cold atmospheric plasma (CAP); robotic AI CAP surgical delivery systems; targeted immunotherapies; irreversible electroporation; HIPEC (hyperthermic intraperitoneal chemotherapy); PIPAC (pressurized intraperitoneal aerosol chemotherapy)

(This special issue belongs to the Section Methods and Technologies Development)

Mutagenesis and DNA Methylation in Aging

edited by Steven S. Smith

submission deadline 31 Dec 2026 | Viewed by 443 | Submission Open

Keywords: genome structure evolution; epigenetics; aging; tumorigenesis; endogenous mutagenisis; endogenous decay of methylation patterns

(This special issue belongs to the Section Molecular Cancer Biology)

Arginine and Cancers: Molecular Mechanisms and Anticancer Therapy

edited by

Maria Francesca Baietti

submission deadline 31 Dec 2026 | Viewed by 435 | Submission Open

Keywords: arginine; cancer; therapy; immunotherapy; metabolism

(This special issue belongs to the Section Cancer Therapy)

Genomics and Genetics in Brain Cancer Treatment, Diagonals, and Prognosis

edited by

Nan Hu

submission deadline 31 Dec 2026 | Viewed by 412 | Submission Open

Keywords: genomics; genetics; brain tumor; brain cancer; glioblastoma multiform; glioma; cancer diagnosis; cancer prognosis

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Intercepting Genitourinary Cancers: Emerging Targets and Promising Interventions

edited by Manish Kumar Gupta, Mohan Kamthan and

Venkateshwar Madka

submission deadline 31 Dec 2026 | Viewed by 411 | Submission Open

Keywords: genitourinary cancers; bladder cancer; prostate cancer; kidney cancer; cancer interception; prevention; molecular targeted agent; natural compounds; synthetic molecules; preclinical study; clinical trial; drug repurposing; efficacy evaluation

(This special issue belongs to the Section Molecular Cancer Biology)

Advances in Cancer Biostatistics

edited by Seongho Kim

submission deadline 31 Dec 2026 | Viewed by 402 | Submission Open

Keywords: artificial intelligence; bioinformatics; biostatistics; clinical trial design; computational statistics; electronic medical records; experimental design; machine learning; multi-omics; statistical software

(This special issue belongs to the Section Cancer Informatics and Big Data)

Long-Read Sequencing in Cancer (2nd Edition)

edited by

Luca Ermini

and Patrick Driguez

submission deadline 31 Dec 2026 | Viewed by 394 | Submission Open

Keywords: long-read sequencing; cancer genetics; genomics; transcriptomics; methylomics; cancer research

(This special issue belongs to the Section Molecular Cancer Biology)

Real-World Clinical Studies in Acute Leukemia

edited by

Anna Candoni

submission deadline 31 Dec 2026 | Viewed by 393 | Submission Open

Keywords: acute myeloid leukemia (AML); acute lymphoid leukemia (ALL); refractory/relapsed leukemia; target therapy; FLT3 inhibitors; IDH (1-2) inhibitors; venetoclax; hypomethylating agents; stem cell transplantation (SCT); minimal residual disease (MRD); MRD-driven therapy

(This special issue belongs to the Section Clinical Research in Cancer)

Ras-Directed Therapies: A Revolution

edited by

Naiara Perurena

submission deadline 31 Dec 2026 | Viewed by 385 | Submission Open

Keywords: Ras-driven cancers; Ras inhibitors; Ras degraders; Ras signaling; mechanisms of resistance; combination therapies

(This special issue belongs to the Section Cancer Therapy)

Advances in Health Equity to Reduce Cancer Health Disparities

edited by

Tomi Akinyemiju

submission deadline 31 Dec 2026 | Viewed by 380 | Submission Open

Keywords: cancer health equity; cancer disparities; systemic racism; precision equity; social determinants of health; cancer prevention and early detection; survivorship; community-engaged research; implementation science; clinical trials; qualitative and mixed methods; molecular and multi-omics epidemiology; health systems research; health policy

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Diagnosis and Treatment of Osteosarcoma

edited by

Alexander Lazarides

and

Sarah C Tepper

submission deadline 31 Dec 2026 | Viewed by 351 | Submission Open

Keywords: osteosarcoma; bone sarcoma; diagnosis; imaging; biomarkers; limb salvage; endoprosthetic reconstruction; chemotherapy response; metastatic osteosarcoma; targeted therapy

Early Detection and Strategies for Overcoming Therapy Resistance in Lung Cancer and Mesothelioma

edited by

Katalin Dobra

submission deadline 31 Dec 2026 | Viewed by 341 | Submission Open

Keywords: lung cancer; mesothelioma; screening; biomarker; molecular diagnostics; resistance

(This special issue belongs to the Section Cancer Therapy)

Next-Generation Cancer Therapeutics: Precision Oncology Through Novel Inhibitors and Their Mechanism of Action

edited by

Mona Kamal Saadeldin

Hosam Gharib Abdelhady

and

Mihail Mitov

submission deadline 31 Dec 2026 | Viewed by 339 | Submission Open

Keywords: precision oncology; novel inhibitors; epigenetic targets; cancer metabolism; mechanism of action

(This special issue belongs to the Section Cancer Therapy)

Gene Regulation and Immune Checkpoints in Cancer Immunotherapy: Mechanisms and Therapeutic Opportunities

edited by

Mohanraj Sadasivam

submission deadline 31 Dec 2026 | Viewed by 331 | Submission Open

Keywords: gene regulation; immune checkpoints; cancer immunotherapy; epigenetics; non-coding RNAs; tumor microenvironment; immune resistance; PD-1/PD-L1 pathway; chromatin remodeling; multi-omics profiling

(This special issue belongs to the Section Cancer Immunology and Immunotherapy)

Breast Cancer Evolution—Insights from Single-Cell Genomics

edited by

Cynthia Ma

submission deadline 31 Dec 2026 | Viewed by 329 | Submission Open

Keywords: single-cell genomics; tumor evolution; intratumoral heterogeneity; lineage plasticity; therapy resistance; spatial transcriptomics; tumor microenvironment; clonal dynamics; multi-omics profiling

(This special issue belongs to the Section Molecular Cancer Biology)

Novel Therapeutic Approaches and Resistance Mechanisms in Oral Squamous Cell Carcinoma

edited by

Dali Zheng

submission deadline 31 Dec 2026 | Viewed by 321 | Submission Open

Keywords: oral squamous cell carcinoma; chemoresistance; drug delivery; therapeutic; molecular mechanism

(This special issue belongs to the Section Cancer Therapy)

Magnetic Resonance in Cancer Research (2nd Edition)

edited by Qiuhong He and Marie-France Vidaver

submission deadline 31 Dec 2026 | Viewed by 321 | Submission Open

Keywords: magnetic resonance; cancer; MRI; MRS; MRSI; NMR; DWI; MR; molecular imaging

(This special issue belongs to the Section Methods and Technologies Development)

Novel Insights into Mechanisms of Cancer-Associated Thrombosis: 2nd Edition

edited by Tom A J Mckinnon

submission deadline 31 Dec 2026 | Viewed by 320 | Submission Open

Keywords: cancer; thrombosis; venous; arterial

(This special issue belongs to the Section Molecular Cancer Biology)

Serum Biomarkers to Monitor Cancer Progression and Response to Therapy

edited by

Vincenzo De Falco

submission deadline 31 Dec 2026 | Viewed by 317 | Submission Open

Keywords: biomarkers; cancer; tumor

(This special issue belongs to the Section Tumor Microenvironment)

Progress in Targeted Nanotherapeutic Delivery Systems for Cancer Precision Medicine

edited by

Linlin Zhang

and Dhananjay Suresh

submission deadline 31 Dec 2026 | Viewed by 308 | Submission Open

Keywords: cancer therapy; drug delivery; tumor targeting; nanotechnology; precision medicine; immunotherapy; new approach methodologies (NAMs)

(This special issue belongs to the Section Methods and Technologies Development)

p53 Signaling in Cancer: Current Advances and Future Directions

edited by

Ruiying Zhao

and

Trinh T. T. Phan

submission deadline 31 Dec 2026 | Viewed by 291 | Submission Open

Keywords: p53 signaling; cancer biology; tumor microenvironment; biomarker; therapeutic strategies

(This special issue belongs to the Section Cancer Pathophysiology)

Precision Synergy in Cancer Treatment

edited by

Shigao Huang

and

Ammad Ahmad Farooqi

submission deadline 31 Dec 2026 | Viewed by 291 | Submission Open

Keywords: combination therapy; cancer treatment; radiation protection; cell damage; protective drugs; immunotherapy; targeted therapy; precision medicine; treatment resistance; multimodal therapy; synergistic effects

(This special issue belongs to the Section Cancer Therapy)

Integrated Nuclear Medicine and Radiotherapy Approaches in Head and Neck Tumors

edited by Mansoor M. Ahmed and Kamila Rawojć

submission deadline 31 Dec 2026 | Viewed by 289 | Submission Open

Keywords: glioblastoma; head and neck cancer; nuclear medicine; molecular imaging; PET biomarkers; proton therapy; radio-resistance; image-guided/adaptive radiotherapy; translational oncology

(This special issue belongs to the Section Methods and Technologies Development)

Innovations in Radioligand Therapy for Solid Tumors

edited by

Stefano Panareo

submission deadline 31 Dec 2026 | Viewed by 283 | Submission Open

Keywords: RLT; solid tumors; alpha/beta emitters; theranostic; therapy combination

(This special issue belongs to the Section Cancer Therapy)

Palliative and Supportive Care in Oncology

edited by

Carmen Roch

and Heidrun Golla

submission deadline 31 Dec 2026 | Viewed by 275 | Submission Open

Keywords: screening; timely palliative care; caregivers; symptom control; digitalization; care structures; gender-specific aspects

(This special issue belongs to the Section Cancer Survivorship and Quality of Life)

Novel Therapeutic Classes in Lung Cancer

edited by

Rajat Thawani

and

Rohit Singh

submission deadline 31 Dec 2026 | Viewed by 268 | Submission Open

Keywords: non-small-cell lung cancer; small-cell lung cancer; antibody–drug conjugates; bispecific antibodies; resistance mechanisms; precision oncology; immunotherapy combinations

(This special issue belongs to the Section Cancer Therapy)

Clinical and Translational Applications of Liquid Biopsy in the Diagnosis and Management of Gastrointestinal Cancers

edited by Katsushi Takebayashi

submission deadline 31 Dec 2026 | Viewed by 267 | Submission Open

Keywords: liquid biopsy; gastrointestinal cancer; circulating tumor DNA; biomarkers; cell culture; organoids; minimal residual disease; treatment monitoring; translational oncology

(This special issue belongs to the Section Cancer Causes, Screening and Diagnosis)

Advances and Challenges in Head and Neck Cancer

edited by

Marc Oliva

, Leonor Abreu Ribeiro and Claúdia Vieira

submission deadline 31 Dec 2026 | Viewed by 266 | Submission Open

Keywords: head and neck cancer; biomarkers; immunotherapy; radiosensitizers; multiple tumors

Advancing Theranostics in Oncology: Radiopharmaceuticals from Discovery to Clinical Applications

edited by Hwan Lee, Joseph Lau and

Etienne Rousseau

submission deadline 31 Dec 2026 | Viewed by 262 | Submission Open

Keywords: theranostics; radiopharmaceutical; positron emission tomography; single photon emission computed tomography; targeted radionuclide therapy; dosimetry; cancer

Oncological Outcomes of Active Surveillance Versus Radical Treatment in Localized Prostate Cancer

edited by

Maciej Salagierski

submission deadline 31 Dec 2026 | Viewed by 235 | Submission Open

Keywords: active surveillance; molecular markers; multiparametric magnetic resonance imaging; prostate cancer

Advances in Vaccines for the Treatment and Prevention of Cancer

edited by

Erika J Crosby

and Emilia Diego

submission deadline 31 Dec 2026 | Viewed by 231 | Submission Open

Keywords: cancer vaccines; neoantigens; tumor-specific antigens; mRNA vaccines; viral vector vaccines; dendritic cell vaccines; immunotherapy; adjuvants; biomarkers of vaccine response; personalized cancer vaccines

Advances in Drug Delivery for Brain Tumors

edited by

Hong-Jian Wei

and Cheng-Chia Wu

submission deadline 31 Dec 2026 | Viewed by 226 | Submission Open

Keywords: brain tumors; glioma; drug delivery; blood–brain barrier; focused ultrasound; convection-enhanced delivery; nanoparticle; exosome; drug conjugate

(This special issue belongs to the Section Cancer Drug Development)

Cancer and the Brain: Brain and Tumor Interplay, the Nervous System's Vulnerabilities and Therapeutic Opportunities

edited by Sylvia C. Kurz

submission deadline 31 Dec 2026 | Viewed by 221 | Submission Open

Keywords: neuro-oncology; primary CNS tumors; secondary CNS tumors; neural networks; glioma cell and neuron crosstalk; brain tumor-related epilepsy; neurotoxicity from cellular immunotherapies

Advances in Diagnostics and Prognostics Tools for Prostate Cancer

edited by

Antonio Celia

, Tommaso Silvestri and Sara Riolo

submission deadline 31 Dec 2026 | Viewed by 215 | Submission Open

Keywords: prostate cancer; prostate biopsy; liquid biopsy; tissue biopsy; biomarkers; staging; risk stratification; prognostic tools

Anal Squamous Cell Carcinoma (SCC)

edited by

Evie H. Carchman

submission deadline 31 Dec 2026 | Viewed by 210 | Submission Open

Keywords: HPV; anal cancer; screening; chemoradiotherapy; immunotherapy

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